Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Boc-NH-PEG7-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of targeting ligands to E3 ligases, enhancing the efficacy of targeted protein degradation pathways. Its favorable biocompatibility and linker flexibility make it ideal for various applications in drug discovery and molecular biology research. -
PROTAC Linkers
Azido-PEG11-acid is a PEG-based linker designed for Protein-Targeting Chimera (PROTAC) synthesis. Featuring an azide functional group, it readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds and can also engage in strain-promoted azide-alkyne cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) moieties. This versatile linker is valuable for researchers focused on targeted protein degradation and therapeutic development. -
PROTAC Linker
N-(m-PEG4)-N'-(PEG4-NHS ester)-Cy5 is a PEG-based PROTAC linker designed for efficient protein degradation applications. This compound facilitates the synthesis of PROTACs, enabling targeted degradation of specific proteins through the ubiquitin-proteasome system. Its fluorogenic properties allow for specific detection and tracking in cellular assays, making it an essential tool for researchers investigating targeted protein modulation. -
PROTAC Linkers
Acid-PEG5-TEMPO is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation of specific proteins within cellular environments. Its application in PROTAC development provides a powerful tool for researchers exploring protein modulation and therapeutic strategies in various disease models. -
PROTAC Linker
Propargyl-PEG3-Boc is a polyethylene glycol (PEG)-based linker designed for PROTAC synthesis. It features an alkyne group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing compounds. This compound facilitates the development of targeted protein degradation strategies, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linker
3-Aminophenol-PEG4-methyl is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted degradation mechanisms. Its application in PROTAC development supports studies in protein regulation, therapeutic target identification, and the investigation of protein-homeostasis-related disorders. -
PROTAC Linker
Propargyl-PEG4-5-nitrophenyl carbonate is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its alkyne functionality allows for participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of azide-containing molecules. This compound supports various applications in targeted protein degradation research, enabling the development of innovative therapeutic strategies. -
PROTAC Linker
Bis-PEG4-sulfonic acid is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It facilitates the conjugation of target proteins with E3 ligases, enhancing the recruitment and degradation of specific proteins in cellular systems. This compound is instrumental in developing novel therapeutic strategies for targeted protein degradation in cancer and other diseases. -
PROTAC Linker
Tos-aminoxy-Boc-PEG4-Tos is a PEG-based linker specifically designed for PROTAC (proteolysis-targeting chimera) applications. This compound facilitates the synthesis of PROTACs by enabling the conjugation of target proteins with E3 ligases, thus promoting targeted degradation pathways. Its unique structure enhances solubility and stability, making it a valuable tool for researchers investigating protein regulation mechanisms and drug discovery processes. -
PROTAC Linker
m-PEG7-azide serves as a versatile PEG-based linker for the synthesis of PROTACs, functioning through its azide group. This reagent is effective in click chemistry, specifically participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can facilitate strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) functionalized compounds. This makes m-PEG7-azide a valuable tool for advancing targeted protein degradation research. -
PROTAC Linkers
BOC-NH-PEG2-propene is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the creation of bifunctional molecules that engage target proteins for ubiquitination and degradation. Its flexible structure enhances solubility and biocompatibility, making it suitable for various applications in targeted protein degradation research. -
PROTAC Linker
Biotin-PEG2-NH-Boc is a PEG-based PROTAC linker that incorporates a biotin label for easy detection and affinity purification. This compound plays a crucial role in the design and synthesis of Proteolysis Targeting Chimeras (PROTACs), facilitating targeted protein degradation. Its unique structure allows for enhanced solubility and stability, making it suitable for a variety of biochemical assays and research applications aimed at modulating protein levels in cellular contexts. -
PROTAC Linker
N-Mal-N-bis(PEG2-C2-Boc) is a polyethylene glycol (PEG)-derived PROTAC linker that facilitates the synthesis of proteolysis targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, enabling more efficient target protein degradation. Key applications include drug development and targeted protein modulation in cellular research. -
PROTAC Linker
Ald-CH2-PEG5-Boc is a polyethylene glycol (PEG) and alkyl/ether-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This linker facilitates the conjugation of targeting ligands to E3 ligases, enabling the selective degradation of specific proteins within cellular systems. It plays a crucial role in chemical biology and drug discovery research focused on ubiquitin-proteasome pathways and targeted protein degradation. -
PROTAC Linker
2-[4-(Aminomethyl)triazol-1-yl]ethanamine is a specialized PROTAC linker that serves as a crucial component in targeted protein degradation strategies. This compound facilitates the synthesis of PROTAC CB1R Degrader-1, enabling the effective modulation of cannabinoid receptor 1 (CB1R) levels. Its application in research supports investigations into protein homeostasis and therapeutic approaches for various diseases. -
PROTAC Linkers
Piperidine-C-piperidine-Boc is a PROTAC linker known for its role in targeted protein degradation, specifically in the design of CDK2 degrader 2. This compound facilitates the selective ubiquitination and subsequent proteasomal degradation of target proteins, making it essential for research in cancer biology and therapeutic development. Its unique structure enables researchers to explore novel therapeutic avenues through the modulation of protein levels in various biological contexts. -
PROTAC Linker
N-Benzyl-N-bis-PEG4 is a PEG-based linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective recruitment of E3 ligases, enhancing the targeted degradation of specific proteins within cellular environments. It is a valuable tool for researchers investigating targeted protein degradation and its applications in drug discovery and molecular biology. -
PROTAC Linkers
CH2COOH-PEG9-CH2COOH is a PEG-based linker specifically designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation. Its unique structure supports improved solubility and flexibility, enhancing the efficacy of PROTAC strategies in chemical biology research. -
PROTAC Linker
Hydroxy-PEG3-PFP ester is a polyethylene glycol (PEG)-based PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances solubility and biocompatibility, making it a valuable tool in the development of targeted protein degradation methodologies. Hydroxy-PEG3-PFP ester is particularly useful for research applications involving targeted therapy and the modulation of protein levels within cellular systems. -
PROTAC Linker
(3R,4R)-3-Methyl-4-piperidinol serves as a PROTAC linker, facilitating the targeted degradation of proteins through the proteasome pathway. This compound is essential in the synthesis of innovative PROTAC molecules, such as the BCL6 Degrader-3. Its application in chemical biology aids in studying protein interactions and degradation mechanisms, contributing significantly to drug discovery research. -
PROTAC Linker
[10-(Diethoxy-phosphoryl)-decyl]-phosphonic acid is a versatile alkyl chain-based linker designed for PROTAC (Proteolysis Targeting Chimeras) development. Its unique chemical structure enables efficient conjugation to target proteins, facilitating the targeted degradation of specific cellular proteins. This compound serves as a critical building block in the synthesis of PROTACs, aiding in the advancement of therapeutic strategies in drug discovery and cellular biology research. -
PROTAC Linker
Benzyl-PEG2-acid is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis targeting chimera) synthesis. This compound serves as a crucial component that enhances the solubility and stability of PROTAC molecules. Its incorporation into PROTAC development supports targeted protein degradation studies and facilitates the investigation of cellular signaling pathways. -
PROTAC Linker
Bis-methacrylate-PEG5 is a polyethylene glycol (PEG)-based linker designed for PROTAC (PROteolysis TArgeting Chimeras) synthesis. This flexible linker facilitates the effective conjugation of target proteins to E3 ligases, enhancing the targeted degradation of specific proteins within cells. Its unique properties make it suitable for research applications focused on protein degradation and cellular pathways modulation. -
PROTAC Linkers
Pip-alkyne-Ph-COOCH3 is a versatile PROTAC linker designed for the synthesis of PROTAC ARD-266. This compound features an alkyne group, facilitating its use in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc). It plays a critical role in forming stable linkages between target proteins and E3 ligases, supporting research in targeted protein degradation and related therapeutic applications. -
PROTAC Linkers
Br-PEG6-C2-acid is a PEG-derived linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound enables the conjugation of target proteins to E3 ligases, facilitating targeted protein degradation. It is valuable for research applications focusing on elucidating protein function and therapeutics development in cancer and other diseases. -
PROTAC Linker
(S,R,S)-AHPC-amide-PEG5-C2-azide is a PROTAC linker designed to facilitate the formation of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that allows for bioconjugation and can be utilized in the targeted degradation of specific proteins. Its unique structure enables researchers to explore various biological pathways and therapeutic targets in chemical biology studies and drug development efforts. -
PROTAC Linker
Boc-piperazine-pyridine-COOH is a PROTAC linker that facilitates the synthesis of targeted protein degradation molecules. Its structure includes a piperazine and pyridine moiety, making it valuable for the development of bifunctional compounds aimed at modulating protein levels within cells. This linker is essential in research focused on targeted therapy applications and studies investigating protein homeostasis mechanisms. -
PROTAC Linkers
N-Me-N-bis(PEG4-acid) is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the solubility and cellular permeability of PROTACs, facilitating the effective degradation of target proteins. Key research applications include targeted protein degradation studies and the development of novel therapeutic agents in cancer and other diseases. -
PROTAC Linker
NH2-Ph-NH-cyclohexane-NH-Boc is a PROTAC linker that facilitates the creation of targeted protein degradation systems. This compound is integral in the synthesis of PROTAC erf3a Degrader-1, enabling the selective degradation of specific proteins within cellular environments. It is especially useful in the study of protein homeostasis and the development of innovative therapeutic strategies. -
PROTAC Linker
Carboxyrhodamine 110-PEG4-alkyne is a PEG (polyethylene glycol)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). It facilitates the effective conjugation of target proteins to an E3 ligase for selective degradation. This compound is essential for researchers investigating targeted protein degradation mechanisms and developing novel therapeutic strategies. Its properties enable precise modulation of biological activity in various cellular contexts. -
PROTAC Linker
Azido-PEG10-azide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it a versatile tool for bioconjugation and targeted protein degradation research. -
PROTAC Linkers
Boc-Aminooxy-PEG4-CH2CO2H is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of ligand components, enabling the selective degradation of target proteins through the ubiquitin-proteasome system. Its chemical structure allows for improved solubility and bioavailability in various biological applications, making it a valuable tool in targeted protein degradation research. -
PROTAC Linker
t-Boc-N-amido-PEG6-Tos is a PEG-based linker designed for the development of PROTACs (Proteolysis Targeting Chimeras). This reagent effectively facilitates the conjugation of protein ligands, enhancing compound solubility and stability. Its primary application lies in the synthesis of PROTACs for targeted protein degradation studies, making it an essential tool in drug discovery and therapeutic research. -
PROTAC Linker
Carboxy-PEG2-sulfonic acid is a polyethylene glycol (PEG) based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective conjugation of target proteins to ubiquitin ligases, enhancing the targeted degradation of specific proteins. Biological applications include investigating protein regulation and discovery of therapeutic agents through targeted protein degradation mechanisms. -
PROTAC Linker
Bromoacetamido-PEG8-Boc is a polyethylene glycol (PEG)-based linker designed for use in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligase recruiters, promoting targeted protein degradation. It is particularly useful in chemical biology and drug discovery applications, where precise modulation of protein levels is required for studying cellular processes and therapeutic interventions. -
PROTAC Linker
N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne moiety that enables efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in PROTAC development facilitates targeted protein degradation, making it a valuable tool for researchers in drug discovery and chemical biology. -
PROTAC Linker
Active-mono-sulfone-PEG8-acid is a PEG-based linker designed for use in the development of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target ligands to E3 ligase components, thereby promoting targeted protein degradation. It offers significant potential in various biological research applications, including drug discovery and therapeutic development, by optimizing the spatial arrangement for effective and selective ubiquitination. -
PROTAC Linkers
Boc-Pip-alkyne-Ph-COOH is a PROTAC linker designed for use in the synthesis of targeted protein degraders. It facilitates the development of PROTACs, including ARD-266, which effectively promotes degradation of the androgen receptor in AR-positive prostate cancer cell lines such as LNCaP, VCaP, and 22Rv1, exhibiting DC50 values of 0.2-1 nM. This compound features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it essential for click chemistry applications in chemical biology research. -
PROTAC Linkers
Azide-PEG6-Tos is a PEG-based linker designed for use in the synthesis of PROTACs, targeting the PROTAC technology. This compound features an azide functional group, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-functionalized partners. Its versatility makes it a valuable tool for chemical biology research focused on targeted protein degradation. -
PROTAC Linkers
Bromo-PEG3-THP is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, enabling the selective degradation of specific proteins within cellular contexts. It is ideal for research applications focusing on targeted protein degradation and the development of novel therapeutic strategies. -
PROTAC Linkers
Boc-C1-PEG3-C4-OBn is a versatile PROTAC linker that incorporates a polyethylene glycol (PEG) structure. This compound facilitates the synthesis of various PROTACs, including the SGK3 degrader-1. By connecting ligands for E3 ubiquitin ligases and target proteins, Boc-C1-PEG3-C4-OBn is instrumental in harnessing the ubiquitin-proteasome system for the selective degradation of target proteins, providing valuable insights for protein regulation studies and therapeutic applications. -
PROTAC Linker
Fmoc-PEG6-NHS ester is a polyethylene glycol (PEG)-derived linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of E3 ligase ligands with target proteins, enabling targeted protein degradation. This compound is essential for research in pharmacology, particularly in the development of innovative therapeutic strategies that leverage the ubiquitin-proteasome system. -
PROTAC Linker
N-(Mal-PEG6)-N-bis(PEG7-TCO) is a PEG-based linker specifically designed for PROTAC synthesis. This compound features a TCO moiety that facilitates the inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-containing molecules, enabling effective targeting and degradation of proteins. It is widely used in chemical biology to create novel therapeutics and to study protein interactions and degradation pathways. -
PROTAC Linker
2-(1-(Boc)Piperidin-4-yl)-2,2-difluoroacetic acid serves as a versatile PROTAC linker essential for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ubiquitin ligases, enabling targeted degradation of specific proteins within cellular pathways. Its application is crucial in the development of innovative therapeutic strategies for diseases related to protein dysregulation. -
PROTAC Linker
2-(9-Bromononyl)-1,3-dioxolane is a crucial PROTAC linker designed to facilitate the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound provides flexibility and enhances the efficacy of targeted protein degradation applications. Its structural characteristics make it suitable for diverse research endeavors in chemical biology and therapeutic development. -
PROTAC Linker
12-Methoxy-12-oxododecanoic acid functions as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is instrumental in connecting target ligands with E3 ligase recruiters, enhancing the degradation of specific proteins through the cellular ubiquitin-proteasome system. Its unique structure supports the efficient creation of PROTACs for use in various research applications, including studies on targeted protein degradation and the exploration of therapeutic interventions. -
PROTAC Linker
MeNH-PEG2-NHMe is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This versatile linker facilitates the conjugation of target proteins with E3 ubiquitin ligases, enhancing the specificity and affinity in targeted protein degradation applications. Its structural properties contribute to improved solubility and bioavailability, making it suitable for various biochemical assays and drug discovery research. -
PROTAC Linker
(S,R,S)-AHPC-PEG2-NHS ester is a synthetic linker designed for use in PROTAC (Proteolysis Targeting Chimera) applications. Its structure features an E3 ligase ligand coupled with a polyethylene glycol (PEG) spacer, enhancing solubility in aqueous environments. The reactive NHS ester functional group allows for efficient conjugation with amine-containing compounds, facilitating the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
m-PEG11-Br is a polyethylene glycol (PEG) based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates efficient protein degradation by linking a ligand to an E3 ubiquitin ligase. m-PEG11-Br is essential for the development of novel PROTACs aimed at targeted protein modulation in various biological research applications. -
PROTAC Linker
tert-Butyl (trans-3-formylcyclobutyl)carbamate is a novel PROTAC linker that facilitates the development of Proteolysis Targeting Chimeras (PROTACs). Its unique structure allows for efficient conjugation to E3 ligase ligands and target proteins, promoting targeted ubiquitination and subsequent degradation. This reagent is valuable for researchers investigating protein degradation pathways and therapeutic interventions in various diseases.
