Catalog No.
Product Name
Application
Product Information
Citations
-
PROTAC Linker
Mal-PEG2-C2-Boc is a poly(ethylene glycol) (PEG)-based linker designed for PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, enabling the selective degradation of specific proteins within cells. Its application is crucial in the development of novel therapeutic strategies for various diseases through targeted protein modulation. -
PROTAC Linkers
APN-C3-PEG4-azide is a PEG-based PROTAC linker featuring an azide functional group, designed for the synthesis of PROTACs. It facilitates the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. This versatile linker is essential for drug development studies involving targeted protein degradation and can enhance the efficiency of modular PROTAC assembly. -
PROTAC Linkers
Hydroxy-PEG5-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of bifunctional molecules that target and degrade specific proteins, enhancing selective protein degradation research. Its incorporation in PROTAC design allows for improved solubility and bioavailability, making it a valuable tool in biochemical and pharmacological studies. -
PROTAC Linker
Bis-propargyl-PEG7 is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This reagent facilitates the construction of polymer-linked multimers of guanosine-3', 5'-cyclic monophosphates. As a click chemistry reagent, Bis-propargyl-PEG7 features an alkyne group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling efficient conjugation with azide-containing molecules for various biological research applications. -
PROTAC Linker
Tos-PEG4-THP is a polyethylene glycol (PEG) based PROTAC linker designed for the synthesis of PROTAC molecules. This compound facilitates the development of targeted protein degraders, specifically enhancing the degradation of K-Ras through the formation of a PROTAC complex. It is suitable for research applications that involve targeted protein degradation strategies in cellular and molecular biology studies. -
PROTAC Linker
Aminooxy-PEG3-acid is a polyethylene glycol (PEG)-based linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of PROTACs by providing a flexible and stable connection between the target protein and the E3 ubiquitin ligase. Its key biological activity enhances the efficacy of protein degradation in targeted therapeutics, making it suitable for research in targeted protein modulation and degradation strategies. -
PROTAC Linker
Boc-NH-PEG3-propargyl is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its unique structure facilitates efficient conjugation in biochemical applications, making it valuable in targeted protein degradation studies. -
PROTAC Linkers
AM-Imidazole-PA-Boc is a versatile PROTAC linker characterized by its alkyl chain structure. It plays a critical role in the design and synthesis of PROTAC IRAK4 degrader-1, facilitating targeted protein degradation. This compound is essential for researchers exploring the therapeutic potential of targeted protein degradation in various signaling pathways and disease models. -
PROTAC Linker
Boc-Aminooxy-PEG4-Tos is a PEG-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Its aminooxy moiety facilitates the formation of stable covalent bonds with target proteins, enhancing the efficiency of targeted degradation. This compound plays a crucial role in drug discovery and development, particularly in researching targeted protein degradation pathways. -
PROTAC Linker
Benzyl-PEG2-Tos is a polyethylene glycol (PEG) based linker designed specifically for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the efficient degradation of target proteins by promoting the formation of a ternary complex between an E3 ubiquitin ligase and the target protein. Its biocompatibility and solubility characteristics make it suitable for a variety of applications in chemical biology and therapeutic development involving targeted protein degradation strategies. -
PROTAC Linker
Boc-NH-PEG11-OH is a polyethylene glycol (PEG)-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the formation of PROTACs that can selectively degrade target proteins through the ubiquitin-proteasome system. Its application is crucial in advancing research in targeted protein degradation and therapeutic development. -
PROTAC Linker
N-Me-N-bis-PEG4 is a polyethylene glycol (PEG)-based linker specifically designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of target ligands and E3 ligase binding domains, enhancing the efficacy and selectivity of PROTACs. It is suitable for various bioconjugation applications, enabling researchers to explore targeted protein degradation mechanisms in cellular studies. -
PROTAC Linker
Boc-Piperazine-2-F-Ph-CHO is a specialized PROTAC linker designed for the targeted degradation of proteins through the ubiquitin-proteasome pathway. This compound facilitates the synthesis of bifunctional molecules that can selectively degrade target proteins, making it a valuable tool in chemical biology and drug discovery research. Its unique structure and functionality enable the development of novel therapeutic agents aimed at precise cellular regulation. -
PROTAC Linker
Mal-N-bis(PEG4-C2-acid) is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound effectively facilitates the recruitment of E3 ubiquitin ligases, enabling targeted protein degradation. Its application in research includes the development of novel therapeutic strategies for modulating protein levels in various biological contexts. -
PROTAC Linker
TFP-PEG3-TFP is a PEG-based PROTAC linker designed for the synthesis of PROTAC (PROteolysis TArgeting Chimeras) compounds. This linker facilitates the formation of heterobifunctional molecules that engage E3 ligases for targeted protein degradation. It is suitable for applications in drug development and chemical biology, allowing researchers to explore novel therapeutic strategies through targeted modulation of protein levels. -
PROTAC Linker
Methylamino-PEG2-Boc is a PEG-linked PROTAC linker designed for the synthesis of PROTAC molecules. This compound facilitates the targeted degradation of proteins by enabling the conjugation of E3 ligase recruiters to the target proteins. It is commonly utilized in drug discovery and development studies focusing on selective protein degradation. -
PROTAC Linker
THP-PEG4-OH is a polyethylene glycol (PEG) based linker utilized in the construction of PROTACs (Proteolysis Targeting Chimeras). This linker facilitates the effective targeting and degradation of specific proteins, providing a valuable tool in the study of protein regulation and therapeutic development. Its application in PROTAC synthesis enhances the bioavailability and specificity of these bifunctional molecules, advancing research in targeted protein degradation. -
PROTAC Linker
Propargyl-PEG6-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis-targeting chimeras). This compound features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-functionalized molecules. Propargyl-PEG6-Boc is instrumental in optimizing PROTAC design for targeted protein degradation studies, facilitating the development of novel therapeutic strategies in chemical biology research. -
PROTAC Linker
Biotin-PEG3-oxyamine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the delivery of E3 ligase recruiters to target proteins, enhancing the selectivity and efficacy of targeted protein degradation. Its biotin moiety allows for convenient isolation and detection of labeled proteins in various biological assays, making it a valuable tool in drug discovery and proteomics research. -
PROTAC Linker
Boc-NH-PPG2 is an alkyl/ether-based linker primarily utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the design of bifunctional molecules that promote the targeted degradation of specific proteins, enabling insights into protein functionality and degradation pathways. Its application is crucial for research projects aimed at advancing targeted protein degradation technologies and developing novel therapeutic strategies. -
PROTAC Linker
Fmoc-Lys (biotin-PEG4)-OH is a biotin-tagged, polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound serves as a crucial component in the development of targeted protein degradation strategies, facilitating the conjugation of target proteins for selective degradation. Its unique biotin functionality allows for easy monitoring and purification in research applications focused on modulating protein expression and function. -
PROTAC Linker
Mal-PFP ester is a strategically designed PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). It features an alkyl/ether backbone that enhances the linkage between the warhead and E3 ligase, promoting targeted protein degradation. This compound is essential for researchers looking to develop novel PROTACs for therapeutic applications in cancer and other diseases. -
PROTAC Linkers
Acid-PEG4-S-S-PEG4-acid is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This linker features a disulfide bond, enabling controlled release of the target protein after cellular uptake. Its application is crucial in the development of targeted protein degradation strategies for research in drug development and disease modeling. -
PROTAC Linkers
Me-Tet-PEG4-NH2 hydrochloride is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs. This compound features a tetrazine moiety that facilitates an inverse electron demand Diels-Alder (iEDDA) reaction with TCO-containing molecules, enabling efficient conjugation. Its unique properties make it valuable for drug development and targeted protein degradation studies. -
PROTAC Linkers
Tri(Amino-PEG4-amide)-amine is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of ligands to E3 ligases, enabling targeted protein degradation. Its unique structure enhances solubility and stability, making it suitable for various biochemical applications in drug discovery and therapeutic research related to targeted protein modulation. -
PROTAC Linker
Lipoamido-PEG4-azide is a PEG-based linker designed for use in PROTAC synthesis. This compound features an azide group capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing compounds, making it a versatile tool in chemical research for targeted protein degradation studies. -
PROTAC Linkers
HO-PEG21-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates selective degradation of target proteins by linking an E3 ligase to the protein of interest, promoting ubiquitination and subsequent proteasomal degradation. HO-PEG21-OH is integral for advancing research in targeted protein degradation and understanding protein regulation mechanisms in various biological contexts. -
PROTAC Linker
Mal-amido-PEG4-TFP ester is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation. Its versatility in linker design and efficient conjugation chemistry make it an essential component in PROTAC research and development efforts. -
PROTAC Linkers
Mal-PEG6-Boc is a PEG-based linker designed for the assembly of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of E3 ligase receptors to target proteins, enabling targeted degradation in cellular systems. Its application is vital in drug discovery and development, particularly in the design of novel therapeutic agents that harness the ubiquitin-proteasome pathway for targeted protein modulation. -
PROTAC linker
Aminooxy-PEG1-azide is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) functionalized compounds, enhancing its versatility in chemical biology applications. -
PROTAC Linkers
Hydroxy-PEG4-methyl acetate is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of novel proteolysis-targeting strategies by enhancing solubility and stability. It is particularly valuable in research applications focused on targeted protein degradation and cellular protein modulation. -
PROTAC linker
Aminooxy-PEG4-azide is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. With its azide functional group, it effectively participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, as well as DBCO or BCN derivatives. This reagent is essential for enhancing the specificity and efficacy of targeted protein degradation approaches in chemical biology research. -
PROTAC Linker
Mal-PEG5-NHS ester is a PEG-based PROTAC linker that facilitates the construction of Proteolysis Targeting Chimeras (PROTACs). Its primary mechanism involves the formation of covalent bonds, enhancing the stability and efficacy of the resulting PROTACs. This linker is essential for research applications aimed at targeted protein degradation, enabling focused studies in cellular pathways and therapeutic interventions for various diseases. -
PROTAC Linkers
t-Boc-N-amido-PEG15-Br is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a t-Boc (tert-butoxycarbonyl) protecting group, which facilitates the formation of stable linkages in the targeted degradation of proteins. It serves as a crucial component for researchers aiming to develop innovative therapeutic approaches by harnessing the cellular ubiquitin-proteasome system. Its unique structural attributes enable the preparation of diverse PROTAC constructs for exploring targeted protein degradation in various biological contexts. -
PROTAC Linker
Bromoacetamido-PEG4-C2-Boc is a PEG-based linker designed for protein degradation applications utilizing the PROTAC (Proteolysis Targeting Chimera) technology. This compound facilitates the synthesis of PROTACs by providing a suitable platform for coupling target proteins with E3 ligases, enhancing the selective degradation of unwanted proteins. Its unique structure supports improved solubility and biocompatibility, making it valuable in drug development and targeted protein modulation research. -
PROTAC Linker
Boc-Pip-butyn is a PROTAC linker featuring an alkyl/ether backbone and an alkyne functional group. This reagent facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, enabling the assembly of bifunctional probes. Boc-Pip-butyn is essential in the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation studies and related applications in chemical biology research. -
PROTAC Linker
Tos-PEG2-OH is a polyethylene glycol (PEG)-based linker specifically designed for the development of PROTAC (Proteolysis Targeting Chimera) molecules. This compound facilitates the formation of PROTACs by connecting the ligand to an E3 ubiquitin ligase, thus enabling targeted protein degradation. It is essential for researchers looking to design and synthesize effective PROTACs for various applications in therapeutic development and target validation. -
PROTAC Linkers
m-PEG8-thiol is a polyethylene glycol (PEG) derivative designed as a PROTAC linker, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the solubility and stability of target-specific PROTACs, promoting effective protein degradation through the ubiquitin-proteasome system. m-PEG8-thiol is suitable for applications in drug discovery and chemical biology research, particularly in studies involving targeted protein modulation. -
PROTAC Linker
Methyltetrazine-Sulfo-NHS ester sodium is a recognized PROTAC linker designed for the synthesis of degradation-targeting chimeras. This compound facilitates the conjugation of ligands to proteins of interest, enabling targeted protein degradation studies. Its application spans various areas of research, including drug development and molecular biology, where precise modulation of protein activity is required. -
PROTAC Linker
Cbz-NH-PEG2-C2-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins by connecting E3 ligases with target proteins through a flexible linker architecture. Its unique structure enhances the efficacy and specificity of PROTAC development, making it a valuable tool for researchers in drug discovery and protein regulation studies. -
PROTAC Linker
Boc-N-Amido-PEG4-propargyl is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). Its alkyne functionality enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing compounds. This reagent serves as a valuable tool in chemical biology research, facilitating the development of targeted protein degradation strategies. -
PROTAC Linker
Biotin-PEG3-CH2COOH is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins via the ubiquitin-proteasome pathway, aiding in the exploration of proteomic interactions and therapeutic potential. Its biotin moiety allows for easy detection and purification, making it an essential tool for researchers in drug discovery and cellular biology. -
PROTAC Linkers
m-PEG5-NHS ester is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound enables the conjugation of proteins, facilitating the targeted degradation of specific proteins within cellular environments. It is a valuable tool for researchers studying protein-protein interactions, targeted protein degradation, and the development of novel therapeutic strategies. -
PROTAC Linkers
Methyltetrazine-PEG8-PFP ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound effectively facilitates the formation of targeted protein degradation complexes by linking the E3 ligase to the protein of interest. Its unique structure enhances solubility and bioavailability, making it suitable for various applications in chemical biology and drug discovery. -
PROTAC Linker
Mal-PEG2-NH2 serves as a polyethylene glycol (PEG)-based linker for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of PROTACs by linking E3 ligases to target proteins, promoting targeted degradation. Its use is critical in drug discovery, advancing the development of therapeutic agents that can selectively eliminate specific proteins within biological systems. -
PROTAC Linkers
Br-PEG6-C2-NHBoc is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. It facilitates the conjugation of target proteins to E3 ligases, enhancing the efficiency of targeted protein degradation. This compound is integral for researchers developing innovative therapeutic strategies in cancer, neurodegenerative diseases, and other conditions where selective protein modulation is beneficial. -
PROTAC Linkers
Tos-PEG5-Boc is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This linker facilitates the conjugation of target proteins with E3 ligases, enhancing targeted protein degradation. Its unique structure enables improved solubility and optimal flexibility, making it a valuable tool for researchers exploring targeted therapies and protein modulation in diverse biological studies. -
PROTAC Linker
Propargyl-PEG2-CH2COOH is a PEG-based linker designed for the synthesis of PROTACs, functioning through the formation of stable covalent bonds. This compound features an alkyne moiety that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its application in PROTAC development supports targeted protein degradation studies, making it a valuable tool for researchers investigating cellular mechanisms and therapeutic interventions. -
PROTAC Linker
Boc-NH-PEG2-CONH-PEG2-COOH is a synthesized PROTAC linker that facilitates the design of proteolysis targeting chimeras (PROTACs). This compound effectively connects target proteins to E3 ligases, enhancing targeted protein degradation. It is suitable for use in research focused on therapeutic applications, particularly in the study of protein regulation and degradation pathways. -
PROTAC Linker
(Tert-Butyldimethylsiloxy)Acetaldehyde is a versatile PROTAC linker designed to facilitate the development of targeted protein degraders. This compound enables the efficient synthesis of PROTACs, which are utilized in drug discovery and development to modulate protein levels by harnessing the ubiquitin-proteasome system. Its structural features make it suitable for assembling novel degrader constructs in various biological research applications.
