Catalog No.
Product Name
Application
Product Information
Citations
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Calcium Channel Blocker
Verapamil hydrochloride is a calcium channel blocker primarily targeting L-type calcium channels. It exhibits potent inhibitory activity on P-glycoprotein and CYP3A4, contributing to its pharmacological profile. This compound is widely utilized in research related to hypertension, cardiac arrhythmias, and angina, facilitating studies on cardiovascular function and drug metabolism. -
L-type Calcium Chanel Inhibitor
Diltiazem is an orally active L-type calcium channel blocker that exerts antihypertensive and antiarrhythmic effects. It is utilized in research related to cardiac arrhythmias, hypertension, and angina pectoris, making it valuable for studies focused on cardiovascular health. Its mechanism of action contributes to the modulation of calcium influx, which is critical in various cardiac and vascular functions. -
NMDA Receptor Inhibitor
Bupivacaine is an NMDA receptor inhibitor that modulates neuronal excitability by blocking sodium, L-calcium, and potassium channels. It exhibits potent inhibition of SCN5A channels, with an IC50 of 69.5 μM. This compound is primarily utilized in research focused on chronic pain mechanisms and therapeutic interventions. -
Calcium Channels Antagonist
Fluspirilene is a non-competitive antagonist of L-type calcium channels, demonstrating an IC50 of 0.03 μM. This compound exhibits significant antipsychotic activity, making it a valuable tool for research on schizophrenia and related neuropsychiatric disorders. Its long-acting injectable formulation facilitates studies on sustained pharmacological effects in therapeutic applications. -
T Calcium Channel Antagonist
Ulixacaltamide is a potent T-type calcium channel antagonist that demonstrates significant efficacy in modulating neurological disorders. It has been shown to slow the progression of epilepsy and effectively reduce tremors in an alkaline tremor animal model. Additionally, Ulixacaltamide reverses thermal hyperalgesia, providing a mechanism for pain relief in various preclinical settings. This compound is valuable for research applications focusing on neurological function and pain management. -
SERCA Blocker
JTV-519 hemifumarate is a selective blocker of the sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA), with additional activity as a partial agonist of ryanodine receptors in striated muscle. It exhibits antiarrhythmic and cardioprotective properties, making it a valuable tool for research on cardiac function and rhythm disorders. This compound is useful in studies exploring calcium handling in myocardial cells and its implications for heart disease therapies. -
T-type Calcium Channel Blocker
TTA-P2 is a selective T-type calcium channel blocker with a primary mechanism of inhibiting calcium influx through T-type channels, exhibiting an IC50 of 22 nM. This compound demonstrates significant biological activity by reducing mechanical hypersensitivity and alleviating both acute and chronic pain. Additionally, TTA-P2 lowers firing rates in neurons associated with temporal lobe epilepsy, effectively controlling synaptically evoked burst firing. Research applications include investigations into neurological disorders such as tremor and absence epilepsy. -
Calcium Channel Inhibitor
Tetracaine hydrochloride is a calcium channel inhibitor that effectively blocks the voltage-sensitive release of Ca2+ from the sarcoplasmic reticulum. This compound exhibits significant biological activity and is primarily utilized in topical applications within ophthalmology, as well as serving as an antipruritic agent. Its mechanism of action makes it valuable for research in pain relief and modulation of calcium signaling pathways. -
SERCA2a Activator
SERCA2a Activator 1 is an activator of the sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a (SERCA2a). This compound alleviates the inhibitory effects of phospholamban, thereby improving both systolic and diastolic cardiac functions. SERCA2a Activator 1 is primarily utilized in research related to heart failure and cardiac physiology. -
Calcium Ions Activator
Calcium citrate tetrahydrate is a calcium ions activator that efficiently releases calcium ions, enhancing biological activity in various applications. Its rapid solubility and ability to maintain elevated calcium ion concentrations make it particularly useful for research focused on bone formation and mineralization. This reagent is essential for studies investigating calcium-related signaling pathways and the effects of calcium on cellular processes. -
Calcium Channel Blocker
Prenylamine is a calcium channel blocker belonging to the amphetamine chemical class. It acts by inhibiting calcium influx through voltage-gated calcium channels, leading to vasodilation. This compound has potential applications in the research of cardiovascular conditions, particularly angina pectoris, by modulating vascular tone and reducing myocardial oxygen demand. -
Stable Isotope
Verapamil-d3 hydrochloride is a deuterium-labeled derivative of the calcium channel blocker, verapamil hydrochloride. It serves as a potent inhibitor of P-glycoprotein (P-gp) and CYP3A4, facilitating detailed pharmacological studies. This stable isotope is primarily utilized in research related to hypertension, cardiac arrhythmias, and angina, providing insight into drug metabolism and transport mechanisms in various biological systems. -
Calcium Receptor Activator
γ-Glutamylserine (γ-Glu-Ser) is a calcium receptor activator that plays a critical role in various cellular signaling pathways. This compound exhibits potential neuroprotective effects, making it relevant for research in Parkinson's disease. Additionally, γ-Glutamylserine may be utilized in studies focused on metabolic disorders, including diabetes and obesity. -
Phenylalkylamine Calcium Antagonist
Gallopamil hydrochloride is a phenylalkylamine calcium antagonist that exhibits potent antiarrhythmic and vasodilatory properties. It effectively inhibits acid secretion in a concentration-dependent manner, with an IC50 value of 10.9 μM. This compound is utilized in various research applications focused on cardiovascular function and gastrointestinal acid regulation. -
Calcium Channel
D-myo-Inositol-1,3,4,5-tetraphosphate sodium functions as a signaling molecule by regulating calcium channels. It is produced through the phosphorylation of inositol 1,4,5-trisphosphate by inositol 1,4,5-triphosphate 3-kinase. This compound is utilized in research focused on cellular signaling pathways, particularly those involving calcium mobilization and inositol phosphate metabolism. Its key biological activity makes it valuable for studies exploring neurotransmission, smooth muscle contraction, and other calcium-dependent processes. -
Calcium Channel Inhibitor
Lidoflazine is a potent inhibitor of calcium channels, specifically known for its high affinity blockade of the HERG potassium channel. This compound exhibits antianginal properties, making it relevant in studies related to cardiac function and arrhythmias. Notably, Lidoflazine is associated with a risk of QT interval prolongation and ventricular arrhythmia, which underscores its importance in pharmacological research aiming to understand cardiovascular safety profiles. -
Calcium Channel
PPZ2 is a diacylglycerol (DAG)-activated agonist of the TRPC3, TRPC6, and TRPC7 calcium channels. It promotes neuronal development and survival through its ability to elicit cation currents and calcium ion (Ca(2+)) influx in cultured central neurons in a dose-dependent manner. PPZ2 induces BDNF-like neurite outgrowth and provides neuroprotection, effects that are negated following TRPC channel knockdown or inhibition. Additionally, PPZ2 enhances the activation of the calcium-dependent transcription factor cAMP response element binding protein, highlighting the role of calcium signaling in its neurotrophic actions. -
Calcium Channel Inhibitor
Pranidipine is a potent, long-acting 1,4-dihydropyridine calcium channel inhibitor, specifically designed to modulate calcium influx in vascular smooth muscle cells. Its primary biological activity involves the reduction of blood pressure, making it an effective antihypertensive agent. This compound is widely used in cardiovascular research to investigate mechanisms underlying hypertension and to evaluate therapeutic strategies for managing elevated blood pressure. -
Calcium Influx Inhibitor
Carboxyamidotriazole Orotate is an orotate salt of Carboxyamidotriazole, a potent inhibitor of calcium influx. It acts primarily as a cytostatic agent targeting nonvoltage-operated calcium channels and disrupting calcium-mediated signaling pathways. This compound demonstrates notable anti-tumor, anti-inflammatory, and antiangiogenic properties, making it valuable in cancer research and the study of inflammatory diseases. -
L-type calcium channel Blocker
(R)-Nimodipine is an L-type calcium channel blocker that effectively penetrates the blood-brain barrier, with an IC50 value of 5 nM. By inhibiting calcium channels on the hypothalamic-pituitary-adrenal axis, (R)-Nimodipine reduces corticosterone release, thereby mitigating memory impairment and behavioral abnormalities associated with immobilization stress. This compound is frequently utilized in research focused on aneurysmal subarachnoid hemorrhage, cerebral ischemia, epilepsy, age-related neurodegenerative diseases, and the effects of alcohol intoxication. -
Calcium Channel Blocker
Nemadipine-A is a selective inhibitor of the EGL-19 L-type calcium channel. This compound demonstrates the ability to sensitize TRAIL-resistant cancer cells to TRAIL-mediated apoptosis. It is primarily utilized in research focused on cancer therapy and calcium signaling pathways. -
Calcium Channel Blocker
Methyl homoveratrate functions as a voltage-sensitive calcium channel blocker. This compound serves as a metabolite of RWJ-26240 and can be detected in plasma, urine, and fecal extracts. Its role in calcium channel inhibition makes it a valuable tool for investigating calcium signaling pathways and related physiological processes in various research applications. -
Calcium Channel Antagonist
Praeruptorin C serves as a calcium channel antagonist, exhibiting a pD2′ value of 5.7. Derived from Peucedanum praeruptorum, this bioactive compound plays a significant role in modulating calcium influx across cellular membranes. Research applications include studies on cardiovascular function and smooth muscle contraction, making it a valuable tool for investigating calcium-related physiological processes. -
Ligand for the α2δ Subunit of Voltage-gated Calcium Channels
Crisugabalin is a selective ligand targeting the α2δ subunit of voltage-gated calcium channels, exhibiting an IC50 of 3.96 nM in rat models. This compound effectively inhibits the binding of [3H]gabapentin to the α2δ subunit, leading to reduced calcium influx and decreased neuronal excitability, ultimately impairing nociceptive transmission. Crisugabalin has demonstrated efficacy in alleviating mechanical allodynia and various pain models, including neuropathic and inflammatory pain. Its applications are relevant in research contexts involving chronic pain syndromes such as diabetic neuropathy, fibromyalgia, and postherpetic neuralgia. -
Calcium Channel Antagonist
(+)-Niguldipine hydrochloride is a calcium channel antagonist that effectively induces vasodilation by inhibiting calcium influx through cell membranes. This compound demonstrates significant biological activity by antagonizing U-46619-induced coronary vasoconstriction in guinea pig Langendorff heart preparations, with a pID50 value of 11.37. Additionally, it binds to calcium channels in guinea pig skeletal muscle membranes with a Ki of 9.75 and exhibits blood pressure-lowering effects in spontaneously hypertensive rats, with a pED30 of 7.1. (+)-Niguldipine hydrochloride is utilized in research related to cardiovascular diseases, including hypertension, angina pectoris, and arrhythmias. -
Calcium Channel Antagonist
Clopimozide is a calcium channel antagonist that inhibits [3H]nitrendipine binding with an IC50 value of 17 nM. This orally active antipsychotic agent is utilized in research to investigate both negative and positive symptoms of schizophrenia, contributing to a deeper understanding of the neurobiological mechanisms underlying this disorder. Its selective action on calcium channels allows for targeted studies in pharmacology and therapeutics related to schizophrenia. -
Calcium Channel Antagonist
BTT-266 is a calcium channel antagonist that functions by inhibiting the interaction between CaVα1-AID and CaVβ3, exhibiting a Ki value of 1.4 μM. It effectively modulates the activation of voltage-dependent CaV2.2 channels. BTT-266 demonstrates analgesic properties in models of neuropathic pain, making it a valuable tool for research into pain modulation and potential therapeutic applications. -
Calcium Channel
2-Chloro-ATP sodium is an analog of ATP that acts as an antagonist of the purinergic P2Y1 receptor, inhibiting intracellular calcium mobilization induced by ADP in Jurkat cells with a Ki of 2.3 μM. Additionally, it serves as an agonist for the purinergic P2X receptor, generating inward currents in HEK293 cells with varying affinities (EC50 of 0.5 and 2.5 μM). This compound also induces concentration-dependent relaxation of precontracted guinea pig cecal strips. Furthermore, 2-Chloro-ATP sodium is utilized to investigate substrate specificity among cyclic nucleotide-dependent protein kinases, including protein kinase A (PKA) and PKG. -
Calcium Channel Inhibitor
Nothofagin is a dihydrochalcone that acts as a calcium channel inhibitor. By blocking calcium influx, it downregulates NF-κB translocation, providing a mechanism to modulate inflammatory responses. This compound exhibits antioxidant properties and has potential applications in research related to septic responses and vascular inflammation. -
Calcium Channel Blocker
MONIRO-1 is a selective inhibitor of T-type and N-type calcium channels, demonstrating IC50 values of 34 µM, 3.3 µM, 1.7 µM, and 7.2 µM against hCav2.2, hCav3.1, hCav3.2, and hCav3.3, respectively, while exhibiting minimal activity against L-type calcium channels. Its ability to modulate calcium influx makes MONIRO-1 a valuable tool for research into pain pathways and epilepsy mechanisms. This compound is instrumental for studies focused on the pharmacological modulation of calcium channels in neuronal excitability. -
SERCA Inhibitor
CAD204520 dihydrochloride is a selective SERCA inhibitor with an IC50 of 0.34 μM. This compound specifically targets mutated NOTCH1 proteins, demonstrating significant relevance in the study of T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL). It is a valuable tool for research investigating the therapeutic potential and mechanisms of these cancers. -
SERCA Inhibitor
CAD204520 is a selective inhibitor of the Sarcoplasmic Reticulum Calcium ATPase (SERCA), demonstrating an IC50 value of 0.34 μM. This compound specifically targets mutated NOTCH1 proteins more effectively than wild-type, making it a valuable tool for studying T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL). CAD204520 is suitable for research aimed at understanding the molecular mechanisms and therapeutic strategies in these malignancies. -
Calcium Channel
Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist that targets calcium channels. It has been shown to effectively attenuate simulated ischemia and reperfusion (sIR)-induced calcium oscillations in cardiomyocytes. This compound serves as a valuable tool for research in cardiac physiology and the mechanistic study of calcium signaling pathways. -
Calcium Channel Inhibitor
Heteroclitin D is a lignan derived from Kadsura medicinal plants, functioning primarily as a calcium channel inhibitor. It exhibits significant biological activity by inhibiting L-type calcium channels, which are critical in various physiological processes. This compound is suitable for research applications focusing on calcium signaling, neuroprotection, and studies related to oxidative stress and lipid peroxidation. -
Calcium Channel Modulator
BBT is a calcium channel modulator that enhances glucose-stimulated insulin secretion (GSIS) while exhibiting anti-hyperglycemic activity. In models of type 2 diabetes, BBT protects pancreatic β-cells from cytokine- or streptozotocin-induced cell death. Its mechanism of action involves the cAMP/PKA signaling pathway and the long-lasting activation of L-type voltage-dependent calcium channels and CaMK2 pathways, making it a valuable tool for diabetic research and therapeutic studies. -
Calcium Channel Inhibitor
Yangambin is a furofuran lignan that functions as a calcium channel inhibitor, targeting voltage-gated Ca2+ channels. This compound effectively reduces intracellular calcium levels in vascular smooth muscle cells, promoting peripheral vasodilation. Additionally, Yangambin demonstrates antiallergic activity by inhibiting β-hexosaminidase release with an IC50 of 33.8 μM and exhibits anti-inflammatory properties with an IC50 of 37.4 μM, making it valuable for research in vascular biology and inflammation. -
Calcium Channel Antagonist
Anipamil is a calcium channel antagonist that primarily inhibits L-type calcium channels. This compound exhibits significant vasodilatory effects, making it valuable in the management of cardiovascular conditions. It has applications in both clinical and preclinical research settings centered around cardiovascular disease and related pharmacological studies. -
Calcium Channel Antagonist
Devapamil is a calcium channel antagonist that selectively inhibits L-type calcium channels. Its primary mechanism involves blocking calcium influx into cardiac and smooth muscle cells, which results in reduced contractility and vascular resistance. Devapamil exhibits significant antiarrhythmic activity and is utilized in research related to cardiovascular diseases, hypertension, and calcium signaling pathways. -
Calcium Channel Blocker
Cronidipine is a calcium channel blocker that primarily targets L-type calcium channels. It exhibits potent vasodilatory effects, making it valuable in cardiovascular disease research, particularly in the study of hypertension and related disorders. This compound aids in elucidating the mechanisms of calcium signaling and its implications in vascular function. -
Calcium Channel Antagonist
YS-201 is a dihydropyridine-type calcium channel antagonist that selectively inhibits L-type calcium channels. This compound exhibits significant biological activity in reducing calcium influx, which makes it a valuable candidate for the treatment of cardiovascular conditions such as angina pectoris and hypertension. Its role in calcium signaling research also supports investigations into related pathophysiological processes. -
Calcium Channel Inhibitor
PD0176078 is a selective N-type calcium channel inhibitor, primarily targeting voltage-gated calcium channels. It exhibits significant biological activity by effectively blocking calcium influx, which modulates neurotransmitter release and can influence pain signaling pathways. This compound is valuable for research applications focused on neuropharmacology and the investigation of pain mechanisms. -
Calcium Channel Blocker
Nemadipine B is a calcium channel blocker and an antagonist of EGL-19. It has been shown to induce Egl, Vab, and Gro phenotypes in Caenorhabditis elegans, making it a valuable tool for studying calcium signaling pathways and their effects on neuronal function. Its applications extend to various areas of research, including neurobiology and developmental biology, facilitating insights into calcium channel modulation in living organisms. -
Calcium Channel Antagonist
Calcium Channel Antagonist 2 (Compound 154) is a selective antagonist of calcium channels, exhibiting an IC50 range of 5-20 μM. This compound is instrumental in the exploration of calcium channel-mediated pathologies, including pain and diabetes. It serves as a valuable tool for understanding the role of calcium influx in various biological processes and the development of potential therapeutic strategies. -
N-type Calcium Channels Antagonist
Ziconotide is a potent and selective antagonist of N-type calcium channels. By blocking these channels, Ziconotide effectively reduces synaptic transmission and is utilized in chronic pain research. This peptide is an important tool for studying pain mechanisms and the physiological roles of calcium channel modulation in neuronal signaling. -
Calcium Channel Blocker
Amlodipine mesylate is a potent dihydropyridine calcium channel blocker that inhibits voltage-dependent L-type calcium channels, leading to decreased calcium influx. This mechanism results in vasodilation and reduced cardiac workload, making it an important agent in the study of hypertension and ischemic heart disease. Amlodipine mesylate is also being explored for its potential applications in cancer research due to its effects on vascular dynamics. -
Cav3.1/Cav3.2/Cav3.3 Inhibitor
ML218 hydrochloride is a selective inhibitor of T-type calcium channels, specifically Cav3.1, Cav3.2, and Cav3.3, exhibiting IC50 values of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. This compound effectively inhibits burst activity in subthalamic nucleus neurons and demonstrates minimal interference with L- or N-type calcium channels, KATP channels, or hERG potassium channels. Additionally, ML218 hydrochloride has the capability to penetrate the blood-brain barrier, making it a valuable tool for neurological research applications. -
Calcium Channel Antagonist
Mibefradil dihydrochloride hydrate is a potent calcium channel antagonist primarily targeting low-voltage-activated (T) calcium channels. This compound exhibits a higher affinity for T-type channels compared to high-voltage-activated (L) channels, making it an effective antihypertensive agent. Mibefradil dihydrochloride hydrate is utilized in research to investigate calcium signaling pathways and their implications in cardiovascular health. -
Stable Isotope
(R)-Amlodipine-d4 is a stable isotope-labeled form of (R)-Amlodipine, primarily targeting calcium channels. This deuterated compound is utilized in pharmacokinetic studies and metabolic research to track drug metabolism and distribution in various biological systems. Its use aids in the understanding of the pharmacological effects and biological activity of (R)-Amlodipine in cardiovascular research. -
Calcium Channel Inhibitor
Etripamil hydrochloride is a potent L-type calcium channel inhibitor primarily used in the research of paroxysmal supraventricular tachycardia (PSVT). By blocking calcium influx through slow calcium channels, it effectively slows down atrioventricular node conduction and extends the refractory period of the atrioventricular node. This compound is valuable for studying cardiac electrophysiology and the mechanisms underlying arrhythmias. -
Stable Isotope
Lercanidipine-13C,d3 hydrochloride is a stable isotope-labeled form of Lercanidipine hydrochloride, a third-generation dihydropyridine calcium channel blocker (DHP-CCB). It exhibits prolonged antihypertensive effects and offers renoprotective benefits. This compound is valuable for pharmacokinetic studies and mechanistic research involving calcium signaling and cardiovascular physiology.
