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PDK1
Inhibitory Selectivity
| Catalog No. | Inhibitor Name | PDK-1 | Other Targets |
|---|---|---|---|
| A10681 | OSU-03012 | ** | |
| A11148 | BX-795 | **** | TBK1/IKKɛ,c-Kit,CDK2/CyclinE |
| A11149 | BX-912 | *** | PKA,KDR,CDK2/CyclinE |
| A11032 | PHT-427 | * | Akt |
| A12767 | GSK2334470 | *** | |
| A12881 | BX-517 | **** | |
| A11511 | NVP-BAG956 | * | PI3K |
| A13484 | PS 48 | * |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
11 Item(s)
per page
| Catalog No. | Product Name | Application | Product Information |
|---|---|---|---|
A16185 |
PDK1 inhibitor |
PDK1 inhibitor |
PDK1 inhibitor, potent, ATP-competitive and selective dual PI3K and PDPK1 inhibitor (IC50 values 34 nM and 94 nM for PDK1 and p-T308-PKB inhibition, respectively.
|
A11528 |
PDK1 inhibitor |
PDK1 inhibitor |
PDK1 inhibitor is a potent and selective inhibitor of PDK1 with potential as anticancer agent.
|
A11032 SALE |
PHT-427 |
AKT Inhibitor |
PHT-427 is a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
|
A12881 |
BX-517
|
PDK1 inhibitor |
BX-517 is a potent and selective inhibitor of PDK1 that binds to the ATP binding pocket of the protein (IC50 = 6 nM).
|
A13484 SALE |
PS 48 |
PDK1 inhibitor |
PS 48 is an allosteric phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd = 10.3 μM).
|
A12767 SALE |
GSK 2334470 |
PDK1 Inhibitor |
GSK 2334470 is a potent 3-phosphoinositide-dependent protein kinase (PDK1) inhibitor (IC50 ~ 10 nM).
|
A11511 |
NVP-BAG956 |
PI3K/PDK-1 Inhibitor |
NVP-BAG956 acts as a potent, reversible, and ATP-competitive PI 3-K/PDK1 dual kinase inhibitor, displaying much reduced potency against VEGFR1 (IC50 = 2.56 uM) and little or no activity toward a panel of 15 other kinases (IC50 >10 uM).
|
A11149 SALE |
BX-912 |
PDK1 inhibitor |
BX-912 is an inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1).
|
A11148 SALE |
BX-795 |
PDK-1 inhibitor |
BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis.
|
A10681 SALE |
OSU-03012 |
PDK-1 inhibitor |
OSU-03012 is a novel celecoxib derivative, without cyclooxygenase-2 inhibitory activity, capable of inducing apoptosis in various cancer cells types.
|
A16279 |
TEPP-46 |
PKM2 activator |
TEPP-46 is a potent and selective activator of recombinant pyruvate kinase M2 (PKM2) with half-maximum activating concentration (AC50 value) of 92 nM, and little or no activity versus PKM1, PKL and PKR.
|
11 Item(s)
per page