Catalog No.
Product Name
Application
Product Information
Citations
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Neuropeptide Y1 Antagonist
J-115814 is a potent and selective antagonist of the neuropeptide Y1 receptor, exhibiting Ki values of 1.4 nM for human Y1, 1.8 nM for rat Y1, and 1.9 nM for mouse Y1, with significantly lower affinity for other neuropeptide Y receptors. This compound has demonstrated the ability to inhibit feeding behaviors, making it a valuable tool in obesity and appetite regulation research. Its specificity and potency make J-115814 suitable for studies investigating neuropeptide signaling and related physiological processes. -
Neuropeptide Y Receptor Antagonist
FR252384 is a potent antagonist of the neuropeptide Y-Y5 receptor, demonstrating an IC50 of 2.3 nM. This compound plays a significant role in research related to appetite regulation, anxiety, and stress responses. Its ability to selectively inhibit neuropeptide Y signaling makes it a valuable tool for investigating the underlying mechanisms of these biological processes. -
Neurotensin Octapeptide
Xenopsin is a neurotensin-like octapeptide derived from the skin of Xenopus laevis. It primarily functions as an inhibitor of Tetragastrin-stimulated gastric acid secretion, making it valuable for studies related to gastrointestinal physiology and acid regulation. Research applications include investigations into peptide signaling pathways and gastrointestinal disorders. -
Opioid Peptide
β-Casomorphin, bovine, is an opioid peptide that primarily targets opioid receptors. With an IC50 value of 14 μM in binding assays, it demonstrates significant affinity for these receptors. This compound is utilized in research applications focused on the study of pain modulation, addiction, and the physiological effects of opioid peptides in various biological contexts. -
μ-opioid Agonist
Acetyl tetrapeptide-15 is a synthetic peptide that functions as a μ-opioid agonist. It mimics the action of endomorphin-2, promoting selective anti-nociceptive effects that alleviate skin hyperreactivity associated with inflammatory, chronic, and neuropathic pain. By enhancing the threshold of neuronal excitability through μ-opioid receptor pathways, Acetyl tetrapeptide-15 is primarily utilized in cosmetic formulations aimed at sensitive skin. -
Tetrapeptide
Bilaid B is a tetrapeptide that resembles opioid peptides with a distinct LDLD amino acid configuration. This unique arrangement enhances its biological activity and specificity for opioid receptors. Bilaid B is primarily used in research applications focusing on pain modulation and neuropharmacology, making it a valuable tool for studying opioid receptor function and therapeutic potentials. -
Nociceptin/Orphanin FQ Peptide Receptor Antagonist
MK-5757 is a potent Nociceptin/Orphanin FQ Peptide Receptor antagonist. It has been shown to improve cerebral blood flow and mitigate ischemic damage, making it valuable for studying neurological disorders. This compound is particularly relevant for research into traumatic brain injury and other neurodegenerative conditions characterized by abnormal neurological symptoms. -
Opioid Peptide
α-Neoendorphin (1-8) is an octapeptide derived from the N-terminal region of the endogenous opioid peptide α-Neoendorphin. It primarily targets opioid receptors, exerting analgesic effects and modulating pain responses in various biological systems. This peptide is utilized in research applications focused on pain management, neurobiology, and the study of opioid signaling pathways. -
Bioactive Peptide
Deltorphin, a bioactive peptide, is a potent and selective agonist for the delta-opioid receptor. Isolated from the skin of the South American frog, Phyllomedusa sauvagei, Deltorphin exhibits significant analgesic properties. This compound is widely used in research applications focused on pain modulation, addiction, and the pharmacological characterization of opioid receptors. -
Opioid Neuropeptide
β-Endorphin (rat) is an endogenous opioid neuropeptide that primarily targets opioid receptors, playing a key role in pain modulation. Its analgesic properties make it significant in studies related to pain management and the regulation of food intake in satiated states. This reagent is valuable for research investigating neurological disorders, including analgesia and drug addiction. -
Kappa Opiate Receptor Agonist
Peptide E is a potent kappa opiate receptor agonist that exhibits strong binding affinity with an IC50 value of 0.39 μM. This compound is valuable for studying the role of kappa receptors in the central nervous system. Its biological activity makes it suitable for research focused on pain modulation, addiction, and other neurological disorders. -
ANP Peptide Fragment
ANP (1-30), frog is a peptide fragment of atrial natriuretic peptide that exhibits natriuretic, diuretic, and vasorelaxant properties. This compound is valuable for research in cardiovascular physiology and fluid homeostasis, as it plays a crucial role in regulating blood pressure and electrolyte balance. Its unique properties make ANP (1-30), frog an essential tool for investigations into cardiac function and therapeutic potential for hypertension-related disorders. -
Mitochondrial N-formyl Peptide
N-Formyl-MMYALF is a potent mitochondrial N-formyl peptide (mtFP) that selectively targets calcium ion depletion in the endoplasmic reticulum. This compound effectively inhibits the FPR-1-mediated chemotactic response of polymorphonuclear leukocytes (PMNs) to bacterial peptides, making it valuable for research in inflammation and immune response. Its utility in investigating mitochondrial function and leukocyte signaling pathways underscores its significance in the study of cellular calcium dynamics and immune modulation. -
FPRs Binding Peptide
N-Formyl-Met-Ala-Ser is a peptide that specifically binds to formyl peptide receptors (FPRs) on neutrophils. This interaction plays a crucial role in the regulation of immune responses and chemotactic activity. N-Formyl-Met-Ala-Ser is valuable for research applications related to inflammation, host defense mechanisms, and the study of neutrophil behavior. -
Bioactive Peptide
WRW4-OH is a bioactive peptide that selectively inhibits the binding of the FPRL1 agonist WKYMVm to its corresponding receptor. FPRL1 plays a crucial role as a classical chemoattractant receptor found in phagocytic cells within the peripheral blood and brain. The modulation of FPRL1 is of significant interest in research related to inflammatory responses and neurodegenerative disorders, making WRW4-OH a valuable tool for studies in immunology and neurobiology. -
Neuropeptide
Neuromedin S (human) is a neuropeptide comprising 33 amino acids, functioning primarily as a ligand for the orphan G-protein coupled receptor FM-4/TGR-1 and the neuromedin U receptor 2 (NMUR2). This peptide plays a crucial role in the regulation of body weight homeostasis, making it valuable for research in metabolic disorders and neurobiology. Its unique mechanism of action positions Neuromedin S as an essential tool for studying the signaling pathways associated with energy balance and obesity-related conditions. -
vasoactive Peptide
Endothelin-3 is a 21-amino acid vasoactive peptide that targets G-protein-coupled receptors, specifically ET-RA and ET-RB. This peptide plays a critical role in regulating vascular tone and blood pressure through its potent vasoconstrictive properties. It is primarily used in research applications related to cardiovascular physiology and pathology, as well as in studies investigating the role of endothelins in various disease models across human, mouse, rabbit, and rat systems. -
Neuropeptide Hormone
Corazonin is a conserved neuropeptide hormone that functions as a central regulator of caste identity and behavior in social insects. Its differential expression in worker and forager populations underscores its significant role in social organization and behavior within various insect species. This peptide is valuable for research into neurobiology, insect physiology, and social behavior dynamics. -
Pentapeptide
GLP-1(32-36)amide is a pentapeptide derived from the C terminus of the glucoregulatory hormone GLP-1. This compound has been shown to inhibit weight gain and positively influence whole-body glucose metabolism in diabetic mouse models. It serves as a valuable tool for studying metabolic disorders and potential therapeutic strategies for diabetes management. -
GLP-1 Peptides
GLP-1 (1-36) amide (human, rat) is a molecular variant of the glucagon-like peptide 1 (GLP-1) family. This peptide demonstrates the ability to stimulate [14C]aminopyrine accumulation in enzymatically dispersed rat parietal cells, indicating its role in gut hormone regulation. It is useful for research applications focused on metabolic disorders, glucose homeostasis, and appetite suppression, providing insights into obesity and diabetes mechanisms. -
GCGR Agonist
Glucagon-like peptide 1 (1-37), human is a potent agonist of the glucagon receptor (GCGR). This peptide plays a critical role in glucose metabolism and insulin signaling, making it valuable for research in diabetes and metabolic disorders. Its biological activity includes enhancing insulin secretion, inhibiting glucagon release, and promoting satiety, which are important for studies on obesity and diabetes therapies. -
Glicentin-related Pancreatic Polypeptide
GRPP (human) is a 30 amino acid peptide derived from glucagon, targeting the Glicentin-related Pancreatic Polypeptide. It is known to induce modest increases in plasma insulin levels while decreasing plasma glucagon concentrations. GRPP (human) serves as a valuable tool for research into pancreatic function and the regulation of glucose metabolism. Its specific effects on insulin and glucagon make it pertinent for studies related to metabolic disorders. -
Peptide
Exendin-4 (3-39) is a peptide that functions as a selective agonist for the Glucagon-like peptide-1 receptor (GLP-1r). This truncated variant of Exendin-4 is missing the first two amino acids, while retaining its bioactivity. Exendin-4 (3-39) is primarily employed in research exploring metabolic diseases, diabetes, and the hypothalamic-pituitary-adrenal (HPA) axis. Its structural modifications allow for investigations into receptor interactions and signaling pathways related to GLP-1r. -
Polypeptide
PHI-27 (porcine) is a 27 amino acid polypeptide that serves as a crucial tool for investigating peptide hormones and other biologically active peptides. Its structural properties enable researchers to explore peptide interactions and functions, making it valuable in studies related to endocrinology and cellular signaling. This reagent supports the identification and characterization of peptide-based signaling pathways, contributing to advancements in peptide research and therapeutic developments. -
GCGR Agonist
Neuropeptide Y, porcine, is a peptide found in porcine brain that acts as a GCGR agonist. This compound is known for its ability to inhibit secretin-stimulated pancreatic secretion, making it a valuable tool for studying pancreatic function and regulation. Its applications extend to research on energy homeostasis, appetite regulation, and potential therapeutic interventions in metabolic disorders. -
Vasodilatory Neuropeptide
Helospectin I is a vasoactive neuropeptide belonging to the vasoactive intestinal peptide (VIP) family. It exhibits significant vasodilatory and antihypertensive effects, contributing to a reduction in blood pressure. Initially isolated from the salivary gland venom of the lizard Heloderma suspectum, Helospectin I is valuable for research involving cardiovascular physiology and neuropeptide signaling pathways. -
Polypeptide
Gastric Inhibitory Polypeptide (6-30) amide (human) is a polypeptide that functions as an incretin hormone, primarily targeting insulin secretion in the pancreas. This fragment plays a pivotal role in glucose metabolism and regulation. Its biological activity makes it valuable for research applications focused on diabetes, obesity, and related metabolic disorders. -
Vasodilatory Neuropeptide
Helospectin II is a vasodilatory neuropeptide belonging to the vasoactive intestinal peptide (VIP) family. It exhibits significant vasodilatory and antihypertensive properties, effectively reducing blood pressure. This peptide was originally isolated from the salivary gland venom of the lizard Heloderma suspectum and serves as a valuable tool for research into cardiovascular functions and neuropeptide signaling pathways. -
Auxin Releases Peptide Analog
AZP-531 is an analog of unacylated ghrelin, primarily targeting the ghrelin receptor to enhance glycemic control and promote weight reduction. This compound exhibits significant biological activity in metabolic studies, making it a valuable tool in obesity and diabetes research. Its application extends to exploring the mechanisms of appetite regulation and energy homeostasis. -
Neuropeptide Hormone
Somatostatin-25 is a naturally occurring neuropeptide hormone that primarily inhibits the secretion of growth hormone. This regulatory activity plays a crucial role in various physiological processes, including the modulation of endocrine functions and gastrointestinal activities. It is widely utilized in research to investigate growth hormone regulation and its implications in disorders related to endocrine signaling. -
Glucagon Peptide
(Asp28)-Glucagon (1-29) is a modified form of the glucagon peptide, where aspartic acid (Asp) has been introduced at position 28 to enhance its aqueous solubility in physiological pH buffers. This structural optimization preserves the biological activity characteristic of glucagon. It serves as a valuable reagent for research applications that investigate glucagon's role in glucose metabolism, diabetes, and other metabolic disorders in human, rat, and porcine models. -
Hormone-like Actions Peptide
Phoenixin-14 (PNX-14) is a hormone-like peptide that activates the AHA GnRH system, producing anxiolytic effects in murine models. Additionally, PNX-14 exhibits neuroprotective properties by inhibiting cytotoxicity induced by ischemia/reperfusion in microglial cells. This compound serves as a valuable tool for research into stress response and neuroinflammatory processes. -
PrRP Fragment
Prolactin-Releasing Peptide (12-31), rat is a fragment of prolactin-releasing peptide (PrRP) that selectively targets GPR10 receptors. This peptide exhibits significant biological activity by stimulating calcium mobilization in CHOK1 cells transfected with the PrRP receptor. It is useful for research applications involving neuropeptide signaling and the role of GPR10 in hormonal regulation. -
GPR10 Ligand
Prolactin Releasing Peptide (1-31), human is a potent ligand for the GPR10 receptor, facilitating the release of prolactin. This peptide exhibits high affinity binding, with Ki values of 1.03 nM for human GPR10 and 0.33 nM for rat GPR10. It is a valuable tool for investigating the hypothalamo-pituitary axis and studying prolactin-related physiological processes. -
Neuropeptide
Zebrafish Kisspeptin-1 is a key neuropeptide that primarily targets the regulation of gonadotropin-releasing hormone (GnRH) release. This peptide plays a crucial role in the modulation of the reproductive system in zebrafish. It is widely utilized in research related to reproductive biology, neuroendocrine signaling, and developmental studies, providing insights into the mechanisms underlying reproduction and hormonal regulation. -
Antireproductive Tripeptide
Threonyl-seryl-lysine is an antireproductive tripeptide that exhibits antigonadotropic activity by binding to luteinizing hormone-releasing hormone (LHRH) at a specific site within residues 2-5. This compound is instrumental in the study of reproductive biology, particularly in understanding the regulatory mechanisms of gonadotropin secretion. Its ability to modulate hormone levels makes it a valuable tool for research applications related to fertility and reproductive health. -
Polypeptide
(Des-Pyr1)-LHRH is a modified polypeptide designed for research into hormone receptor interactions. It plays a crucial role in the study of gonadotropin-releasing hormone (GnRH) and has applications in peptide screening for protein interactions, functional assays, and epitope mapping. This reagent is particularly valuable in agent research and development, contributing to advancements in reproductive biology and endocrinology. -
GAP
GnRH Associated Peptide (25-53), human targets gonadotropin-releasing hormone (GnRH) and serves as a crucial fragment of the human GnRH-associated peptide (hGAP-25-53). This peptide is suitable as an immunogen for the generation of specific antiserum including MC-1, MC-2, and MC-3. By connecting to the luteinizing hormone-releasing hormone (LH-RH) sequence via a three-amino acid processing site, it plays a significant role in reproductive hormone regulation and offers valuable applications in endocrinology and reproductive biology research. -
Peptide Hormone
(Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH is a synthetic peptide hormone designed to interact with the luteinizing hormone-releasing hormone (LHRH) receptor. This compound exhibits key biological activities related to hormone regulation and neuroendocrine function. Its applications include research in reproductive biology, endocrine signaling pathways, and potential therapeutic investigations in hormone-related disorders. -
Active Peptide
(Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH II (chicken) is an active peptide that targets the luteinizing hormone-releasing hormone (LHRH) receptor. This compound is known for its role in regulating gonadotropin release and influencing reproductive hormone signaling. It is valuable for biochemical studies related to reproductive biology, neuroendocrine signaling, and the development of therapeutic agents targeting reproductive disorders. -
Polypeptide
Glp-His-Pro-Gly-NH2 is a polypeptide that functions primarily as a stimulant for gonadotrophin release, specifically luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This peptide plays a crucial role in reproductive physiology and is valuable in research applications related to hormone regulation, fertility studies, and endocrine system investigations. Its ability to modulate hormone secretion makes it a useful reagent for studying pituitary function and related hormonal pathways. -
Polypeptide
LHRH (1-5) free acid is a polypeptide derived from the cleavage of luteinizing hormone-releasing hormone at the Tyr55-Gly66 site. This compound can be further processed into LHRH (1-3) and LHRH (4-5) fragments through the action of Angiotensin-converting enzyme. It serves as a valuable tool for studying neuroendocrine signaling and reproductive biology, facilitating research into hormone regulation and related physiological processes. -
Hormone Peptide
Human follicular gonadotropin releasing peptide (hF-GRP) is a hormone peptide that primarily stimulates the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. This peptide plays a crucial role in regulating reproductive processes by enhancing gonadotropin release. hF-GRP is valuable for research applications involving reproductive endocrinology, fertility studies, and the regulation of hormonal pathways. -
GAP
GnRH Associated Peptide (1-24), human is a fragment of the human gonadotropin-releasing hormone-associated peptide (GAP) comprising residues 1-24. This peptide is linked to the luteinizing hormone-releasing hormone (LH-RH) sequence via a three-amino-acid processing site, playing a critical role in reproductive hormone regulation. It is primarily utilized in research to study the mechanisms of gonadotropin release and the modulation of fertility-related pathways. -
Peptide
(Ser(tBu)6,Azagly10)-LHRH is a potent aza-GLY analog targeting gonadotropin-releasing hormone receptors. This peptide exhibits significant biological activity in modulation of hormonal signaling pathways, making it valuable for research in reproductive biology and endocrine regulation. It is particularly useful for studies aimed at understanding potentiation and inhibition of luteinizing hormone release in various biological systems. -
Polypeptide
(D-Leu6)-LHRH (1-8) is a synthetic polypeptide known for its role as a gonadotropin-releasing hormone analogue, primarily targeting the pituitary gland. It exhibits significant biological activity by modulating hormonal release, making it valuable in studies of reproductive physiology and endocrinology. This reagent is widely utilized in peptide screening for protein interactions, functional analysis, and epitope mapping, advancing research in therapeutic agent development. -
Peptide
(D-His2)-Goserelin is a peptide analog derived from Goserelin, which mimics the structure of gonadotropin-releasing hormone (GnRH/LHRH). This compound serves primarily as an agonist of GnRH receptors, influencing the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Its biological activity makes it valuable in research focused on reproductive biology, endocrinology, and fertility treatments. -
Polypeptide
(Des-Gly10,D-His2,D-Trp6,Pro-NHEt9)-LHRH is a synthetic polypeptide that serves as a potent analog of Luteinizing Hormone-Releasing Hormone (LHRH), targeting the neuroendocrine system. It exhibits significant biological activity in regulating hormone release, making it valuable for research applications related to reproductive biology and endocrine function. This reagent can facilitate peptide screening studies for immunoassays, protein interactions, and functional analyses, particularly in the context of drug development and therapeutic interventions. -
Polypeptide
(Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH is a synthesized polypeptide designed to modulate gonadotropin release hormone (GnRH) signaling pathways. This compound exhibits significant biological activity in influencing reproductive hormone regulation, making it a valuable tool in endocrinology research. It is particularly applicable in studies focused on peptide interactions, functional analysis, and epitope mapping, contributing to the advancement of therapeutic agents in reproductive health and related fields. -
Polypeptide
(Des-Gly10,D-His2,D-His(Bzl)6,Pro-NHEt9)-LHRH is a synthesized polypeptide designed to target luteinizing hormone-releasing hormone (LHRH) receptors. This compound exhibits biological activity relevant to the modulation of reproductive hormone pathways, making it valuable in research focused on endocrine function and signaling. It is particularly useful for applications in peptide screening, protein interaction studies, and functional analysis within the context of agent development in reproductive biology.
