• Sign In
  • FAQ
  • Create an Account
Currency
USD currency flagUSD
Toggle Nav
My Cart
Menu
Account
Settings
Currency
USD currency flagUSD
  • Home
  • Stem Cells/Wnt

Stem Cells/Wnt

Items 51-100 of 667

Page
per page
Set Descending Direction
Catalog No.
Product Name
Application
Product Information
Citations
  1. A12737
    IWR-1-endo

    Wnt inhibitor

    IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription.
    Quick View
  2. A12741
    LY2090314

    GSK-3 inhibitor

    LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) which plays an important role in many pathways, including initiation of protein synthesis, cell proliferation, cell differentiation, and apoptosis.
    Quick View
  3. A12358
    A 83-01

    TGF-β/ALK5 inhibitor

    A83-01 is a selective inhibitor of the transforming growth factor-beta type I receptor ALK5, the Nodal receptor ALK4, and the nodal receptor ALK7
    Quick View
  4. A12418
    HhAntag
    HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway.
    Quick View
  5. A12433
    Flurizan

    gamma-secretase modulator

    Flurizan is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity.
    Quick View
  6. A12469
    IDE1

    definitive endoderm formation inducer

    IDE1 is a potent cell-permeable definitive endoderm formation inducer (EC50 = 125 nM, ESC) similar to IDE 2.
    Quick View
  7. A12491
    MBP146-78

    PKG inhibitor

    MBP146-78 is a potent and selective inhibitor of cGMP dependent protein kinases.
    Quick View
  8. A12624
    Casein Kinase II Inhibitor IV

    Epidermal keratinocyte differentiation inducer

    Casein Kinase II Inhibitor IV is a small-molecule inducer of epidermal keratinocyte differentiation.
    Quick View
  9. A12707
    IWP-2

    Wnt inhibitor

    IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks beta-catenin accumulation. Wnt/b-catenin ('canonical') pathway maintains transcriptional programs that enable stem cells to remain multipotent.
    Quick View
  10. A12775
    PF-5274857

    Smoothened Inhibitor

    PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ?? 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ?? 1.4 nmol/L in cells.
    Quick View
  11. A12917
    Forskolin

    PDE inhibitor

    Forskolin is a cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties.
    Quick View
  12. A12920
    Hh-Ag1.5

    Hedgehog inhibitor

    Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50 ~1 nM.
    Quick View
  13. A12925
    JK 184

    Hedgehog inhibitor

    JK184 is potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM).
    Quick View
  14. A13060
    AZD2858

    GSK-3β inhibitor

    AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats.
    Quick View
  15. A13095
    SANT-1

    Sonic hedgehog inhibitor

    SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).
    Quick View
  16. A13192
    IWP-3

    Wnt inhibitor

    IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC?????€ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC?????€ = 1.2 μM).
    Quick View
  17. A13217
    TC-E 5006

    Gamma-secretase modulator

    TC-E 5006 is a gamma-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo.
    Quick View
  18. A13316
    RS-246204
    RS-246204 is a R-spondin-1 substitute compound that is able initiate small intestinal organoids without the use of the R-spondin-1 protein.
    Quick View
  19. A11194
    MK-0752

    Gamma-secretase inhibitor

    MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated.
    Quick View
  20. A11223
    TWS119

    GSK-3 Inhibitor

    TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM.
    Quick View
  21. A11246
    GDC-0068 (Ipatasertib, RG-7440)

    Akt Inhibitor

    GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays
    Quick View
  22. A11258
    Begacestat (GSI-953)

    γ-secretase inhibitor

    Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Quick View
  23. A11259
    Nirogacestat (PF-03084014)

    γ-secretase inhibitor

    PF-03084014 is a reversible and selective inhibitor of γ-secretase with IC50 value of 6.2 nM .
    Quick View
  24. A11337
    BMS 433796

    γ-Secretase Inhibitor

    BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease.
    Quick View
  25. A11351
    TAK-441

    Hedgehog inhibitor

    TAK-441 is a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor.
    Quick View
  26. A11425
    gamma-secretase modulator 1

    Gamma-secretase modulator

    gamma-secretase modulator 1 is a gamma-secretase modulator, gamma-secretase modulator 1 is useful for Alzheimer's disease.
    Quick View
  27. A11427
    gamma-secretase modulator 2

    Gamma-secretase modulator

    gamma-secretase modulator 2 is a potent and selective gamma-secretase modulator for treatment of Alzheimer's disease.
    Quick View
  28. A11442
    GANT 58

    GLI antagonist

    GANT 58 is a potent Gli antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM.
    Quick View
  29. A11781
    PF-670462 dihydrochloride

    Casein kinase inhibitor

    Potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.
    Quick View
  30. A11903
    Prostaglandin E2

    Prostaglandin Receptor Agonist

    Prostaglandin E2 is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.
    Quick View
  31. A11941
    TDZD-8

    GSK-3 Inhibitor

    TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity
    Quick View
  32. A13544
    Crenigacestat (LY3039478)

    Notch inhibitor

    LY3039478 is a orally bioavailable, novel small molecule Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested.
    Quick View
  33. A13574
    LH 846

    CK1 inhibitor

    LH 846 is a selective inhibitor of casein kinase (CK) 1δ (IC50 values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α)
    Quick View
  34. A13584
    A-3 Hydrochloride

    PKA, PKG, Casein Kinase I and II inhibitor

    A-3 Hydrochloride is an inhibitor of PKA (cAMP-dependent protein kinase, Ki=4.3μM) and cGMP-dependent protein kinase, Ki=3.8μM, PKC (protein kinase C, Ki=47μM), casein kinase I and II, and MLCK (myosin light chain kinase) ( Ki=7.4μM).
    Quick View
  35. A13662
    Flurbiprofen Axetil

    gamma-secretase inhibitor

    Flurbiprofen Axetil is potentnon-steroidal anti-inflammatory drug(NSAID).
    Quick View
  36. A13669
    SPL-707

    SPPL2a inhibitor

    SPL-707 is a potent, selective and orally available signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC50 of 80 nM.
    Quick View
  37. A13710
    Prodigiosin
    Prodigiosin (Prodigiosine) is a secondary metabolite of Symbiotic bacteria, with anti-fungal and anti-cancer activity.
    Quick View
  38. A13949
    D4476

    CK1 Inhibitor

    D4476 is a cell-permeant inhibitor of casein kinase 1.
    Quick View
  39. A13977
    TMCB

    CK2/ERK8 inhibitor

    MCB has been shown to inhibit both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8/MAPK15) (IC50 = 0.50 uM for both CK2 and ERK8).
    Quick View
  40. A13978
    IWP-L6

    PORCN inhibitor

    IWP-L6 is a potent inhibitor of Porcupine (Porcn), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5 nM).
    Quick View
  41. A13986
    WAY-316606

    sFRP-1 inhibitor

    WAY-316606 is a small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.
    Quick View
  42. A14009
    TAPI-2

    TACE/MMP inhibitor

    TAPI-2 is an inhibitor of TACE, ADAMs, ACE secretase, and other MMPs (metalloproteinases). TAPI-2 blocks release of DCC7, APP, TNFα, L-selectin, NOTCH, TGFα, IL-6R9, erbB2/HER2, and ACE. This inhibitor has been used in tissue culture.
    Quick View
  43. A14088
    LY-900009

    Notch inhibitor

    LY-900009 is a potent inhibitor of Notch with IC50 value of 0.27 nM.
    Quick View
  44. A14101
    TTP-22

    CK2 inhibitor

    TTP 22 is a high affinity, casein kinase 2 (CK2) inhibitor (IC50= 0.1uM, Ki= 40nM). In addition, TTP 22 shows selectivity for CK2 over JNK3, ROCK1, and MET (inhibitory effects displayed at greater than 10 uM). TTP 22 is highly conserved serine/threonine protein kinase that is also involved in cell proliferation, cell differentiation and apoptosis.
    Quick View
  45. A14196
    IM-12

    GSK-3β inhibitor

    IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling.
    Quick View
  46. A14303
    1-Azakenpaullone

    GSK-3β inhibitor

    1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.
    Quick View
  47. A15764
    IC 261

    CK1δ and CK1ε inhibitor

    IC 261 is CK1δ and CK1ε inhibitor.
    Quick View
  48. A15773
    Cardiogenol C

    Cardiogenol C is a potent and cell permeable inducer of embryonic stem cell differentiation in cardiomyocytes displaying an Ec50 of 100nm.

    Quick View
  49. A15840
    ETC-159

    Wnt inhibitor

    ETC-159 is a potent and specific inhibitor of Wnt secretion. ETC-159 inhibits beta-catenin reporter activity in a dose-dependent manner with an IC50 of 2.9 nM.
    Quick View
  50. A15899
    L-685458

    γ-secretase inhibitor

    L-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
    Quick View

Items 51-100 of 667

Page
per page
Set Descending Direction
Shop By
Shopping Options
Category
Actions
  1. Inhibitor 491items
  2. Agonist 6items
  3. Antagonist 6items
  4. Activator 5items
  5. Modulator 13items
  6. Inducer 2items
  7. Stabilizer 1item
Target
  1. PASK 1item
  2. TNKS1/PARP5A 1item
  3. TNKS2/PARP5B 1item
  4. Akt2 1item
  5. Akt3 1item
  6. ERK8 2items