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Catalog No.
Product Name
Application
Product Information
Citations
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HIV Protease inhibitor
Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease.Ritonavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. -
DDP-4 inhibitor
Sitagliptin phosphate is an anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release , stimulates the insulin release and lowers blood glucose. -
protein tyrosine phosphatases inhibitor
Sodium orthovanadate is the chemical compound Na3VO4. It is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue. -
reversible Protease inhibitor
Ubenimex, also known as NK 421 and Bestatin, is a CD13 inhibitor. Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism. Ubenimex synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma. Ubenimex inhibits cell proliferation, migration and invasion by inhibiting the expression of APN and inducing autophagic cell death in prostate cancer cells. -
Protease Inhibitor Cocktail
Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) is used in mammalian cell lysates or tissue extracts to increase protein stability.
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CNS penetrant Aldose Reductase inhibitor
AT-007 is an orally active central nervous system (CNS) penetrant Aldose Reductase inhibitor for treatment of Galactosemia with an IC50 value of 100 pM. AT-007 reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats. -
Tyrosinase Inhibitor
Norartocarpetin is a potent tyrosinase inhibitor, demonstrating significant inhibition with an IC50 value of 0.47 μM. This compound serves as an effective antibrowning agent for food systems research and exhibits notable anticancer activity against lung carcinoma cells (NCI-H460) with an IC50 of 22 μM. Its antiproliferative effects are mediated through targeting the Ras/Raf/MAPK signaling pathway, inducing mitochondrial-mediated apoptosis, causing S-phase cell cycle arrest, and inhibiting cell migration and invasion in human lung carcinoma cells. -
HIV Protease Inhibitor
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives. -
PTPN1/PTPN2 Inhibitor
Osunprotafib (ABBV-CLS-484) is an orally active and selective active site PTPN1 (IC50: 2.5 nM) and PTPN2(IC50: 1.8 nM) inhibitor. Osunprotafib has 6-8-fold weaker activity on PTPN9 and no detectable activity on SHP-1 or SHP-2. Osunprotafib increases the sensitivity of human cancer cell lines to IFNγ. Osunprotafib generates robust anti-tumor immunity by enhancing JAK-STAT signalling and reducing T cell dysfunction. -
MMP Inhibitor
o-Phenanthroline monohydrate is a potent MMP inhibitor that acts by chelating divalent metal ions, particularly iron (Fe2+), forming a stable red complex that absorbs light maximally at 510 nm. This compound has demonstrated the ability to prevent chromosomal aberrations in cells exposed to streptozotocin, thereby highlighting its significance in cellular and molecular biology research. It is widely utilized in studies investigating metalloproteinases and their role in various biological processes and disease states. -
Caspase Inhibitor
Z-VA-DL-D-FMK is an irreversible caspase inhibitor that targets and binds to caspases, modulating their activity. This compound enhances the sensitivity of TNF-α, thereby influencing apoptotic pathways. Additionally, Z-VA-DL-D-FMK has been shown to activate HIV replication in infected T cells, such as ACH-2, making it valuable for studies in cell signaling and viral reactivation. -
Caspase-1 Inhibitor
Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable inhibitor of caspase-1, a key enzyme involved in inflammatory processes and programmed cell death. This compound demonstrates significant antitumor activity by modulating inflammatory responses and apoptosis. It is suitable for research applications focused on understanding caspase-1's role in cancer biology and related inflammatory diseases. -
Caspase Inhibitor
Ac-VEID-CHO is a potent peptide-derived caspase inhibitor that targets Caspase-3, Caspase-6, and Caspase-7, displaying IC50 values of 13.6 nM, 16.2 nM, and 162.1 nM, respectively. Additionally, it inhibits VEIDase activity with an IC50 of 0.49 µM. This compound is valuable for research into neurodegenerative diseases, including Alzheimer’s and Huntington’s disease, facilitating the study of apoptotic pathways and potential therapeutic interventions. -
Caspase-1 Inhibitor
Ac-Trp-Glu-His-Asp-Aldehyde is a selective inhibitor of caspase-1, demonstrating a remarkable Ki value of 56 pM. This compound plays a crucial role in the modulation of inflammatory processes by inhibiting the activation of caspase-1, an essential enzyme in the maturation of pro-inflammatory cytokines. It is widely utilized in research focused on innate immunity, inflammation, and therapeutic approaches for diseases driven by caspase-1 activity. -
Caspase Inhibitor
Ac-VAD-CMK is a pan-caspase inhibitor that effectively targets and inhibits various caspases, including caspases 1, 3, and 7. This compound is utilized in research to study apoptotic pathways and cell death mechanisms. Its application extends to investigating inflammation and neurodegenerative diseases where caspase activity is a critical factor. -
Caspase 4/5/9 Inhibitor
Ac-AAVALLPAVLLALLAP-LEHD-CHO is a potent inhibitor of caspases 4, 5, and 9. This compound demonstrates protective effects in MCF-7 cells treated with Neocarzinostatin, highlighting its potential applications in apoptosis research and cell survival studies. Its ability to modulate caspase activity makes it a valuable tool for investigating pathways related to cell death and disease mechanisms. -
Caspase-2/3 Inhibitor
Ac-VDVAD-CHO is a potent inhibitor of caspase-2 and caspase-3, with IC50 values of 46 nM and 15 nM, respectively. This compound effectively interferes with apoptotic signaling pathways, making it a valuable tool for research into cell death mechanisms. It is suitable for applications involving the study of apoptosis, neurodegeneration, and cancer. -
Caspase Inhibitor
Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor that specifically targets and inhibits caspase activity. This compound effectively prevents the dissipation of mitochondrial membrane potential (MMP) and the release of cytochrome c in cells exposed to hypoxic conditions. Ac-VAD-CHO is widely used in research applications aimed at studying apoptosis and cell survival mechanisms. -
Caspase Inhibitor
Ac-LEHD-CHO is a selective inhibitor of caspase-8 and caspase-9. It effectively blocks apoptosis in hepatocytes and prevents hepatotoxicity induced by GalN/TNF-α. This compound is valuable for research applications involving cell death pathways and liver-related diseases. -
Caspase 3 Inhibitor, GSDME Inhibitor
Ac-DMLD-CMK is a potent inhibitor of caspase 3 and GSDME, functioning by binding directly to the catalytic domain of caspase-3. This compound effectively obstructs caspase-3-mediated cleavage of GSDME, thereby modulating the caspase 3-GSDME signaling pathway. Its primary biological activity includes the reduction of pyroptosis and apoptosis, as well as the suppression of inflammatory cytokines such as LDH, IL-6, IL-1β, and IL-18. Ac-DMLD-CMK shows potential in mitigating renal function decline, renal tubular epithelial cell damage, and chemotherapeutic nephrotoxicity. -
Caspase-1 Inhibitor
CZL80 is a potent caspase-1 inhibitor with an IC50 of 0.01 μM, capable of penetrating the blood-brain barrier. This compound is valuable for studying inflammatory pathways in neurological disorders, notably in the context of febrile seizures and their correlation with increased susceptibility to epilepsy. Research applications include investigating the role of caspase-1 in neuroinflammation and other brain-related pathologies. -
Caspase Like Protease Inhibitor
Ac-YVAD-FMK is a selective inhibitor of caspase 1-like proteases. It functions by covalently modifying the active site cysteine, thus blocking the enzymatic activity of these proteases. This compound is valuable in the study of inflammation and cell death pathways, particularly in research focused on the mechanisms of pyroptosis and other caspase-associated processes. -
Caspase Inhibitor
Z-LEED-FMK is a selective inhibitor of caspase-4 and caspase-13. This compound effectively inhibits the processing of caspase-1 in macrophages infected with S. typhimurium, making it a valuable tool for studying apoptosis and inflammatory pathways. Its specificity and inhibitory effects are significant for research applications in cell death mechanisms and inflammatory response investigations. -
Caspase 8 Inhibitor
Boc-AEVD-CHO is a selective inhibitor of Caspase 8, a crucial enzyme involved in apoptotic pathways. This compound is valuable for investigating the mechanisms of apoptosis as well as the roles of Caspase 8 in various immune and inflammatory diseases. Researchers can utilize Boc-AEVD-CHO to better understand cellular processes related to programmed cell death and inflammation regulation. -
Caspase 3 Inhibitor
Cimiside E, a caspase 3 inhibitor, is a triterpene xyloside known for its pro-apoptotic effects on gastric cancer cells, displaying an IC50 value of 14.58 μM. This compound induces cell cycle arrest in the G2/M phase and mediates apoptosis via activation of the caspase cascade across both extrinsic and intrinsic pathways. Cimiside E is a valuable tool in cancer research, particularly in studies focusing on apoptosis and cell cycle modulation. -
Caspase-8 Inhibitor
IETD-CHO is a selective inhibitor of caspase-8, a crucial enzyme in the apoptotic signaling pathway. By blocking caspase-8 activity, this reagent prevents the activation of downstream effector caspases, allowing for the study of programmed cell death mechanisms. IETD-CHO is widely used in research applications focused on apoptosis, inflammation, and related cell signaling processes. -
Caspase-9 Inhibitor
Caspase-9 Inhibitor III (Ac-LEHD-cmk) targets and inhibits caspase-9, a critical component of the apoptotic pathway. This reagent demonstrates protective effects against ischemia-reperfusion-induced myocardial injury, making it valuable for studying cardiac apoptosis and related pathological conditions. It can be utilized in research focused on cellular survival mechanisms and the modulation of programmed cell death. -
δ-Secretase Inhibitor
δ-Secretase inhibitor 11 is a potent and selective inhibitor targeting δ-secretase, displaying an IC50 of 0.7 μM. This compound effectively interacts with both the active and allosteric sites of δ-secretase, resulting in the attenuation of tau and amyloid precursor protein cleavage. Its oral bioavailability and blood-brain barrier penetration make it suitable for in vivo studies, particularly in transgenic mouse models. δ-Secretase inhibitor 11 is a valuable tool for Alzheimer's disease research, facilitating investigations into the mechanisms underlying synaptic dysfunction and cognitive impairments. -
Caspase Inhibitor
Ac-FLTD-CMK is a selective inhibitor of inflammatory caspases, specifically targeting caspases-1, -4, -5, and -11, with IC50 values of 46.7 nM, 1.49 μM, and 329 nM, respectively. This compound is derived from gasdermin D (GSDMD) and does not inhibit apoptotic caspases such as caspase-3. Ac-FLTD-CMK is instrumental in research applications focused on inflammatory processes, providing valuable insights into caspase-mediated pathways and their implications in various diseases. -
Caspase-4 inhibitor
Z-LEVD-FMK is a cell-permeable inhibitor of caspase-4, a key player in the apoptotic signaling pathway. This reagent effectively blocks endoplasmic reticulum stress-induced apoptosis in cancer cells, making it a valuable tool for studying cell death mechanisms and developing therapeutic strategies in oncology research. Its specificity for caspase-4 facilitates investigations into its role in various cellular stress responses. -
Caspase Inhibitor
Z-VAD-CHO is a potent, irreversible inhibitor of caspases, primarily targeting caspase-1 with a Ki value of 0.008 μM. This compound effectively modulates apoptotic pathways and is instrumental in studies related to inflammation and cell death. Z-VAD-CHO is widely utilized in research to investigate the role of caspases in various cellular processes and disease models. -
Caspase-1/3 Inhibitor
Z-YVAD-CMK is a potent inhibitor of caspase-1 and caspase-3, key enzymes involved in the apoptosis and inflammatory processes. By selectively blocking these caspases, Z-YVAD-CMK is invaluable for research applications focused on cell death pathways and inflammatory responses. It is particularly useful in studies investigating the role of caspases in disease models, including neurodegeneration and cancer. -
MMP-3/Caspase-1 Inhibitor
Berkeleyamide B is a dual inhibitor of matrix metalloproteinase-3 (MMP-3) and caspase-1, targeting key enzymes involved in inflammation and tissue remodeling. This compound demonstrates significant biological activity in modulating apoptotic pathways and inflammatory responses. Berkeleyamide B is applicable in research focused on cancer and inflammatory diseases, including conditions such as rheumatoid arthritis. -
Caspase-3 Inhibitor
Caspase-3-IN-3 is a selective inhibitor of caspase-3, a crucial executioner enzyme in the apoptosis pathway. This compound has been shown to enhance cellular ATP levels, inhibit caspase-3 activity, and reduce nitrite production. Additionally, Caspase-3-IN-3 mitigates cytokine-induced apoptosis and restores insulin secretion stimulated by glucose, making it a valuable tool for research in apoptosis, metabolic disorders, and cellular energy regulation. -
Caspase-3 Inhibitor
Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a potent and cell-permeable inhibitor of caspase-3, acting through irreversible binding to the activated form in apoptotic cells. This reagent exhibits significant fluorescence, allowing for quantitative analysis via flow cytometry, microwell plate readers, or fluorescence microscopy. Its application is crucial for studying apoptosis and characterizing caspase-3 activity in various biological systems. -
Caspase Inhibitor
VX-166 is a pan caspase inhibitor that modulates apoptosis by targeting caspase enzymes. This compound is instrumental in investigating Non-Alcoholic Fatty Liver Disease (NAFLD), nonalcoholic steatohepatitis (NASH), and alcoholic steatohepatitis (ASH), as well as other conditions characterized by liver fibrosis, steatosis, or inflammation. Its ability to inhibit caspase activity makes it a valuable tool for research in liver pathology and related diseases. -
Caspase 3/7 Inhibitor
CAY10406 is a selective inhibitor of caspase 3 and caspase 7. This compound effectively reduces the expression of the 28-kDa IL-1β fragment, making it useful for studies related to apoptosis and inflammatory processes. Notably, CAY10406 exhibits minimal cytotoxicity at concentrations up to 10 μM, allowing for safer applications in cellular assays. -
MMP-3/Caspase-1 Inhibitor
Berkeleyamide C is a selective inhibitor of matrix metalloproteinase-3 (MMP-3) and caspase-1. This compound effectively blocks MMP-3-mediated tumor cell invasion and metastasis, while also inhibiting the abnormal activation of inflammation and apoptosis associated with caspase-1. Berkeleyamide C is valuable for research applications focused on cancer biology and inflammation-related diseases. -
Caspase-6 Inhibitor
ED11 is a selective inhibitor of caspase-6, demonstrating an IC50 of 12.12 nM. By competing with Huntingtin (Htt) for the active site of caspase-6, ED11 effectively reduces Htt cleavage. Notably, ED11 possesses the ability to cross the blood-brain barrier, making it a valuable reagent for research into Huntington's disease and related neurodegenerative disorders. -
Caspase-9 Inhibitor
Z-LEHD-FMK TFA is a selective and irreversible inhibitor of caspase-9, primarily involved in the apoptosis pathway. This compound demonstrates significant neuroprotective effects, particularly in models of spinal cord injury, and has been shown to mitigate lethal reperfusion injury. It is a valuable tool for research focused on therapeutic strategies against apoptotic cell death and neuroprotection. -
Proteasome Inhibitor
TP-110 is a selective proteasome inhibitor that targets the protease-like activity of the 20S proteasome, leaving trypsin-like and peptidyl-glutamyl peptide hydrolysis activities unaffected. This compound effectively disrupts the NF-κB signaling pathway, leading to activation of caspases 3, 8, and 9, and subsequent PARP cleavage, while decreasing levels of anti-apoptotic proteins cIAP-1 and XIAP. TP-110 induces G2/M phase cell cycle arrest and promotes apoptosis in cancer cells, making it a valuable tool for researching various malignancies, including prostate cancer and multiple myeloma. -
Caspase Inhibitor
Ac-DMQD-CHO is a selective inhibitor of caspase 3, exhibiting an IC50 of 39 nM. This compound effectively reduces apoptosis, making it a valuable tool in studies related to neuroprotection and cellular survival. Its application in research can aid in the exploration of therapeutic strategies targeting neurodegenerative diseases and apoptosis-related conditions. -
Caspase-8 Inhibitor
Z-LE(OMe)TD(OMe)-FMK is a selective inhibitor of caspase-8, a key enzyme involved in the apoptotic pathway. By inhibiting caspase-8 activity, this reagent effectively prevents apoptosis in various cell types, making it a valuable tool for studying cell survival mechanisms. It is widely used in research applications focused on programmed cell death and related signaling pathways. -
Caspase-3 Inhibitor
Ac-DMQD-AMC is a selective inhibitor of caspase-3, a critical executioner caspase in the apoptosis pathway. This compound features an aromatic amine structure and is synthesized using the aminium-based coupling reagent HATU alongside 2,4,6-trimethylpyridine (TMP). Ac-DMQD-AMC is suitable for research applications focused on studying apoptosis, cellular signaling, and the role of caspases in various diseases. -
Caspase-3 Inhibitor
Ac-AAVALLPAVLLALLAP-DEVD-CHO is a specific and reversible inhibitor of caspase-3, a key executioner in the apoptotic pathway. This compound effectively reduces caspase-3 activity, making it a valuable tool for studying apoptosis and cell death mechanisms in various biological contexts. Its application extends to research on neurodegenerative diseases, cancer, and other conditions where caspase-3 plays a pivotal role in cellular regulation. -
Caspase-4 Inhibitor
Ac-AAVALLPAVLLALLAP-LEVD-CHO is a cell-permeable inhibitor of caspase-4, a crucial mediator of inflammation and cell death pathways. This compound demonstrates notable antitumor activity, making it a valuable tool for studying caspase-related mechanisms in cancer research. Its ability to selectively inhibit caspase-4 can provide insights into therapeutic strategies aimed at mitigating inflammatory responses and promoting cell survival. -
Caspase-12 Inhibitor
Z-ATAD-FMK is a selective inhibitor of caspase-12, playing a crucial role in modulating apoptotic processes triggered by endoplasmic reticulum stress. By inhibiting caspase-12 activity, Z-ATAD-FMK effectively reduces downstream activation of caspase-9, thereby interfering with the apoptotic signaling pathways. This compound is valuable for research applications investigating the mechanisms of ER stress-induced apoptosis and cellular responses to stress. -
Caspase-1/4 Inhibitor
VRT-043198 is a selective inhibitor of caspase-1 and caspase-4, functioning primarily as an interleukin-converting enzyme inhibitor. It demonstrates potent inhibition with Ki values of 0.8 nM for caspase-1 and 0.6 nM for caspase-4. This compound is capable of crossing the blood-brain barrier, making it valuable for research applications related to neuroinflammation and cytokine regulation.
