PDK1

Inhibitory Selectivity
Catalog No.Inhibitor Name PDK-1 Other Targets
A10681OSU-03012
**
A11148BX-795
****
TBK1/IKKɛ,c-Kit,CDK2/CyclinE
A11149BX-912
***
PKA,KDR,CDK2/CyclinE
A11032PHT-427
*
Akt
A12767GSK2334470
***
A12881 BX-517
****
A11511NVP-BAG956
*
PI3K
A13484PS 48
*

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A12881

BX-517

PDK1 inhibitor
BX-517 is a potent and selective inhibitor of PDK1 that binds to the ATP binding pocket of the protein (IC50 = 6 nM).
A11148 SALE

BX-795

PDK-1 inhibitor
BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis.
A11149 SALE

BX-912

PDK1 inhibitor
BX-912 is an inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1).
A12767 SALE

GSK 2334470

PDK1 Inhibitor
GSK 2334470 is a potent 3-phosphoinositide-dependent protein kinase (PDK1) inhibitor (IC50 ~ 10 nM).
A11511

NVP-BAG956

PI3K/PDK-1 Inhibitor
NVP-BAG956 acts as a potent, reversible, and ATP-competitive PI 3-K/PDK1 dual kinase inhibitor, displaying much reduced potency against VEGFR1 (IC50 = 2.56 uM) and little or no activity toward a panel of 15 other kinases (IC50 >10 uM).
A10681 SALE

OSU-03012

PDK-1 inhibitor
OSU-03012 is a novel celecoxib derivative, without cyclooxygenase-2 inhibitory activity, capable of inducing apoptosis in various cancer cells types.
A16185

PDK1 inhibitor

PDK1 inhibitor
PDK1 inhibitor, potent, ATP-competitive and selective dual PI3K and PDPK1 inhibitor (IC50 values 34 nM and 94 nM for PDK1 and p-T308-PKB inhibition, respectively.
A11528

PDK1 inhibitor

PDK1 inhibitor
PDK1 inhibitor is a potent and selective inhibitor of PDK1 with potential as anticancer agent.
A11032 SALE

PHT-427

AKT Inhibitor
PHT-427 is a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
A13484 SALE

PS 48

PDK1 inhibitor
PS 48 is an allosteric phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd = 10.3 μM).

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