BX-795

Catalog No.: A11148

PDK-1 inhibitor

BX-795

BX-795 Chemical Structure

CAS NO. 702675-74-9

BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis.

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10 mg

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Special Price $96.00

25 mg

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50 mg

Regular Price: $420.00

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100 mg

Regular Price: $800.00

Special Price $640.00

10mM * 1mL in DMSO

Regular Price: $130.00

Special Price $104.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168

Biological Activity

BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis.
Targets
Target Value
TBK1/IKK?
PDK-1IC50: 6nM
c-KitIC50: 320nM
CDK2/CyclinEIC50: 430nM
Chk1IC50: 510nM
GSK-3βIC50: 620nM
PKAIC50: 840nM
KDRIC50: 1.1μM
T-FynIC50: 6.4μM
PKCIC50: 9.3μM
EGFRIC50: >10μM
Insulin ReceptorIC50: >10μM
In vitro (25°C) DMSO 88 mg/mL (148.78 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG +2% Tween 80+ddH2O 3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.91 mL 84.53 mL 169.06 mL
0.5 mM 3.38 mL 16.91 mL 33.81 mL
1 mM 1.69 mL 8.45 mL 16.91 mL
5 mM 0.34 mL 1.69 mL 3.38 mL

*The above data is based on the productmolecular weight 591.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11148
Actions Inhibitor
CAS No. 702675-74-9
Formula C23H26IN7O2S
M. Wt 591.5
Purity >98%
Synonyms BX795
SMILES C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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