JNJ-5207787 is a selective nonpeptidic antagonist of the neuropeptide Y Y2 receptor, designed to penetrate the blood-brain barrier effectively. It demonstrates strong inhibition of peptide YY (PYY) binding, with pIC50 values of 7.0 and 7.1 for the human and rat Y2 receptors, respectively. This compound exhibits over 100-fold selectivity against human Y1, Y4, and Y5 receptors, making it a valuable tool for research into neuropeptide Y signaling pathways and their roles in various physiological processes.
JNJ-5207787 is a selective nonpeptidic antagonist of the neuropeptide Y Y2 receptor, designed to penetrate the blood-brain barrier effectively. It demonstrates strong inhibition of peptide YY (PYY) binding, with pIC50 values of 7.0 and 7.1 for the human and rat Y2 receptors, respectively. This compound exhibits over 100-fold selectivity against human Y1, Y4, and Y5 receptors, making it a valuable tool for research into neuropeptide Y signaling pathways and their roles in various physiological processes.
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