Catalog No.
Product Name
Application
Product Information
Citations
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Neuropeptide
α-CGRP (mouse, rat) is a neuropeptide that primarily targets the neuromuscular junction and functions as a potent vasodilator. It is known to induce a decrease in blood pressure and an increase in heart rate upon peripheral administration, and it also promotes relaxation of colonic smooth muscle. This peptide is valuable for research applications in cardiovascular studies, pro-inflammatory responses, migraine pathophysiology, and metabolic processes. -
Calcitonin Peptide
β-CGRP, human is a member of the calcitonin peptide family and functions through binding to the calcitonin-receptor-like receptor (CRLR) in conjunction with receptor-activity-modifying proteins (RAMPs). It exhibits high affinity, with IC50 values of 1 nM for the CRLR/RAMP1 complex and 300 nM for the CRLR/RAMP2 complex in cellular assays. This peptide is crucial for research in pain modulation, migraine mechanisms, and neurobiological studies. -
CGRP Receptor Activator
Calcitonin Gene Related Peptide II (rat) is a CGRP receptor activator that functions as a potent and enduring vasodilator. It plays a crucial role in the regulation of vascular tone and blood pressure. This peptide is utilized in research on cardiovascular diseases, aiding in the exploration of therapeutic strategies for conditions such as hypertension and vascular dysfunction. -
Bioactive Peptide
Biotin-Gastrin-1, human (1-17) is a bioactive peptide that functions through the gastrin receptor. It plays a critical role in stimulating gastric acid secretion and promoting gastrointestinal motility. This compound is invaluable for research applications involving digestive physiology, cancer biology, and peptide signaling pathways. -
Peptide Hormone
Gastrin I (Rat Gastrin-17) is a peptide hormone that primarily stimulates gastric acid secretion. It plays a crucial role in digestive processes by promoting the production of gastric acid, thereby facilitating digestion and nutrient absorption. This compound is essential for research applications related to gastrointestinal physiology and peptic disorders. -
CCK Derivative
Cholecystokinin Octapeptide, desulfated TFA is a synthetic derivative of the endogenous hormone cholecystokinin (CCK), which primarily targets CCK receptors. This peptide exhibits key biological activities related to digestion and satiety regulation, making it valuable in studies of gastrointestinal physiology and appetite control. It is frequently utilized in research applications investigating the role of CCK in various biological processes, including pancreatic enzyme secretion and gastric motility. -
Bioactive Peptide
[Lys3]-Bombesin is a bioactive peptide that targets the gastrin-releasing peptide receptor (GRPR). Its primary application includes PET imaging for detecting GRPR-positive prostate cancer, facilitating non-invasive tumor visualization. Additionally, [Lys3]-Bombesin can be utilized in immunoconjugates with monoclonal antibodies to selectively induce CD64-dependent lysis of small cell carcinoma by monocytes and neutrophils, providing insights into targeted cancer therapies. -
Peptide Hormone
CCK (26-31) sulfated is a peptide hormone fragment that plays a crucial role in gastrointestinal function and neuroendocrine signaling. This bioactive peptide is involved in stimulating digestive processes, modulating appetite, and influencing anxiety-related behavior. Research applications include studies on gut-brain interactions, appetite regulation, and the pharmacological effects of peptide hormones in both physiological and pathological contexts. -
C-terminal heptapeptide of CCK
CCK (27-33) is the C-terminal heptapeptide derived from cholecystokinin (CCK), which primarily targets CCK receptors. This peptide plays a significant role in stimulating gallbladder contraction and promoting pancreatic enzyme secretion, making it crucial for investigating digestive processes. CCK (27-33) is utilized in research applications focusing on gastrointestinal physiology and receptor signaling pathways. -
Acidic Peptide
Minigastrin is an acidic peptide that primarily targets the gastrin receptor. It plays a crucial role in stimulating gastric acid secretion and is utilized in research applications involving gastrointestinal physiology and pathology. Minigastrin can be employed to investigate peptide-peptide interactions and their implications in digestive disorders. -
Human Gastrin I Peptide
Gastrin I (1-14), human is the 1-14 fragment of the human gastrin I peptide, which acts as an endogenous gastrointestinal hormone. This peptide plays a crucial role in regulating gastric acid secretion, influencing digestive processes. It is predominantly used in research applications focused on gastrointestinal physiology and peptic disorders. -
Neuropeptide
Neuropeptide SF (human) serves as a neuropeptide that primarily targets the regulation of paraventricular corticotrophin-releasing hormone (CRH) release. This neuropeptide enhances the release of adrenocorticotropic hormone (ACTH) and increases plasma corticosterone levels, playing a crucial role in modulating circadian functions, including motor center activity and the hypothalamic-pituitary-adrenal (HPA) axis. It is useful for research applications focused on stress response and circadian rhythm regulation. -
Neuropeptide
Neuropeptide SF (human) acetate is a neuropeptide that targets the paraventricular nucleus to enhance corticotrophin-releasing hormone (CRH) release. It is known to elevate plasma levels of adrenocorticotropic hormone (ACTH) and corticosterone, playing a vital role in the regulation of circadian functions, including motor activity and the hypothalamic-pituitary-adrenal (HPA) axis. This reagent is useful in research applications related to stress response, endocrine signaling, and neuroendocrine regulation. -
CRH Receptor Ligand
Stresscopin-related peptide (human) is a specific ligand for the corticotropin-releasing hormone (CRH) receptor type 2. It is known to suppress food intake, delay gastric emptying, and reduce heat-induced edema. This peptide plays a crucial role in maintaining homeostasis following stress and is valuable for research into stress-related disorders and physiological responses. -
CXCR4 Inhibitor
Peptide R is a cyclic peptide that functions as a specific antagonist of the CXCR4 receptor. It demonstrates significant efficacy in remodeling tumor stroma, making it a valuable tool for tumor research. Its ability to modulate the tumor microenvironment highlights its potential applications in cancer therapy and investigation into tumor progression mechanisms. -
peptide
Polyphemusin II-Derived Peptide (T140) is a potent CXCR4 inhibitor that effectively blocks HIV-1 entry into host cells. Its mechanism involves disrupting the interaction between CXCR4 and the HIV-1 envelope glycoprotein, offering a targeted approach to HIV research. Additionally, T140 has been shown to inhibit the binding of the anti-CXCR4 monoclonal antibody (12G5) to its receptor, making it a valuable tool for studying CXCR4-related pathways and potential therapeutic interventions in viral infections. -
Radiolabeled Peptide
Pentixather is a radiolabeled peptide that specifically targets the CXCR4 receptor. By interfering with the CXCR4/CXCL12 signaling axis, Pentixather disrupts the interaction between leukemic cells and the bone marrow microenvironment, thereby promoting the release of leukemic cells from the protective niche and increasing their sensitivity to therapeutics. This compound is valuable for research applications in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). -
apoE-mimetic Peptide
COG112 is an antennapedia-linked apoE-mimetic peptide that targets inflammatory pathways. It effectively attenuates nitric oxide production and inhibits the expression of CXC chemokines such as KC and MIP-2. Additionally, COG112 reduces the nuclear translocation of NF-κB and inhibits the phosphorylation of IκB-α, thereby preventing its degradation. This peptide is valuable for research applications focused on modulating inflammatory responses, particularly in the context of Citrobacter rodentium infection. -
Inflammatory Peptide
Peptide 78 is an inflammatory peptide that functions as a chemotactic cytokine, belonging to the IL-8 or C-X-C chemokine supergene family. This 78 amino acid protein is essential for the recruitment of neutrophils to sites of inflammation, particularly in rheumatoid arthritis (RA) pathology. Its role in promoting neutrophil migration makes Peptide 78 a valuable tool for research into inflammatory diseases and immune responses. -
Secretoneurin Peptide Fragment
Secretoneurin, rat, is a 33-amino acid polypeptide derived from the proteolytic processing of secretogranin II (SgII). This peptide plays a significant role in neuropharmacology by stimulating dopamine release in the rat striatum, both in vivo and in vitro. Additionally, Secretoneurin exhibits a potent chemotactic effect on monocytes and eosinophils, while showing no significant activity against granulocytes. This makes it valuable for research applications focused on neurobiology and immune response mechanisms. -
Peptide-Drug Conjugate
PhAc-ALGP-Dox is a peptide-drug conjugate designed for targeted anticancer therapy. This prodrug demonstrates significant cytotoxic activity against triple-negative breast cancer (TNBC) cell lines, with IC50 values ranging from 311 nM to 34.25 μM for E0771, MDA-MB-231, and MDA-MB-468, as well as exhibiting effects on colorectal carcinoma (CrC) cells (LS 174T) and normal epithelial cells. Its unique mechanism allows for selective delivery of doxorubicin, making it a valuable tool for research applications focused on improving chemotherapy efficacy and reducing off-target effects in cancer treatment. -
Peptide
BPP 5a is a bradykinin-potentiating peptide known for its vasorelaxant properties, derived from Bothrops jararaca venom. This peptide functions as an angiotensin-converting enzyme (ACE) inhibitor with a Ki value of 400 nM. BPP 5a is primarily utilized in research focused on hypertension and cardiovascular diseases, offering insights into potential therapeutic applications. -
Bioinspired Peptide
DDDEEKC is a bioinspired peptide that selectively adsorbs onto enamel surfaces, mimicking the function of statherin, a salivary protein. This peptide acts as a guiding agent for the remineralization of tooth enamel, significantly enhancing the regeneration of hydroxyapatite (HAP). DDDEEKC is valuable for research focused on in-situ repair of enamel demineralization, including conditions such as dental caries. -
Antitumor Peptide
Tezuvotide tetraxetan is an antitumor peptide designed to target cancer cells through specific receptor interactions. It exhibits potent antineoplastic activity, making it a valuable tool for studying tumor biology and therapeutic approaches in cancer research. Its mechanism of action and specificity provide insights into potential applications in targeted therapies and clinical investigations. -
Polypeptide
Ganipatide is a glucose-dependent insulinotropic polypeptide consisting of 31 amino acids. It plays a pivotal role in enhancing insulin secretion in response to food intake, making it significant in the study of glucose metabolism and diabetes management. This polypeptide is useful for investigating mechanisms of insulin regulation and potential therapeutic approaches for type 2 diabetes. -
Peptide for BH3 Profiling
MS1 peptide is a significant tool for BH3 profiling, designed to enhance the depolarization of mitochondrial membranes in melanoma cells, particularly those pre-treated with Encorafenib. This peptide serves as a valuable research reagent for investigating the mechanisms underlying BRAFV600E melanoma and its response to targeted therapies. Its application facilitates the exploration of apoptotic signaling pathways in cancer research, aiding in the development of novel therapeutic strategies. -
P53 Activating Peptide
PK7088 is a pyrazole-based compound that serves as a specific p53 activating peptide. It facilitates the reactivation of mutant p53, restoring its wild-type functionalities. Due to its ability to enhance p53 activity, PK7088 demonstrates significant anticancer properties, making it a valuable tool in cancer research aimed at targeting p53 mutations. -
Anticancer Peptide
PNC-27 is a chimeric anticancer peptide that targets HDM-2 through its p53-like structure. It induces selective membrane pore formation, leading to the lysis of cancer cells. This reagent is particularly applicable in research focused on acute myeloid leukemia and offers insights into mechanisms of apoptosis and tumor suppression. -
Bioactive Peptide
p53 CBS is a bioactive peptide that corresponds to the consensus binding sequence of the p53 tumor suppressor protein. This peptide is crucial for studying p53-DNA interactions and provides insights into the regulation of gene expression in response to cellular stress. Research applications include elucidating the mechanisms of p53-mediated transcriptional activation and investigating its role in tumorigenesis and apoptosis. -
Peptide
p53 (17-26) is a peptide derived from the MDM2 binding domain of the tumor suppressor p53, with a binding affinity (Kd) of 50 nM for MDM2. This peptide demonstrates significant biological activity by inducing necrosis in cancer cells through disruption of cellular integrity and nuclear membrane damage. Research applications for p53 (17-26) include studies focused on pancreatic cancer and the development of therapeutic strategies targeting MDM2-mediated pathways. -
Tumor Suppressor Peptide
p53 (232-240) is a peptide derived from the 232-240 amino acid sequence of the human tumor suppressor protein p53. This peptide enhances binding affinity to the Major Histocompatibility Complex (MHC), thus increasing its immunogenicity and bolstering the immune system's response to tumor antigens. p53 (232-240) is valuable in cancer vaccine development and studies focused on tumor cell recognition and clearance by immune cells. -
Inducing Peptide
Peptide 234CM is an inducing peptide that features isoleucine at position 3, reflecting a point mutation in p53 codon 234. This peptide is known to elicit strong cytotoxic T cell (CTL) responses and robust antitumor immune responses against the mutant form of p53. It is valuable in immunological research focusing on cancer therapy and the enhancement of immune response mechanisms. -
MDM2/p53 Inhibitor
Phage-derived 12/1 peptide is a potent inhibitor of the MDM2/p53 interaction, effectively disrupting the binding between MDM2 and p53, as well as MDMX and p53. This peptide demonstrates significant antitumor activity, exhibiting IC50 values of 0.15 μM for MDM2 and 1.25 μM for MDMX. It serves as a valuable tool for research investigating the modulation of p53 activity and the therapeutic potential in targeting MDM2/MDMX pathways in cancer. -
Polypeptide
N1-Glutathionyl-spermidine disulfide acts as a substrate for trypanothione reductase, an enzyme critical in the redox regulation of trypanothione in certain organisms. This compound plays a significant role in cellular antioxidant defense mechanisms and is relevant for studies involving oxidative stress and redox biology. Its use can enhance understanding of trypanosomatid parasites and the biochemical pathways they exploit, facilitating research in parasitology and drug development. -
Antiparasitic Agent
Cycloaspeptide A is an antiparasitic agent derived from the endophytic fungus Penicillium janczewskii. It exhibits potent biological activity against various parasitic organisms, making it a valuable tool in parasitology research. This compound holds promise for further exploration in the development of novel therapeutic strategies to combat parasitic infections. -
Tetrapeptide
AGPV is a tetrapeptide that demonstrates potential for the prevention of schistosome parasite infections. This compound may be valuable in research focused on developing novel therapeutic strategies for schistosomiasis, a significant public health concern. Its biological activity warrants exploration in parasitology and drug development applications. -
Chromogenic Peptide Substrate
Bz-Pro-Phe-Arg-pNA is a chromogenic peptide substrate designed for the detection and study of plasma and glandular kallikrein, cysteine proteinase (Cruzipain), and trypsin. This substrate facilitates real-time monitoring of enzyme activity through colorimetric changes, making it a valuable tool in biochemical assays. Additionally, Bz-Pro-Phe-Arg-pNA is applicable in Factor XII assays, enhancing research in coagulation and protease activity. -
Antiplasmodial Peptide
Koshidacin B is an antiplasmodial cyclic tetrapeptide that exhibits potent activity against Plasmodium falciparum, with IC50 values of 0.89 μM for the FCR3 strain and 0.83 μM for the K1 strain. This compound effectively suppresses malaria parasites in vivo, making it a valuable tool for research in parasitic infections and the development of novel antimalarial therapies. -
Cyclodepsipeptide
Isariin D is a cyclodepsipeptide derived from the fungus Isaria felina, known for its potent insecticidal properties. This compound demonstrates significant biological activity against Galleria mellonella larvae, making it a valuable tool in entomological research and pest management studies. Its unique mechanism may provide insights into insect physiology and the development of natural insecticides. -
Cyclodepsipeptide
Isariin A is a cyclodepsipeptide derived from the fungus Isaria cretacea, known for its antimalarial properties. Research indicates its potential efficacy in inhibiting the proliferation of malaria parasites, making it a valuable compound for studies targeting malaria treatment and understanding related biological pathways. -
Cyclodepsipeptide
Isariin B is a cyclodepsipeptide derived from the fungus Isaria felina, recognized for its antimalarial properties. This compound demonstrates significant biological activity against Plasmodium species, making it a valuable tool in malaria research. Its unique structure and mechanism of action offer potential for the development of novel therapeutic agents in combating malaria. -
Retroviral Envelope Peptide
CKS-17 is a synthetic retroviral envelope peptide that targets the highly conserved amino acid sequences within the transmembrane envelope protein of various animal and human retroviruses. This peptide functions as an immunomodulatory epitope, exhibiting suppressive properties on numerous immune functions. CKS-17 is valuable for research applications focused on retroviral biology, immune modulation, and the development of therapeutic strategies against retroviral infections. -
HIV Inhibitor
(D-Ala)-Peptide T is an octapeptide that acts as an HIV inhibitor by targeting the HIV-1 envelope glycoprotein gp120. This compound has been shown to release chemokines and protect against neuronal death induced by gp120. It is a valuable reagent for research into infectious diseases and neurological disorders, particularly AIDS-related dementia. -
Polypeptide
HIV-2 Peptide is a polypeptide utilized in research focusing on HIV-2. It serves as a valuable tool for protein interaction studies, functional analysis, and epitope screening, particularly in the context of agent research and development. This peptide facilitates the understanding of immune responses and the development of therapeutic strategies related to HIV-2 infections. -
Peptide
(Cys47)-HIV-1 tat Protein (47-57) is a peptide known for its ability to facilitate membrane translocation. This peptide can be utilized to modify the surface of magnetic pharmaceuticals, significantly enhancing their uptake into target cells. It serves as a valuable tool in drug delivery systems and cellular uptake studies in research applications. -
Cell-Penetrating Peptide
TAT (47-57), FAM-labeled is a cell-penetrating peptide (CPP) that enhances the delivery of therapeutic agents into cells. This peptide facilitates the transport of various cargoes, making it a valuable tool for intracellular drug delivery studies. Its FAM labeling allows for easy monitoring and tracking in biological systems, enabling researchers to explore applications in drug formulation and cellular uptake mechanisms. -
Antimicrobial Peptides
Siamycin III is an antimicrobial peptide that exhibits activity against HIV-1. It is primarily used in research applications focusing on antiviral mechanisms and the development of therapies targeting viral infections. The compound's ability to interfere with viral replication makes it a valuable tool for studies in HIV-1 biology and treatment strategies. -
HIV Entry Inhibitor
T-peptide is an HIV entry inhibitor that functions as a Tuftsin analog, effectively targeting HIV infection. This compound is known to mitigate cellular immunosuppression and enhance survival rates in septic mouse models. Additionally, T-peptide demonstrates the ability to inhibit the growth of residual tumor cells following surgical resection, making it a valuable tool for oncological and infectious disease research applications. -
HIV-1 gp120 Peptide
Peptide T TFA is an octapeptide derived from the V2 region of the HIV-1 gp120 protein. It functions as a ligand for the CD4 receptor, effectively inhibiting the binding of HIV to this receptor. This compound is valuable in research applications focused on HIV-1 infection mechanisms and the development of potential therapeutic interventions. -
HIV Peptide Epitope
HIV gp120 (318-327) is a peptide epitope derived from the C-terminal region of the HIV-1 strain IIIB envelope glycoprotein. This sequence, known as the I10 peptide, is involved in the immune response and is part of the V3 peptide epitope relevant for HIV vaccine research. Although HIV gp120 (318-327) does not contain the A2 anchor residues recognized by cytotoxic T lymphocytes, it possesses structural characteristics that facilitate promiscuous binding to A2, making it valuable for studying HIV immunogenicity and vaccine development.
