Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
Azido-PEG4-THP is a PEG-based linker designed for use in the synthesis of PROTACs. It features an azide group that facilitates click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This versatility makes Azido-PEG4-THP an essential tool in chemical biology for the development of targeted protein degradation strategies. -
PROTAC Linkers
Propargyl-PEG-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of various warheads to the E3 ligase, promoting targeted degradation of specific proteins within cells. It is particularly valuable in the development of novel therapeutic agents aimed at modulating protein levels and investigating cellular pathways implicated in various diseases. -
PROTAC Linkers
DBCO-PEG9-DBCO is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features a DBCO ( dibenzocyclooctyne) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its ability to create covalent bonds enhances the stability and efficacy of PROTACs, making it a valuable tool for targeted protein degradation studies and drug discovery applications. -
PROTAC linker
N-PEG3-N'-(propargyl-PEG4)-Cy5 is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an alkyne group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its applications extend to chemical biology and drug discovery, particularly in the development of innovative therapeutic strategies targeting specific protein interactions. -
PROTAC Linker
Dde Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker designed for the synthesis of targeted protein degradation agents. This compound functions through click chemistry, featuring an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its unique structure and reactivity make it a valuable tool for advancing research in targeted protein degradation and other applications in chemical biology. -
PROTAC Linker
Br-PEG3-ethyl acetate is a polyethylene glycol (PEG)-derived linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of targeting moieties to E3 ligase, enabling the selective degradation of target proteins through the ubiquitin-proteasome system. It is utilized in research applications aiming to develop novel therapeutic strategies for diseases involving aberrant protein accumulation. -
PROTAC Linkers
Azido-PEG12-propargyl is a versatile PEG-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as enabling ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds. Its effective application in the development of PROTACs supports targeted protein degradation research, offering significant potential for therapeutic interventions in various diseases. -
PROTAC Linkers
t-Boc-Aminooxy-PEG7-amine is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an aminooxy functional group that facilitates the conjugation of ligands to E3 ligase, enabling targeted degradation of specific proteins. This compound is essential for researchers developing novel PROTAC therapeutics and studying targeted protein degradation mechanisms. -
PROTAC Linkers
2-Amino-1,3-bis(carboxylethoxy)propane is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It serves as a versatile connector that facilitates the conjugation of targeting ligands to E3 ligases, enabling targeted protein degradation. This compound is valuable in the development of novel therapeutic agents aimed at selectively modulating protein levels within cells. -
PROTAC Linker
Biotin-PEG2-C4-alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functionality, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in PROTAC development facilitates targeted protein degradation, making it essential for research in therapeutic protein modulation and drug discovery. -
PROTAC Linker
N-Boc-N-bis(PEG4-azide) is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide group enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) reactions involving DBCO or BCN groups, making it a versatile tool for chemical biology applications, including drug discovery and development. -
PROTAC Linkers
m-PEG3-Sulfone-PEG3-acid is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of targeting and E3 ligase recruiters, enhancing the development of targeted protein degradation applications. Its properties support the design of PROTACs for research in cellular mechanisms and therapeutic interventions in various diseases, including cancer. -
PROTAC Linker
Bis-propargyl-PEG6 is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the assembly of polymer-linked multimers, particularly of guanosine-3', 5'-cyclic monophosphates. As a click chemistry reagent, Bis-propargyl-PEG6 contains an alkyne functionality that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, making it valuable for various bioconjugation applications in chemical biology. -
PROTAC Linkers
Hydroxy-PEG2-CH2COONa is a polyethylene glycol (PEG) based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances solubility and biocompatibility, thereby improving the pharmacological properties of novel PROTACs. It is essential for studies targeting selective protein degradation and for advancing research in targeted therapies. -
PROTAC Linkers
m-PEG3-Propanoyl chloride is a polyethylene glycol (PEG) based linker designed for the synthesis of PROTAC (Proteolysis Targeting Chimeras). It enables the formation of potent PROTACs that selectively target and degrade specific proteins within cells. This compound is essential for researchers focusing on targeted protein degradation and drug development in various biological studies. -
PROTAC Linker
Benzyl-PEG3-amine is a polyethylene glycol (PEG)-based linker designed for PROTAC (proteolysis-targeting chimera) applications. This compound serves as a crucial component in the synthesis of PROTACs, enabling targeted protein degradation. Its flexible structure facilitates the conjugation of different ligands, enhancing the efficacy of drug discovery and biomedical research focused on protein modulation and disease intervention. -
PROTAC Linker
Thiol-PEG3-phosphonic acid ethyl ester is a PEG-based PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This compound is crucial for the development of targeted protein degradation strategies, enabling researchers to selectively modulate protein levels. Its application extends to synthetic biology and drug discovery, providing a versatile tool for exploring complex cellular mechanisms. -
PROTAC Linkers
Propargyl-PEG5-PFP ester is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an alkyne functional group, enabling its application in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its ability to create stable linkages makes it valuable for advancing research in targeted therapeutic strategies and bioconjugation. -
PROTAC Linker
Butoxycarbonyl-PEG5-sulfonic acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. This compound facilitates the coupling of target proteins to E3 ligases, enabling targeted protein degradation. Its applications include drug discovery and development within the realm of targeted therapeutics and protein modulation studies. -
PROTAC Linkers
6-Hydroxy-1-(4-(2-hydroxyethyl)piperazin-1-yl)hexan-1-one serves as a key linker in the development of PROTAC molecules targeting METTL3. This compound is integral for facilitating the degradation of specific proteins, thereby enabling cellular pathway modulation and functional studies. Researchers can employ this linker to explore targeted protein degradation applications in various biological contexts. -
PROTAC Linkers
Hexane-1,6-diyldiphosphonic acid serves as an alkyl chain-based linker for PROTAC (Proteolysis Targeting Chimeras) applications. This reagent facilitates the synthesis of PROTACs by providing a functionalized scaffold that connects target proteins to E3 ligases, enabling targeted protein degradation. It is crucial for researchers developing PROTACs to study cellular processes and therapeutic interventions in various diseases. -
PROTAC Linkers
Hydroxy-PEG7-Boc is a polyethylene glycol (PEG)-derived PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, thereby improving their therapeutic efficacy. Its unique structure allows for effective conjugation to various ligands, making it suitable for a range of research applications in targeted protein degradation and drug discovery. -
PROTAC Linker
6-Bromohexylphosphonic acid is a versatile alkyl chain-based PROTAC linker that facilitates the development of targeted protein degradation (PROTAC) agents. This compound plays a crucial role in the synthesis of PROTACs, enabling the selective degradation of specific proteins in various biological pathways. Its structural properties enhance molecular interactions, making it an essential tool for researchers investigating novel therapeutic approaches in cancer and other diseases. -
PROTAC Linker
Mal-PEG8-Boc is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the effective conjugation of target proteins and E3 ligases, enhancing the selective degradation of specific proteins within the cell. Its application in PROTAC development supports research in targeted protein degradation and chemical biology. -
PROTAC Linker
BnO-PEG5-Boc is a PEG-based linker specifically designed for proteolysis-targeting chimera (PROTAC) synthesis. This compound facilitates the assembly of PROTAC molecules by linking a target protein ligand to an E3 ligase ligand, enhancing the degradation of targeted proteins. Its application in chemical biology research supports the development of novel therapeutic strategies through targeted protein degradation. -
PROTAC Linkers
Amino-PEG10-acid is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. Its amino functionality facilitates the covalent attachment of target proteins to E3 ligases, enabling targeted protein degradation. This reagent is essential for researchers looking to develop novel PROTACs for studying protein function and developing potential therapeutic agents. -
PROTAC Linker
m-PEG4-O-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features an NHS ester that facilitates the conjugation with target proteins, enabling targeted protein degradation. Its unique structure enhances solubility and stability in biochemical applications, making it suitable for research focused on innovative therapeutic strategies in drug discovery and biochemistry. -
PROTAC Linkers
Propenyl-PEG3-Propenyl is a PEG-based linker designed for PROTAC (proteolysis targeting chimera) applications. This compound facilitates the construction of PROTACs, enabling targeted protein degradation. It enhances the solubility and biocompatibility of PROTAC molecules, making it a valuable tool in drug discovery and development for studying protein regulation and therapeutic intervention. -
PROTAC linker
2-(2-Aminoethoxy)ethyl hydrogen carbonate is a PROTAC linker utilized in targeted protein degradation studies. This compound plays a crucial role in the synthesis of innovative degraders like OZD-MET 01, facilitating the development of selective therapeutic agents. Its unique structural properties contribute to advancements in drug discovery and the modulation of protein levels in cellular systems. -
PROTAC Linker
Benzyloxy carbonyl-PEG3-C2-acid is a PEG-based PROTAC linker designed to facilitate the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, enabling effective protein degradation in various biological contexts. It is essential for researchers looking to develop innovative therapeutics through targeted protein modulation and degradation. -
PROTAC Linker
DSPE-PEG4-acid is a PEG-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, enabling efficient targeted degradation of specific proteins. It is suited for applications in drug discovery and functional protein studies, providing researchers with a vital tool for studying protein modulation and therapeutic intervention mechanisms. -
PROTAC Linker
SCO-PEG4-COOH is a PROTAC linker that facilitates targeted degradation of proteins via the ubiquitin-proteasome system. This compound features a synthetic PEG (polyethylene glycol) spacer, enabling efficient conjugation with amino groups while its SCO moiety is designed to react selectively with amino acid residues, particularly lysine, in proteins or peptides. It is widely utilized in the development of bifunctional compounds and the study of protein interactions within cellular environments. Its biocompatibility and versatility make it a valuable tool for chemical biology and therapeutic research applications. -
PROTAC Linker
Acid-PEG3-PFP ester is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the conjugation of protein ligands to E3 ligase substrates, enabling the targeted degradation of specific proteins. Its application in PROTAC technology supports research in targeted protein modulation and therapeutic development. -
PROTAC Linker
Diethyl 7-bromoheptylphosphonate is an alkyl chain-based PROTAC linker that facilitates targeted protein degradation through the recruitment of E3 ubiquitin ligases. This compound plays a critical role in the synthesis of PROTACs, enabling the modulation of protein activity in various biological research applications. It is useful in studies related to protein homeostasis, therapeutic targeting, and drug discovery efforts. -
PROTAC Linker
Mal-amino-sulfo is an alkyl/ether-based PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by linking E3 ligases to target proteins, thereby enhancing their ubiquitination and subsequent proteasomal degradation. Mal-amino-sulfo is suitable for researchers aiming to develop novel therapeutic strategies through targeted protein degradation. -
PROTAC Linker
Cbz-NH-PEG5-C2-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of PROTACs by connecting target proteins to E3 ligases, enabling targeted degradation of proteins of interest. Its versatile design supports various biological applications in drug discovery, particularly in the study of protein regulation and therapeutic targeting. -
PROTAC Linkers
Benzyl-PEG9-THP is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the targeted degradation of specific proteins through the ubiquitin-proteasome system, advancing research in various biological pathways. Its unique structure promotes effective protein-protein interactions essential for the development of innovative therapeutic strategies. -
PROTAC Linker
N-(m-PEG4)-N'-(PEG4-acid)-Cy5 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the attachment of targeting ligands to ubiquitin ligase partners, enabling selective degradation of target proteins. Its unique structure enhances solubility and stability, making it suitable for various biological applications in chemical biology and drug discovery studies. -
PROTAC Linkers
Bromo-PEG2-NHS ester is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling the selective degradation of specific proteins within cells. Its application in drug discovery and development makes it a valuable tool for researchers aiming to modulate protein levels through targeted protein degradation strategies. -
PROTAC Linkers
Boc-HyNic-PEG1-mal is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the development of bifunctional molecules that engage E3 ligases and target specific proteins for ubiquitination and degradation. It is suitable for applications in targeted protein degradation studies and therapeutic research, contributing to advancements in protein modulation strategies. -
PROTAC Linker
Acid-C2-PEG3-NHS ester is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins for enhanced selective degradation in cellular assays. Its properties make it an essential tool for researchers exploring targeted protein degradation and drug discovery applications. -
PROTAC Linker
Boc-NH-PEG4-C3-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the efficient conjugation of target proteins and E3 ligases, enabling targeted protein degradation. Its unique structure enhances solubility and stability, making it suitable for various biological applications in drug discovery and development. -
PROTAC Linker
1-(t-Boc-Aminooxy)-3-aminooxy-propane is an alkyl/ether-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This versatile compound facilitates the selective degradation of target proteins through the modulation of ubiquitin-proteasome pathways. Its unique properties make it ideal for research applications in targeted protein degradation, enabling advancements in drug development and therapeutic strategies. -
PROTAC Linkers
Methylamino-PEG3-acid is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) compounds. This linker facilitates the selective degradation of target proteins through the ubiquitin-proteasome system, enabling studies in protein modulation and targeted therapy. Methylamino-PEG3-acid is essential for researchers exploring the development of innovative therapeutic strategies in areas such as cancer and other protein misfolding diseases. -
PROTAC Linker
m-PEG3-Tos is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) applications. This compound enables the effective synthesis of targeted degrader molecules, facilitating the selective degradation of proteins within cells. Its innovative structure enhances solubility and promotes optimal biological activity, making it a valuable tool for researchers in drug discovery and chemical biology. -
PROTAC Linker
m-PEG5-Tos is a PEG-based PROTAC linker designed to facilitate targeted protein degradation. This compound serves as a critical building block in the synthesis of Silymarin, enhancing the specificity and efficacy of PROTAC molecules. Research applications include studies on protein modulation and the development of targeted therapies in various disease models. The unique structure of m-PEG5-Tos enables efficient conjugation with target proteins, promoting innovative approaches in chemical biology. -
PROTAC Linker
Ald-CH2-PEG3-CH2-Boc is a PEG- and alkyl/ether-based PROTAC linker designed to facilitate the construction of proteolysis-targeting chimeras (PROTACs). This linker plays a crucial role in synthesizing SGK3 kinase PROTAC degraders, enabling selective degradation of target proteins. Its unique structure enhances solubility and promotes effective engagement with target proteins for research applications in targeted protein degradation and mechanistic studies of cellular pathways. -
PROTAC Linkers
TCO-PEG8-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a TCO (trans-cyclooctene) moiety, enabling it to participate in inverse electron demand Diels-Alder reactions with tetrazine-conjugated molecules. Its utility in click chemistry makes it a valuable tool for researchers aiming to develop innovative therapeutics targeting specific proteins for degradation. -
PROTAC Linker
Azido-PEG6-PFP ester is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules. Its utility in click chemistry facilitates the development of targeted protein degradation strategies in various biological research applications. -
PROTAC linker
L-Azidohomoalanine is a versatile click chemistry reagent designed as an alkyl chain-based linker for PROTAC synthesis. It features an azide functional group enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, L-Azidohomoalanine can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. Its unique properties make it suitable for research applications involving targeted protein degradation and modular assembly of multifunctional biomolecules.
