Degalactotigonin is a saponin-selective inhibitor that targets key pathways, including EGFR, GSK3β, and Hedgehog/Gli1. It effectively inhibits EGFR phosphorylation and the downstream Akt/ERK signaling pathway, while also disrupting the Hedgehog/Gli1 pathway through the inactivation of GSK3β. These actions result in the induction of apoptosis in cancer cells, cell cycle arrest, and inhibition of cell migration and invasion. Degalactotigonin is suitable for research focused on malignant tumors, particularly pancreatic cancer and osteosarcoma.
Degalactotigonin is a saponin-selective inhibitor that targets key pathways, including EGFR, GSK3β, and Hedgehog/Gli1. It effectively inhibits EGFR phosphorylation and the downstream Akt/ERK signaling pathway, while also disrupting the Hedgehog/Gli1 pathway through the inactivation of GSK3β. These actions result in the induction of apoptosis in cancer cells, cell cycle arrest, and inhibition of cell migration and invasion. Degalactotigonin is suitable for research focused on malignant tumors, particularly pancreatic cancer and osteosarcoma.
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