PY-60 is a potent and selective small-molecule activator of YAP transcriptional activity that targets annexin A2 (ANXA2) with a dissociation constant (Kᴅ) of 1.4 µM. By directly binding to ANXA2, PY-60 antagonizes its inhibitory regulation of YAP, thereby enhancing YAP-dependent gene expression and promoting transcriptional activation within the Hippo signaling pathway.
PY-60 is a potent and selective small-molecule activator of YAP transcriptional activity that targets annexin A2 (ANXA2) with a dissociation constant (Kᴅ) of 1.4 µM. By directly binding to ANXA2, PY-60 antagonizes its inhibitory regulation of YAP, thereby enhancing YAP-dependent gene expression and promoting transcriptional activation within the Hippo signaling pathway.
Product Information
Catalog Num
A24554
Formula
C16H15N3O2S
Molecular Weight
313.37
CAS Number
2765218-56-0
SMILES
O=C(C1=NOC(C2=CC=CC=C2)=C1)NCCCC3=NC=CS3
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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