Catalog No.
Product Name
Application
Product Information
Citations
-
PROTAC Linker
Cl-PEG4-acid is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the development of targeted protein degradation strategies by enabling the selective recruitment of E3 ligases to the target protein. Cl-PEG4-acid demonstrates high versatility in various chemical conditions, making it an essential component for researchers focusing on targeted protein modulation and degradation in therapeutic applications. -
PROTAC Linker
NH-bis(PEG2-C2-Boc) is a versatile alkyl/ether-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the assembly of PROTACs by providing a flexible and effective connection between target proteins and E3 ligases. Its application in chemical biology enhances the development of targeted protein degradation strategies, enabling researchers to investigate protein functions and therapeutic interventions in various biological contexts. -
PROTAC Linkers
DBCO-NHCO-PEG6-Biotin is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling the conjugation of biotin for enhanced target protein degradation. This reagent is ideal for applications in chemical biology and drug discovery, particularly in the development of advanced therapeutic modalities. -
PROTAC Linker
Hydroxy-PEG2-CH2-Boc is a polyethylene glycol (PEG) and alkyl-based PROTAC linker that facilitates the synthesis of PROTAC molecules. This compound enhances the solubility and stability of the resulting PROTACs, making it a valuable tool in targeted protein degradation research. Its unique structure allows for improved delivery and activity, enabling enhanced studies in protein interactions and cellular processes. -
PROTAC Linkers
Hydroxy-PEG2-CH2COOH is a polyethylene glycol (PEG) based linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTAC molecules, facilitating their application in targeted protein degradation studies. Its versatile structure makes it suitable for a range of biochemical and cellular assays, contributing to advancements in drug discovery and therapeutic development. -
PROTAC Linker
Azido-PEG1-PFP ester is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Azido-PEG1-PFP ester can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, facilitating targeted protein degradation studies in chemical biology research. -
PROTAC Linkers
NH2-PEG8-OH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of protein ligands and E3 ligase recruiters, enabling targeted protein degradation. It is instrumental in the development of novel therapeutic strategies aimed at modulating protein function in various biological contexts. -
PROTAC Linker
N-Boc-PEG10-alcohol is a polyethylene glycol (PEG)-based linker designed for the construction of PROTACs (proteolysis-targeting chimeras). This compound facilitates the selective degradation of target proteins by linking a ligand for the target protein to an E3 ubiquitin ligase. Its application in PROTAC synthesis underscores its significance in the development of targeted protein degradation strategies for therapeutic intervention. -
PROTAC Linkers
Azido-PEG9-NHS ester is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. Characterized by its azide functional group, this compound facilitates click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynyl-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile reagent for chemical biology applications. -
PROTAC Linker
PC DBCO-PEG4-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs, functioning as a critical component in targeted protein degradation. This compound features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-functionalized molecules. It serves as a valuable tool in chemical biology for developing novel therapeutic strategies by enabling the creation of bifunctional compounds that can modulate protein interactions. -
PROTAC linker
Cbz-NH-PEG1-CH2CH2COOH is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins by promoting the action of E3 ligases. Its unique structure allows for enhanced solubility and biocompatibility, making it suitable for applications in targeted protein degradation research and drug development. -
PROTAC Linker
Cl-PEG2-acid is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) applications. It facilitates the efficient synthesis of PROTACs, enabling targeted protein degradation in various biological systems. This compound can be utilized in the development of novel therapeutics aimed at specific protein targets, enhancing both the selectivity and efficacy of drug discovery efforts. -
PROTAC Linker
Azido-PEG4-4-nitrophenyl carbonate functions as a potent linker for the creation of PROTACs, facilitating targeted protein degradation. This PEG-based compound incorporates an azide group, enabling its use in click chemistry via copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized molecules. This reagent is valuable in chemical biology studies focused on targeted therapeutics and protein manipulation. -
PROTAC Linkers
N-(acid-PEG3)-N-bis(PEG3-azide) is a PEG-based linker designed for use in the synthesis of PROTACs. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-functionalized compounds, making it a versatile tool for modular assembly in chemical biology research. -
PROTAC Linkers
SMPH Crosslinker is an alkyl/ether-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of stable ternary complexes between a target protein and an E3 ligase, promoting targeted ubiquitination and degradation. Its unique structure supports various research applications in protein degradation studies, therapeutic development, and targeted protein modulation. -
PROTAC Linkers
Azido-PEG23-amine is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis, enabling targeted protein degradation. This compound features an azide functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool for chemical biology and drug discovery applications. -
PROTAC Linker
Biotin-PEG7-amine is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves facilitating the recruitment of E3 ligases to target proteins for ubiquitination and subsequent degradation. This compound plays a crucial role in the development of targeted protein degradation strategies, enabling researchers to manipulate protein levels in various biological contexts. Biotin-PEG7-amine is essential for advancing research in the field of targeted therapies and cellular protein regulation. -
PROTAC Linker
Mal-amido-PEG6-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted protein degradation through the ubiquitin-proteasome system. It serves as a crucial tool in chemical biology for developing novel therapeutic agents and understanding cellular protein regulation. -
PROTAC Linker
Azido-PEG4-(CH2)3OH is a PEG-based linker specifically designed for the synthesis of PROTACs. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified partners, making it a versatile tool for modular drug design and protein degradation applications in chemical biology research. -
PROTAC Linker
Tos-PEG4-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, thereby promoting ubiquitination and degradation of specific proteins of interest. Its versatile application makes it invaluable for researchers exploring targeted protein degradation and novel therapeutic strategies. -
PROTAC Linker
Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker that facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions. Its unique properties make it suitable for applications in targeted protein degradation research, aiding in the development of innovative therapeutic strategies. -
PROTAC Linkers
Azido-PEG3-chloroacetamide is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with entities bearing DBCO or BCN groups, facilitating the assembly of complex PROTACs for targeted protein degradation studies. -
PROTAC Linker
Bpin-Cyclohexene-C-COOEt is a PROTAC linker designed for targeted protein degradation applications. This compound facilitates the synthesis of PROTAC SMARCA2/4-degrader-8, enabling selective degradation of specific proteins within the cell. Its structural properties enhance the effectiveness of PROTAC compounds in research related to protein regulation and therapeutic development. -
PROTAC Linker
5-Hexynal is a versatile PROTAC linker that facilitates the synthesis of target-specific PROTAC molecules, such as iRucaparib-TP3. It plays a crucial role in the formation of proteolysis-targeting chimeras, enabling the selective degradation of proteins of interest. This compound is essential for researchers investigating novel therapeutic strategies in targeted protein degradation and drug discovery applications. -
PROTAC Linkers
m-PEG5-SH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis targeting chimera) synthesis. It facilitates the formation of PROTACs by providing a flexible, hydrophilic spacer that enhances solubility and improves the efficacy of targeted protein degradation. This reagent is essential for researchers developing novel therapeutic strategies aimed at manipulating cellular protein turnover and studying protein interactions. Its application is pivotal in advancing the field of targeted protein degradation and drug discovery. -
PROTAC Linkers
m-PEG13-NHS ester is a polyethylene glycol (PEG) derivative designed for use as a linker in PROTAC (Proteolysis Targeting Chimera) synthesis. This reactive NHS ester enables the efficient conjugation of target ligands to E3 ligase moieties, facilitating the assembly of bifunctional molecules that promote targeted protein degradation. Its application enhances the development of novel therapeutic agents in drug discovery and functional proteomics research. -
PROTAC Linkers
m-PEG2-azide is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features an azide functional group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it a versatile tool for the development of targeted protein degradation strategies. Its applications are essential for advancing research in protein modulation and therapeutic development. -
PROTAC Linkers
Tos-PEG4-t-butyl ester is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs. This compound plays a critical role in the development of targeted protein degraders, facilitating the design of molecules such as BI-3663, which selectively degrades protein tyrosine kinase 2 (PTK2) via cereblon-mediated E3 ligase recruitment. BI-3663 demonstrates significant inhibitory activity against PTK2, with an IC50 value of 18 nM, making Tos-PEG4-t-butyl ester a valuable reagent for research in targeted protein degradation and therapeutic applications. -
PROTAC Linker
m-PEG4-phosphonic acid is a polyethylene glycol (PEG)-derived linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimera) molecules. This compound facilitates the formation of stable linkages between target proteins and E3 ligases, enhancing the specificity and efficacy of protein degradation. Its application in PROTAC development makes it a valuable tool for researchers exploring targeted protein regulation and therapeutic interventions in various diseases. -
PROTAC Linker
Bromo-PEG2-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a bromo group that facilitates the conjugation of warheads to the E3 ligase, enhancing the specificity and efficacy of targeted protein degradation. Bromo-PEG2-CH2-Boc is valuable in research applications involving targeted protein modulation and therapeutic development. -
PROTAC Linkers
m-PEG3-azide is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. Its azide functional group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. This versatility makes m-PEG3-azide an essential tool for researchers exploring innovative therapeutic strategies and providing insights into protein regulation mechanisms. -
PROTAC Linkers
PEG3-methylamine is a polyethylene glycol (PEG)-derived linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of PROTACs by enhancing solubility and stability while optimizing the binding interactions with target proteins. Its application in drug discovery allows researchers to create innovative therapeutic agents aimed at selective protein degradation, thus offering new strategies for treating various diseases. -
PROTAC Linkers
DBCO-NHCO-PEG2-maleimide is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a DBCO (dibenzocyclooctyne) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its application in PROTAC development facilitates targeted degradation of specific proteins, enhancing research in pharmacology and therapeutic discovery. -
PROTAC Linker
Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker designed for use in protein degradation research. This compound features an alkyne functional group, enabling its role as a click chemistry reagent capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing partners. It is instrumental in the synthesis of Thalidomide-O-PEG2-propargyl, facilitating advancements in targeted protein degradation studies. -
PROTAC Linker
Iodine-C3-O-C3-PEG-Boc is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the bioactivity and stability of PROTACs by facilitating target protein ubiquitination and subsequent degradation. Its application in drug discovery and development makes it a valuable tool for investigating protein function and modulation in cellular contexts. -
PROTAC Linkers
Ald-Ph-PEG6-acid is a PEG-derived PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of covalent bonds between a target protein and an E3 ligase, promoting targeted degradation pathways. Its use is critical in advancing research applications related to targeted protein degradation and therapeutic development. -
PROTAC Linker
Fmoc-PEG5-NHS ester is a polyethylene glycol (PEG) linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins with E3 ligases, thereby promoting targeted protein degradation. Fmoc-PEG5-NHS ester is particularly valuable in research applications involving selective modulation of protein levels and the study of cellular pathways. -
PROTAC Linkers
Azido-PEG8-hydrazide is a PEG-based linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways. This reagent features an azide group, enabling its engagement in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can facilitate strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when paired with DBCO or BCN functionalized compounds, making it a versatile tool for bioconjugation in chemical biology research. -
PROTAC Linkers
Thiol-PEG4-NH2 hydrochloride is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a thiol group which facilitates the conjugation to target proteins, enhancing the development of targeted degradation strategies. It serves as a crucial component in creating PROTACs for studying protein regulation and degradation pathways in cellular models. -
PROTAC Linkers
Bromoacetamido-PEG3-azide is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds. The versatility of Bromoacetamido-PEG3-azide makes it a valuable tool for chemical biology and therapeutic development. -
PROTAC Linker
(+)–Biotin-SLC is a bifunctional linker designed for PROTAC synthesis, characterized by an alkyl chain structure. It facilitates the conjugation of biotin to a target protein, enabling the targeted degradation of proteins via the ubiquitin-proteasome pathway. This reagent is valuable for researchers exploring selective protein modulation and degradation mechanisms in cellular studies. -
PROTAC Linkers
TCO-PEG6-amine is a PEG-derived linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) compounds. This linker facilitates the development of bifunctional molecules to selectively degrade target proteins via the ubiquitin-proteasome system. Its unique structure enables effective conjugation with other moieties, contributing to research applications in targeted protein degradation and molecular biochemistry. -
PROTAC Linkers
Tos-PEG6-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of functional PROTAC molecules, enabling targeted protein degradation. Its use is crucial in developing novel therapeutic strategies aimed at modulating protein levels in various biological contexts. -
PROTAC Linkers
Biotin-nPEG-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the efficient conjugation of target proteins with E3 ligases, enhancing the selective degradation of specific proteins within cellular environments. It is essential for researchers aiming to study protein degradation pathways and investigate therapeutic approaches in chemical biology. -
PROTAC Linker
Cbz-NH-PEG3-C2-acid is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a carbobenzyloxy (Cbz) protecting group and a three-unit polyethylene glycol (PEG) spacer, facilitating optimal conjugation and stability. Its application is pivotal in the development of targeted protein degradation strategies, enhancing the efficacy of drug discovery efforts in various therapeutic areas. -
PROTAC Linker
m-PEG5-CH2CH2COOH is a polyethylene glycol (PEG) linker designed for use in PROTAC (PROteolysis TArgeting Chimera) synthesis. It facilitates the conjugation of ligands to E3 ligase recruiters, enhancing targeted protein degradation mechanisms. This reagent is crucial for the development of bifunctional molecules in drug discovery and research applications focused on modulating protein levels within cells. -
PROTAC Linkers
Azido-PEG24-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Azido-PEG24-acid is suitable for strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool in chemical biology and protein degradation research applications. -
PROTAC Linker
Bis-PEG4-PFP ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates the effective conjugation of target proteins to E3 ligases, enhancing protein degradation through the ubiquitin-proteasome system. Its versatile application in chemical biology makes it an essential tool for researchers exploring targeted protein degradation and therapeutic development. -
PROTAC Linker
Thiol-PEG3-acetic acid is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling the selective degradation of specific proteins within cellular environments. Its application is crucial in developing PROTACs for targeted protein degradation studies and therapeutic research. -
PROTAC Linker
Bromoacetamido-PEG4-NHS ester is a PEGylated linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation. Its applications extend to chemical biology and drug discovery, where it aids in the development of innovative therapeutic strategies by modulating protein expression levels.
