Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). Its structure allows for effective conjugation with various target proteins and E3 ligases, enabling the selective degradation of specific intracellular proteins. This reagent is essential for researchers aiming to explore targeted protein degradation mechanisms and develop innovative therapeutic strategies. -
PROTAC Linker
Ms-PEG8-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a Boc-protected amine that facilitates conjugation to target proteins, enhancing the efficient recruitment of E3 ligases. Ms-PEG8-Boc plays a critical role in research applications focused on targeted protein degradation, enabling the study of protein function and therapeutic development in various disease models. -
PROTAC Linkers
m-PEG2-Amino is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of targeted protein degradation strategies by providing a flexible and hydrophilic backbone. Its application in the construction of PROTACs enables researchers to enhance the selectivity and efficacy of targeted therapies. -
PROTAC Linker
Succinamic acid functions primarily as a linker in the construction of PROTAC molecules. This compound has been characterized as a weak inhibitor of human LL-xylose reductase, exhibiting an IC50 value of 1.45 mM. Its structural properties make it instrumental in synthesizing compounds such as CQ-16, facilitating advancements in targeted protein degradation research. -
PROTAC Linker
Azido-PEG9-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, facilitating the conjugation of alkyne- or DBCO/BCN-containing molecules, respectively. Its versatility makes Azido-PEG9-Boc a valuable tool for researchers developing targeted protein degradation strategies. -
PROTAC Linkers
(+)-Biotin-PEG2-hydrazide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the recruitment of E3 ligases to target proteins, thereby promoting their ubiquitination and subsequent degradation. Its application is critical in the development of novel therapeutic strategies for various diseases, particularly in the field of targeted protein degradation research. -
PROTAC linker
N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7 is a PEG-based linker designed for PROTAC synthesis. It features an azide functional group enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing compounds. This versatile linker is valuable for optimizing PROTAC constructs in chemical biology research. -
PROTAC Linker
Boc-NHCH2-Ph-pyrimidine-NH2 serves as a versatile linker for PROTAC (Proteolysis Targeting Chimeras) applications. By facilitating the conjugation of target proteins with E3 ligases, this compound enhances the selective degradation of proteins of interest. Its unique structure allows for improved target engagement and therapeutic potency, making it an essential tool for drug discovery and chemical biology research focused on targeted protein degradation. -
PROTAC Linker
N-Boc-N-bis(PEG3-azide) is a PEG-based PROTAC linker that facilitates the synthesis of targeted protein degraders. This compound features an azide group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool for researchers in the field of protein degradation and chemical biology. -
PROTAC Linkers
N-Me-N-bis-PEG3 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, thereby enhancing the targeted degradation of specific proteins in cellular studies. Its application is crucial in the development of innovative therapeutics that modulate protein levels to investigate biological pathways and disease mechanisms. -
PROTAC linker
Boc-N-Amido-PEG5-MS is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins through the recruitment of E3 ligases, enhancing targeted therapeutic strategies in chemical biology. Its application extends to various fields including drug discovery and the development of novel therapeutic agents aimed at specific molecular targets. -
PROTAC Linkers
Propargyl-PEG11-methane serves as a versatile PEG-based linker for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in PROTAC design makes it a valuable reagent for targeted protein degradation studies and drug discovery research. -
PROTAC Linker
m-PEG4-propargyl is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. Featuring an alkyne group, this compound serves as a click chemistry reagent, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. It is instrumental in the development of targeted protein degradation strategies and can be utilized in various research applications focusing on protein modulation and therapeutic discovery. -
PROTAC Linker
N-(Tos-PEG4)-N-bis(PEG4-Boc) is a PEG-based linker designed for use in the development of PROTAC (proteolysis-targeting chimeras) applications. This compound facilitates the conjugation of ligand-recruiting components to E3 ligase adapters, enabling targeted protein degradation mechanisms. Its flexible PEG structure enhances solubility and biocompatibility, making it suitable for various biochemical and pharmacological investigations in drug discovery and development. -
PROTAC Linker
Boc-Aminooxy-PEG1-C2-NH2 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the selective degradation of proteins within cellular systems. It is an essential tool for researchers investigating targeted protein modulation and ubiquitin-proteasome system dynamics. -
PROTAC Linker
1,1,1-Trifluoroethyl-PEG4-amine is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the development of targeted protein degradation strategies by linking proteins of interest to E3 ligases, enhancing their ubiquitination and subsequent degradation. Its unique trifluoroethyl moiety provides distinct chemical properties that may improve solubility and linker stability, making it suitable for various applications in chemical biology and drug discovery. -
PROTAC Linkers
N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a PEG-based linker designed for the synthesis of PROTACs. This reagent features a DBCO group that allows for efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its biotin component enhances labeling and purification processes, making it valuable in target protein degradation studies and other biochemical applications. -
PROTAC Linkers
Boc-NH-PEG10-CH2CH2COOH is a polyethylene glycol (PEG)-derived linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances the solubility and pharmacokinetic properties of PROTACs, promoting efficient protein degradation and targeted therapeutic efficacy. Its carboxylic acid functionality facilitates conjugation to target ligands, making it a valuable tool in chemical biology and drug discovery research focused on novel therapeutics. -
PROTAC Linkers
Benzyl-PEG24-MS is a PEG-based linker designed for use in the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the precise conjugation of target protein ligands and ubiquitin E3 ligase binding domains, enhancing the design of bifunctional molecules for targeted protein degradation. Its unique structure allows for increased solubility and improved biocompatibility, making it suitable for various applications in the study of targeted therapies and protein modulation. -
PROTAC Linkers
Amino-PEG23-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of ligand and E3 ligase components, enhancing the selective degradation of target proteins. Its unique structural properties make it suitable for various applications in target protein modulation and therapeutic development. -
PROTAC Linkers
TCO-PEG6-NHS ester is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This intermediary compound facilitates the conjugation of targeting ligands to E3 ligases, thereby enhancing the efficiency of targeted protein degradation. Its versatile applications in drug discovery make it a valuable tool for researchers investigating protein modulation and degradation pathways. -
PROTAC Linkers
6-Maleimidocaproic acid-PFP ester is a versatile PROTAC linker that features an alkyl chain structure. It facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs) by enabling the conjugation of target proteins to E3 ligases. This reagent is essential for applications in targeted protein degradation studies and can enhance the development of novel therapeutics in cancer research and other diseases. -
PROTAC Linker
3-Hydroxyazetidine-Cyclohexanol serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras. Its chemical structure is designed to enhance the efficacy of targeted protein degradation, making it a valuable tool in drug discovery and development research. This compound is instrumental in the synthesis of ALK PROTACs, contributing to advancements in targeted therapies for various cancers. -
PROTAC Linker
Benzyl-PEG8-THP is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound promotes the targeted degradation of specific proteins through an E3 ubiquitin ligase-mediated pathway. Its application is essential in drug discovery and development for creating novel therapeutics that modulate protein levels in a highly selective manner. -
PROTAC Linker
Ald-Ph-amido-C2-PEG3-NH-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of targeted protein degradation systems by connecting target proteins to E3 ligases. It enhances selectivity and efficiency in protein degradation studies, making it a valuable tool for research in targeted therapeutics and cellular pathways. -
PROTAC linker
Hydroxy-Amino-bis(PEG2-propargyl) serves as a PEG-based PROTAC linker, facilitating the design of proteolysis-targeting chimeras (PROTACs). This versatile compound features an alkyne moiety, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its application in research supports the development of targeted protein degradation strategies, enhancing the exploration of protein functions and therapeutic interventions. -
PROTAC Linkers
Thiol-C9-PEG4-acid is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of target proteins to E3 ligases, enhancing the degradation of selected proteins within cellular systems. This compound is essential for researchers exploring targeted protein degradation and related therapeutic modalities in various biological contexts. -
PROTAC Linkers
CHO-CH2-PEG1-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the development of bifunctional molecules that promote targeted degradation of specific proteins, enabling innovative therapeutic strategies. Its hydrophilic nature enhances solubility, making it suitable for various biological applications in chemical biology and medicinal chemistry research. -
PROTAC Linker
Azide-PEG7-Tos is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. Its versatility in click chemistry expands the potential for targeted protein degradation studies, making it an essential tool for researchers in areas such as drug discovery and targeted therapy development. -
PROTAC Linkers
Bromo-PEG4-NHS ester is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligase recruiting components, enhancing the efficacy of targeted protein degradation. Its versatile chemical properties make it suitable for various applications in chemical biology research, particularly in the development of novel therapeutics focusing on selective protein modulation. -
PROTAC Linkers
Hydroxy-PEG12-Boc is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves facilitating the conjugation of target proteins to E3 ligases, thereby promoting targeted degradation pathways. Hydroxy-PEG12-Boc enhances cellular permeability and solubility of PROTACs, making it essential for studies in targeted protein degradation and cellular biotechnology research. -
PROTAC Linker
Azido-PEG3-phosphonic acid ethyl ester is a PEG-based linker designed for PROTAC synthesis, targeting the ubiquitin-proteasome system to facilitate protein degradation. This compound features an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules that possess DBCO or BCN groups, making it a valuable tool for developing targeted protein degradation strategies in chemical biology research. -
PROTAC Linkers
Azido-PEG8-C1-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds. Its versatility in click chemistry makes it an invaluable tool for researchers focused on targeted protein degradation and biochemical studies. -
PROTAC Linkers
Benzyl-PEG9-Ots is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by linking E3 ligase adapters to a specific protein of interest. Its application in PROTAC development enables advancements in cellular research and therapeutic strategies by modulating protein levels within biological systems. -
PROTAC Linker
Ms-PEG12-m is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This versatile linker facilitates the conjugation of target proteins and E3 ligase moieties, enhancing the pharmacological properties of PROTAC candidates. It is valuable in chemical biology research focused on targeted protein degradation and therapeutic development. -
PROTAC Linkers
m-PEG6-C6-phosphonic acid ethyl ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of bifunctional molecules that induce targeted protein degradation through the ubiquitin-proteasome pathway. Its unique structural properties enable efficient conjugation and enhanced solubility, making it suitable for advancing research in targeted therapeutic strategies and drug development. -
PROTAC Linkers
m-PEG4-CH2-methyl ester is a polyethylene glycol (PEG) and alkyl/ester-based PROTAC linker that serves as a crucial component in the synthesis of PROTAC molecules. This versatile linker enhances the solubility and pharmacokinetic properties of the resultant PROTACs. It is primarily utilized in drug discovery and development research, particularly for targeted protein degradation applications. -
PROTAC Linker
Azido-PEG1-methyl ester is a versatile PROTAC linker featuring an azide moiety, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This reagent is a valuable tool in click chemistry, capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing and DBCO or BCN-modified molecules, respectively. Its application enhances the development of targeted protein degradation strategies in chemical biology and drug discovery. -
PROTAC Linker
Methylamino-PEG5-azide is a PEG-based linker designed for use in PROTAC synthesis, targeting protein degradation pathways. Featuring an azide moiety, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalities. This versatile reagent is essential for the development of novel PROTAC compounds, facilitating targeted protein degradation research and applications in drug discovery. -
PROTAC Linker
Azido-PEG8-C-Boc is a PEG-based linker designed for the synthesis of PROTACs, targeting targeted protein degradation pathways. This compound features an azide functional group, enabling the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne-containing molecules, as well as the strain-promoted alkyne-azide cycloaddition (SPAAC) reaction with DBCO or BCN-modified substrates. Its applications are vital in the development of innovative therapeutic strategies in chemical biology and drug discovery. -
PROTAC Linkers
Tetrahydropyranyldiethyleneglycol is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the creation of bifunctional molecules that efficiently induce targeted degradation of specific proteins, enabling researchers to investigate protein function and therapeutic interventions. It is an essential tool in drug discovery and development, particularly for studies focused on targeted protein degradation pathways. -
PROTAC Linkers
Bis-(m-PEG4)-amidohexanoic acid is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound enables the formation of stable and efficient PROTACs, facilitating the selective degradation of target proteins. It serves as a crucial tool in drug development and molecular biology research, particularly for studying protein interactions and the modulation of cellular pathways. -
PROTAC Linker
N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a PEG-based linker designed for use in the synthesis of PROTAC molecules. Functioning as a click chemistry reagent, it features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized molecules, facilitating the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
Bis-acrylate-PEG5 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted degradation through the ubiquitin-proteasome system. Bis-acrylate-PEG5 is instrumental in advancing research in targeted protein degradation and therapeutic development. -
PROTAC linker
Pyrene-PEG2-azide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an azide functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN groups. This reagent is essential for the development of targeted protein degradation strategies and offers versatility in chemical biology applications. -
Linker
C1-BCEA-Acm is a chemical linker utilized for the synthesis of polyubiquitin chains and ubiquitin-modified substrates. It facilitates the attachment of ubiquitin moieties, thereby allowing for the study of ubiquitination processes in various biological contexts. This reagent is essential for researchers investigating protein degradation, cellular signaling, and related pathways involving ubiquitin signaling. -
PROTAC Linker
Carboxy-PEG4-sulfonic acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a carboxylic acid functional group that enhances solubility and facilitates conjugation, making it ideal for generating bifunctional compounds that promote targeted protein degradation. Its application in PROTAC development enables researchers to explore novel therapeutic strategies by selectively modulating protein levels in cellular environments. -
PROTAC Linker
Ph-PEG3 is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of target proteins to E3 ligases, promoting targeted degradation of specific proteins within cellular systems. This compound is instrumental in the development of PROTAC-based therapies aimed at modulating protein levels for research applications in drug discovery and disease treatment. -
PROTAC Linker
N-Ethylpropionamide-PEG1-Br is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the selective degradation of target proteins through the recruitment of the E3 ubiquitin ligase, enhancing cellular clearance of unwanted proteins. It serves as a valuable tool for researchers investigating targeted protein degradation and the development of novel therapeutic strategies. -
PROTAC Linkers
Mal-PEG10-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins, enhancing the selective degradation of specific proteins via the ubiquitin-proteasome system. Its utility in PROTAC development makes it a valuable tool for researchers studying protein turnover and targeted protein degradation mechanisms.
