Catalog No.
Product Name
Application
Product Information
Citations
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PI3Kδ/CK1ε Inhibitor
Umbralisib tosylate is a potent and selective dual inhibitor of PI3Kδ and casein kinase-1-ε (CK1ε), exhibiting an EC50 of 22.2 nM and 6.0 μM, respectively. This compound demonstrates significant immunomodulatory effects on T cells from chronic lymphocytic leukemia (CLL) patients. Umbralisib tosylate is primarily utilized in research focused on hematological malignancies to elucidate its therapeutic potential and mechanisms of action. -
PI3Kδ/CK1ε Inhibitor
Umbralisib sulfate is a potent and selective dual inhibitor of PI3Kδ and casein kinase-1-ε (CK1ε), with EC50 values of 22.2 nM and 6.0 μM, respectively. This compound demonstrates notable immunomodulatory effects on T cells in chronic lymphocytic leukemia (CLL). Umbralisib sulfate is a valuable tool for research into hematological malignancies, facilitating studies on cell signaling pathways and potential therapeutic strategies. -
CK1 Inhibitor
PF-4800567 hydrochloride is a potent and selective inhibitor of casein kinase 1 (CK1), exhibiting an IC50 of 32 nM. It demonstrates over 20-fold selectivity for CK1α when compared to CK1δ, with an IC50 value of 711 nM. This compound is valuable for investigating the distinct roles of these kinases in various signaling pathways, making it an essential tool for research in cellular signaling and kinase-related studies. -
CK1δ Inhibitor
Casein kinase 1δ-IN-9 is a potent inhibitor of casein kinase 1δ (CK1δ), a key regulator in various cellular processes. This compound is particularly relevant for research focused on neurodegenerative disorders, including Alzheimer's disease, by modulating CK1δ activity. Its ability to influence signaling pathways makes it a valuable tool for investigating disease mechanisms and potential therapeutic interventions. -
Casein Kinase Inhibitor
Casein kinase 1δ-IN-20 is a selective inhibitor of casein kinase 1δ, targeting this enzyme's crucial role in various cellular processes. This compound exhibits significant biological activity relevant to the modulation of signaling pathways involved in neurodegenerative diseases, including Alzheimer's disease. Its application in research can aid in unraveling the mechanisms underlying these conditions and support the development of therapeutic strategies. -
Casein Kinase II Substrate
Casein Kinase II Receptor Peptide serves as a substrate for casein kinase II, exhibiting a Km value of 500 µM. This peptide is utilized for assessing casein kinase II activity in crude enzyme preparations, facilitating research in signal transduction and cellular regulation. Its application is crucial for understanding various biological processes influenced by casein kinase II. -
CK1 Inhibitor
CK1δ-IN-10 is a selective inhibitor of casein kinase 1 delta (CK1δ), exhibiting an IC50 value of 0.255 μM. This compound is utilized in research applications focusing on signal transduction pathways, cell cycle regulation, and protein phosphorylation. Its ability to modulate CK1δ activity makes it a valuable tool for investigating the roles of this kinase in various cellular processes and diseases. -
Casein Kinase Inhibitor
Casein kinase 1δ-IN-21 is a potent inhibitor of casein kinase 1δ, a key regulator in various signaling pathways. By selectively targeting this kinase, it demonstrates significant potential for modulating cellular processes associated with neurodegenerative diseases, including Alzheimer's disease. This compound is valuable for research into the therapeutic mechanisms and targets of such conditions. -
CK1 Inhibitor
Casein kinase 1δ-IN-27 is a selective inhibitor of casein kinase 1, effectively targeting CK1α, CK1δ, CK1ε, and p38α with IC50 values of 22 nM, 16.5 nM, 9.41 nM, and 14.8 nM, respectively. Notably, it demonstrates significant activity in inhibiting DUX4 expression with an IC50 of 10 nM. This reagent is valuable for research applications focused on CK1-related signaling pathways and their implications in various biological processes. -
Casein Kinase Inhibitor
Casein kinase 1δ-IN-26 is a selective inhibitor of casein kinase 1δ, which plays a crucial role in various cellular processes, including circadian rhythm regulation and signal transduction. Its potent inhibitory action makes it a valuable tool for investigating the mechanisms underlying neurodegenerative diseases, particularly Alzheimer's disease. Researchers can utilize this compound to explore therapeutic strategies and biochemical pathways associated with CK1δ-related pathologies. -
Casein kinase 1δ Inhibitor
Casein kinase 1δ-IN-13 is a selective inhibitor of Casein kinase 1δ, a serine/threonine kinase involved in various cellular processes. This compound has shown promise in modulating signaling pathways implicated in neurodegenerative diseases. Its application in research may provide insights into therapeutic strategies for conditions characterized by altered kinase activity. -
CK2 Inhibitor
CK2-IN-3 is a selective and potent inhibitor of casein kinase 2 (CK2), exhibiting a Kd of 12 nM and IC50 values of 1.51 μM for CK2α and 7.64 μM for CK2α’. This compound demonstrates significant biological activity in suppressing CK2 activity and is primarily utilized in cancer research to explore therapeutic strategies targeting CK2-dependent signaling pathways. -
CK2 Inhibitor
CK2-IN-8 is a potent CK2 inhibitor that demonstrates biological activity against the serine/threonine kinase casein kinase 2 (CK2). With an IC50 value exceeding 33 μM, it is suitable for research applications targeting CK2 in various signaling pathways. This compound is instrumental for studies exploring the role of CK2 in cellular processes such as proliferation, apoptosis, and oncogenesis. -
Casein Kinase Inhibitor
Casein kinase 1δ-IN-23 is a selective inhibitor of casein kinase 1δ. This compound exhibits significant biological activity in inhibiting the kinase, thereby providing valuable insights into molecular mechanisms. It is particularly applicable in research focused on neurodegenerative diseases, including Alzheimer's disease, facilitating the exploration of therapeutic targets associated with these conditions. -
CK1δ Inhibitor
Casein kinase 1δ-IN-4 is a potent inhibitor of casein kinase 1δ (CK1δ). This compound exhibits significant biological activity in modulating kinase signaling pathways and has potential applications in the study of neurodegenerative diseases, particularly Alzheimer's disease. Its selective inhibition may contribute to a better understanding of CK1δ's role in neurobiology and therapeutic strategies. -
CK1ε Inhibitor
SR-4133 is a selective inhibitor of Casein Kinase 1 epsilon (CK1ε) with an IC50 value of 58 nM. This compound binds effectively to the ATP-binding site of CK1ε, leading to significant inhibition of cell growth in bladder cancer models at nanomolar concentrations. Additionally, SR-4133 disrupts the phosphorylation of 4E-BP1, making it valuable for research applications in cancer biology and signaling pathways. -
Casein kinase 1d Inhibitor
WAY-353591 is a selective inhibitor of casein kinase 1δ. It effectively inhibits tyrosinase enzyme activity, exhibiting an IC50 value of 131 μM. This compound is utilized in the study of neurodegenerative diseases, providing valuable insights into the underlying mechanisms and potential therapeutic targets. -
CK1 Inhibitor
CK1-IN-2 hydrochloride is a potent inhibitor of casein kinase 1 (CK1), demonstrating IC50 values of 123 nM for CK1a, 19.8 nM for CK1d, 26.8 nM for CK1e, and 74.3 nM for p38a. This compound is valuable for research applications focused on cellular signaling pathways and the modulation of CK1-related processes. Its selective inhibition can help elucidate the role of CK1 in various biological contexts, including cancer and neurodegenerative diseases. -
Casein kinase 1δ Inhibitor
Casein kinase 1δ-IN-7 is a selective inhibitor of casein kinase 1δ, a serine/threonine protein kinase involved in various cellular processes. This compound has demonstrated potential in the study of neurodegenerative disorders, particularly Alzheimer's disease, by modulating pathways associated with tau phosphorylation and aggregation. Its application in research may provide insights into the molecular mechanisms underlying these conditions and aid in the development of therapeutic strategies. -
Phosphate Prodrug of BMS-135
BMS-159 is an orally bioavailable phosphate prodrug of BMS-135, functioning as a potent ATP-competitive inhibitor of casein kinase 2 (CK2). This compound exhibits significant biological activity in inhibiting CK2, which is implicated in various cellular processes. BMS-159 is utilized in research focusing on neurological disorders and tumor biology, providing valuable insights into therapeutic strategies targeting CK2-related pathways. -
Casein Kinase Inhibitor
Casein kinase 1δ-IN-24 is a selective inhibitor of casein kinase 1δ, a key enzyme involved in cellular signaling. This compound exhibits significant inhibitory activity, making it a valuable tool for research into neurodegenerative diseases, including Alzheimer's disease. The modulation of casein kinase 1δ activity can provide insights into disease mechanisms and potential therapeutic strategies. -
CK1δ Inhibitor
Casein kinase 1δ-IN-10 is a selective inhibitor of casein kinase 1δ (CK1δ), a serine/threonine kinase involved in various cellular processes such as circadian rhythm regulation and Wnt signaling. This compound's inhibition of CK1δ may provide insights into its role in disease mechanisms, particularly in cancer and neurodegenerative disorders. Its application in research can facilitate the study of CK1δ's functions and contribute to the development of targeted therapeutic strategies. -
CK2 Inhibitor
TID43 is a potent inhibitor of Casein Kinase 2 (CK2), exhibiting an IC50 of 0.3 μM. This compound demonstrates significant anti-angiogenic activity, making it a valuable tool for research into angiogenesis and related biological processes. TID43 can be employed in studies focused on cancer biology and the modulation of cellular signaling pathways influenced by CK2 activity. -
CK1 Inhibitor
CK1-IN-3 is a selective inhibitor of casein kinase 1 (CK1), demonstrating an IC50 of 2.22 µM for CK1δ. This compound is pivotal for the study of CK1-related signaling pathways and has potential applications in understanding various cellular processes, including circadian rhythms and cancer biology. Researchers can utilize CK1-IN-3 to explore the role of CK1 inhibition in therapeutic development and in the investigation of disease mechanisms. -
CK2 Inhibitor
CK2-IN-11 is an allosteric inhibitor of Casein Kinase 2 (CK2), exhibiting high selectivity with IC50 values of 19.3 nM for the CK2α2β2 isoform and 15.6 nM for CK2α′2β2. This compound is important for studies involving CK2's role in cellular processes such as proliferation, apoptosis, and signaling pathways. Its potent inhibition makes CK2-IN-11 a valuable tool for research applications focusing on cancer biology and the modulation of CK2-related pathways. -
CK2/PIM1 Inhibitor
CK2/PIM1-IN-1 is a selective inhibitor targeting casein kinase 2 (CK2) and PIM1, demonstrating IC50 values of 3.787 μM and 4.327 μM, respectively. This compound is designed for research into proliferative disorders, particularly cancer, and has potential applications in studying kinase-related conditions such as inflammation, pain, vascular disorders, pathogenic infections, and certain immunological disorders. -
Casein kinase 1δ Inhibitor
Casein kinase 1δ-IN-14 is a selective inhibitor of casein kinase 1δ, a key regulator of various cellular signaling pathways. This compound is primarily utilized in research related to neurodegenerative diseases, including Alzheimer's disease, by facilitating the understanding of CK1δ's role in neurobiology and potential therapeutic interventions. Its inhibitory properties make it a valuable tool for elucidating molecular mechanisms involved in neurodegeneration and related disorders. -
CK1δ Inhibitor
Casein kinase 1δ-IN-16 is a potent inhibitor of casein kinase 1δ (CK1δ). This compound plays a significant role in the regulation of various cellular processes, making it valuable for investigating pathways associated with neurodegenerative disorders. Researchers can utilize Casein kinase 1δ-IN-16 to explore its potential therapeutic effects and functional mechanisms in related studies. -
CK2 Inhibitor
BMS-135 is a potent and selective ATP-competitive inhibitor of casein kinase 2 (CK2), demonstrating IC50 values of 0.8 nM and 0.3 nM for the CK2α and CK2α′ isoforms, respectively. By mimicking ATP, BMS-135 effectively binds to the active site of CK2, inhibiting its serine/threonine phosphorylation activity. This inhibition results in the suppression of cellular proliferation and exhibits anti-tumor properties. BMS-135 is particularly relevant for research applications in colon cancer studies. -
CK2 Peptide Substrate
Casein Kinase II Substrate is specifically designed for use as a peptide substrate in studies involving casein kinase II (CK2). This substrate can be selectively phosphorylated by CK2, making it a valuable tool for investigating the enzyme's activity and regulatory mechanisms. It is suitable for various research applications, including signal transduction studies and the exploration of phosphoprotein functions in cellular processes. -
CK1δ Inhibitor
CK1δ-IN-1 is a selective inhibitor of casein kinase 1 delta (CK1δ), a key regulator in various signaling pathways. This compound has been demonstrated to exhibit potential therapeutic effects in neurodegenerative diseases, particularly Alzheimer's disease. Its inhibition of CK1δ allows for exploration of its role in modulating disease-related processes and can aid in the development of targeted treatments. -
CK2 Inhibitor
CK2-IN-1 is a potent inhibitor of Casein Kinase 2 (CK2) with an IC50 of 150 nM. This compound plays a crucial role in regulating cell signaling, protein synthesis, and tumor progression. CK2-IN-1 is utilized in research applications focusing on cancer biology, cellular metabolism, and neurodegenerative diseases, thereby providing valuable insights into disease mechanisms and potential therapeutic strategies. -
CK1 Inhibitor
CK1γ-IN-1 is a non-selective inhibitor of casein kinase 1 (CK1) with IC50 values of 780 nM for CK1γ1, 570 nM for CK1γ2, and 990 nM for CK1γ3. This compound is valuable for research applications focused on elucidating the role of CK1γ in various biological processes. Its non-specific binding characteristics allow for exploration of CK1γ-related pathways and interactions in cell signaling studies. -
Selective p38α Inhibitor
AMG-548 hydrochloride is a selective inhibitor targeting p38α with a Ki of 0.5 nM and shows moderate selectivity for p38β (Ki=36 nM), while exhibiting over 1000-fold selectivity against p38γ and p38δ. This compound effectively inhibits TNFα production in whole blood stimulated by LPS, with an IC50 of 3 nM. Additionally, AMG-548 hydrochloride disrupts Wnt signaling through the direct inhibition of Casein kinase 1 isoforms δ and ε, making it a valuable reagent for studies in inflammation and cancer research. -
CK1δ Inhibitor
CK1δ-IN-3 is a selective inhibitor of casein kinase 1δ (CK1δ), a key regulator in various cellular processes. This compound exhibits significant biological activity, making it a valuable tool for investigating the role of CK1δ in neurodegenerative disorders. Researchers can utilize CK1δ-IN-3 to explore therapeutic avenues in conditions where CK1δ dysregulation is implicated. -
Casein Kinase Inhibitor
Casein kinase 1δ-IN-25 is a potent inhibitor of casein kinase 1δ, a key regulator involved in various cellular processes. This compound demonstrates significant biological activity in modulating signaling pathways associated with neurodegenerative disorders, including Alzheimer's disease. It serves as a valuable tool for research aimed at understanding the mechanisms underlying these conditions and exploring potential therapeutic strategies. -
CK1 Inhibitor
Casein kinase 1δ-IN-28 is a selective inhibitor of Casein Kinase 1 (CK1) with an IC50 of 0.0146 μM. This compound demonstrates significant potential for modulating CK1-mediated pathways, making it a valuable tool for studies in cell signaling and cancer research. Additionally, Casein kinase 1δ-IN-28 shows a metabolite rate of 52% in human liver microsomes, indicating its metabolic stability for in vitro applications. -
Casein Kinase Inhibitor
PF-670462 is a selective inhibitor of Casein Kinase I ε/δ, known for its role in modulating circadian rhythms. This compound effectively influences the timing and progression of these rhythms, making it a valuable tool for research into circadian biology and related disorders. Its specificity and potency allow for detailed studies on the regulation of circadian-controlled processes. -
Casein Kinase Inhibitor
Casein kinase 1δ-IN-15 is a potent inhibitor of Casein Kinase 1 δ (CK1δ), demonstrating an IC50 of 0.045 μM. This compound is instrumental in research aimed at elucidating the role of CK1δ in various cellular processes, including cell proliferation and circadian rhythm regulation. Its use in biochemical studies provides valuable insights into the modulation of CK1δ-related pathways, making it a critical tool for exploring therapeutic interventions in cancer and other CK1δ-related diseases. -
Casein Kinase 2 Inhibitor
CHX-3107 is a selective inhibitor of Casein Kinase 2 (CK2), a serine/threonine kinase involved in various cellular processes including cell proliferation and apoptosis. By inhibiting CK2, CHX-3107 disrupts downstream signaling pathways, making it a valuable tool for studying CK2's role in cancer biology and other diseases. This compound is utilized in research applications focused on the modulation of kinase activity and its impact on cellular functions. -
Casein Kinase Substrate
Casein Kinase Substrates 3 is designed as a specific substrate for casein kinases. This compound is utilized in biochemical assays to investigate casein kinase activity and signaling pathways. By enabling the study of phosphorylation events, it aids in the understanding of cellular processes regulated by casein kinases, making it valuable for research in cancer, neurobiology, and metabolic disorders. -
Casein Kinase Inhibitor
Casein kinase 1δ-IN-19 is a selective inhibitor of casein kinase 1δ, a key enzyme involved in various signaling pathways. This compound exhibits potent inhibitory activity, making it valuable for investigating the molecular mechanisms underlying neurodegenerative diseases, including Alzheimer's disease. It serves as an important tool for researchers exploring therapeutic strategies targeting CK1δ in these conditions. -
Casein Kinase 1d Inhibitor
WAY-606344 is an inhibitor of Casein kinase 1δ, a key regulatory enzyme involved in various cellular processes. This compound is primarily investigated for its potential in Alzheimer's disease research, where modulation of kinase activity may impact neurodegenerative pathways. Its application in studying CK1δ signaling can contribute to understanding disease mechanisms and the development of therapeutic strategies. -
CK-1δ Inhibitor
Casein kinase 1δ-IN-5 is a selective inhibitor of casein kinase 1δ, exhibiting an IC50 of 47 nM. This compound demonstrates neuroprotective and anti-inflammatory effects in vitro, making it a valuable tool for studying neurodegenerative diseases. Its ability to modulate CK-1δ activity provides insights into various cellular processes and potential therapeutic applications in neurological research. -
CK1δ Inhibitor
Casein kinase 1δ-IN-17 is a selective inhibitor of casein kinase 1δ (CK1δ). This compound has shown potential in modulating CK1δ activity, which plays a significant role in various cellular processes. Its primary application is in the research of neurodegenerative disorders, where targeting CK1δ may provide insights into disease mechanisms and therapeutic strategies. -
CK2 Inhibtor
CK2-IN-7 is an inhibitor of casein kinase 2 (CK2), a serine/threonine kinase involved in various cellular processes including cell proliferation and apoptosis. This compound exhibits a synergistic effect when used in combination with the structurally distinct CK2 probe, SGC-CK2-1, demonstrating enhanced activity against cancer. CK2-IN-7 is a valuable tool for researchers investigating CK2's role in cancer biology and for exploring therapeutic strategies targeting this pathway. -
Casein Kinase Inhibitor
Casein kinase 1δ-IN-22 is a potent inhibitor of casein kinase 1δ, an enzyme implicated in various cellular processes. This compound is valuable for investigating the role of casein kinase 1δ in neurodegenerative diseases, including Alzheimer's disease. Its inhibitory activity allows for the exploration of cellular signaling pathways and potential therapeutic strategies targeting CK1δ-related disorders. -
CK1δ Inhibitor
Casein kinase 1δ-IN-18 is a selective inhibitor of casein kinase 1δ (CK1δ). This compound is valuable in research focused on neurodegenerative disorders, where CK1δ plays a critical role in various signaling pathways. By inhibiting CK1δ, Casein kinase 1δ-IN-18 can help elucidate the mechanisms underlying these diseases and aid in the development of potential therapeutic strategies. -
CK1 Inhibitor
CK1δ-IN-9 is a potent inhibitor of casein kinase 1 delta (CK1δ) with an IC50 value of 1.4 nM. This compound also demonstrates inhibitory effects on p38α and p38β with IC50 values of 0.25 μM and 0.78 μM, respectively. CK1δ-IN-9 has favorable pharmacokinetic properties, including 70% oral bioavailability and moderate clearance, making it suitable for research applications in kinase signaling pathways and therapeutic potential in related diseases. -
CK2 Inhibitor
CX-5279 is a selective inhibitor of casein kinase 2 (CK2), exhibiting IC50 values of 2.73 nM for nCK2 and 0.91 nM for CK2α. This compound demonstrates variable sensitivity to specific mutations, with altered IC50 values of 13.8 nM, 12.5 nM, and 23.35 nM for mutations at Val66 and Ile174. Although CX-5279 shows limited inhibitory activity against PIM1 (IC50 = 8.52 μM), it has been reported to possess anti-proliferative effects in various cancer cell lines. This reagent is applicable in research focused on pancreatic cancer and leukemia.
