Hippo

Verteporfin is a small molecule that inhibits TEAD, YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin.

XMU-MP-1 is a reversible and selective MST1/2 inhibitor with IC50 values of 71.1??12.9 nM and 38.1 ?? 6.9 nM against MST1 and MST2, respectively.

EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.

I3MT-3 is a selective inhibitor of 3-Mercaptopyruvate sulfurtransferase (3MST), exhibiting an IC50 value of 2.7 μM, demonstrating its potency against this target. The compound selectively interacts with a persulfurated cysteine residue within the active site of 3MST, ensuring minimal off-target activity. I3MT-3 is ideal for studies investigating the role of hydrogen sulfide and its metabolic pathways, as well as potential therapeutic applications related to sulfur metabolism.

IHMT-MST1-58 is a potent and selective inhibitor of the mammalian STE20-like protein 1 kinase (MST1), demonstrating an IC50 value of 23 nM. This compound is valuable for investigating the role of MST1 in cellular signaling pathways and can be utilized in research focused on Type 1 and Type 2 diabetes. Its oral bioavailability makes it suitable for in vivo studies aimed at elucidating the therapeutic potential of targeting MST1 in metabolic disorders.

BRD2577 is a selective inhibitor of mercaptopyruvate sulfurtransferase (3-MST) with an IC50 value of 9.9 μM. This compound effectively reduces hydrogen sulfide (H2S) production in colon carcinoma cells, providing insights into the metabolic pathways associated with this cancer type. While BRD2577 shows minimal impact on colon cancer cell proliferation and mitochondrial function, it serves as a valuable tool for investigating the role of H2S in colon cancer biology and therapeutic strategies.

JA310 is a selective MST3 kinase inhibitor, demonstrating high cellular potency with an EC50 value of 106 nM. This compound serves as a valuable tool in studying MST3's role in cellular signaling pathways and its involvement in various diseases. JA310 can be utilized in research applications focused on the modulation of MST3 activity and its effects on cell proliferation, survival, and migration.

MR24 is a selective inhibitor of mammalian STE20-like kinases MST3 and MST4. It demonstrates an EC50 of 57 nM for MST3 and 583 nM for MST4, highlighting its targeted activity. MR24 induces G1 phase cell cycle arrest, making it a valuable tool for investigating cell cycle regulation. This compound is particularly relevant for cancer research, including studies focused on breast, liver, and lung cancers.