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A 83-01
Catalog No.: A12358
TGF-β/ALK5 inhibitor
A83-01 is a selective inhibitor of the transforming growth factor-beta type I receptor ALK5, the Nodal receptor ALK4, and the nodal receptor ALK7
Adooq Products cited in reputable paper
Adooq's A 83-01 has been cited by 24 publications
Kyunghyun Park, .et al. , Advanced Therapeutics , 2024, 7(6) Yuko Nagashima, .et al. , Research Square , 2024, June 4th Shota Mizuno, .et al. , Biol Pharm Bull , 2024, 47(1):120-129 PMID: 38171772 Andreea Manole, .et al. , Cell Rep , 2023, Dec 26;42(12):113466 PMID: 38039131 Claudia Z Han, .et al. , Immunity , 2023, Sep 12;56(9):2152-2171 PMID: 37582369 Yomogi Shiota Sato, .et al. , Biomed Pharmacother , 2023, Sep;165:115079 PMID: 37413906 Yomogi Sato, .et al. , Biomed Pharmacother , 2023, Jun;162:114651 PMID: 37030135 Dan Zhao, .et al. , Poult Sci , 2022, Mar; 101(3): 101642 PMID: 35016046 Anna Nakanishi, .et al. , Regen Ther , 2022, Sep 9;21:351-361 PMID: 36161099 Amira Abugomaa, .et al. , Biomed Pharmacother , 2022, Oct;154:113597 PMID: 36030590 Isamu Ogawa, .et al. , Biomaterials , 2022, Sep;288:121696 PMID: 36038421 Mohamed Elbadawy, .et al. , Authorea , 2020, October 20 Daichi Onozato, .et al. , Biol Pharm Bull , 2020, 43(7), 1088-1095 Amira Abugomaa, .et al. , Sci Rep , 2020, Jun 10;10(1):9393 PMID: 32523078 Jing-Yu Lin, .et al. , Cell Discov , 2020, 6: 20 PMID: 32284878 Kondo S, .et al. , Biol Open , 2020, Jan 9;9(1) PMID: 31919043 Onozato D, .et al. , Drug Metab Dispos , 2018, Nov;46(11):1572-1580 PMID: 29615438 Usui T, .et al. , Curr Protoc Toxicol , 2018, Feb 21;75:22.6.1-22.6.7 PMID: 29512123 Kondo S, .et al. , Inflamm Res , 2018, Dec;67(11-12):975-984 PMID: 30317465 Onozato D, .et al. , Stem Cells Dev , 2018, Aug 1;27(15):1033-1045 PMID: 29742964 Tatsuya Usui, .et al. , Int J Mol Sci , 2018, Apr; 19(4): 1098 PMID: 29642386 Tatsuya Usui, .et al. , Cancer Sci , 2017, Dec; 108(12): 2383-2392 PMID: 29024204 Tatsuya Usui, .et al. , Physiol Rep , 2017, Jun; 5(12): e13318 PMID: 28642339 Tatsuya Usui, .et al. , Stem Cells Int , 2016, 2016: 7053872 PMID: 28119740
Biological Activity
Discription
A83-01 is a selective inhibitor of the transforming growth factor-beta type I receptor ALK5, the Nodal receptor ALK4, and the nodal receptor ALK7
Targets
Solubility
In vitro
DMSO
21 mg/mL (49.82 mM)
Water
<1 mg/mL
Ethanol
<1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
0.1 mM
23.72 mL
118.62 mL
237.24 mL
0.5 mM
4.74 mL
23.72 mL
47.45 mL
1 mM
2.37 mL
11.86 mL
23.72 mL
5 mM
0.47 mL
2.37 mL
4.74 mL
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
* Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1 V1 = C2 V2
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