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  • Stem Cells/Wnt

Stem Cells/Wnt

Items 51-100 of 664

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  1. A11970
    Dorsomorphin (BML-275)

    AMPK inhibitor

    BML-275 is a cell-permeable pyrazolopyrimidine compound shown to be an AMP-activated protein kinase (AMPK) and fatty acid synthase inhibitor.
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  2. A12358
    A 83-01

    TGF-β/ALK5 inhibitor

    A83-01 is a selective inhibitor of the transforming growth factor-beta type I receptor ALK5, the Nodal receptor ALK4, and the nodal receptor ALK7
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  3. A12362
    KY02111

    Wnt inhibitor

    KY02111 is a potent and selective Wnt signaling pathway inhibitor discovered by a cell-based screening, which promotes differentiation of hESCs/iPSCs to cardiomyocytes when used at the second stage of differenitation.
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  4. A12418
    HhAntag
    HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway.
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  5. A12433
    Flurizan

    gamma-secretase modulator

    Flurizan is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity.
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  6. A12444
    BMS 299897

    γ-secretase inhibitor

    BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo.
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  7. A12469
    IDE1

    definitive endoderm formation inducer

    IDE1 is a potent cell-permeable definitive endoderm formation inducer (EC50 = 125 nM, ESC) similar to IDE 2.
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  8. A12491
    MBP146-78

    PKG inhibitor

    MBP146-78 is a potent and selective inhibitor of cGMP dependent protein kinases.
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  9. A12624
    Casein Kinase II Inhibitor IV

    Epidermal keratinocyte differentiation inducer

    Casein Kinase II Inhibitor IV is a small-molecule inducer of epidermal keratinocyte differentiation.
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  10. A12658
    Verteporfin

    YAP inhibitor

    Verteporfin is a small molecule that inhibits TEAD, YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin.

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  11. A12707
    IWP-2

    Wnt inhibitor

    IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks beta-catenin accumulation. Wnt/b-catenin ('canonical') pathway maintains transcriptional programs that enable stem cells to remain multipotent.
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  12. A12737
    IWR-1-endo

    Wnt inhibitor

    IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription.
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  13. A12741
    LY2090314

    GSK-3 inhibitor

    LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) which plays an important role in many pathways, including initiation of protein synthesis, cell proliferation, cell differentiation, and apoptosis.
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  14. A12775
    PF-5274857

    Smoothened Inhibitor

    PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ?? 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ?? 1.4 nmol/L in cells.
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  15. A12816
    LGK-974

    PORCN inhibitor

    LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay.
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  16. A12819
    AZD1080

    GSK3 inhibitor

    AZD1080 is a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans.
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  17. A12820
    DMH-1

    BMP inhibitor

    DMH-1 is a selective inhibitor of the bone morphogenic protein (BMP) ALK2 receptor (IC50 = 108 nM).
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  18. A12917
    Forskolin

    PDE inhibitor

    Forskolin is a cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties.
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  19. A12920
    Hh-Ag1.5

    Hedgehog inhibitor

    Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50 ~1 nM.
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  20. A12925
    JK 184

    Hedgehog inhibitor

    JK184 is potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM).
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  21. A12951
    Wnt-C59

    PORCN/Wnt inhibitor

    Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay.
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  22. A13060
    AZD2858

    GSK-3β inhibitor

    AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats.
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  23. A13095
    SANT-1

    Sonic hedgehog inhibitor

    SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).
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  24. A13192
    IWP-3

    Wnt inhibitor

    IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC?????€ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC?????€ = 1.2 μM).
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  25. A13217
    TC-E 5006

    Gamma-secretase modulator

    TC-E 5006 is a gamma-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo.
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  26. A13252
    GANT61

    GLI antagonist

    GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.
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  27. A13316
    RS-246204
    RS-246204 is a R-spondin-1 substitute compound that is able initiate small intestinal organoids without the use of the R-spondin-1 protein.
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  28. A13544
    Crenigacestat (LY3039478)

    Notch inhibitor

    LY3039478 is a orally bioavailable, novel small molecule Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested.
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  29. A13574
    LH 846

    CK1 inhibitor

    LH 846 is a selective inhibitor of casein kinase (CK) 1δ (IC50 values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α)
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  30. A13584
    A-3 Hydrochloride

    PKA, PKG, Casein Kinase I and II inhibitor

    A-3 Hydrochloride is an inhibitor of PKA (cAMP-dependent protein kinase, Ki=4.3μM) and cGMP-dependent protein kinase, Ki=3.8μM, PKC (protein kinase C, Ki=47μM), casein kinase I and II, and MLCK (myosin light chain kinase) ( Ki=7.4μM).
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  31. A13662
    Flurbiprofen Axetil

    gamma-secretase inhibitor

    Flurbiprofen Axetil is potentnon-steroidal anti-inflammatory drug(NSAID).
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  32. A13669
    SPL-707

    SPPL2a inhibitor

    SPL-707 is a potent, selective and orally available signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC50 of 80 nM.
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  33. A13710
    Prodigiosin
    Prodigiosin (Prodigiosine) is a secondary metabolite of Symbiotic bacteria, with anti-fungal and anti-cancer activity.
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  34. A13720
    Dorsomorphin 2HCl

    BMP inhibitor

    Dorsomorphin, also known as BML-275, is a selective small molecule inhibitor of BMP signaling, which promotes cardiomyogenesis in embryonic stem cells. Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling.
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  35. A13728
    AR-A 014418

    GSK-3 inhibitor

    AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
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  36. A13795
    FH535

    β-Catenin/Tcf Inhibitor

    FH535 is an inhibitor of Wnt/β-catenin and PPAR, with anti-tumor activities.
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  37. A13815
    FLI-06

    Gamma-secretase inhibitor

    FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.
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  38. A13949
    D4476

    CK1 Inhibitor

    D4476 is a cell-permeant inhibitor of casein kinase 1.
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  39. A13977
    TMCB

    CK2/ERK8 inhibitor

    MCB has been shown to inhibit both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8/MAPK15) (IC50 = 0.50 uM for both CK2 and ERK8).
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  40. A13978
    IWP-L6

    PORCN inhibitor

    IWP-L6 is a potent inhibitor of Porcupine (Porcn), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5 nM).
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  41. A13986
    WAY-316606

    sFRP-1 inhibitor

    WAY-316606 is a small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.
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  42. A14009
    TAPI-2

    TACE/MMP inhibitor

    TAPI-2 is an inhibitor of TACE, ADAMs, ACE secretase, and other MMPs (metalloproteinases). TAPI-2 blocks release of DCC7, APP, TNFα, L-selectin, NOTCH, TGFα, IL-6R9, erbB2/HER2, and ACE. This inhibitor has been used in tissue culture.
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  43. A14088
    LY-900009

    Notch inhibitor

    LY-900009 is a potent inhibitor of Notch with IC50 value of 0.27 nM.
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  44. A14101
    TTP-22

    CK2 inhibitor

    TTP 22 is a high affinity, casein kinase 2 (CK2) inhibitor (IC50= 0.1uM, Ki= 40nM). In addition, TTP 22 shows selectivity for CK2 over JNK3, ROCK1, and MET (inhibitory effects displayed at greater than 10 uM). TTP 22 is highly conserved serine/threonine protein kinase that is also involved in cell proliferation, cell differentiation and apoptosis.
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  45. A14196
    IM-12

    GSK-3β inhibitor

    IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3β (GSK-3β) inhibitor, activating downstream components of canonical Wnt signaling.
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  46. A14303
    1-Azakenpaullone

    GSK-3β inhibitor

    1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.
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  47. A14381
    BC2059

    beta-catenin inhibitor

    BC2059 is an orally bioavailable and potent beta-catenin inhibitor.
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  48. A15069
    DMAT

    CK2 inhibitor

    DMAT is a potent and specific CK2 inhibitor with an IC50 of 0.13 uM.
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  49. A15090
    gamma-secretase modulator 3

    gamma-secretase modulator

    gamma-secretase modulator 3 is a gamma-secretase modulator.
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  50. A15229
    Salinomycin sodium salt
    Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug.
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Items 51-100 of 664

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  1. Inhibitor 158items
  2. Agonist 6items
  3. Antagonist 6items
  4. Activator 5items
  5. Modulator 13items
  6. Inducer 2items
  7. Stabilizer 1item
Target
  1. PASK 1item
  2. TNKS1/PARP5A 1item
  3. TNKS2/PARP5B 1item
  4. Akt2 1item
  5. Akt3 1item
  6. ERK8 2items