COG112 is an antennapedia-linked apoE-mimetic peptide that targets inflammatory pathways. It effectively attenuates nitric oxide production and inhibits the expression of CXC chemokines such as KC and MIP-2. Additionally, COG112 reduces the nuclear translocation of NF-κB and inhibits the phosphorylation of IκB-α, thereby preventing its degradation. This peptide is valuable for research applications focused on modulating inflammatory responses, particularly in the context of Citrobacter rodentium infection.
COG112 is an antennapedia-linked apoE-mimetic peptide that targets inflammatory pathways. It effectively attenuates nitric oxide production and inhibits the expression of CXC chemokines such as KC and MIP-2. Additionally, COG112 reduces the nuclear translocation of NF-κB and inhibits the phosphorylation of IκB-α, thereby preventing its degradation. This peptide is valuable for research applications focused on modulating inflammatory responses, particularly in the context of Citrobacter rodentium infection.
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