Catalog No.
Product Name
Application
Product Information
Citations
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Gastrointestinal Peptide
Peptide YY (pig) is a 36-amino acid gastrointestinal peptide primarily isolated from porcine duodenum. Its primary mechanism involves the activation of the Y2 receptor, leading to decreased appetite and food intake. In addition to its regulatory role in appetite, Peptide YY (pig) influences intestinal motility and has effects on the cardiovascular system, making it valuable for research in metabolic and gastrointestinal studies. -
Neurohormone-like Peptide
Levitide is a neurohormone-like peptide derived from the skin secretions of the South African frog Xenopus laevis. Comprised of 88 residues, Levitide features a sequence that includes the bioactive levitide peptide at the C-terminus, known for its potential role in modulating neurohormonal activities. This peptide is of interest in research applications related to neurobiology, endocrinology, and the study of amphibian physiology. -
Neuropeptide Y Receptor Agonist
Pancreatic Polypeptide, rat is a neuropeptide Y receptor agonist, exhibiting high affinity for the NPYR4 subtype. This peptide plays a significant role in the regulation of appetite, energy balance, and pancreatic functions. It is widely utilized in research focused on metabolic disorders, neurobiology, and gastrointestinal physiology. -
Neuropeptide Y Y2 Receptor Antagonist
(R)-JNJ-31020028 is a potent and selective antagonist of the neuropeptide Y Y2 receptor, demonstrating high affinity with pIC50 values of 8.07, 8.22, and 8.21 for human, rat, and mouse Y2 receptors, respectively. It exhibits over 100-fold selectivity against human Y1, Y4, and Y5 receptors. This compound has been shown to elicit antidepressant-like effects, making it a valuable tool for research in neuropsychiatric disorders and therapeutics targeting neuropeptide signaling pathways. -
Neuropeptide Y
Neuropeptide Y (2-36) (porcine) is a neuropeptide that interacts primarily with neuropeptide Y receptors, exhibiting high homology (97.14%) to its rat and human counterparts. This peptide functions as an agonist for Y5, Y2, and Y1 receptors, with EC50 values of 1.2, 1.6, and 3.4 nM, respectively. Neuropeptide Y (2-36) (porcine) is an important tool for research in obesity, appetite regulation, and related eating disorders, facilitating the exploration of neuropeptide signaling pathways in these conditions. -
Neuropeptide
Galanin-Like Peptide (porcine) is a 60 amino acid neuropeptide primarily known for its interaction with the GALR2 receptor, exhibiting a high affinity with an IC50 of 0.24 nM, while demonstrating a lower affinity for the GALR1 receptor (IC50 of 4.3 nM). This peptide plays a crucial role in neurobiological processes and serves as a valuable tool for research into neuropeptide signaling, neural regulation, and related physiological functions. Its unique properties make it suitable for various studies in neurobiology, including investigations of appetite regulation and stress response. -
Neuropeptide
Neuropeptide Y (human) free acid is the deamidated variant of Neuropeptide Y, a key neuropeptide involved in various physiological processes. This compound lacks amidation at the C-terminal tyrosine, which is essential for triggering G protein signaling pathways. Its study is crucial for understanding neuropeptide signaling mechanisms, potential roles in appetite regulation, stress response, and various neurological disorders. This reagent is valuable for research in neurobiology and pharmacology, particularly in exploring the functional implications of peptide modifications. -
Neuropeptide YY Receptor Antagonist
GR231118 is a selective antagonist for the human neuropeptide Y (NPY) Y1 receptor, exhibiting a competitive inhibition with a pKi of 10.4. This compound also demonstrates potent agonist activity at the human NPY Y4 receptor (pEC50=8.6; pKi=9.6) and weak agonist activity at both human and rat NPY Y2 and Y5 receptors. Additionally, GR231118 has significant affinity for the mouse NPY Y6 receptor (pKi=8.8), making it a valuable tool for studying neuropeptide Y signaling pathways and their implications in various physiological and pathological conditions. -
Neuropeptide Y Y1 Receptor Antagonist
BIBO3304 free base is a potent nonpeptide antagonist of the neuropeptide Y Y1 receptor. It demonstrates subnanomolar affinity for human and rat Y1 receptors, with IC50 values of 0.38 nM and 0.72 nM, respectively. This compound effectively inhibits food intake stimulated by neuropeptide Y (NPY) and fasting conditions, making it a valuable tool for studies related to appetite regulation and metabolic disorders. -
Y2 Receptor Agonist
Neuropeptide Y (22-36) is a peptide fragment that acts as a selective agonist for the Y2 receptor. With subnanomolar affinity, it modulates various physiological processes, including appetite regulation, circadian rhythms, and stress response. This compound is valuable in neurobiological research, particularly in studies exploring the role of neuropeptides in neuroendocrine function and behavioral responses. -
Neuropeptide FF Receptor Agonist
Neuropeptide SF (mouse, rat) is a potent agonist of the neuropeptide FF receptors, exhibiting Ki values of 48.4 nM for NPFF1 and 12.1 nM for NPFF2. This compound enhances the sustained current of heterologously expressed acid-sensing ion channel 3 (ASIC3), making it a valuable tool in studies related to pain modulation and neuropeptide signaling. Neuropeptide SF is ideal for research investigating neurophysiological processes and receptor interactions within neural pathways. -
Neuropeptide Y Receptor Antagonist
PD 160170 is a neuropeptide Y receptor antagonist that specifically targets neuropeptide Y receptors involved in the regulation of various physiological processes. This compound demonstrates significant biological activity in promoting red blood cell transfusion independence and increasing hemoglobin levels, making it a valuable tool for research in myelodysplastic syndromes and associated anemias. Its mechanism of action may provide insights into the modulation of erythropoiesis and potential therapeutic avenues for hematological disorders. -
Galanin/Galanin Receptor Ligand
Galanin (1-13)-Neuropeptide Y (25-36) amide is a high-affinity ligand for galanin receptors, acting primarily through the modulation of galanin signaling pathways. This peptide demonstrates significant biological activity in neuropeptide signaling and is relevant for research applications focusing on neurobiology, appetite regulation, and stress response mechanisms. Its use can enhance understanding of galanin's role in various physiological and pathological processes. -
Neuropeptide Y
Neuropeptide Y (3-36) (porcine) is an agonist specifically targeting the neuropeptide Y (NPY) receptor subtype Y2. This peptide has been demonstrated to stimulate feeding behavior in rat models. Its high selectivity for the Y2 receptor makes it a valuable tool for investigating NPY signaling pathways and their implications in appetite regulation and related metabolic disorders. -
Neuropeptide
Galanin-Like Peptide (human) is a 60 amino acid neuropeptide that primarily targets neuropeptide signaling pathways. This peptide is crucial in regulating feeding behavior, body weight, and energy metabolism. It serves as an important tool in research focused on understanding obesity, metabolic disorders, and appetite control. -
Neuropeptide Y1Receptor Antagonist
BMS-193885 (L-Lactic acid) is a potent and selective antagonist of the neuropeptide Y1 receptor. It exhibits a Ki value of 3.3 nM, demonstrating its high affinity for the receptor while competitively inhibiting neuropeptide Y binding. This compound is relevant for research applications related to appetite regulation and obesity, as it effectively reduces food intake and body weight through central Y1 receptor inhibition. -
Neuropeptide Y1 Antagonist
J-115814 is a potent and selective antagonist of the neuropeptide Y1 receptor, exhibiting Ki values of 1.4 nM for human Y1, 1.8 nM for rat Y1, and 1.9 nM for mouse Y1, with significantly lower affinity for other neuropeptide Y receptors. This compound has demonstrated the ability to inhibit feeding behaviors, making it a valuable tool in obesity and appetite regulation research. Its specificity and potency make J-115814 suitable for studies investigating neuropeptide signaling and related physiological processes. -
Neuropeptide Y Receptor Antagonist
FR252384 is a potent antagonist of the neuropeptide Y-Y5 receptor, demonstrating an IC50 of 2.3 nM. This compound plays a significant role in research related to appetite regulation, anxiety, and stress responses. Its ability to selectively inhibit neuropeptide Y signaling makes it a valuable tool for investigating the underlying mechanisms of these biological processes. -
Neurotensin Octapeptide
Xenopsin is a neurotensin-like octapeptide derived from the skin of Xenopus laevis. It primarily functions as an inhibitor of Tetragastrin-stimulated gastric acid secretion, making it valuable for studies related to gastrointestinal physiology and acid regulation. Research applications include investigations into peptide signaling pathways and gastrointestinal disorders. -
Opioid Peptide
β-Casomorphin, bovine, is an opioid peptide that primarily targets opioid receptors. With an IC50 value of 14 μM in binding assays, it demonstrates significant affinity for these receptors. This compound is utilized in research applications focused on the study of pain modulation, addiction, and the physiological effects of opioid peptides in various biological contexts. -
μ-opioid Agonist
Acetyl tetrapeptide-15 is a synthetic peptide that functions as a μ-opioid agonist. It mimics the action of endomorphin-2, promoting selective anti-nociceptive effects that alleviate skin hyperreactivity associated with inflammatory, chronic, and neuropathic pain. By enhancing the threshold of neuronal excitability through μ-opioid receptor pathways, Acetyl tetrapeptide-15 is primarily utilized in cosmetic formulations aimed at sensitive skin. -
Tetrapeptide
Bilaid B is a tetrapeptide that resembles opioid peptides with a distinct LDLD amino acid configuration. This unique arrangement enhances its biological activity and specificity for opioid receptors. Bilaid B is primarily used in research applications focusing on pain modulation and neuropharmacology, making it a valuable tool for studying opioid receptor function and therapeutic potentials. -
Nociceptin/Orphanin FQ Peptide Receptor Antagonist
MK-5757 is a potent Nociceptin/Orphanin FQ Peptide Receptor antagonist. It has been shown to improve cerebral blood flow and mitigate ischemic damage, making it valuable for studying neurological disorders. This compound is particularly relevant for research into traumatic brain injury and other neurodegenerative conditions characterized by abnormal neurological symptoms. -
Opioid Peptide
α-Neoendorphin (1-8) is an octapeptide derived from the N-terminal region of the endogenous opioid peptide α-Neoendorphin. It primarily targets opioid receptors, exerting analgesic effects and modulating pain responses in various biological systems. This peptide is utilized in research applications focused on pain management, neurobiology, and the study of opioid signaling pathways. -
Bioactive Peptide
Deltorphin, a bioactive peptide, is a potent and selective agonist for the delta-opioid receptor. Isolated from the skin of the South American frog, Phyllomedusa sauvagei, Deltorphin exhibits significant analgesic properties. This compound is widely used in research applications focused on pain modulation, addiction, and the pharmacological characterization of opioid receptors. -
Opioid Neuropeptide
β-Endorphin (rat) is an endogenous opioid neuropeptide that primarily targets opioid receptors, playing a key role in pain modulation. Its analgesic properties make it significant in studies related to pain management and the regulation of food intake in satiated states. This reagent is valuable for research investigating neurological disorders, including analgesia and drug addiction. -
Kappa Opiate Receptor Agonist
Peptide E is a potent kappa opiate receptor agonist that exhibits strong binding affinity with an IC50 value of 0.39 μM. This compound is valuable for studying the role of kappa receptors in the central nervous system. Its biological activity makes it suitable for research focused on pain modulation, addiction, and other neurological disorders. -
ANP Peptide Fragment
ANP (1-30), frog is a peptide fragment of atrial natriuretic peptide that exhibits natriuretic, diuretic, and vasorelaxant properties. This compound is valuable for research in cardiovascular physiology and fluid homeostasis, as it plays a crucial role in regulating blood pressure and electrolyte balance. Its unique properties make ANP (1-30), frog an essential tool for investigations into cardiac function and therapeutic potential for hypertension-related disorders. -
Mitochondrial N-formyl Peptide
N-Formyl-MMYALF is a potent mitochondrial N-formyl peptide (mtFP) that selectively targets calcium ion depletion in the endoplasmic reticulum. This compound effectively inhibits the FPR-1-mediated chemotactic response of polymorphonuclear leukocytes (PMNs) to bacterial peptides, making it valuable for research in inflammation and immune response. Its utility in investigating mitochondrial function and leukocyte signaling pathways underscores its significance in the study of cellular calcium dynamics and immune modulation. -
FPRs Binding Peptide
N-Formyl-Met-Ala-Ser is a peptide that specifically binds to formyl peptide receptors (FPRs) on neutrophils. This interaction plays a crucial role in the regulation of immune responses and chemotactic activity. N-Formyl-Met-Ala-Ser is valuable for research applications related to inflammation, host defense mechanisms, and the study of neutrophil behavior. -
Bioactive Peptide
WRW4-OH is a bioactive peptide that selectively inhibits the binding of the FPRL1 agonist WKYMVm to its corresponding receptor. FPRL1 plays a crucial role as a classical chemoattractant receptor found in phagocytic cells within the peripheral blood and brain. The modulation of FPRL1 is of significant interest in research related to inflammatory responses and neurodegenerative disorders, making WRW4-OH a valuable tool for studies in immunology and neurobiology. -
Neuropeptide
Neuromedin S (human) is a neuropeptide comprising 33 amino acids, functioning primarily as a ligand for the orphan G-protein coupled receptor FM-4/TGR-1 and the neuromedin U receptor 2 (NMUR2). This peptide plays a crucial role in the regulation of body weight homeostasis, making it valuable for research in metabolic disorders and neurobiology. Its unique mechanism of action positions Neuromedin S as an essential tool for studying the signaling pathways associated with energy balance and obesity-related conditions. -
vasoactive Peptide
Endothelin-3 is a 21-amino acid vasoactive peptide that targets G-protein-coupled receptors, specifically ET-RA and ET-RB. This peptide plays a critical role in regulating vascular tone and blood pressure through its potent vasoconstrictive properties. It is primarily used in research applications related to cardiovascular physiology and pathology, as well as in studies investigating the role of endothelins in various disease models across human, mouse, rabbit, and rat systems. -
Neuropeptide Hormone
Corazonin is a conserved neuropeptide hormone that functions as a central regulator of caste identity and behavior in social insects. Its differential expression in worker and forager populations underscores its significant role in social organization and behavior within various insect species. This peptide is valuable for research into neurobiology, insect physiology, and social behavior dynamics. -
Pentapeptide
GLP-1(32-36)amide is a pentapeptide derived from the C terminus of the glucoregulatory hormone GLP-1. This compound has been shown to inhibit weight gain and positively influence whole-body glucose metabolism in diabetic mouse models. It serves as a valuable tool for studying metabolic disorders and potential therapeutic strategies for diabetes management. -
GLP-1 Peptides
GLP-1 (1-36) amide (human, rat) is a molecular variant of the glucagon-like peptide 1 (GLP-1) family. This peptide demonstrates the ability to stimulate [14C]aminopyrine accumulation in enzymatically dispersed rat parietal cells, indicating its role in gut hormone regulation. It is useful for research applications focused on metabolic disorders, glucose homeostasis, and appetite suppression, providing insights into obesity and diabetes mechanisms. -
GCGR Agonist
Glucagon-like peptide 1 (1-37), human is a potent agonist of the glucagon receptor (GCGR). This peptide plays a critical role in glucose metabolism and insulin signaling, making it valuable for research in diabetes and metabolic disorders. Its biological activity includes enhancing insulin secretion, inhibiting glucagon release, and promoting satiety, which are important for studies on obesity and diabetes therapies. -
Glicentin-related Pancreatic Polypeptide
GRPP (human) is a 30 amino acid peptide derived from glucagon, targeting the Glicentin-related Pancreatic Polypeptide. It is known to induce modest increases in plasma insulin levels while decreasing plasma glucagon concentrations. GRPP (human) serves as a valuable tool for research into pancreatic function and the regulation of glucose metabolism. Its specific effects on insulin and glucagon make it pertinent for studies related to metabolic disorders. -
Peptide
Exendin-4 (3-39) is a peptide that functions as a selective agonist for the Glucagon-like peptide-1 receptor (GLP-1r). This truncated variant of Exendin-4 is missing the first two amino acids, while retaining its bioactivity. Exendin-4 (3-39) is primarily employed in research exploring metabolic diseases, diabetes, and the hypothalamic-pituitary-adrenal (HPA) axis. Its structural modifications allow for investigations into receptor interactions and signaling pathways related to GLP-1r. -
Polypeptide
PHI-27 (porcine) is a 27 amino acid polypeptide that serves as a crucial tool for investigating peptide hormones and other biologically active peptides. Its structural properties enable researchers to explore peptide interactions and functions, making it valuable in studies related to endocrinology and cellular signaling. This reagent supports the identification and characterization of peptide-based signaling pathways, contributing to advancements in peptide research and therapeutic developments. -
GCGR Agonist
Neuropeptide Y, porcine, is a peptide found in porcine brain that acts as a GCGR agonist. This compound is known for its ability to inhibit secretin-stimulated pancreatic secretion, making it a valuable tool for studying pancreatic function and regulation. Its applications extend to research on energy homeostasis, appetite regulation, and potential therapeutic interventions in metabolic disorders. -
Vasodilatory Neuropeptide
Helospectin I is a vasoactive neuropeptide belonging to the vasoactive intestinal peptide (VIP) family. It exhibits significant vasodilatory and antihypertensive effects, contributing to a reduction in blood pressure. Initially isolated from the salivary gland venom of the lizard Heloderma suspectum, Helospectin I is valuable for research involving cardiovascular physiology and neuropeptide signaling pathways. -
Polypeptide
Gastric Inhibitory Polypeptide (6-30) amide (human) is a polypeptide that functions as an incretin hormone, primarily targeting insulin secretion in the pancreas. This fragment plays a pivotal role in glucose metabolism and regulation. Its biological activity makes it valuable for research applications focused on diabetes, obesity, and related metabolic disorders. -
Vasodilatory Neuropeptide
Helospectin II is a vasodilatory neuropeptide belonging to the vasoactive intestinal peptide (VIP) family. It exhibits significant vasodilatory and antihypertensive properties, effectively reducing blood pressure. This peptide was originally isolated from the salivary gland venom of the lizard Heloderma suspectum and serves as a valuable tool for research into cardiovascular functions and neuropeptide signaling pathways. -
Auxin Releases Peptide Analog
AZP-531 is an analog of unacylated ghrelin, primarily targeting the ghrelin receptor to enhance glycemic control and promote weight reduction. This compound exhibits significant biological activity in metabolic studies, making it a valuable tool in obesity and diabetes research. Its application extends to exploring the mechanisms of appetite regulation and energy homeostasis. -
Neuropeptide Hormone
Somatostatin-25 is a naturally occurring neuropeptide hormone that primarily inhibits the secretion of growth hormone. This regulatory activity plays a crucial role in various physiological processes, including the modulation of endocrine functions and gastrointestinal activities. It is widely utilized in research to investigate growth hormone regulation and its implications in disorders related to endocrine signaling. -
Glucagon Peptide
(Asp28)-Glucagon (1-29) is a modified form of the glucagon peptide, where aspartic acid (Asp) has been introduced at position 28 to enhance its aqueous solubility in physiological pH buffers. This structural optimization preserves the biological activity characteristic of glucagon. It serves as a valuable reagent for research applications that investigate glucagon's role in glucose metabolism, diabetes, and other metabolic disorders in human, rat, and porcine models. -
Hormone-like Actions Peptide
Phoenixin-14 (PNX-14) is a hormone-like peptide that activates the AHA GnRH system, producing anxiolytic effects in murine models. Additionally, PNX-14 exhibits neuroprotective properties by inhibiting cytotoxicity induced by ischemia/reperfusion in microglial cells. This compound serves as a valuable tool for research into stress response and neuroinflammatory processes. -
PrRP Fragment
Prolactin-Releasing Peptide (12-31), rat is a fragment of prolactin-releasing peptide (PrRP) that selectively targets GPR10 receptors. This peptide exhibits significant biological activity by stimulating calcium mobilization in CHOK1 cells transfected with the PrRP receptor. It is useful for research applications involving neuropeptide signaling and the role of GPR10 in hormonal regulation. -
GPR10 Ligand
Prolactin Releasing Peptide (1-31), human is a potent ligand for the GPR10 receptor, facilitating the release of prolactin. This peptide exhibits high affinity binding, with Ki values of 1.03 nM for human GPR10 and 0.33 nM for rat GPR10. It is a valuable tool for investigating the hypothalamo-pituitary axis and studying prolactin-related physiological processes.
