Catalog No.
Product Name
Application
Product Information
Citations
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CaVAb Inhibitor
UK-59811 hydrochloride is a Br-dihydropyridine derivative that functions as a potent inhibitor of the bacterial homotetrameric voltage-gated calcium channel, CaVAb, with an IC50 value of 194 nM. It serves as a valuable tool for studying calcium ion transport and its physiological implications in bacterial systems. Its specific action on CaVAb makes it suitable for research applications focused on calcium signaling and channel modulation. -
T-type Calcium Channel Inhibitor
IAA65 is a potent inhibitor of T-type calcium channels, exhibiting an IC50 value of 18.9 µM. This compound is primarily utilized in research related to epilepsy, aiding in the investigation of calcium channel modulation and its effects on neuronal excitability. IAA65 may facilitate the exploration of therapeutic strategies targeting T-type calcium channels for seizure management. -
Calcium Antagonist
UK 55444 is a calcium antagonist that primarily targets L-type calcium channels. It exhibits coronary vasodilator activity, making it relevant for research focused on cardiovascular physiology. UK 55444 is utilized in studies investigating the modulation of vascular tone and the role of calcium in myocardial function. -
Calcium Channel Blocker
Niludipine is an orally active calcium channel blocker primarily used for vasodilation and antihypertensive therapy. It has been shown to improve early fatal ventricular arrhythmias induced by acute myocardial ischemia in animal models. In addition, Niludipine effectively reduces left ventricular systolic and diastolic loads during pacing-induced angina pectoris. This compound is valuable for research into cardiovascular diseases, including coronary heart disease and myocardial ischemia. -
Calcium Channel
SB-237376 is a selective inhibitor of calcium channels, specifically targeting the L-type calcium current (I(Ca,L)) at elevated concentrations. Additionally, it effectively blocks the rapidly activating delayed rectifier potassium current (I(Kr)) with an IC50 value of 0.42 μM. This compound is valuable in studies focused on cellular signaling, cardiomyocyte function, and other physiological processes involving calcium channel modulation. -
Calcium Channel Antagonist
PD-217014-methyl ester is a calcium channel antagonist that acts as an αδ ligand, exhibiting significant visceral analgesic properties. This compound shows potential in inhibiting visceral hypersensitivity, and its anti-hyperalgesic effects are dose-dependent. It may be useful for research applications focused on pain management and the modulation of sensory signaling pathways. -
T-type Calcium Channel Inhibitor
IAB15 is a potent inhibitor of T-type calcium channels, which play a crucial role in regulating neuronal excitability and neurotransmitter release. This compound demonstrates significant activity in modulating calcium ion influx, making it a valuable tool in epilepsy research. Its ability to selectively target these channels positions IAB15 as an important reagent for studying calcium signaling pathways and their implications in seizure disorders. -
Calcium Channel
BBR 2160 is a dihydropyridine calcium channel antagonist that primarily targets voltage-gated calcium channels. This compound exhibits significant cardiac electrophysiological effects, including the reduction of myocardial contractility and prolongation of action potential duration. BBR 2160 is suitable for research applications focused on cardiac function and calcium signaling in cardiovascular studies. -
Potassium/Sodium Channel Inhibitor
Huwentoxin I is a peptide toxin that specifically inhibits voltage-gated sodium channels and N-type calcium channels. This compound has demonstrated significant inhibitory effects on sodium channels in both rat hippocampus and cockroach dorsal unpaired median (DUM) neurons, with IC50 values of 66.1 nM and 4.80 nM, respectively. Huwentoxin I is valuable for studies focused on neuronal excitability and channelopathy-related research applications. -
Calcium Channel Antagonist
Calcium Channel Antagonist 6 (Compound 328) selectively inhibits the voltage-gated calcium channel CaV2.2 with an IC50 value of 0.37 μM. This compound effectively blocks neuron depolarization-induced Ca2+ influx, making it a valuable tool for investigating mechanisms underlying neuropathic pain. Its specificity and potency position it as a promising candidate for further research in pain-related studies. -
Cav 3.2 Inhibitor
Cav 3.2 inhibitor 1 is a selective inhibitor of the Cav 3.2 T-type calcium channel, exhibiting minimal interaction with dopamine D2 receptors. This compound is valuable for studying mechanisms underlying somatic and visceral pain, making it a significant tool in pain research and potential therapeutic development. -
Isotope-Labeled Compound
Ethacrynic acid D5 is a deuterium-labeled analog of Ethacrynic acid, primarily targeting glutathione S-transferases (GSTs). This compound exhibits diuretic properties and serves as a potent inhibitor of the NF-kB signaling pathway, with implications in modulating leukotriene formation. Additionally, it inhibits L-type voltage-dependent and store-operated calcium channels, contributing to the relaxation of airway smooth muscle cells. Ethacrynic acid D5 also demonstrates anti-inflammatory effects, evidenced by its ability to reduce retinoid-induced ear edema in murine models, making it valuable in related research applications. -
Calcium Channel Antagonist
Calcium Channel Antagonist 1 is a selective antagonist of calcium channels, inhibiting calcium influx in neuronal tissues. This compound demonstrates critical biological activity in modulating neurotransmission and has applications in the study of neurological disorders. Its use can facilitate research into calcium-mediated signaling pathways relevant to various neurodegenerative conditions. -
Antihypertensive Agent
Vatanidipine is an orally active dihydropyridine calcium channel blocker with prominent antihypertensive properties. It demonstrates significant vasodilatory effects and effectively inhibits the release of noradrenaline from sympathetic nerve endings. This mechanism makes Vatanidipine useful for studying hypertension and related cardiovascular conditions in research applications. -
Cav 3.2 Inhibitor
Cav 3.2 Inhibitor 4 is a selective inhibitor targeting the Cav 3.2 T-type calcium channel, exhibiting an IC50 of 0.6 μM. This compound is primarily researched for its potential in investigating atrial fibrillation and related cardiac conditions. Its peripheral restriction enhances its utility in studying physiological processes influenced by Cav 3.2 activity in diverse experimental settings. -
Calcium Channel
GZ4 is a potent calcium channel inhibitor, exerting direct inhibitory effects on cell surface calcium currents. This compound effectively reduces mechanical hyperalgesia in models of neuropathic pain, specifically in spinal nerve ligation scenarios. Unlike gabapentin, GZ4 demonstrates a more rapid onset of action, reinforcing its potential for targeting calcium channel activity in pain modulation research. -
Stable Isotope
Lercanidipine-13C,d3-1 hydrochloride is a stable isotope-labeled variant of Lercanidipine hydrochloride, a third-generation dihydropyridine calcium channel blocker. This compound exhibits potent antihypertensive properties and provides renal protection. It is particularly useful in pharmacokinetic studies, enabling the investigation of metabolic pathways and the evaluation of drug interactions in hypertension research. -
Calcium Channel Inhibitor
Calcicludine is a potent inhibitor of high-voltage-activated calcium channels, with a particular affinity for L-type calcium channels. Derived from the venom of the green mamba, this protein toxin plays a critical role in studies investigating calcium signaling and neurotransmitter release. Its unique mechanism makes Calcicludine a valuable tool for researchers exploring neuronal excitability and muscle contraction pathways. -
Antianginal Compound
Elgodipine is an orally active dihydropyridine calcium antagonist primarily used in antianginal research. It selectively inhibits T-type and L-type calcium channels with IC50 values of 32 nM and 2.3 nM, respectively. By reducing systemic vascular resistance, Elgodipine enhances systolic cardiac function, making it valuable for studies focused on cardiovascular health and angina treatment. -
L-type Calcium Channel Blocker
Norverapamil-d7 is a deuterium-labeled derivative of Norverapamil, which selectively targets L-type calcium channels. As an N-demethylated metabolite of Verapamil, it functions as an effective calcium channel blocker and inhibits P-glycoprotein (P-gp) activity. This reagent is suitable for research applications related to cardiovascular physiology, drug absorption studies, and pharmacokinetics involving P-gp transport mechanisms. -
Calcium Channel Blocker, Cholesterol Acyltransferase Inhibitor
Belfosdil functions as a selective calcium channel blocker while also inhibiting acyl coenzyme A cholesterol acyltransferase (ACAT). This dual action contributes to its role in modulating calcium influx and lipid metabolism. Belfosdil is utilized in research focused on cardiovascular and metabolic diseases, exploring its potential for therapeutic applications. -
Stable Isotope
L-Phenylalanine-d is a deuterium-labeled form of the essential amino acid L-Phenylalanine, which serves as a stable isotope. This compound acts as an antagonist to the α2δ subunit of voltage-dependent calcium channels, exhibiting a Ki value of 980 nM. Additionally, L-Phenylalanine-d competitively inhibits glycine- and glutamate-binding sites on N-methyl-D-aspartate receptors (NMDARs) with a KB of 573 μM. It finds applications in research related to neuropharmacology and the synthesis of various pharmaceuticals and food flavorings. -
Stable Isotope
(S)-Lercanidipine-d3 hydrochloride is a deuterium-labeled form of the antihypertensive agent Lercanidipine. It acts primarily as a calcium channel blocker, inhibiting the influx of calcium ions into vascular smooth muscle and cardiac tissue, leading to vasodilation and reduced blood pressure. This stable isotope is useful in pharmacokinetic studies, metabolic research, and drug development to trace the pharmacological effects and biodistribution of the parent compound. -
Calcium Channel Antagonist
(R)-Niguldipine is a calcium channel antagonist that effectively blocks calcium channels, leading to vasodilation by reducing the influx of calcium ions across cell membranes. It demonstrates potent inhibition of U-46619-induced coronary artery contraction in guinea pig Langendorff hearts, with a pID50 of 9.93, and displays high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (Ki of 8.10). (R)-Niguldipine also significantly lowers blood pressure in spontaneously hypertensive rats (pED30 of 5.55), making it a valuable compound for research in cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias. -
Cavα2δ1/NET Inhibitor
Cavα2δ1&NET-IN-2 is a dual inhibitor targeting the α2δ-1 subunit of voltage-gated calcium channels and the norepinephrine transporter (NET). It demonstrates effective inhibition of Cavα2δ-1 with a Ki of 454 nM and exhibits potent inhibition of NET with a Ki of 59 nM and an IC50 of 7 nM. This compound is valuable for research focused on pain mechanisms and the associated neurotransmitter systems. -
Calcium Channel Antagonist
AK-2-38 is a calcium channel antagonist that functions by inhibiting voltage-gated calcium channels, thereby modulating calcium influx in cardiac and smooth muscle tissues. In addition to its antagonistic properties, AK-2-38 exhibits partial agonist effects on isolated guinea pig left atrium, which may influence cardiac contractility. This compound is valuable for research applications targeting cardiovascular physiology and pharmacology. -
Calcium Antagonist
KT-362 is an intracellular calcium antagonist that selectively modulates calcium signaling pathways. It effectively inhibits norepinephrine-induced contractions and interferes with inositol phosphate accumulation in vivo, demonstrating its role in regulating vascular smooth muscle function. This compound is of interest for research applications focused on cardiovascular physiology and calcium signaling mechanisms. -
Calcium Channel Blocker
(2-Chlorophenyl)diphenylmethanol is a calcium channel blocker that inhibits sI(AHP) with an IC50 ranging from 1 to 2 μM. This compound is relevant in research aimed at understanding calcium channel modulation and its effects on neuronal excitability. Its weak inhibitory activity makes it a useful tool for exploring calcium dynamics in various biological contexts. -
Calcium Channel Inhibitor
Levosemotiadil is a calcium channel inhibitor that demonstrates increased binding affinity to human serum albumin (HSA) compared to its R-isomer. Research utilizing high-performance frontal analysis (HPFA) indicates that levosemotiadil binds approximately three times more strongly to HSA than semotiadil, with specific interactions at the diazepam binding site. The binding affinity of both enantiomers is diminished in the presence of diazepam, while warfarin shows no effect. These properties underscore levosemotiadil's potential as a Ca- and Na-channel blocker, making it a valuable compound for exploring its pharmacokinetics and therapeutic applications. -
Calcium Antagonist
Naltiazem is a thiazepinone-type calcium antagonist that selectively inhibits calcium influx in cardiac and vascular smooth muscle cells. Its primary biological activity includes the inhibition of platelet aggregation, both in vitro and in vivo. This compound is particularly valuable in cardiovascular research, where it can be utilized to study calcium signaling pathways and their implications in various diseases. -
Calcium Antagonist
Phenchlobenpyrrone is a selective neuronal calcium antagonist that effectively crosses the blood-brain barrier. This compound demonstrates the capability to mildly inhibit acetylcholinesterase (AChE) activity, along with inhibiting amyloid-beta (Aβ) aggregation and promoting the clearance of Aβ oligomers. Additionally, Phenchlobenpyrrone reduces abnormal phosphorylation of Tau protein. This agent is valuable for research applications focused on Alzheimer's disease and related neurodegenerative conditions. -
Calcium Channel
Niguldipine is a calcium channel blocker that primarily targets voltage-gated calcium channels to modulate cardiovascular function. It effectively reduces both systolic and diastolic blood pressure while simultaneously increasing heart rate and cardiac output. Additionally, Niguldipine promotes dose-dependent increases in coronary blood flow and transiently enhances renal and femoral artery perfusion. Its influence on myocardial metabolism is minimal, making it a valuable compound for cardiovascular research applications. -
Calcium Channels Inhibitor
ω-Grammotoxin SIA is a selective inhibitor of P/Q and N-type voltage-gated calcium channels, derived from spider venom. This protein toxin is instrumental in studying calcium's role in neuronal and cardiovascular signaling pathways. Its unique mechanism allows researchers to explore its potential applications in understanding and treating various neurological and cardiovascular diseases. -
Ca2+ Antagonist
Iganidipine dihydrochloride is a calcium (Ca2+) antagonist that selectively inhibits L-type calcium channels. This compound demonstrates significant vasodilatory properties, making it relevant for cardiovascular research, particularly in studies focused on hypertension and related disorders. Its ability to modulate calcium influx can provide valuable insights into calcium signaling pathways and the pharmacological responses to cardiovascular agents. -
α2δ-1 Inhibitor
(rel)-Mirogabalin is an inhibitor of the α2δ-1 subunit of voltage-dependent calcium channels. It is primarily used in research focused on neuropathic pain modulation and may also play a role in studying anxiety disorders. Its ability to regulate calcium influx makes it a significant compound for investigating therapeutic potentials in calcium-related pathophysiologies. -
Nicardipine Enantiomer
(S)-Nicardipine is the S enantiomer of Nicardipine, functioning primarily as a calcium channel blocker. With an IC50 of 1 μM, it effectively inhibits cardiac calcium channels, making it a valuable compound in the study of cardiovascular conditions. This reagent is applicable in research focused on chronic stable angina and hypertension management, providing insights into calcium channel modulation and related therapeutic interventions. -
Calcium Channel Blocker
(S)-Lercanidipine hydrochloride is a potent calcium channel blocker that selectively inhibits L-type calcium channels. By reducing calcium influx, it effectively lowers vascular resistance and promotes vasodilation, making it crucial in the treatment of hypertension. This compound is utilized in cardiovascular research to explore mechanisms of calcium channel modulation and its effects on cardiac function. -
Calcium Channel Antagonist
AJ-3941 is an orally active cerebrovascular-selective calcium channel antagonist that exerts anti-lipid peroxidative effects. It demonstrates the ability to reduce brain infarction and edema following permanent focal cerebral ischemia. This compound serves as a valuable tool for research into cerebrovascular conditions and related neurological disorders. -
Calcium Ion Antagonist
m-Nisoldipine is a dihydropyridine calcium ion antagonist primarily targeting L-type calcium channels. It demonstrates significant effects on cardiovascular parameters, such as increasing cardiac output and heart index while minimizing negative inotropic effects on myocardial tissue. This compound exhibits a unique selectivity for the thoracic aorta, making it a valuable reagent for research into cardiovascular diseases and related therapeutic interventions. -
Calcium Channel Blocker
Cav 2.2/3.2 Blocker 1 is a selective inhibitor of neuronal calcium channels, specifically targeting Cav2.2 and Cav3.2 with IC50 values of 78 μM and 80 μM, respectively. This compound effectively modulates calcium influx in neurons, making it valuable for research into neurological disorders and pain mechanisms. It has the capability to penetrate the central nervous system, facilitating studies on its effects in a CNS context. -
Calcium Channel Inhibitor
(S)-Lercanidipine is a calcium channel blocker that exhibits antihypertensive and neuroprotective activities. It effectively reduces oxidative stress and has been shown to protect auditory sensory hair cells from noise-induced damage. In vitro studies demonstrate that (S)-Lercanidipine enhances cell viability, particularly at lower concentrations, and significantly lowers the hearing threshold in mice following noise exposure. Its antioxidant properties are characterized by an increase in the expression of antioxidant enzyme genes and a decrease in oxidative enzyme gene expression, suggesting its potential for mitigating noise-induced hearing loss and preserving outer hair cell viability. -
Calcium Channel Antagonist
Calcium Channel Antagonist 3 is a potent inhibitor of voltage-gated calcium channels, exhibiting an IC50 value ranging from 5 to 20 μM. This compound effectively modulates calcium influx in excitable cells, making it valuable for studies related to cardiac and neuronal signaling. Its ability to inhibit calcium channel activity makes it a useful tool for investigating various physiological and pathological processes related to calcium homeostasis. -
Nicardipine Enantiomer
(R)-Nicardipine is the R enantiomer of Nicardipine, a potent calcium channel blocker. It exhibits an IC50 of 1 μM against cardiac calcium channels, making it pivotal in the study of cardiovascular functions. This compound is primarily utilized in research related to chronic stable angina and hypertension management. -
Calcium Channel Blocker
dl-Tetrandrine is a potent calcium channel blocker that inhibits voltage-dependent calcium channels, selectively blocking Ca2+ influx with an IC50 ranging from 1-10 μM. This compound exhibits significant anti-inflammatory, immunosuppressive, and anti-arrhythmic properties by preventing intracellular calcium overload. dl-Tetrandrine is of particular interest in research related to autoimmune diseases, including rheumatoid arthritis, cardiovascular disorders, and the reversal of multidrug resistance in tumor cells. -
Cavα2δ1/NET Inhibitor
Cavα2δ1&NET-IN-1 is a dual inhibitor targeting the α2δ-1 subunit of voltage-gated calcium channels and the norepinephrine transporter (NET). This compound demonstrates inhibition of Cavα2δ-1 with a Ki value of 112 nM, and inhibits NET with a Ki of 383 nM and an IC50 of 67 nM. Cavα2δ1&NET-IN-1 is suitable for research applications focused on pain mechanisms and related therapeutic pathways. -
Calcium Channel Antagonist
RQ-00311651 is a selective T-type calcium channel antagonist that predominantly targets the Cav3.2 isoform, which is implicated in neuropathic and visceral pain modulation. This compound effectively inhibits T currents in HEK293 cells expressing human Cav3.1 and Cav3.2, as well as reducing calcium signaling induced by elevated potassium levels. Additionally, RQ-00311651 demonstrates antiallergic effects and has shown efficacy in preclinical models, including reduction of acute pancreatitis and cystitis in mice following administration via oral or intraperitoneal routes. This compound offers significant potential for research in pain management and related pathological conditions. -
Calcium Channel Antagonist
sFTX-3.3 is a calcium channel antagonist that exhibits inhibitory activity with IC50 values of approximately 0.24 mM for P-type channels and 0.70 mM for N-type channels. This compound is utilized in research applications focused on neurophysiology and cardiovascular studies, where modulation of calcium influx is critical. sFTX-3.3 can aid in elucidating the role of calcium channels in various physiological and pathological processes. -
Vasodilator
Cimicifugic acid D (2-Caffeoylpiscidic acid) is a benzyltartaric acid ester that acts as a vasodilator, promoting endothelium-independent relaxation in precontracted rat aortic strips. Its primary mechanism involves the inhibition of extracellular Ca2+ influx through receptor-operated calcium channels (ROC), effectively countering norepinephrine-induced contractions. Notably, Cimicifugic acid D does not interfere with voltage-dependent calcium channels or K+-induced contractions, making it a valuable tool for studying vascular smooth muscle responses and calcium signaling pathways. -
Calcium Channel Inhibitor
Cav 3.2 inhibitor 2 is a selective inhibitor of Cav3.2 T-type Ca2+ channels, exhibiting an IC50 of 0.09339 μM under a -80 mV holding potential. This compound effectively reduces T-channel-dependent somatic and visceral pain in murine models, making it a valuable tool for investigating intractable pain mechanisms. Its ability to modulate calcium channel activity positions Cav 3.2 inhibitor 2 as a significant agent in pain research and therapeutic development. -
Stable Isotope
Norverapamil-d7 hydrochloride is a deuterium-labeled analog of Norverapamil, functioning primarily as a stable isotope. This compound is an N-demethylated metabolite of Verapamil and acts as an L-type calcium channel blocker while inhibiting P-glycoprotein (P-gp) functions. It's utilized in pharmacokinetic studies to investigate drug metabolism and transport mechanisms.
