IWR-1-endo

Catalog No.: A12737

Wnt inhibitor

IWR-1-endo

IWR-1-endo Chemical Structure

CAS NO. 1127442-82-3

IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $70.00

Special Price $63.00

25 mg

Regular Price: $150.00

Special Price $135.00

50 mg

Regular Price: $250.00

Special Price $225.00

100 mg

Regular Price: $450.00

Special Price $405.00

10mM * 1mL in DMSO

Regular Price: $88.00

Special Price $79.20

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription.
Targets
Wnt (L-cells expressing Wnt3A)
180 nM
In vitro DMSO 30 mg/mL (73.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.42 mL 122.12 mL 244.24 mL
0.5 mM 4.88 mL 24.42 mL 48.85 mL
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL

*The above data is based on the productmolecular weight 409.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12737
Actions Inhibitor
M. Wt 409.44
Formula C25H19N3O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1127442-82-3
Synonyms N/A
SMILES C1C2C=CC1C3C2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6

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