Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
N-Boc-PEG23-bromide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the attachment of target proteins to E3 ligases, enabling targeted protein degradation. Its hydrophilic properties enhance solubility and improve pharmacokinetic properties, making it suitable for diverse applications in drug discovery and development. -
PROTAC Linker
1,1,1-Trifluoroethyl-PEG4-alcohol is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the reversible conjugation of ligands to target proteins, promoting their ubiquitination and subsequent degradation through the proteasome pathway. It is an invaluable tool for researchers studying targeted protein degradation mechanisms and developing innovative therapeutic strategies. -
PROTAC Linker
Bis-propargyl-PEG10 is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Featuring an alkyne moiety, this compound facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-functionalized molecules. Its utility in forming stable linkages enhances the development of targeted protein degradation strategies in therapeutic research applications. -
PROTAC Linker
Boc-Aminooxy-PEG3-azide is a versatile PEG-based linker utilized in the synthesis of PROTACs (proteolysis targeting chimeras). This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) derivatives. Its application in PROTAC development enables efficient targeting and degradation of specific proteins, making it valuable for research in targeted protein degradation and related fields. -
PROTAC Linker
S-acetyl-PEG3-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. Its acetylated form enhances solubility and biocompatibility, making it suitable for targeted protein degradation studies. This linker facilitates the development of novel therapeutic agents by optimizing the delivery and efficacy of PROTACs in various biological applications. -
PROTAC Linkers
Tetraethyl heptane-1,7-diylbis(phosphonate) is a versatile linker utilized in the development of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound features an alkyl chain structure that facilitates the construction of bifunctional PROTACs, allowing for targeted protein degradation. It is instrumental in studies of targeted therapy and has applications in various drug discovery research efforts aimed at modulating protein levels within cellular systems. -
PROTAC Linkers
Benzyl-PEG6-t-butyl ester serves as a PEG-based linker for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound provides a flexible and stable connection between the ligand and E3 ligase components, facilitating the efficient degradation of target proteins. Its utilization in research supports the development of innovative therapeutic strategies through targeted protein degradation. -
PROTAC Linker
PEG4-bis(phosphonic acid diethyl ester) is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimera) applications. Its primary mechanism involves facilitating the conjugation of targeting moieties to E3 ligases, enhancing the proteolytic degradation of target proteins. This compound is instrumental in the development of innovative therapeutics through targeted protein degradation strategies, making it an essential reagent for research in drug discovery and cellular mechanisms. -
PROTAC Linker
Propargyl-PEG3-CH2COOH is a PEG-based linker specifically designed for PROTAC synthesis. This compound features an alkyne functionality, enabling it to participate in copper-catalyzed azide-alkyne cycloadditions (CuAAc) with azide-containing molecules. Its key biological activity facilitates the development of targeted protein degradation strategies, making it suitable for various chemical biology applications in the study of protein regulation and therapeutic interventions. -
PROTAC Linker
3,4-Dibromo-Mal-PEG2-amine is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of targeted protein degradation strategies by linking E3 ligases to substrates. Its application is crucial in studies focusing on protein modulation in various disease contexts, including cancer and neurodegenerative disorders. -
PROTAC Linker
Pyrene-amido-PEG4-azide is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). It features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that have DBCO or BCN functionalities, making it a versatile tool for targeted protein degradation studies. -
PROTAC Linkers
DBCO-PEG1-amine is a polyethylene glycol (PEG) based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a dibenzocyclooctyne (DBCO) functional group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG1-amine enhances the modularity and functionality of PROTACs, making it instrumental in targeted protein degradation research and therapeutic applications. -
PROTAC Linkers
t-Boc-Amido-PEG23-Amine is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of targeting and warhead moieties to enhance the selective degradation of proteins. Its hydrophilic nature aids in improving solubility and bioavailability, making it an essential tool for researchers in drug discovery and protein regulation studies. -
PROTAC Linker
Fluorescein-PEG5-acid is a polyethylene glycol (PEG) linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of bifunctional molecules that can engage target proteins for ubiquitination and degradation. Its fluorescent properties also enable monitoring and tracking of PROTAC activity in biological assays, making it a valuable tool for research focused on targeted protein degradation and cellular processes. -
PROTAC Linker
Mal-NH-PEG2-CH2CH2COOPFP ester is a PEG-based linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the covalent attachment of target proteins to E3 ligases, enabling targeted protein degradation. Its application is crucial in research focused on therapeutic interventions that harness the ubiquitin-proteasome system for modulating protein levels in various disease contexts. -
PROTAC Linkers
2-(Azido-PEG3-amido)-1,3-bis(NHS ester) is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) applications. This compound features an azide functional group which allows for versatile click chemistry reactions, including copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. It is instrumental in the synthesis of targeted protein degraders, facilitating effective drug development and biological research studies. -
PROTAC Linker
PEG3-bis-(ethyl phosphonate) is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, promoting selective degradation of specific proteins through the ubiquitin-proteasome pathway. Its application extends to various research fields, including drug discovery and functional proteomics, aiding in the development of targeted therapies. -
PROTAC Linker
Azido-PEG5-S-methyl ethanethioate functions as a versatile linker in the synthesis of PROTACs, utilizing its PEG-based structure to enhance solubility and stability. This reagent features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne moieties and entities containing DBCO or BCN groups, respectively. Its utility in PROTAC development makes it an essential tool for researchers investigating targeted protein degradation mechanisms. -
PROTAC Linker
HO-CONH-C3-PEG3-NH2 is a versatile linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) compounds. This reagent enhances the stability and solubility of PROTACs, facilitating the targeted degradation of specific proteins. Its application is pivotal in studies focused on protein homeostasis, cancer therapeutics, and the development of novel drug modalities. -
PROTAC Linker
DNP-NH-PEG2-C2-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound enhances cellular permeability and stability of PROTAC molecules. Its application facilitates the targeted degradation of specific proteins, supporting research in protein interaction and therapeutic development. -
PROTAC Linkers
m-PEG5-nitrile is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of bifunctional molecules that engage E3 ubiquitin ligases, enhancing targeted protein degradation. Its use is critical in drug development, particularly in studies focused on innovative therapeutic strategies for the modulation of protein levels in various biological contexts. -
PROTAC Linker
m-PEG3-0-benzaldehyde is a polyethylene glycol (PEG)-derived linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound is essential for the construction of bifunctional molecules that facilitate targeted protein degradation, enabling researchers to study protein dynamics and cellular mechanisms. Its versatile properties make it suitable for applications in drug development and the exploration of novel therapeutic strategies in various diseases. -
PROTAC linker
endo-BCN-PEG8-acid serves as a PEG-based linker for PROTAC (Proteolysis Targeting Chimera) synthesis, enabling targeted protein degradation. This compound features a BCN moiety, allowing for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its high efficiency and versatility make it an essential reagent for research in targeted therapeutic strategies and cellular signaling studies. -
PROTAC Linkers
Ald-CH2-PEG8-azide is a PEG-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). It features an azide functional group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. This versatility makes Ald-CH2-PEG8-azide ideal for applications in targeted protein degradation and medicinal chemistry research. -
PROTAC Linkers
m-PEG12-Mal is a polyethylene glycol (PEG) based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the assembly of PROTACs by providing a flexible and solubilizing linker that can enhance cellular uptake and target specificity. It is particularly useful in the development of novel therapeutics that harness the ubiquitin-proteasome system for targeted protein degradation in various biological applications. -
PROTAC Linkers
Ms-PEG7-MS is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the recruitment of E3 ubiquitin ligases to target proteins, promoting targeted protein degradation. Its flexibility and hydrophilicity enhance the efficacy and solubility of PROTAC constructs, making it valuable in drug discovery and development research. -
PROTAC Linkers
Azido-PEG16-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Featuring an azide functional group, this compound is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN moieties. This reagent is essential for facilitating the precise assembly of PROTACs, contributing to advancements in targeted protein degradation research. -
PROTAC Linker
Amino-PEG4-benzyl ester is a PEG-based linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the incorporation of a linker moiety that enhances the stability and cellular uptake of PROTACs. Its application is essential in target-specific protein degradation research, enabling the modulation of protein levels with high precision. -
PROTAC Linker
7-Oxoheptanoic acid serves as a versatile linker for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the selective degradation of target proteins by connecting E3 ligases to target proteins, thereby modulating cellular activities. Its application is critical in innovative drug design and protein modulation research, enabling the development of therapeutics that can selectively eliminate disease-associated proteins. -
PROTAC Linker
Benzyl-PEG7-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (PROteolysis TArgeting Chimeras). This compound facilitates the efficient conjugation of target proteins to E3 ligases, enhancing protein degradation pathways. Its applications extend to chemical biology and drug development, making it a valuable tool for researchers investigating targeted protein degradation mechanisms. -
PROTAC Linker
SPDP-PEG6-NHS ester is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation of specific proteins in cellular contexts. It is applicable in various research areas, including targeted protein degradation and therapeutic development. -
PROTAC Linker
Carboxyrhodamine 110-PEG3-Azide is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that permits efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-modified partners. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, making it versatile for various click chemistry applications in chemical biology research. -
PROTAC Linker
DBCO-PEG1 is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This reagent is crucial for the development of targeted protein degradation strategies in chemical biology research, facilitating the efficient assembly of bifunctional small molecules for therapeutic applications. -
PROTAC Linker
Amino-PEG11-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its primary function is to facilitate the conjugation between a target protein ligand and an E3 ligase ligand, promoting targeted protein degradation. This compound is valuable in drug discovery and development, enabling the investigation of protein function and the modulation of cellular pathways through proteolysis. -
PROTAC Linker
NH-bis(m-PEG4) is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to ubiquitin ligases, enhancing the targeted degradation of specific proteins within cellular systems. Its versatility in various biochemical applications makes it an essential tool for researchers developing novel therapeutics that leverage the ubiquitin-proteasome pathway. -
PROTAC Linker
Azido-PEG8-azide is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. It features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, this compound can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized partners, making it a versatile tool for applications in targeted protein degradation research. -
PROTAC Linkers
Diketone-PEG4-PFP ester is a PEG-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the assembly of bifunctional molecules that enhance substrate degradation via the ubiquitin-proteasome system. Its robust chemical properties enable efficient conjugation to various targeting and E3 ligase components, making it a vital tool for researchers investigating targeted protein degradation. -
PROTAC Linker
Propargyl-PEG3-sulfone-PEG3-propargyl is a PEG-based linker designed for the synthesis of PROTACs through its unique functionality in click chemistry. This compound features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling efficient conjugation with azide-containing molecules. Its application in the development of targeted protein degradation systems provides researchers with a versatile tool for studying protein interactions and cellular pathways. -
PROTAC linker
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 is a PEG-based PROTAC linker designed to facilitate the synthesis of PROTACs. This compound features an alkyne functional group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its applications in chemical biology include the development of targeted protein degradation strategies, allowing for innovative therapeutic approaches in drug discovery and research. -
PROTAC Linker
Tos-PEG3-C2-methyl ester is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of proteins by linking an E3 ligase ligand to a warhead, enabling precise modulation of protein levels in biological systems. It serves as a valuable tool in drug discovery, particularly in the development of novel therapeutic agents aimed at degrading disease-related proteins. -
PROTAC Linker
Bis-aminooxy-PEG7 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the successful conjugation of target proteins to ligands, enabling selective degradation of proteins of interest via the ubiquitin-proteasome system. Its application in PROTAC development is crucial for advancing studies in targeted protein degradation and therapeutic interventions in various diseases. -
PROTAC Linkers
TCO-PEG6-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features a TCO (Trans-Cyclooctene) moiety that enables efficient ligation with a specific cyclopropene partner, facilitating the selective degradation of target proteins. This compound is essential for researchers developing targeted protein degradation strategies and studying cellular processes involving controlled protein levels. -
PROTAC Linker
Propargyl-PEG8-SH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring an alkyne group, this compound facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, enabling efficient conjugation in chemical biology applications. Its utility in developing targeted protein degradation strategies makes it a valuable reagent for researchers focusing on novel therapeutic approaches and drug discovery. -
PROTAC Linker
Bis-propargyl-PEG8 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functional group, allowing it to facilitate copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties make Bis-propargyl-PEG8 a valuable tool in chemical biology and drug development, particularly in the creation of targeted protein degradation systems. -
PROTAC Linker
Boc-NH-Piperidine-C5-OH is a specialized PROTAC linker utilized in targeted protein degradation strategies. This compound plays a crucial role in the synthesis of PROTAC molecules, specifically facilitating the formation of PIN1 degrader-1. Its application enables precise modulation of protein levels within cellular environments, making it valuable for research in proteomics and targeted therapy development. -
PROTAC Linker
Biotin-C1-PEG3-C3-amine TFA is a PEG-based linker utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates targeted protein degradation by conjugating an E3 ligase ligand with a protein of interest, enhancing the efficacy of PROTAC-based strategies in biochemical research. Its unique structure allows for improved solubility and potency within various cellular contexts, making it a valuable tool for studies in chemical biology and therapeutic development. -
PROTAC Linker
Propargyl-PEG4-Sulfone-PEG4-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound features an alkyne group, facilitating click chemistry applications through copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing partners. Its unique structure enables selective protein degradation, making it a valuable tool in the advancement of targeted protein modulation and drug discovery research. -
PROTAC Linkers
Acid-PEG9-NHS ester is a polyethylene glycol (PEG) linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing selective protein degradation pathways. It is an essential tool for researchers focusing on targeted protein modulation and therapeutic applications in cancer and other diseases. -
PROTAC Linkers
Benzyl-PEG5-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). It enhances the solubility and stability of PROTAC constructs, enabling the selective degradation of target proteins through the ubiquitin-proteasome system. This versatile linker is instrumental in the development of therapeutic agents for targeted protein degradation research. -
PROTAC Linker
Benzyl-PEG3-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the effective conjugation of target proteins with E3 ligases, enhancing the degradation of specific proteins in cellular systems. Its application is critical in chemical biology research, particularly in studies focused on targeted protein degradation and therapeutic development.
