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A 83-01

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TGF-β/ALK5 inhibitor

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Catalog No. A12358

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
A 83-01 5mg A12358-5

Regular Price: $60.00

Special Price: $54.00

A 83-01 10mg A12358-10

Regular Price: $90.00

Special Price: $81.00

A 83-01 25mg A12358-25

Regular Price: $180.00

Special Price: $162.00

A 83-01 50mg A12358-50

Regular Price: $280.00

Special Price: $252.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

A83-01 is a TGF-β kinase/activin receptor like kinase (ALK5) inhibitor.

A 83-01

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Publications citing Adooq Products
A 83-01 Citations (8)
  • Onozato D, .et al. Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells, Drug Metab Dispos, 2018, Nov;46(11):1572-1580 PMID: 29615438
  • Usui T, .et al. Preparation of Human Primary Colon Tissue-Derived Organoid Using Air Liquid Interface Culture, Curr Protoc Toxicol, 2018, Feb 21;75:22.6.1-22.6.7 PMID: 29512123
  • Kondo S, .et al. Using human iPS cell-derived enterocytes as novel in vitro model for the evaluation of human intestinal mucosal damage, Inflamm Res, 2018, Dec;67(11-12):975-984 PMID: 30317465
  • Onozato D, .et al. Efficient Generation of Cynomolgus Monkey Induced Pluripotent Stem Cell-Derived Intestinal Organoids with Pharmacokinetic Functions, Stem Cells Dev, 2018, Aug 1;27(15):1033-1045 PMID: 29742964
  • Tatsuya Usui, .et al. Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture, Int J Mol Sci, 2018, Apr; 19(4): 1098 PMID: 29642386
  • Tatsuya Usui, .et al. Establishment of a dog primary prostate cancer organoid using the urine cancer stem cells, Cancer Sci, 2017, Dec; 108(12): 2383-2392 PMID: 29024204
  • Tatsuya Usui, .et al. Establishment of a novel three-dimensional primary culture model for hippocampal neurogenesis, Physiol Rep, 2017, Jun; 5(12): e13318 PMID: 28642339
  • Tatsuya Usui, .et al. Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment, Stem Cells Int, 2016, 2016: 7053872 PMID: 28119740

Chemical Information

Catalog Num A12358
Actions Inhibitor
M. Wt 421.52
Formula C25H19N5S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 909910-43-6
Synonyms A83-01, A-83-01
SMILES CC1=CC=CC(=N1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5

Biological Activity

Description
A83-01 is a TGF-β kinase/activin receptor like kinase (ALK5) inhibitor.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.72 mL 118.62 mL 237.24mL
0.5 mM 4.74 mL 23.72 mL 47.45 mL
1 mM 2.37 mL 11.86 mL 23.72 mL
5 mM 0.47 mL 2.37 mL 4.74 mL

*The above data is based on the productmolecular weight 421.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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