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Biological Activity
PDK1 inhibitor, potent, ATP-competitive and selective dual PI3K and PDPK1 inhibitor (IC50 values 34 nM and 94 nM for PDK1 and p-T308-PKB inhibition, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.7 mL | 118.52 mL | 237.03 mL |
| 0.5 mM | 4.74 mL | 23.7 mL | 47.41 mL |
| 1 mM | 2.37 mL | 11.85 mL | 23.7 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.74 mL |
*The above data is based on the productmolecular weight 421.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16185 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 853909-77-0 |
| Formula | C25H15N5.HCl |
| M. Wt | 421.88 |
| Purity | >98% |
| SMILES | C1=CC(=CN=C1)C#CC2=CC3=C4C(=CN=C3C=C2)N=CN4C5=CC=C(C=C5)CC#N.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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