Catalog No.
Product Name
Application
Product Information
Citations
-
PROTAC Linker
SPDP-C6-NHS ester is an alkyl/ether-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of specific target proteins to E3 ligases, enhancing the selective degradation of proteins in cellular studies. It plays a vital role in drug discovery and development by enabling targeted protein modulation and offers a valuable tool for investigating biological pathways. -
PROTAC Linker
HS-PEG3-CH2CH2NH2 is a PEGylated PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of efficient and selective PROTAC molecules by enhancing solubility and cellular uptake. It is essential for research applications focusing on targeted protein degradation and drug discovery in various therapeutic areas. -
PROTAC Linker
Glycyl-l-serine is a PROTAC linker that integrates glycine and serine to facilitate targeted protein degradation. This compound's unique structure supports the development of various PROTACs, enhancing their efficacy in selective protein removal. Glycyl-l-serine is particularly useful in the synthesis of advanced PROTAC molecules, including FPP29, making it an essential tool for researchers in the field of targeted protein degradation. -
PROTAC Linker
Propargyl-PEG2-Boc is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring an alkyne functional group, it enables efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This compound facilitates targeted protein degradation studies, contributing to advancements in therapeutic research and drug development. -
PROTAC Linker
Propynyl-PEG1-Ac is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) applications. This compound features an alkyne group that facilitates click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. It is instrumental in the synthesis of advanced PROTACs, enabling the selective targeting and degradation of specific proteins, thereby advancing therapeutic research in drug discovery and development. -
PROTAC Linkers
N-(Acid-PEG2)-N-bis(PEG3-azide) serves as a PEG-based linker for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool in chemical biology and drug development. -
PROTAC Linker
Hydroxy-PEG5-C2-methyl ester is a polyethylene glycol (PEG)-derived PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and cellular permeability of PROTACs, thereby contributing to their efficacy in targeted protein degradation. Its application is pivotal in the synthesis of novel PROTACs for studying protein interactions and therapeutic development in various diseases. -
PROTAC Linkers
Azido-PEG8-CH2COO-PFP is a PEGylated PROTAC linker designed to facilitate the synthesis of targeted protein degraders. Functioning as a click chemistry reagent, it features an azide group that engages in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) reactions involving DBCO or BCN groups. This compound is essential for researchers focused on developing novel therapeutic strategies through protein modulation. -
PROTAC Linkers
DBCO-PEG5-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its primary mechanism involves the DBCO group, which enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound is essential for facilitating site-specific conjugation in PROTAC development, contributing to targeted protein degradation in cellular research and therapeutic applications. -
PROTAC Linker
Boc-C1-PEG3-C4-OH is a versatile PROTAC linker that incorporates an alkyl/ether composition, facilitating the development of a variety of PROTAC molecules. This compound effectively bridges two distinct ligands: one targeting an E3 ubiquitin ligase and the other directed towards the protein of interest. By harnessing the ubiquitin-proteasome system, PROTACs built with Boc-C1-PEG3-C4-OH demonstrate selective protein degradation capabilities, making them valuable tools for research in targeted protein modulation and therapeutic intervention. -
PROTAC Linker
Boc-Aminooxy-PEG4-NH2 is a PEG-derived linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of compounds that target specific proteins for degradation via the ubiquitin-proteasome system. Its efficient linkage properties enhance the effectiveness of PROTACs in various research applications, including targeted protein degradation and the study of protein interactions. -
PROTAC Linkers
m-PEG3-succinimidyl carbonate functions as a PEG-based linker for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It enables the formation of stable connections between target proteins and E3 ligases, facilitating targeted protein degradation. This compound is valuable in drug discovery and development, particularly in studies focused on modulating protein levels and function through innovative therapeutic strategies. -
PROTAC Linkers
m-PEG3-Aminooxy is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of bifunctional molecules that can induce targeted protein degradation, thereby enabling selective modulation of protein levels within cells. m-PEG3-Aminooxy is valuable for researchers investigating protein-protein interactions, cellular signaling, and targeted therapeutics. -
PROTAC Linkers
Hydroxy-PEG6-CH2-Boc is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the effective conjugation of target proteins with E3 ligases, facilitating targeted protein degradation. Its versatility makes it suitable for various applications in drug discovery and development, particularly in studies focused on controlling protein levels in cellular contexts. -
PROTAC Linker
Chloro-PEG2-Boc is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the efficient coupling of target-binding ligands to E3 ligase recruitment moieties, enhancing the development of novel therapeutic agents. Its unique structure promotes solubility and bioavailability, making it an essential tool for researchers investigating targeted protein degradation pathways. -
PROTAC Linker
Fmoc-PEG3-C2-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC molecules. Its primary mechanism involves facilitating the conjugation of target proteins to E3 ligases, thereby enhancing targeted protein degradation. This compound is essential for researchers investigating protein modulation and degradation pathways, offering a versatile tool for the development of innovative therapeutic strategies. -
PROTAC Linker
Sulfo DBCO-PEG4-Maleimide is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This reagent features a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating targeted protein degradation. Its unique properties make it valuable for applications in chemical biology and drug discovery. -
PROTAC Linker
Cyclohexane-1,4-diamine is a versatile PROTAC linker utilized in the synthesis of targeted protein degraders. It serves to facilitate the assembly of PROTACs, enhancing their effectiveness in promoting ubiquitin-mediated degradation of specific proteins. This compound is essential for researchers engaged in drug development, particularly in the fields of oncology and targeted therapy applications. -
PROTAC Linker
tert-Butyl hex-5-ynoate serves as a crucial linker in the synthesis of PROTACs, specifically for the development of targeted protein degraders such as the cGAS degrader-1. This compound facilitates the creation of bifunctional molecules that engage the ubiquitin-proteasome system, thereby promoting the degradation of specific target proteins. Its application in PROTAC technology underscores its importance in advancing research in targeted therapeutics and protein modulation. -
PROTAC Linker
Mal-PEG5-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimera) molecules. This compound facilitates the assembly of bifunctional ligands that can recruit E3 ligases to target proteins for ubiquitination and subsequent degradation. Its utility in the development of PROTACs makes it a valuable tool for researchers studying targeted protein degradation and related therapeutic applications. -
PROTAC Linker
Propargyl-PEG8-OH is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne group, allowing it to serve as a click chemistry reagent through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in PROTAC development enables targeted protein degradation, making it a valuable tool for researchers focused on selective modulation of protein levels and pathways. -
PROTACT Linker
2-(2-(2-(6-Azidohexanamido)ethoxy)ethoxy)acetic acid serves as a PROTACT linker, facilitating the synthesis of P60-L3-VHL. This compound features an azide group enabling its utilization in click chemistry, specifically through the copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool in chemical research and bioconjugation applications. -
PROTAC Linker
Mal-C2-cyclohexylcarboxyl-hydrazide hydrochloride is a versatile PROTAC linker designed for targeted protein degradation applications. This hydrazide compound facilitates the formation of bifunctional molecules, promoting the effective assembly of E3 ligases and target proteins. It serves as a key building block in the development of novel PROTACs for studying protein dynamics and therapeutic interventions in various diseases. -
PROTAC Linker
m-PEG2-O-Ph-3-NH2 is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the connection between target proteins and E3 ligases, enabling targeted protein degradation, which is crucial for studying protein function and disease mechanisms. Its application in the development of PROTACs enhances the ability to manipulate cellular pathways and offers potential therapeutic strategies in various diseases, including cancer. -
PROTAC Linker
m-PEG2-O-Ph-NH2 is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTAC (proteolysis-targeting chimera) molecules. This compound enhances solubility and stability, facilitating the effective coupling of target ligands and E3 ligase recruiters. Its application extends to the development of targeted protein degradation strategies in chemical biology and drug discovery research. -
PROTAC Linker
N-(Azido-PEG4)-biocytin serves as a PEG-based linker for PROTAC applications, facilitating targeted protein degradation through its unique chemical reactivity. This reagent incorporates an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. Its versatility makes it a valuable tool in chemical biology for the synthesis of PROTACs and other bioconjugates. -
PROTAC Linker
Methylamino-PEG1-Boc is a polyethylene glycol (PEG)-based linker designed for use in proteolysis-targeting chimera (PROTAC) synthesis. The compound enables the formation of stable PROTACs by facilitating the conjugation of target proteins to E3 ligases, thereby promoting targeted protein degradation. It is particularly valuable in the development of novel therapeutic agents aimed at various diseases through the modulation of protein levels in cellular systems. -
PROTAC Linker
Fluorescein-PEG6-bis-NHS ester is a polyethylene glycol (PEG)-derived linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a fluorescein moiety that facilitates fluorescence detection, making it valuable for monitoring the effectiveness of protein degradation in cellular assays. Its efficient conjugation properties enable the construction of novel PROTACs, promoting targeted protein degradation in various biological research applications. -
PROTAC Linkers
Biotin-PEG6-alcohol is a biotin-conjugated polyethylene glycol (PEG) linker designed for use in the development of PROTAC (Proteolysis Targeting Chimera) compounds. This linker facilitates the connection of a target protein ligand with an E3 ligase ligand, enabling the targeted degradation of proteins within cells. Its key role in PROTAC synthesis makes it valuable for researchers investigating protein regulation and degradation pathways in various biological contexts. -
PROTAC Linker
Hydroxy-PEG8-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins, enhancing the efficiency and selectivity of protein degradation processes. It is an essential building block for the development of novel therapeutic agents aimed at selective targeting of pathological proteins in various disease models. -
PROTAC Linker
Azido-PEG2-propargyl is a PEG-based PROTAC linker that facilitates the construction of PROTAC molecules. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing partners. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified compounds. Azido-PEG2-propargyl is essential for researchers aiming to develop targeted protein degradation systems. -
PROTAC linker
N-(Azido-PEG3)-N-Boc-PEG4-Boc is a PEG-based linker designed for use in the synthesis of PROTACs. This compound features an azide functional group that enables its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with reactants containing DBCO or BCN moieties. Its biocompatibility and versatility make it ideal for constructing targeted protein degradation systems in chemical biology research. -
PROTAC Linker
N-(Azido-PEG4)-N-bis(PEG4-acid) is a PEG-based linker for PROTAC (proteolysis-targeting chimeras) synthesis. This compound features an azide group that enables click chemistry, participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynyl-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool for bioconjugation and targeted protein degradation applications in chemical biology research. -
PROTAC Linker
Azido-PEG10-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can facilitate strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when interacting with DBCO or BCN groups. Its versatile reactivity makes it a valuable tool for developing targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
Cbz-PEG2-bromide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis-Targeting Chimeras). This compound facilitates targeted protein degradation by covalently linking E3 ligases and the protein of interest, thereby promoting the ubiquitination and subsequent proteasomal degradation of specific proteins. It is a valuable tool in drug discovery and chemical biology for the development of new therapeutics targeting challenging proteins. -
PROTAC Linkers
Bromoacetyl-PEG3-DBCO is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features a dibenzylcyclooctyne (DBCO) group that enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It plays a critical role in the development of targeted protein degradation strategies, facilitating the formation of highly functionalized PROTACs for various biological research applications. -
PROTAC Linker
Azido-PEG9-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs, functioning through click chemistry mechanisms. This compound contains an azide group, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, facilitating efficient bioconjugation processes. Its utility in PROTAC development makes it a valuable reagent for therapeutic research and target protein degradation studies. -
PROTAC Linkers
Propargyl-PEG17-methane is a PEG-based linker designed for PROTAC synthesis, functioning as a versatile component in targeted protein degradation applications. Its alkyne group enables efficient click chemistry reactions through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This reagent is crucial for the development of innovative therapeutics aimed at selectively modulating protein levels within cellular systems. -
PROTAC Linker
Boc-NH-PEG7-acetic acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins by linking a ligand that recruits an E3 ligase to a target protein. Its unique structure enhances solubility and enables efficient conjugation, making it valuable in drug discovery and development research focused on targeted protein degradation. -
PROTAC Linker
Benzyl-PEG2-azide is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds possessing DBCO or BCN groups. This reagent is instrumental in the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
Biotin-PEG5-amine functions as a biotin-labeled polyethylene glycol (PEG) linker for the development of PROTAC (Proteolysis Targeting Chimera) molecules. This compound facilitates the synthesis of PROTACs by allowing for the precise conjugation of target proteins to E3 ligases, promoting targeted protein degradation. It is valuable in research focusing on protein regulation and therapeutic development. -
PROTAC Linkers
TCO-PEG3-alcohol is a PEG-based linker specifically designed for PROTAC synthesis, functioning primarily through the inverse electron demand Diels-Alder (iEDDA) reaction. This compound features a TCO moiety that enables efficient coupling with tetrazine-conjugated molecules, facilitating the development of targeted protein degradation strategies. Its use in research applications enhances the exploration of protein function and regulation in various biological pathways. -
PROTAC Linkers
DBCO-PEG4-triethoxysilane is a PEG-based PROTAC linker specifically designed for the synthesis of PROTACs. Its DBCO group facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. This compound is instrumental in the development of targeted protein degradation strategies, enhancing research in cancer therapy and other therapeutic areas. -
PROTAC Linkers
m-PEG11-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of targeting ligands to E3 ligase recruiters, enabling the selective degradation of protein targets in cellular systems. Its versatile applications include drug discovery and the study of protein function and regulation through targeted protein degradation. -
PROTAC Linkers
PEG3-C4-OBn is a polyethylene glycol (PEG)-derived linker designed for use in PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the synthesis of PROTAC SGK3 degrader-1, which effectively induces targeted degradation of SGK3, a serine/threonine protein kinase. PEG3-C4-OBn is instrumental in advancing research related to targeted protein degradation and cellular regulation mechanisms. -
PROTAC Linker
TCO4-PEG3-Maleimide is a PROTAC linker designed for targeted protein degradation applications. It features TCO and Maleimide functional groups, enabling precise "click" reactions with tetrazine and thiol compounds, or "mercapto-acrylamide" reactions. This compound facilitates the development of innovative therapeutic modalities by promoting effective protein-interaction dynamics in chemical biology research. -
PROTAC Linker
THP-PEG4-Pyrrolidine(N-Me)-CH2OH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC technology. This linker facilitates the synthesis of novel PROTAC compounds, notably the K-Ras Degrader-1, by promoting the degradation of specific target proteins via the ubiquitin-proteasome pathway. It is particularly useful in studies focused on targeted protein degradation for therapeutic applications. -
PROTAC Linker
Propargyl-PEG8-Boc is a PEG-based linker designed for use in the synthesis of PROTACs. It features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. This versatile linker facilitates research in targeted protein degradation and can be employed in the development of innovative therapeutic strategies. -
PROTAC Linker
Propargyl-PEG12-OH is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of azide-containing molecules. Propargyl-PEG12-OH is essential for developing targeted protein degradation systems and advancing chemical biology research applications. -
PROTAC Linker
N-Mal-N-bis(PEG2-NH-Boc) is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of ligand and E3 ligase components, enhancing the efficacy of targeted protein degradation. Its unique structure supports optimized solubility and stability, making it suitable for a variety of chemical biology applications in protein research and drug discovery.
