Catalog No.
Product Name
Application
Product Information
Citations
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Peptide
[D-Asn5]-Oxytocin is a peptide analog of oxytocin, primarily known for its low oxytocic and vasodepressor activities. Cumulative dose-response studies indicate that [D-Asn5]-Oxytocin exhibits intrinsic activity comparable to that of native oxytocin. This compound is valuable for research in neurobiology and cardiovascular physiology, allowing for the exploration of oxytocin's roles in various biological processes. -
Xenopus Peptide
Hydrin 1′ is a peptide derived from the neurohypophysis of Xenopus, targeting the oxytocin receptor. This compound exhibits significant steroid-releasing activity in vitro within the Xenopus adrenal gland. Hydrin 1′ serves as a valuable tool for research applications focused on oxytocin receptor interactions and fluorescent probing in neurological studies. -
Endogenous Neuropeptide
PACAP (1-38) free acid is a desamido derivative of the endogenous neuropeptide PACAP, specifically targeting the human PAC1 receptor. It is known to stimulate cyclic AMP (cAMP) production in both neuroendocrine NS-1 cells and non-neuroendocrine HEK293 cells. This compound is valuable for research involving neuropeptide signaling pathways and their physiological roles. -
RFamide Neuropeptide
Neuropeptide AF (cattle) is an amidated octadecapeptide that targets RFamide neuropeptide receptors. It serves as a ligand for Mas-related gene receptor A4 (MrgprA4) with an EC50 of approximately 60 nM and MrgprC11 with an EC50 around 300 nM. Additionally, it activates the G protein-coupled receptors NPFF1 and NPFF2, exhibiting EC50 values ranging from 25-325 nM and 1-5 nM, respectively. Neuropeptide AF (cattle) demonstrates anti-opiate properties and plays a significant role in pain modulation research applications. -
MCHR1 (GPR24) Antagonist
Neuropeptide EI (rat) serves as an antagonist of the melanin-concentrating hormone receptor 1 (MCHR1, also known as GPR24). It displays functional activity by antagonizing MCH and exhibiting agonistic properties towards melanocyte-stimulating hormone (MSH). This compound is useful in research applications focused on neuropeptide signaling, metabolism, and behaviors related to feeding and energy balance. -
Cosmetic Peptide
Acetyl hexapeptide-1 acetate is a biomimetic peptide that mimics the activity of α-melanocyte-stimulating hormone (α-MSH). This compound regulates muscle contraction, effectively reducing facial expression lines and serving as a key component in anti-aging skin care formulations targeting dynamic wrinkles. Additionally, Acetyl hexapeptide-1 acetate plays a role in improving premature graying of hair, although continuous usage is necessary to maintain its effects. This peptide is valuable in research focused on mild photo-aged facial skin and the mechanisms of hair pigmentation. -
Cosmetic Peptide
Acetyl hexapeptide-1 is a biomimetic peptide that mimics the action of α-melanocyte-stimulating hormone (α-MSH). It functions by regulating muscle contraction, thereby contributing to the reduction of facial expression lines. This peptide is utilized in anti-aging skincare research, specifically targeting dynamic wrinkles and the improvement of premature gray hair. Continued application over several months is recommended to achieve desired effects, which may reverse upon discontinuation. Acetyl hexapeptide-1 is valuable for studies focused on mild photoaged facial skin and mechanisms underlying premature gray hair. -
Peptide
Codactide is a synthetic octadecapeptide that mimics the action of corticotropin, targeting the corticotropin-releasing hormone receptor. This compound exhibits significant neuroendocrine activity that may modulate stress response pathways. Codactide is primarily utilized in research focused on stress-related disorders and the investigation of hypothalamic-pituitary-adrenal (HPA) axis functions. -
Tripeptide
α-MSH (11-13) is a C-terminal tripeptide of α-MSH that effectively crosses the blood-brain barrier. This compound exhibits notable antipyretic, anti-inflammatory, and antibacterial activities. Additionally, α-MSH (11-13) provides neuroprotective effects following traumatic brain injury by inhibiting excessive microglial activation and reducing neuronal apoptosis. It is applicable in research concerning traumatic brain injury, fever, and bacterial infections. -
MC1R-targeting peptide
DOTA-GGNle-CycMSHhex is a peptide that targets the melanocortin-1 receptor (MC1R), facilitating radionuclide labeling for imaging applications in melanoma. Its specificity for MC1R makes it an invaluable tool for advancing research in melanoma diagnostics and therapeutic monitoring. This compound is designed to aid in the development of targeted imaging techniques, enhancing the visualization of melanoma in research studies. -
Neurotrophic Peptide
ORG-2766 is an adrenocorticotropic hormone (ACTH) 4-9 analog that functions as a neurotrophic peptide. This compound enhances neuroprotective effects and significantly influences behavioral processes, including memory and attention, in animal models. Research has demonstrated its potential to alleviate symptoms associated with experimental allergic neuritis in rats, making it a valuable tool for studies on neuroprotection and cognitive function. -
Melanocortin Peptide
δ-MSH is a melanocortin peptide that acts as a weak ligand for melanocortin receptors (MCRs). It plays a role in various biological processes, including appetite regulation and energy homeostasis. δ-MSH is valuable for research applications focusing on neuroendocrine functions and studies of metabolic disorders. -
Melanocortin Peptide
Lys-γ3-MSH (human) is a melanocortin peptide that targets the melanocortin receptor system, derived from the C-terminal fragment of pro-opiomelanocortin (POMC). It effectively enhances the steroidogenic response of adrenal cells to adrenocorticotrophin (ACTH) and exhibits potent lipolytic activity with an EC50 of 3.56 nM. Lys-γ3-MSH activates hormone-sensitive lipase (HSL) and Perilipin A, making it valuable for research in metabolic regulation and obesity-related studies. -
ACTH Derivative Peptide
Ebiratide is an ACTH 4-9 derivative peptide that acts on the central nervous system to enhance cognitive function. It has been shown to improve memory by promoting acetylcholine metabolism within the rat brain. This compound is valuable for research into neurodegenerative diseases and cognitive disorders. -
Natriuretic Peptide
Rolzavosoritide is a C-type natriuretic peptide that primarily targets natriuretic peptide receptors. This compound is involved in modulating vascular homeostasis, reducing cardiac hypertrophy, and promoting diuresis. It is being investigated for its potential applications in treating heart failure and other cardiovascular diseases. -
Atrial Natriuretic Peptide
Anaritide is a synthetic analogue of atrial natriuretic peptide (ANP) consisting of 25 amino acids. It primarily functions by enhancing glomerular filtration rate through the dilation of afferent arterioles and contraction of efferent arterioles. This reagent is valuable for investigating its impact on acute tubular necrosis and may contribute to improved dialysis-free survival in affected patients. -
Neuropeptide
BNP(1-32), porcine is an atrial natriuretic peptide that primarily targets neuropeptide pathways. This cardiac hormone exhibits significant natriuretic, diuretic, and vasorelaxant effects, making it valuable for cardiovascular research. Furthermore, BNP(1-32) has been shown to influence passive avoidance learning in rodent models, highlighting its potential role in neurobiology studies involving dopaminergic and cholinergic systems, as well as adrenergic receptor interactions. -
Peptide
BNP (1-21), Pro (Human) is a 21-amino acid peptide and a member of the B-type natriuretic peptide family, a cardiac natriuretic hormone. It plays a crucial role in regulating cardiovascular function by promoting natriuresis, diuresis, and vasodilation. Research applications include studies on heart organogenesis and the physiological adaptations during the transition to extrauterine life. BNP serves as an important biomarker in various cardiovascular diseases and helps elucidate the underlying mechanisms of heart function and development. -
ANP Peptide Fragment
Atrial Natriuretic Peptide (7-28), human, canine is a bioactive peptide fragment derived from atrial natriuretic peptide (ANP). This fragment plays a crucial role in cardiovascular homeostasis by promoting natriuresis and vasodilation. It is primarily utilized in research applications focusing on cardiovascular function, heart failure, and the regulatory effects of natriuretic peptides. Additionally, this peptide can serve as a useful tag for various biochemical assays. -
Hypotensive and Diuretic Agent
Brain Natriuretic Peptide-45, rat is a potent hypotensive and diuretic agent derived from rat heart tissue. This circulating form of rat brain natriuretic peptide plays a critical role in regulating blood pressure and sodium homeostasis. Its biological activity is essential for research applications focusing on cardiovascular physiology, heart failure, and fluid balance in animal models. -
ANP Analog
[Tyr8]-Atrial Natriuretic Peptide (5-27), rat is an analog of atrial natriuretic peptide (ANP) that primarily targets smooth muscle relaxation. This peptide is characterized by its ability to induce vasodilation while maintaining stable cGMP levels. Its unique properties make it a valuable tool for research in cardiovascular physiology and pharmacology, particularly in studies examining the regulatory mechanisms of blood pressure and fluid homeostasis. -
Atrial Peptide
[Mpr7, DAla9] ANP (7-28), amide, rat is a modified atrial natriuretic peptide that acts on the NPR-A receptor. This reagent exhibits significant vasodilatory effects and plays a crucial role in regulating cardiovascular homeostasis. It is widely used in research to study cardiac function, blood pressure regulation, and the pathophysiology of heart failure. -
Peptide Neurotransmitter
Neurokinin A TFA is a peptide neurotransmitter belonging to the tachykinin family, primarily targeting the NK-2 receptor. This compound plays a significant role as a mediator in human airway and gastrointestinal tissues, influencing smooth muscle contraction and various physiological processes. It is extensively utilized in research applications exploring neurogenic inflammation, pain signaling, and gastrointestinal motility. -
Neurokinin Receptor Activator
Eledoisin Related Peptide is a neurokinin receptor activator that functions as an analog of Substance P. This peptide is known to stimulate neurons, resulting in various behavioral responses. It serves as a valuable tool for research applications focused on neurokinin signaling pathways and tachykinin receptor interactions. -
Neuropeptide Substance P Antagonist
Octahydroisoindole is a neuropeptide Substance P antagonist that effectively crosses the blood-brain barrier. This compound is vital for investigating movement disorders linked to central nervous system diseases, enabling researchers to explore its potential therapeutic applications in conditions such as pain and neurodegeneration. -
C-terminal Tripeptide of Substance P
Gly-Leu-Met-NH2 is a C-terminal tripeptide derived from Substance P, a neuropeptide known for its role in pain transmission and inflammation. This compound exhibits neuroactive properties that can be utilized in research applications related to neurobiology, pain mechanisms, and neuroinflammatory processes. Its structural similarity to Substance P makes it a valuable tool for studying receptor interactions and signaling pathways associated with neuropeptide functions. -
NK2 Receptor Agonist
γ-Neuropeptide (rabbit) is an endogenous peptide that acts as an agonist for the neurokinin 2 (NK2) receptor. It plays a significant role in regulating the hypothalamic-pituitary-adrenal (HPA) axis and the release of reproductive hormones. This reagent is valuable for studies investigating neurokinin signaling pathways and their implications in stress response and reproductive health. -
Neuropeptide
Substance P (6-11) is a neuropeptide specifically targeting the NK-1 tachykinin receptor. This C-terminal hexapeptideamide derivative of Substance P demonstrates significant biological activity, including the depolarization of motoneurons and a hypotensive effect. It serves as a valuable tool in research applications focused on neurobiology, pain modulation, and cardiovascular studies. -
Neuromessenger
Neuropeptide K is a tachykinin neuromessenger that plays a crucial role in facilitating intercellular communication within the central nervous system. It is involved in various biological activities, such as gallbladder contraction, protein extravasation, hypotension, and bronchial smooth muscle spasms. This reagent is derived from human, porcine, and rat sources, making it suitable for research applications aimed at exploring neuropeptide signaling and its implications in physiological and pathophysiological processes. -
Neuropeptide
Substance P (5-11) is a neuropeptide that primarily targets the NK-1 tachykinin receptor. As a C-terminal heptapeptide of the full Substance P, it plays a critical role in pain transmission and neurogenic inflammation. This compound is commonly used in research applications focused on pain pathways, neurobiology, and receptor pharmacology, providing insights into the functions and mechanisms of neuropeptide activity. -
Peptide
[Tyr8,Nle11] Substance P is an analog of the neuropeptide Substance P, which primarily targets neurokinin receptors. This peptide plays a significant role in various biological processes, including pain transmission and inflammatory responses. It is widely used in research to study nociceptive pathways and the modulation of inflammatory conditions. -
Octapeptide
[Glp5] Substance P (5-11) is an octapeptide that primarily targets neurokinin receptors. This fragment of substance P plays a significant role in the central nervous system (CNS) of rats, where it is known to modulate dopamine release in the striatum. Its ability to influence neurotransmitter dynamics makes it valuable for research in neuropharmacology and studies related to CNS functions and disorders. -
Neuropeptide
Substance P (alligator) is a neuropeptide that plays a crucial role in pain perception, inflammation, and various neurogenic processes. Its amino acid sequence is Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2. This reagent is used in research to elucidate the mechanisms of neurogenic inflammation and to investigate the role of neuropeptides in signaling pathways related to pain and stress responses. Substance P (alligator) is valuable for studying neuropeptide interactions and their implications in various physiological and pathological conditions. -
Neuropeptide
Tyr0-Neurokinin A is a tachykinin neuropeptide that acts as an agonist for the Tachykinin receptor 2 (Tacr2). This compound is significant in the study of metabolic disorders, particularly in understanding the mechanisms underlying insulin resistance, obesity, and diabetes. Its biological activity positions it as a valuable tool for advancing research in neuropeptide signaling and associated therapeutic targets. -
Peptide
Kassinin is a neuropeptide derived from the Kassina frog, classified within the tachykinin family. It functions primarily as a signaling molecule in neuropeptide pathways and is released in response to stress as part of the organism's defense mechanism. This peptide is of interest in research focused on neurobiology, signaling pathways, and the study of amphibian defense mechanisms. -
NPBW1/2 Agonist
Neuropeptide W-23 (human) is an endogenous agonist specifically targeting the NPBW1 (GPR7) and NPBW2 (GPR8) receptors. This neuropeptide plays a significant role in various physiological processes, including appetite regulation and stress response. Neuropeptide W-23 is primarily used in research applications focusing on neurobiology and metabolic disorders, providing insights into neural signaling pathways and potential therapeutic targets. -
Neuropeptide
Biotinyl-neuropeptide W-23 (human) is a biotinylated analog of the neuropeptide W-23, which functions as an agonist of the NPBW1 (GPR7) and NPBW2 (GPR8) receptors. This compound modulates neuropeptide signaling pathways involved in various physiological processes, making it useful for investigating neuropeptide-related functions and signaling mechanisms in research applications. Biotinyl-neuropeptide W-23 facilitates the study of receptor interactions and offers potential insights into neurobiology and drug development. -
NPBW Agonist
(Des-Bromo)-Neuropeptide B (1-23) (human) is an agonist for G-protein coupled receptors GPR7 (NPBW1) and GPR8 (NPBW2). It exhibits high affinity binding with inhibition constants (Kis) of 1.2 nM and 341 nM, respectively. This compound is valuable for investigating the neuropeptide signaling pathways and their roles in various physiological processes. It has applications in studies related to neurobiology, metabolic regulation, and receptor pharmacology. -
Stress Mediator
Neuropeptide W-30 (human) is a significant stress mediator in the central nervous system, primarily targeting the hypothalamus-pituitary-adrenal (HPA) axis and modulating sympathetic outflow. As an endogenous ligand for the orphan G-protein-coupled receptors GPR7 and GPR8, Neuropeptide W-30 (human) binds and activates both receptors at comparable effective doses. This compound plays a crucial role in studies related to stress response and neuroendocrine regulation. -
Stress Mediator
Neuropeptide W-30 (rat) primarily targets the G-protein-coupled receptors GPR7 and GPR8, functioning as a key mediator of stress within the central nervous system. It plays a crucial role in modulating the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow, influencing stress responses. Neuropeptide W-30 (rat) acts as an endogenous ligand for both receptors, demonstrating similar effective doses for binding and activation. This peptide is pertinent for research into stress-related disorders and neuroendocrine functions. -
NPFF1/NPFF2 Receptor Agonist
Neuropeptide FF (NPFF) functions as an agonist for the NPFF1 and NPFF2 receptors, exhibiting Ki values of 2.82 nM and 0.21 nM, respectively. This octapeptide plays a crucial role in mediating various physiological processes, including the modulation of pain, opioids, autonomic function, and neuroendocrine responses. It is involved in the regulation of memory and the control of food and water intake, while also demonstrating significant antiopioid and analgesic properties. Neuropeptide FF is particularly relevant for research into opioid tolerance, morphine-induced analgesia, abstinence syndrome, and pain-related conditions, including inflammatory and neuropathic pain. -
NPFF-Related Peptides
Neuropeptide FF (5-8) is a derivative of Neuropeptide FF that acts as a potent antagonist of NPFF-related receptors. This peptide, with the sequence Q-P-Q-R-F-NH2, exhibits a Ki value of 20.9 nM, indicating its strong binding affinity. It is primarily used in research to study pain modulation, stress responses, and neuroendocrine functions in various biological models. -
PrRP Fragment
Prolactin-Releasing Peptide (12-31), bovine is a peptide fragment of prolactin-releasing peptide (PrRP), which is known for its role in modulating pain through RF-amide signaling. This peptide is primarily utilized in research focused on the nervous system, particularly in studies related to pain pathways and neurological disorders. Its specific biological activity makes it a valuable tool for exploring the mechanisms underlying nervous system diseases. -
Non-peptide NPSR Antagonist
SHA 68 is a potent and selective non-peptide antagonist of the neuropeptide S receptor (NPSR), demonstrating IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107. This compound exhibits limited blood-brain barrier penetration, making it suitable for research on peripheral applications and neuralgia. SHA 68 is valuable for studying the physiological roles of neuropeptide S and its potential implications in pain modulation and neurobiology. -
Neuropeptide
Buccalin is a neuropeptide that primarily targets synaptic transmission at the neuromuscular junction. It effectively reduces the amplitude of motor neuron-induced muscle contractions when externally administered, acting presynaptically without influencing the rate of muscle relaxation. Buccalin diminishes excitatory junction potentials at the ARC while preserving the contractile response elicited directly through acetylcholine. This selective modulation makes it a valuable tool for research on synaptic mechanisms and neuropeptide function in neuromuscular signaling. -
Active Compound
Neuropeptide Y (human, rat, mouse) is an active compound that plays a critical role in neuroprotection and modulation of neuronal activity. It has been shown to protect rat cortical neurons from β-Amyloid-induced toxicity, suggesting its potential relevance in Alzheimer's disease research. This peptide is commonly utilized in studies focused on neurodegenerative disorders and neuronal signaling pathways. -
Gut Hormone
Peptide YY (PYY) is a human gut hormone primarily involved in appetite regulation and the inhibition of pancreatic secretions. It exerts its biological effects by interacting with Neuropeptide Y receptors. This peptide is valuable for research focused on metabolic disorders, appetite control, and the physiology of gastrointestinal hormones. -
Neuropeptide S receptor (NPSR) Agonist
R06039-636 is a potent agonist of the Neuropeptide S receptor (NPSR), exhibiting an EC50 value of 94 nM. This compound plays a crucial role in modulating anxiety and stress responses, making it valuable for research into neuropsychiatric disorders. Its selective activation of NPSR provides insight into neuropeptide signaling pathways and can aid in the development of potential therapeutic strategies. -
NPY Y1 Receptor Agonist
[Leu31,Pro34]-Neuropeptide Y (porcine) is a selective agonist of the neuropeptide Y Y1 receptor. This analog exhibits significant anxiolytic effects, making it a valuable tool for studying anxiety-related disorders. It is predominantly utilized in neuropharmacological research to explore the role of NPY in stress and anxiety modulation. -
Peptide
Neuropeptide Y(29-64) is a peptide fragment comprising 36 amino acids derived from the larger neuropeptide Y. This fragment plays a critical role in modulating various physiological processes, including appetite regulation, anxiety, and stress response. Research applications include exploring neuropeptide signaling pathways and investigating the role of neuropeptides in neuropsychiatric disorders.
