A 83-01

On Sale
Catalog No.: A12358
TGF-β/ALK5 inhibitor
A83-01 is a selective inhibitor of the transforming growth factor-beta type I receptor ALK5, the Nodal receptor ALK4, and the nodal receptor ALK7
Grouped product items
Product Name Price Stock Qty
A 83-01 5mg
Special Price $42.00 Regular Price $60.00
In stock
A 83-01 10mg
Special Price $63.00 Regular Price $90.00
In stock
A 83-01 25mg
Special Price $126.00 Regular Price $180.00
In stock
A 83-01 50mg
Special Price $196.00 Regular Price $280.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's A 83-01 has been cited by 19 publications
  • Yomogi Shiota Sato, .et al. , Biomed Pharmacother, 2023, Sep;165:115079 PMID: 37413906
  • Yomogi Sato, .et al. , Biomed Pharmacother, 2023, Jun;162:114651 PMID: 37030135
  • Dan Zhao, .et al. , Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046
  • Anna Nakanishi, .et al. , Regen Ther, 2022, Sep 9;21:351-361 PMID: 36161099
  • Amira Abugomaa, .et al. , Biomed Pharmacother, 2022, Oct;154:113597 PMID: 36030590
  • Isamu Ogawa, .et al. , Biomaterials, 2022, Sep;288:121696 PMID: 36038421
  • Mohamed Elbadawy, .et al. , Authorea, 2020, October 20
  • Daichi Onozato, .et al. , Biol Pharm Bull, 2020, 43(7), 1088-1095
  • Amira Abugomaa, .et al. , Sci Rep, 2020, Jun 10;10(1):9393 PMID: 32523078
  • Jing-Yu Lin, .et al. , Cell Discov, 2020, 6: 20 PMID: 32284878
  • Kondo S, .et al. , Biol Open, 2020, Jan 9;9(1) PMID: 31919043
  • Onozato D, .et al. , Drug Metab Dispos, 2018, Nov;46(11):1572-1580 PMID: 29615438
  • Usui T, .et al. , Curr Protoc Toxicol, 2018, Feb 21;75:22.6.1-22.6.7 PMID: 29512123
  • Kondo S, .et al. , Inflamm Res, 2018, Dec;67(11-12):975-984 PMID: 30317465
  • Onozato D, .et al. , Stem Cells Dev, 2018, Aug 1;27(15):1033-1045 PMID: 29742964
  • Tatsuya Usui, .et al. , Int J Mol Sci, 2018, Apr; 19(4): 1098 PMID: 29642386
  • Tatsuya Usui, .et al. , Cancer Sci, 2017, Dec; 108(12): 2383-2392 PMID: 29024204
  • Tatsuya Usui, .et al. , Physiol Rep, 2017, Jun; 5(12): e13318 PMID: 28642339
  • Tatsuya Usui, .et al. , Stem Cells Int, 2016, 2016: 7053872 PMID: 28119740
  • Biological Activity
    Discription A83-01 is a selective inhibitor of the transforming growth factor-beta type I receptor ALK5, the Nodal receptor ALK4, and the nodal receptor ALK7
    Targets
    Target Value
    Product Information
    Catalog Num A12358
    Formula C25H19N5S
    Molecular Weight 421.52
    CAS Number 909910-43-6
    SMILES CC1=CC=CC(=N1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5
    Synonyms A83-01, A-83-01
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 21 mg/mL (49.82 mM)
    Water <1 mg/mL
    Ethanol <1 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 23.72 mL 118.62 mL 237.24 mL
    0.5 mM 4.74 mL 23.72 mL 47.45 mL
    1 mM 2.37 mL 11.86 mL 23.72 mL
    5 mM 0.47 mL 2.37 mL 4.74 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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