Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
3-(tert-Butyldimethylsilyloxy)propan-1-amine is a PROTAC linker that serves as a crucial component in the synthesis of proteolysis-targeting chimeras (PROTACs). Its incorporation into PROTAC design facilitates the selective degradation of target proteins, enhancing research in targeted protein modulation and therapeutic development. This compound is valuable for studies focused on protein homeostasis and the exploration of novel cellular pathways. -
PROTAC Linker
Bicyclo[2.2.2]octane-1,4-dicarboxylic acid serves as a essential PROTAC linker in the development of proteolysis-targeting chimeras. This compound facilitates the assembly of targeted protein degradation systems by connecting E3 ligase and protein of interest, promoting efficient ubiquitination and subsequent proteasomal degradation. Its application is particularly valuable in drug discovery and molecular biology research focused on targeted protein modulation. -
PROTAC Linker
tert-Butyl 4-(3-bromopropyl)piperazine-1-carboxylate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins, making it valuable for targeted protein modulation studies. Its application in synthetic biology allows for innovative approaches in drug discovery and therapeutic interventions by leveraging the ubiquitin-proteasome system for protein degradation. -
PROTAC Linker
1-Chloro-3-(3-chloropropoxy)propane is a key PROTAC linker utilized in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins with E3 ligases, promoting targeted degradation pathways. Its application is vital in chemical biology and drug development research, allowing for the selective modulation of protein levels within cells. -
PROTAC Linker
8-Amino-1-octanol is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). By providing a functional handle for the connection of ligand and protein target, this compound enhances the development of targeted protein degradation strategies. 8-Amino-1-octanol is essential for researchers seeking to explore cellular pathways and therapeutic applications through the modulation of protein levels in various biological contexts. -
PROTAC Linker
Fmoc-12-aminododecanoic acid is a PROTAC linker characterized by an alkane chain with a terminal Fmoc-protected amine and a carboxylic acid group. This compound serves as a building block in the synthesis of PROTACs, facilitating targeted protein degradation studies. The Fmoc group can be readily deprotected in basic conditions, releasing a free amine for subsequent conjugations, while the terminal carboxylic acid allows for stable amide bond formation with primary amines using suitable coupling reagents. -
PROTAC Linker
3-Aminobicyclo[1.1.1]pentan-1-ol hydrochloride serves as a useful PROTAC linker, facilitating the development of PROTAC molecules. This compound aids in the targeted protein degradation process, thereby enabling investigations into protein function and regulation. Its role in synthesizing PROTACs makes it valuable for research applications focused on therapeutic interventions in diseases associated with protein dysregulation. -
PROTAC Linker
4-Bromobutoxy-tert-butyl-dimethylsilane is a specialized PROTAC linker designed for the synthesis of PROTAC molecules. This compound facilitates the development of targeted protein degradation strategies by effectively linking target proteins to E3 ligases. Its incorporation into PROTACs enhances the efficiency of protein modulation, making it a valuable tool for research in cellular biology and drug discovery. -
PROTAC Linker
9-(Boc-amino)nonanoic acid functions as a PROTAC linker, featuring an alkane chain that contains a terminal carboxylic acid and a Boc-protected amino group. This compound is instrumental in the synthesis of PROTACs, as its carboxylic acid can efficiently react with primary amines in the presence of coupling agents, such as EDC or HATU, to yield stable amide bonds. The Boc protecting group can be removed under mild acidic conditions, resulting in the formation of the free amine, facilitating subsequent chemical modifications. -
PROTAC Linker
4-tert-Butoxy-4-oxobutanoic acid serves as a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the ubiquitination and subsequent degradation of target proteins, thereby enabling selective modulation of protein levels within cellular systems. It is widely utilized in drug discovery and chemical biology research focused on targeted protein degradation. -
PROTAC Linker
tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate serves as a PROTAC linker, facilitating the design and synthesis of targeted protein degraders. This compound is essential for creating bifunctional molecules that promote ubiquitination and subsequent degradation of specific proteins within cellular environments. Its application in drug discovery and development is pivotal for advancing targeted therapies that can selectively remove pathogenic proteins. -
PROTAC Linker
p-(Methoxycarbonylmethyl)aniline serves as a versatile PROTAC linker facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in connecting target proteins with E3 ligases, thereby promoting selective degradation of specific proteins within cellular systems. Its application is essential in drug discovery and the study of protein dynamics, aiding researchers in understanding protein function and disease mechanisms. -
PROTAC Linker
3-((tert-Butyldimethylsilyl)oxy)propan-1-ol serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in promoting targeted protein degradation by connecting ligand and E3 ligase components. Its unique structure enhances solubility and stability, making it essential for various applications in chemical biology and therapeutic development. -
PROTAC Linker
7-Aminoheptanoic acid serves as a versatile PROTAC linker, facilitating the synthesis of PROTAC molecules designed for targeted protein degradation. This compound enhances the development of bifunctional entities to modulate cellular pathways, making it valuable in therapeutic research aimed at cancer and other diseases. Its structural properties support the formation of linkers that connect E3 ligases to target proteins, playing a crucial role in advancing drug discovery efforts. -
PROTAC Linker
TCO-PEG3-amine is a polyethylene glycol (PEG)-based linker designed for use in proteolysis-targeting chimeras (PROTACs). This compound facilitates the synthesis of PROTACs, enabling targeted degradation of specific proteins within cells. Its unique structure promotes solubility and stability, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linker
Tetrazine-Ph-acid is a specialized linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a tetrazine moiety capable of undergoing an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives, facilitating selective and efficient protein degradation. Its application in the development of PROTACs enables researchers to explore targeted protein modulation and therapeutic interventions in various biological systems. -
PROTAC Linkers
Bis-PEG1-acid is a polyethylene glycol (PEG)-based linker designed for harnessing the proteolysis-targeting chimera (PROTAC) technology. This compound facilitates the synthesis of PROTACs by providing necessary flexibility and solubility, optimizing the delivery of targeted protein degradation. It is particularly useful in the development of innovative therapeutic agents aimed at selectively eliminating specific proteins within pathological contexts. -
PROTAC Linkers
Mal-PEG24-NHS ester is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a maleimide group for selective conjugation to cysteine residues, enhancing the stability and efficacy of PROTAC constructs. Its biocompatibility and hydrophilicity support efficient cellular uptake and biological activity, making it an essential tool in the field of targeted protein degradation. Research applications include the development of novel therapeutics for various diseases through the modulation of protein levels. -
PROTAC Linker
Propargyl-PEG6-NH2 is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring an alkyne functional group, it serves as a click chemistry reagent capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This linker is instrumental in the development of targeted protein degradation strategies, enhancing research in protein regulation and therapeutic applications. -
PROTAC Linkers
Amino-PEG8-amine is an 8-unit polyethylene glycol (PEG) based linker designed for PROTAC (proteolysis targeting chimera) synthesis. This compound facilitates the conjugation of small molecules to E3 ligases, enhancing the development of bifunctional compounds that promote targeted protein degradation. It is a valuable tool in biochemical research, enabling studies on protein modulation and therapeutic interventions in various diseases. -
PROTAC Linkers
THP-PEG3-OH is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective recruitment of E3 ligases to target proteins, enhancing the degradation of specific intracellular proteins. Its application is pivotal in the development of novel therapeutic strategies in targeted protein degradation research. -
PROTAC Linker
NH2-PEG1-CH2CH2-Boc is a polyethylene glycol (PEG) and alkyl/ether-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of PROTACs by providing solubility and enabling targeting of specific proteins for degradation. Its use is essential in chemical biology and drug discovery for the development of targeted protein degradation strategies. -
PROTAC Linker
Bromo-PEG4-acid is a polyethylene glycol (PEG)-based linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). Its bromo functional group enables the conjugation of target proteins, enhancing degradation efficiency through the ubiquitin-proteasome system. This compound is widely utilized in chemical biology for the development of targeted protein degradation strategies in various research applications. -
PROTAC Linker
Boc-NH-PEG8-CH2CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimera) molecules. This compound facilitates the ubiquitination and subsequent degradation of target proteins through targeted approaches in protein regulation studies. Its application is vital for research in cellular signaling, disease pathways, and development of novel therapeutic strategies by enhancing the specificity and efficacy of PROTACs. -
PROTAC Linker
Acid-C2-PEG4-C2-NHS ester is a PEG-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of a protein of interest to an E3 ligase, enhancing targeted protein degradation. Its flexible structure allows for optimal spatial orientation, making it suitable for various research applications in the field of targeted therapy and drug discovery. -
PROTAC Linker
Triethylene glycol bis(p-toluenesulfonate) is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the creation of bifunctional molecules that selectively induce the ubiquitin-proteasome system to degrade targeted proteins. Its properties make it suitable for various research applications in targeted protein degradation and therapeutic development. -
PROTAC Linker
Propargyl-PEG4-alcohol is a PEG-based PROTAC linker that facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an alkyne functional group, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application is critical in chemical biology for the development of targeted protein degradation strategies, enhancing the efficacy of therapeutic agents in various research areas. -
PROTAC Linker
tert-Butyl (6-aminospiro[3.3]heptan-2-yl)carbamate functions as a PROTAC linker, facilitating the development of targeted protein degradation agents. This compound is integral in the synthesis of the PROTAC degrader CPD-39, enabling the selective modulation of protein levels for research applications in cellular biology and therapeutic discovery. Its structural properties support effective interaction with protein targets, making it valuable for studies aimed at understanding protein dynamics and degradation mechanisms. -
PROTAC Linkers
Biotin-PEG6-azide is a biotin-labeled PEG-based linker specifically designed for synthesizing PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool for chemical biology and therapeutic research involving targeted protein degradation. -
PROTAC Linker
Fmoc-NH-PEG1-C2-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of stable complexes that enhance ubiquitination and degradation of target proteins. Its unique structure supports research into targeted protein degradation, leading to potential therapeutic applications in disease modulation and drug development. -
PROTAC Linkers
3-(2-Pyridyldithio)propanoic Acid serves as an alkyl chain-based linker specifically designed for the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the targeted degradation of proteins by bringing together an E3 ligase and a protein of interest, promoting ubiquitination and subsequent proteasomal degradation. Its unique structure and reactivity allow for enhanced stability and efficacy in various research applications involving targeted protein degradation. -
PROTAC Linkers
m-PEG1-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of ligands to E3 ligase while enhancing solubility and bioavailability. It is an essential reagent for researchers developing targeted protein degradation strategies and studying cellular pathways through the modulation of specific protein levels. -
PROTAC Linkers
TCO-PEG2-amine is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of specific proteins through the ubiquitin-proteasome system, making it a valuable tool for chemical biology research. Its flexibility and solubility contribute to improved efficacy in the development of innovative therapeutic strategies targeting various diseases. -
PROTAC Linker
BCN-exo-PEG3-NH2 is a PEG-based linker designed for PROTAC (PROteolysis-TArgeting Chimeras) synthesis. This compound features a BCN (bicyclononyne) group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique properties make it suitable for applications in targeted protein degradation research, enabling precise modulation of protein levels within biological systems. -
PROTAC Linkers
Biotin-PEG2-CH2CH2N3 is a PEG-based linker designed for PROTAC synthesis, targeting protein degradation pathways. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) reactions involving DBCO or BCN-tagged compounds, making it versatile for diverse chemical biology applications, including targeted protein degradation studies. -
PROTAC Linker
Boc-NH-PEG3 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the assembly of PROTACs by providing a flexible and hydrophilic spacer that connects the target ligand and E3 ligase components. Its primary application lies in advancing research in targeted protein degradation, enabling the selective modulation of protein levels within cells. -
PROTAC Linkers
Biotin-PEG12-NHS ester is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the covalent attachment of proteins through biotinylation, enhancing the pharmacokinetic properties of PROTACs. Its unique structure allows for improved solubility and stability, making it a valuable tool in targeted protein degradation research and drug discovery applications. -
PROTACT linker
2-(2-((6-Chlorohexyl)oxy)ethoxy)acetic acid serves as a PROTACT linker, facilitating the targeted protein degradation of SMARCA2 and SMARCA4. This compound enhances the specificity and efficacy of proteolysis-targeting chimeras (PROTACs) by promoting the interaction between ligands and E3 ubiquitin ligases. It is an essential tool for researchers investigating protein homeostasis and therapeutic strategies in various biological contexts. -
PROTAC Linker
Boc-NH-PEG12-NH2 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target protein ligands to E3 ligase recruiters, enhancing the effectiveness of PROTACs in promoting targeted protein degradation. It is a valuable tool for researchers investigating novel therapeutic strategies through the modulation of protein homeostasis. -
PROTAC Linker
2-(4-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperazin-1-yl)acetic acid serves as a versatile PROTAC linker, facilitating the assembly of proteolysis-targeting chimeras. This compound effectively engages with E3 ligases, promoting targeted protein degradation. Its application is pivotal in the design and synthesis of hybrid molecules for research in drug discovery and therapeutic development. -
PROTAC Linker
2-(Bromomethyl)-1,3-dioxolane is a chemical linker specifically designed for use in synthesizing PROTACs (proteolysis-targeting chimeras). This compound facilitates the construction of bifunctional molecules that can selectively induce the degradation of target proteins through the ubiquitin-proteasome system. Its utility in the development of targeted protein degradation strategies makes it valuable for research in drug discovery and therapeutic applications. -
PROTAC Linker
tert-Butyl 8-aminooctanoate is a versatile PROTAC linker designed to facilitate the synthesis of PROTAC molecules. Its structure enables optimal interaction with target proteins, enhancing the overall efficacy of targeted protein degradation assays. This reagent is essential for researchers focused on investigating novel therapeutic strategies involving proteolysis-targeting chimeras. -
PROTAC Linkers
mPEG45-Epoxide is a polyethylene glycol (PEG) derivative featuring polyether units, designed for use as a linker in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the conjugation of ligands to E3 ubiquitin ligases, enabling targeted protein degradation. mPEG45-Epoxide is instrumental in the development of novel therapeutic agents and in studying protein regulation mechanisms within cellular environments. -
PROTAC Linker
4-Boc-aminomethyl-piperidine is a versatile PROTAC linker that facilitates the development of targeted protein degradation therapies. This compound is essential for synthesizing various PROTACs, enabling the selective degradation of specific proteins within cellular pathways. Its application in research helps to advance therapeutic strategies for diseases driven by protein misregulation. -
PROTAC Linker
trans-4-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclohexaneacetic acid acts as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound is instrumental in the synthesis of PROTACs, which harness the cell's ubiquitin-proteasome system for targeted protein degradation. Its unique structure enhances the activity and specificity of PROTACs in various research applications, making it a critical reagent for studies in targeted therapy and protein modulation. -
PROTAC Linker
(E)-tert-Butyldimethyl((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-1-yl)oxy)silane serves as a versatile PROTAC linker, facilitating the assembly of proteolysis-targeting chimeras (PROTACs). This compound enables the selective degradation of target proteins via the ubiquitin-proteasome system and is instrumental in drug discovery and development. Its unique structure allows for effective conjugation, enhancing cellular permeability and targeting specificity in therapeutic applications. -
PROTAC Linker
tert-Butyl (7-azaspiro[3.5]nonan-2-yl)carbamate is a versatile PROTAC linker designed to facilitate the synthesis of PROTAC molecules. This compound enhances the targeted degradation of specific proteins through the ubiquitin-proteasome system, promoting effective protein removal. Its unique structural features support the development of novel therapeutic agents for research in targeted protein degradation. -
PROTAC Linker
tert-Butyl N-{2-azaspiro[3.4]octan-6-yl}carbamate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the selective degradation of target proteins, enhancing cellular studies in target validation and therapeutic development. Its structural properties make it suitable for a variety of research applications in chemical biology and drug discovery. -
PROTAC Linker
tert-Butyl 9-amino-3-azaspiro[5.5]undecane-3-carboxylate serves as a link for PROTAC (proteolysis-targeting chimera) synthesis, facilitating the creation of bifunctional molecules that can selectively target specific proteins for degradation. This compound is instrumental in the field of targeted protein degradation research, enabling the development of novel therapeutics that can modulate protein levels in a controlled manner. -
PROTAC Linker
tert-Butyl (3-(hydroxymethyl)bicyclo[1.1.1]pentan-1-yl)carbamate is a specialized PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of covalent bonds between target proteins and E3 ligases, thus enhancing the ubiquitin-proteasome degradation pathway. Its effectiveness in linking various pharmacophores makes it a valuable tool for researchers exploring targeted protein degradation and related therapeutic applications.
