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Biological Activity
Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease.Ritonavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
Targets
| CYP3A4 | HIV | |||
| In vitro (25°C) | DMSO | 94 mg/mL (130.38 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (4.16 mM) | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.87 mL | 69.36 mL | 138.72 mL |
| 0.5 mM | 2.77 mL | 13.87 mL | 27.74 mL |
| 1 mM | 1.39 mL | 6.94 mL | 13.87 mL |
| 5 mM | 0.28 mL | 1.39 mL | 2.77 mL |
*The above data is based on the productmolecular weight 720.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10799 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 155213-67-5 |
| Formula | C37H48N6O5S2 |
| M. Wt | 720.9 |
| Purity | >98% |
| Synonyms | Norvir, Norvir Softgel |
| SMILES | CC(C)C1=NC(=CS1)CN(C)C(=O)N[[email protected]@H](C(C)C)C(=O)N[[email protected]@H](CC2=CC=CC=C2)C[[email protected]@H]([[email protected]](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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