Catalog No.
Product Name
Application
Product Information
Citations
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NPY Y5 Receptor Agonist
(D-Trp32)-Neuropeptide Y (porcine) is a selective agonist of the neuropeptide Y (NPY) Y5 receptor. It exhibits orexigenic activity, thereby promoting increased food intake, and has been shown to inhibit Forskolin-stimulated cAMP formation. This peptide is valuable for research focusing on appetite regulation and metabolic disorders. -
Neuropeptide Y Receptor Agonist
Pancreatic Polypeptide, bovine, is a 36-amino acid polypeptide that primarily influences the neuropeptide Y (NPY) receptor system. Acting as an agonist of the NPY receptor, it demonstrates high affinity for the NPYR4 subtype and is known to inhibit secretin- and cholecystokinin-induced pancreatic secretion. This compound is valuable in research focused on metabolic regulation, appetite control, and neuroendocrine function. -
Y1 Receptor Agonist
[Leu31,Pro34]-Neuropeptide Y (human, rat) is a selective agonist for the neuropeptide Y Y1 receptor. This compound is known to enhance blood pressure in anesthetized rat models and stimulates food intake. It may also interact with Y4 and Y5 receptors, making it valuable for research into appetite regulation and cardiovascular function. -
Orexigenic Neuropeptide
26Rfa is a human hypothalamic peptide within the RFamide peptide family, primarily targeted at the orexigenic pathways. It functions as an endogenous ligand for the orphan G protein-coupled receptor GPR103, playing a significant role in appetite regulation. This neuropeptide is crucial for research focused on feeding behaviors and metabolic disorders, making it an important reagent in studies of energy homeostasis. -
Y1 Receptor Agonist
[Pro34]Neuropeptide Y, porcine is a selective Y1 receptor agonist that specifically targets neuropeptide Y receptors. It demonstrates significant biological activity by inducing vasoconstriction in the guinea pig caval vein, making it a valuable tool for studying vascular responses and neuropeptide signaling pathways in research applications. This compound can aid in investigating the physiological and pathological roles of neuropeptide Y in cardiovascular function. -
Y1 Receptor Agonist
(Pro34)-Peptide YY (human) is a selective full agonist of the Y1 receptor in the Peptide YY/neuropeptide Y family. This compound is primarily utilized in research exploring the physiological roles of neuropeptides, especially in the regulation of appetite, energy balance, and gut function. Its specificity for the Y1 receptor makes it an important tool for studying receptor signaling pathways and their implications in metabolic disorders. -
Neuropeptide Y Receptor Antagonist
CGP71683 is a highly selective non-peptide antagonist of the neuropeptide Y (NPY) Y(5) receptor. This compound exhibits potent inhibition of receptor activity, making it a valuable tool for studying the physiological and pathological roles of NPY signaling. Its applications extend to obesity research and related metabolic studies, facilitating investigations into appetite regulation and energy homeostasis. -
Neuron Activator
Neuropeptide Y (1-24) (human) acts as a neuron activator and is involved in modulating synaptic transmission and neuronal excitability. This neuropeptide has been demonstrated to significantly inhibit electrically stimulated twitch responses in rat vas deferens, indicating its potential in neuromodulation. Additionally, it enhances N-methyl-D-aspartate (NMDA)-induced neuronal activation in the rat CA3 region of the dorsal hippocampus, making it a valuable tool for studying neurophysiology and neurobiology. -
Neuropeptide
Galanin-Like Peptide (rat) is a 60 amino acid neuropeptide that primarily targets galanin receptors. This peptide is crucial in the regulation of feeding behavior, body weight, and energy metabolism. Its biological activity makes it a valuable tool for research in neurobiology, obesity, and metabolic disorders, providing insights into the mechanisms underlying appetite control and energy homeostasis. -
Gastrointestinal Peptide
Peptide YY (pig) is a 36-amino acid gastrointestinal peptide primarily isolated from porcine duodenum. Its primary mechanism involves the activation of the Y2 receptor, leading to decreased appetite and food intake. In addition to its regulatory role in appetite, Peptide YY (pig) influences intestinal motility and has effects on the cardiovascular system, making it valuable for research in metabolic and gastrointestinal studies. -
Neurohormone-like Peptide
Levitide is a neurohormone-like peptide derived from the skin secretions of the South African frog Xenopus laevis. Comprised of 88 residues, Levitide features a sequence that includes the bioactive levitide peptide at the C-terminus, known for its potential role in modulating neurohormonal activities. This peptide is of interest in research applications related to neurobiology, endocrinology, and the study of amphibian physiology. -
Neuropeptide Y Receptor Agonist
Pancreatic Polypeptide, rat is a neuropeptide Y receptor agonist, exhibiting high affinity for the NPYR4 subtype. This peptide plays a significant role in the regulation of appetite, energy balance, and pancreatic functions. It is widely utilized in research focused on metabolic disorders, neurobiology, and gastrointestinal physiology. -
Neuropeptide Y Y2 Receptor Antagonist
(R)-JNJ-31020028 is a potent and selective antagonist of the neuropeptide Y Y2 receptor, demonstrating high affinity with pIC50 values of 8.07, 8.22, and 8.21 for human, rat, and mouse Y2 receptors, respectively. It exhibits over 100-fold selectivity against human Y1, Y4, and Y5 receptors. This compound has been shown to elicit antidepressant-like effects, making it a valuable tool for research in neuropsychiatric disorders and therapeutics targeting neuropeptide signaling pathways. -
Neuropeptide Y
Neuropeptide Y (2-36) (porcine) is a neuropeptide that interacts primarily with neuropeptide Y receptors, exhibiting high homology (97.14%) to its rat and human counterparts. This peptide functions as an agonist for Y5, Y2, and Y1 receptors, with EC50 values of 1.2, 1.6, and 3.4 nM, respectively. Neuropeptide Y (2-36) (porcine) is an important tool for research in obesity, appetite regulation, and related eating disorders, facilitating the exploration of neuropeptide signaling pathways in these conditions. -
Neuropeptide
Galanin-Like Peptide (porcine) is a 60 amino acid neuropeptide primarily known for its interaction with the GALR2 receptor, exhibiting a high affinity with an IC50 of 0.24 nM, while demonstrating a lower affinity for the GALR1 receptor (IC50 of 4.3 nM). This peptide plays a crucial role in neurobiological processes and serves as a valuable tool for research into neuropeptide signaling, neural regulation, and related physiological functions. Its unique properties make it suitable for various studies in neurobiology, including investigations of appetite regulation and stress response. -
Neuropeptide
Neuropeptide Y (human) free acid is the deamidated variant of Neuropeptide Y, a key neuropeptide involved in various physiological processes. This compound lacks amidation at the C-terminal tyrosine, which is essential for triggering G protein signaling pathways. Its study is crucial for understanding neuropeptide signaling mechanisms, potential roles in appetite regulation, stress response, and various neurological disorders. This reagent is valuable for research in neurobiology and pharmacology, particularly in exploring the functional implications of peptide modifications. -
Neuropeptide YY Receptor Antagonist
GR231118 is a selective antagonist for the human neuropeptide Y (NPY) Y1 receptor, exhibiting a competitive inhibition with a pKi of 10.4. This compound also demonstrates potent agonist activity at the human NPY Y4 receptor (pEC50=8.6; pKi=9.6) and weak agonist activity at both human and rat NPY Y2 and Y5 receptors. Additionally, GR231118 has significant affinity for the mouse NPY Y6 receptor (pKi=8.8), making it a valuable tool for studying neuropeptide Y signaling pathways and their implications in various physiological and pathological conditions. -
Neuropeptide Y Y1 Receptor Antagonist
BIBO3304 free base is a potent nonpeptide antagonist of the neuropeptide Y Y1 receptor. It demonstrates subnanomolar affinity for human and rat Y1 receptors, with IC50 values of 0.38 nM and 0.72 nM, respectively. This compound effectively inhibits food intake stimulated by neuropeptide Y (NPY) and fasting conditions, making it a valuable tool for studies related to appetite regulation and metabolic disorders. -
Y2 Receptor Agonist
Neuropeptide Y (22-36) is a peptide fragment that acts as a selective agonist for the Y2 receptor. With subnanomolar affinity, it modulates various physiological processes, including appetite regulation, circadian rhythms, and stress response. This compound is valuable in neurobiological research, particularly in studies exploring the role of neuropeptides in neuroendocrine function and behavioral responses. -
Neuropeptide FF Receptor Agonist
Neuropeptide SF (mouse, rat) is a potent agonist of the neuropeptide FF receptors, exhibiting Ki values of 48.4 nM for NPFF1 and 12.1 nM for NPFF2. This compound enhances the sustained current of heterologously expressed acid-sensing ion channel 3 (ASIC3), making it a valuable tool in studies related to pain modulation and neuropeptide signaling. Neuropeptide SF is ideal for research investigating neurophysiological processes and receptor interactions within neural pathways. -
Neuropeptide Y Receptor Antagonist
PD 160170 is a neuropeptide Y receptor antagonist that specifically targets neuropeptide Y receptors involved in the regulation of various physiological processes. This compound demonstrates significant biological activity in promoting red blood cell transfusion independence and increasing hemoglobin levels, making it a valuable tool for research in myelodysplastic syndromes and associated anemias. Its mechanism of action may provide insights into the modulation of erythropoiesis and potential therapeutic avenues for hematological disorders. -
Galanin/Galanin Receptor Ligand
Galanin (1-13)-Neuropeptide Y (25-36) amide is a high-affinity ligand for galanin receptors, acting primarily through the modulation of galanin signaling pathways. This peptide demonstrates significant biological activity in neuropeptide signaling and is relevant for research applications focusing on neurobiology, appetite regulation, and stress response mechanisms. Its use can enhance understanding of galanin's role in various physiological and pathological processes. -
Neuropeptide Y
Neuropeptide Y (3-36) (porcine) is an agonist specifically targeting the neuropeptide Y (NPY) receptor subtype Y2. This peptide has been demonstrated to stimulate feeding behavior in rat models. Its high selectivity for the Y2 receptor makes it a valuable tool for investigating NPY signaling pathways and their implications in appetite regulation and related metabolic disorders. -
Neuropeptide
Galanin-Like Peptide (human) is a 60 amino acid neuropeptide that primarily targets neuropeptide signaling pathways. This peptide is crucial in regulating feeding behavior, body weight, and energy metabolism. It serves as an important tool in research focused on understanding obesity, metabolic disorders, and appetite control. -
Neuropeptide Y1Receptor Antagonist
BMS-193885 (L-Lactic acid) is a potent and selective antagonist of the neuropeptide Y1 receptor. It exhibits a Ki value of 3.3 nM, demonstrating its high affinity for the receptor while competitively inhibiting neuropeptide Y binding. This compound is relevant for research applications related to appetite regulation and obesity, as it effectively reduces food intake and body weight through central Y1 receptor inhibition. -
Neuropeptide Y1 Antagonist
J-115814 is a potent and selective antagonist of the neuropeptide Y1 receptor, exhibiting Ki values of 1.4 nM for human Y1, 1.8 nM for rat Y1, and 1.9 nM for mouse Y1, with significantly lower affinity for other neuropeptide Y receptors. This compound has demonstrated the ability to inhibit feeding behaviors, making it a valuable tool in obesity and appetite regulation research. Its specificity and potency make J-115814 suitable for studies investigating neuropeptide signaling and related physiological processes. -
Neuropeptide Y Receptor Antagonist
FR252384 is a potent antagonist of the neuropeptide Y-Y5 receptor, demonstrating an IC50 of 2.3 nM. This compound plays a significant role in research related to appetite regulation, anxiety, and stress responses. Its ability to selectively inhibit neuropeptide Y signaling makes it a valuable tool for investigating the underlying mechanisms of these biological processes. -
Neurotensin Octapeptide
Xenopsin is a neurotensin-like octapeptide derived from the skin of Xenopus laevis. It primarily functions as an inhibitor of Tetragastrin-stimulated gastric acid secretion, making it valuable for studies related to gastrointestinal physiology and acid regulation. Research applications include investigations into peptide signaling pathways and gastrointestinal disorders. -
Opioid Peptide
β-Casomorphin, bovine, is an opioid peptide that primarily targets opioid receptors. With an IC50 value of 14 μM in binding assays, it demonstrates significant affinity for these receptors. This compound is utilized in research applications focused on the study of pain modulation, addiction, and the physiological effects of opioid peptides in various biological contexts. -
μ-opioid Agonist
Acetyl tetrapeptide-15 is a synthetic peptide that functions as a μ-opioid agonist. It mimics the action of endomorphin-2, promoting selective anti-nociceptive effects that alleviate skin hyperreactivity associated with inflammatory, chronic, and neuropathic pain. By enhancing the threshold of neuronal excitability through μ-opioid receptor pathways, Acetyl tetrapeptide-15 is primarily utilized in cosmetic formulations aimed at sensitive skin. -
Tetrapeptide
Bilaid B is a tetrapeptide that resembles opioid peptides with a distinct LDLD amino acid configuration. This unique arrangement enhances its biological activity and specificity for opioid receptors. Bilaid B is primarily used in research applications focusing on pain modulation and neuropharmacology, making it a valuable tool for studying opioid receptor function and therapeutic potentials. -
Nociceptin/Orphanin FQ Peptide Receptor Antagonist
MK-5757 is a potent Nociceptin/Orphanin FQ Peptide Receptor antagonist. It has been shown to improve cerebral blood flow and mitigate ischemic damage, making it valuable for studying neurological disorders. This compound is particularly relevant for research into traumatic brain injury and other neurodegenerative conditions characterized by abnormal neurological symptoms. -
Opioid Peptide
α-Neoendorphin (1-8) is an octapeptide derived from the N-terminal region of the endogenous opioid peptide α-Neoendorphin. It primarily targets opioid receptors, exerting analgesic effects and modulating pain responses in various biological systems. This peptide is utilized in research applications focused on pain management, neurobiology, and the study of opioid signaling pathways. -
Bioactive Peptide
Deltorphin, a bioactive peptide, is a potent and selective agonist for the delta-opioid receptor. Isolated from the skin of the South American frog, Phyllomedusa sauvagei, Deltorphin exhibits significant analgesic properties. This compound is widely used in research applications focused on pain modulation, addiction, and the pharmacological characterization of opioid receptors. -
Opioid Neuropeptide
β-Endorphin (rat) is an endogenous opioid neuropeptide that primarily targets opioid receptors, playing a key role in pain modulation. Its analgesic properties make it significant in studies related to pain management and the regulation of food intake in satiated states. This reagent is valuable for research investigating neurological disorders, including analgesia and drug addiction. -
Kappa Opiate Receptor Agonist
Peptide E is a potent kappa opiate receptor agonist that exhibits strong binding affinity with an IC50 value of 0.39 μM. This compound is valuable for studying the role of kappa receptors in the central nervous system. Its biological activity makes it suitable for research focused on pain modulation, addiction, and other neurological disorders. -
Opioid Peptide
Biphalin TFA is a potent opioid peptide analog designed for effective interaction with opioid receptors, demonstrating a dual enkephalin pharmacophore structure that facilitates blood-brain barrier penetration. This compound exhibits significant analgesic properties in various pain models, including acute, neuropathic, and chronic settings. Additionally, Biphalin TFA has been shown to possess antiviral, antiproliferative, anti-inflammatory, and neuroprotective activities, making it a valuable tool for research in pain management and related therapeutic areas. -
Neuropeptide
Dynorphin B (1-9) is a neuropeptide derived from the N-terminal cleavage of dynorphin B. This peptide is implicated in various neurological processes and has been shown to modulate pain and stress responses. Research applications include studies on opioid receptor interactions and investigations into the neurochemical pathways involved in nociception and behavioral responses. The formation of Dynorphin B (1-9) can be inhibited by N-ethylmaleimide (NEM), highlighting its relevance in studying cysteine peptidases. -
Contraceptive Tetrapeptide
Kentsin (Thr-Pro-Arg-Lys) is a contraceptive tetrapeptide that inhibits ovulation by preventing the maturation of Graafian follicles. This mechanism occurs without binding to opioid receptors, making Kentsin a unique compound of interest in reproductive biology. Additionally, it exhibits opiate-like effects on gastrointestinal motility, highlighting its potential applications in both fertility regulation and gastrointestinal research. -
Neuropeptide
Nocistatin is a neuropeptide that acts as an endogenous ligand for the orphan opioid receptor-like receptor. It functions as a functional antagonist of neuropeptide nociceptin/orphanin FQ (Noc/OFQ), inhibiting 5-HT release through a Gi/o protein-mediated pathway. Nocistatin has been shown to block nociceptin-induced allodynia and hyperalgesia, making it a valuable tool for research into pain mechanisms and neuropeptide signaling. -
Opioid Receptor Inhibitor
Neuropeptide AF (human) is an endogenous peptide that acts as an opioid receptor inhibitor. This neuropeptide plays a critical role in modulating pain and stress responses, making it a valuable tool for studies focused on opioid signaling pathways. Research applications include investigations into pain management, addiction, and the physiological effects of endogenous opioid peptides. -
Neuropeptide
β-Endorphin, rat is a neuropeptide that plays a significant role in cardiovascular regulation. This peptide induces profound muscular rigidity and immobility in rat models, mimicking a catatonic state. It is commonly used in research studies focused on pain modulation, stress response, and neurobiology. -
Opioid Peptide Derivative
[DAla2, DArg6] Dynorphin A (1-13) (porcine) is a modified opioid peptide targeting opioid receptors in the peripheral nervous system. This derivative exhibits enhanced stability compared to its parent compound, dynorphin (1-13), demonstrating increased resistance to enzymatic degradation. Its unique properties make it a valuable tool for studying opioid receptor signaling and evaluating potential therapeutic applications in pain management and neuropharmacology. -
Peptide
Acetalin-2 is an opioid peptide characterized by the sequence Ac-Arg-Phe-Met-Trp-Met-Arg-NH2. It exhibits selective binding to μ-opioid receptors, as indicated by a Ki value of 93.3 nM for [3H]DAMGO, demonstrating its potential for studying opioid receptor functions. This compound is applicable in research related to pain management, addiction, and neurobiology, providing valuable insights into opioid signaling pathways. -
Peptide
[DAla2] Dynorphin A (1-13), amide (porcine) is a peptide that primarily targets the κ opioid receptors. This compound exhibits potential agonist activity, making it valuable for exploring the physiological roles of dynorphins in the nervous system. Its utility spans various research applications, including studies on pain modulation, stress response, and neuropharmacology. -
Opioid Peptide
N-Acetyl-α-Endorphin is an acetylated form of the endogenous opioid peptide α-Endorphin, modified at the N-terminal. This compound primarily targets opioid receptors and exhibits significant analgesic properties. It is widely utilized in research focusing on pain management, addiction, and the modulation of neuronal signaling pathways associated with opioid activity. -
Neuromodulatory Peptide
Tyr-W-MIF-1 is a neuromodulatory peptide that exhibits both opiate and anti-opiate activities. This opioid tetrapeptide has been shown to induce analgesia, making it a valuable tool for pain research and neuropharmacology studies. Its unique properties allow researchers to explore the mechanisms underlying pain modulation and potential therapeutic applications for pain management. -
Peptides
Dynorphin A (1-13) amide is an endogenous opioid peptide that acts primarily as a kappa opioid receptor agonist. This peptide exhibits potent modulation of pain pathways, demonstrating the ability to antagonize morphine-induced analgesia. It is utilized in research applications focused on pain management, addiction studies, and the exploration of opioid signaling mechanisms. -
Opioid Peptide
β-Casomorphin is an opioid peptide that primarily acts as an agonist at opioid receptors. This compound exhibits biological activity associated with pain modulation, gastrointestinal function, and is relevant in studies of addiction and opioid signaling pathways. β-Casomorphin serves as a valuable tool in pharmacological research to understand the implications of opioid peptides in various physiological processes. -
Polypeptide
Orexin A (16-33) is a biologically active fragment of the orexin A peptide, functioning primarily as a polypeptide modulator. This compound has been shown to interact with orexin receptors, playing a crucial role in regulating various physiological processes such as appetite, arousal, and circadian rhythms. Research applications include studies on sleep disorders, metabolic regulation, and neurobiological pathways associated with energy homeostasis.
