Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
TCO-PEG4-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound serves as a versatile building block to facilitate the recruitment of E3 ligases for targeted protein degradation, enabling the modulation of protein levels in biological systems. Its application in the development of PROTACs supports research into therapeutic strategies for various diseases by allowing precise control over protein function and turnover. -
PROTAC Linkers
m-PEG10-NHS ester is a polyethylene glycol (PEG) derivative serving as a versatile PROTAC linker. It facilitates the conjugation of target substrates to E3 ligases, enabling the development of proteolysis-targeting chimeras (PROTACs). This compound is essential for researchers focusing on targeted protein degradation and novel therapeutic strategies in drug discovery. Its hydrophilic nature enhances solubility and biocompatibility in biological systems. -
PROTAC Linkers
Ald-CH2-PEG10-Boc is a PEG-based PROTAC linker that facilitates the construction of PROTAC (PROteolysis TArgeting Chimeras) molecules. This linker enhances the solubility and stability of the conjugates, promoting effective ubiquitination and degradation of target proteins. Ald-CH2-PEG10-Boc is instrumental in chemical biology research for the development of targeted protein degradation strategies, aiding in the investigation of protein function and the treatment of diseases through targeted therapeutic approaches. -
PROTAC Linker
Benzyl-PEG4-MS is a polyethylene glycol (PEG) linker designed for use in proteolysis-targeting chimeras (PROTACs). It facilitates the conjugation of protein degraders, enhancing the efficacy of targeted protein degradation by improving solubility and pharmacokinetic properties. This reagent is essential for researchers focusing on the development of novel therapeutic strategies targeting specific proteins for degradation in various biological contexts. -
PROTAC Linker
Boc-NHCH2-Ph-Py-NH2 is a PROTAC linker designed to facilitate targeted protein degradation through the recruitment of E3 ligases. This compound enhances the stability and efficacy of PROTAC molecules by providing a flexible and efficient connection between the target protein and the ligase. Its utilization in research applications supports the development of innovative therapeutic strategies in the field of targeted protein modulation. -
PROTAC Linkers
2-Bromo-2,2-dimethyl-acetamido-PEG3-acid is a PEG-based linker designed specifically for the synthesis of PROTAC (Proteolysis Targeting Chimera) compounds. This linker facilitates the development of bifunctional molecules that can recruit E3 ubiquitin ligases for targeted protein degradation. Its application in research allows for innovative approaches to modulate protein levels and explore the therapeutic potential of targeted protein degradation strategies. -
PROTAC Linker
(2-Aminoethyl)carbamic acid serves as a PROTAC linker within the PEG class, facilitating the development of protein degraders. This compound is instrumental in synthesizing QS-57, enabling targeted protein modulation in various research applications. Its structure supports efficient conjugation for enhanced bioactivity and specificity in cellular studies. -
PROTAC Linker
t-Boc-Aminooxy-PEG11-amine is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates the development of targeted protein degradation strategies by linking an E3 ligase ligand with a protein of interest. Its unique structure enhances solubility and flexibility, making it suitable for various research applications in cellular biology and drug discovery. -
PROTAC Linker
Benzyl-PEG6-MS is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective conjugation of E3 ligases and target proteins, enhancing the efficiency of targeted protein degradation. Its structural properties support the development of novel therapeutics by allowing precise control over the pharmacological properties of PROTAC molecules. -
PROTAC Linker
Propargyl-PEG4-CH2-methyl ester functions as a PEG-based linker for the synthesis of PROTACs (proteolysis-targeting chimeras). Its alkyne group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the assembly of complex molecular architectures. This compound is essential for researchers aiming to develop targeted protein degradation technologies in drug discovery and chemical biology. -
PROTAC Linker
2-(Biotin-amido)-1,3-bis-(C1-PEG1-acid) functions as a PEG-based linker for PROTAC (proteolysis-targeting chimera) technology. This compound facilitates the conjugation of biotin to target proteins, enabling the development of targeted protein degradation systems. Its use is essential in synthesizing novel PROTACs for research applications aimed at understanding protein functionality and therapeutic interventions. -
PROTAC linker
N-(PEG1-OH)-N-Boc-PEG2-propargyl is a polyethylene glycol (PEG)-based linker designed for PROTAC synthesis. This compound features an alkyne group that facilitates the copper-catalyzed azide-alkyne cycloaddition (CuAAc) reaction, enabling efficient conjugation with azide-containing molecules. N-(PEG1-OH)-N-Boc-PEG2-propargyl is ideal for applications in targeted protein degradation studies and the development of novel therapeutic agents. -
PROTAC linker
Methyltetrazine-amido-PEG7-azide is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it is suitable for strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules that have dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups, making it a versatile tool in chemical biology and drug development. -
PROTAC Linkers
DBCO-PEG2-NH-Boc is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a dibenzocyclooctyne (DBCO) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG2-NH-Boc facilitates the construction of complex bioconjugates, making it a valuable tool for targeted protein degradation studies in chemical biology and drug discovery. -
PROTAC Linker
Fmoc-N-amido-PEG3-azide is a PEG-based linker designed for use in the synthesis of PROTACs, functioning primarily through click chemistry. This compound features an azide group that allows for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it a versatile tool in chemical biology research and therapeutic development. -
PROTAC linker
Boc-Aminooxy-PEG1-azide is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an azide group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules and can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized compounds. This reagent is pivotal for studies in targeted protein degradation, providing a versatile tool for advancing research in cell biology and therapeutic development. -
PROTAC Linker
rel-Biotin-PEG3-C3-NH2 is a PEG-based linker specifically designed for the construction of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins by promoting the engagement of E3 ubiquitin ligases. Its biological activity is essential for advancing research in protein homeostasis and therapeutic applications targeting disease-related proteins. -
PROTAC Linker
Propargyl-PEG4-tetra-Ac-beta-D-galactose is a PEG-based linker designed for use in the development of PROTAC (Proteolysis Targeting Chimera) molecules. This compound facilitates efficient conjugation for targeted protein degradation, making it a valuable tool in chemical biology research. It serves as a critical component in the synthesis of bifunctional PROTACs, enabling the selective modulation of protein levels within cells. -
PROTAC Linker
DNP-NH-PEG4-C2-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective conjugation of target proteins and E3 ligase recruitment for targeted protein degradation. Its unique structure allows for enhanced solubility and stability, making it suitable for various biological applications in chemical biology and drug development research. -
PROTAC Linkers
MS-PEG10-THP is a polyethylene glycol (PEG) based linker designed for use in the development of PROTAC (proteolysis-targeting chimera) compounds. This linker promotes efficient conjugation of target proteins to E3 ligases, facilitating targeted protein degradation. It is applicable in various research contexts involving protein modulation and therapeutic development aimed at disease-associated proteins. -
PROTAC Linker
COOEt-bicyclo[2.2.2]octane-CHO is a specialized PROTAC linker that facilitates the conjugation of E3 ligase ligands with SMARCA2 ligands. This compound plays a critical role in developing PROTAC SMARCA2 degrader-6, enabling targeted degradation of SMARCA2 proteins. Its unique structure enhances the efficiency of protein modulation strategies, making it suitable for applications in cancer research and drug discovery focused on proteolysis-targeting chimera technologies. -
PROTAC Linkers
m-PEG37-acid is a polyethylene glycol (PEG)-based linker designed for use in proteolysis targeting chimeras (PROTACs) synthesis. This compound facilitates the construction of PROTACs, enabling targeted protein degradation, which is a valuable strategy in chemical biology and therapeutic development. Its application is crucial for enhancing the solubility and stability of PROTAC constructs, making it an essential reagent in protein engineering and drug discovery research. -
PROTAC Linker
Tos-PEG1-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for the development of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target ligands to E3 ligase recruiters, enhancing the effectiveness of targeted protein degradation. Its biochemical properties support various applications in chemical biology and protein modulation research, making it a valuable tool in drug discovery and therapeutic development. -
PROTAC linker
N-(Azido-PEG4)-N-Boc-PEG4-Boc is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide moiety, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing substrates. Additionally, it is suitable for strain-promoted alkyne-azide cycloaddition (SPAAC) with trans-cyclooctene derivatives, allowing for versatile conjugation strategies in chemical biology studies. -
PROTAC Linker
Propargyl-PEG4-methylamine is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimeras) synthesis. Its alkyne group enables efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of azide-containing partners. This reagent is valuable for researchers investigating targeted protein degradation and developing novel therapeutic strategies. -
PROTAC Linker
4-(1,3-Dioxolan-2-yl)phenethyl methanesulfonate serves as a critical linker in the development of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates targeted protein degradation, making it a valuable tool for studying protein function and regulation. It is notably utilized in the synthesis of PROTAC SMARCA2/4-degrader-27, advancing research in targeted therapies and cellular protein modulation. -
PROTAC Linkers
Ms-PEG3-CH2CH2COOH is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the formation of bifunctional molecules that enhance targeted protein degradation. Its applications include the development of novel therapeutic agents for cancer and other diseases through targeted modulation of protein levels. -
PROTAC Linker
NH2-PEG-phenol-PEG-COOtBu is a PEG-based PROTAC linker designed to enhance the coupling efficiency for targeted protein degradation. Its primary mechanism involves facilitating the synthesis of PROTACs, enabling them to recruit E3 ligases for ubiquitination of target proteins. This compound serves as a valuable tool in the development of PROTACs, including applications in cancer research and the study of protein degradation pathways. -
PROTAC Linkers
2,3,4,6-Tetra-o-acetyl-alpha-galactosylpyranosyl bromide is a versatile PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the stability and efficacy of PROTACs, allowing for targeted degradation of specific proteins within cellular environments. It is particularly useful in chemical biology and drug discovery applications aimed at developing novel therapeutic strategies. -
PROTAC Linker
NH2-PEG1-C1-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) compounds. This versatile linker facilitates the formation of PROTACs, which promote targeted protein degradation, thereby enabling the study of protein function and validation of therapeutic targets. Its applications include drug discovery and development aimed at modulating intracellular protein levels. -
PROTAC Linker
N-Mal-N-bis(PEG4-amine) is a polyethylene glycol (PEG) based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This linker facilitates the recruitment of E3 ligases, enhancing target protein degradation via the ubiquitin-proteasome pathway. Its versatility makes it suitable for research applications focused on targeted protein degradation and therapeutic development in various disease models. -
PROTAC Linkers
m-PEG4-CH2-acid is a polyethylene glycol (PEG) derivative designed as a PROTAC linker facilitating the development of proteolysis-targeting chimeras. This compound enhances the solubility and bioavailability of PROTACs, promoting targeted protein degradation. m-PEG4-CH2-acid is essential for researchers aiming to design and optimize PROTAC molecules for studying protein homeostasis and therapeutic interventions in various diseases. -
PROTAC Linker
Hydroxy-Amino-bis(PEG1-C2-Boc) is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an alkyl/ether structure that enhances solubility and stability in biological systems. It plays a crucial role in facilitating targeted protein degradation, making it valuable for research applications in drug discovery and cellular biology. Its unique properties enable effective coupling of target proteins to E3 ligases, advancing the development of innovative therapeutic strategies. -
PROTAC Linker
Bromo-PEG3-phosphonic acid diethyl ester is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. Its structural features facilitate efficient conjugation to target proteins, enhancing the stability and efficacy of PROTAC molecules. This reagent is ideal for research applications focused on targeted protein degradation and the modulation of cellular signaling pathways. -
PROTAC Linkers
Ald-Ph-amido-C2-PEG2-amine is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the effective conjugation of E3 ligase recruiters and protein targets, enhancing the chemical degradation of specific proteins within the cell. It is particularly useful in chemical biology studies aimed at developing novel therapeutic strategies through targeted protein degradation. -
PROTAC Linkers
NH-bis(m-PEG8) is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances solubility and promotes optimal molecular stability, making it suitable for targeted protein degradation studies. NH-bis(m-PEG8) is particularly valuable in research applications focused on elucidating protein interactions and pathways, as well as in the development of therapeutic strategies utilizing targeted protein degradation. -
PROTAC Linker
m-PEG2-4-nitrophenyl carbonate is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It facilitates the effective conjugation of targeting moieties to E3 ligase ligands, enabling the targeted degradation of specific proteins. This compound is essential for researchers investigating protein regulation and therapeutic applications in targeted protein degradation. -
PROTAC Linker
Azido-PEG7-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized partners. This versatility supports the development of targeted protein degradation technologies in cellular and molecular biology research. -
PROTAC Linkers
BnOH-NH-bis-(C2-S)-propane-O-isoprene ester serves as an alkyl ether-based linker in the synthesis of PROTACs (proteolysis-targeting chimeras). Its design facilitates the precise assembly of heterobifunctional molecules that engage ubiquitin-proteasome system pathways. This linker is crucial for exploring targeted protein degradation mechanisms in various biological studies. -
PROTAC Linkers
Tetraethyl decane-1,10-diylbis(phosphonate) is a phosphonate-based linker designed for use in the development of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of specific proteins by linking E3 ligases with the protein of interest, enhancing cellular activity through the modulation of protein turnover. Its unique structure allows for effective construction of PROTACs, making it a valuable tool in drug discovery and research focused on targeted protein degradation. -
PROTAC Linker
m-PEG4-CH2-alcohol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound enhances the solubility and pharmacokinetic properties of PROTAC molecules, facilitating targeted protein degradation in various biological systems. Its unique structure promotes effective conjugation between the ligand and the E3 ligase, making it a valuable tool in drug discovery and development. -
PROTAC Linker
m-PEG15-acetic acid is a polyethylene glycol (PEG)-derived linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its unique properties enhance the solubility and stability of PROTAC conjugates, facilitating intracellular delivery and target degradation. This reagent is essential for researchers developing novel targeted protein degradation strategies in drug discovery and biochemical studies. -
PROTAC Linker
Boc-PEG5-methyl ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the efficient conjugation of target proteins and E3 ligases, enabling targeted protein degradation. Its use in PROTAC development supports research applications in drug discovery and the investigation of protein regulation pathways. -
PROTAC Linkers
CH2COOH-PEG12-CH2COOH is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of targeted protein degradation strategies by linking E3 ligases to protein targets, enhancing cellular selectivity and efficacy. It is suitable for use in various research applications focused on elucidating protein function and investigating therapeutic interventions in disease models. -
PROTAC Linker
Boc-Aminooxy-PEG2-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of ligand and target proteins, enhancing the development of novel targeted protein degradation therapeutics. Its application is particularly valuable in research areas focusing on targeted drug discovery and the modulation of protein levels in various biological systems. -
PROTAC Linkers
Cbz-aminooxy-PEG8-acid is a PEG-based PROTAC linker designed for the development of proteolysis-targeting chimeras (PROTACs). This compound features an aminooxy group that facilitates the covalent attachment of target proteins, enhancing selective degradation. Its application in drug discovery and chemical biology makes it an essential tool for researchers focused on targeted protein modulation and therapeutic development. -
PROTAC Linker
Lipoamido-PEG8-acid is a PEG-based PROTAC linker designed for the synthesis of PROTACs. Its structure facilitates the formation of heterobifunctional agents that promote targeted protein degradation. This compound is crucial for researchers investigating targeted therapy strategies and the modulation of protein activity in cellular processes. -
PROTAC Linkers
HO-PEG5-CH2COOH is a polyethylene glycol (PEG)-based linker utilized in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of an E3 ligase and target protein, enabling targeted protein degradation. HO-PEG5-CH2COOH is essential for researchers studying the development of PROTACs in various biological systems and therapeutic applications. -
PROTAC Linker
m-PEG-acid is a polyethylene glycol (PEG)-based linker designed for use in the development of PROTAC (Proteolysis Targeting Chimeras) molecules. Its primary mechanism facilitates the selective ubiquitination and degradation of target proteins. This compound is essential in the synthesis of novel PROTACs, enhancing chemical stability and solubility while improving their biological activity in research applications focused on targeted protein degradation. -
PROTAC Linker
Amino-PEG6-acetic acid is a polyethylene glycol (PEG)-based linker utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound serves as a versatile and efficient tool to facilitate the development of targeted protein degradation strategies. Its biochemical properties enhance solubility and flexibility, making it suitable for various applications in drug discovery and biological research focusing on protein modulation.
