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Urantide

Catalog No.: A63983
urotensin-II Receptor Antagonist Peptide
Urantide is a selective and competitive antagonist of the urotensin-II (UT) receptor, exhibiting a pKB of 8.3. This peptide effectively inhibits human urotensin-II (hU-II)-induced contractions in rat thoracic aorta ex vivo. Urantide is valuable for investigating the (patho)physiological roles of hU-II in the mammalian cardiovascular system, making it an important tool for related research applications.
Urantide 669089-53-6 urotensin-II Receptor Antagonist Peptide
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Size Price Stock Qty
10mg
$280.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionUrantide is a selective and competitive antagonist of the urotensin-II (UT) receptor, exhibiting a pKB of 8.3. This peptide effectively inhibits human urotensin-II (hU-II)-induced contractions in rat thoracic aorta ex vivo. Urantide is valuable for investigating the (patho)physiological roles of hU-II in the mammalian cardiovascular system, making it an important tool for related research applications.
Product Information
Catalog NumA63983
FormulaC51H66N10O12S2
Molecular Weight1075.26
CAS Number669089-53-6
SequenceAsp-{Pen}-Phe-{d-Trp}-{Orn}-Tyr-Cys-Val (Disulfide bridge: Pen2-Cys7)
Sequence shorteningD-{Pen}-F-{d-Trp}-{Orn}-YCV (Disulfide bridge: Pen2-Cys7)
SMILESC(C=1C=2C(NC1)=CC=CC2)[C@H]3NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@@H](NC([C@H](CC(O)=O)N)=O)C(C)(C)SSC[C@@H](C(N[C@@H](C(C)C)C(O)=O)=O)NC(=O)[C@H](CC5=CC=C(O)C=C5)NC(=O)[C@H](CCCN)NC3=O
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GPCR/G Protein > Urotensin Receptor
Peptides