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$0.00 Biological Activity
CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 7.01 mL | 35.05 mL | 70.1 mL |
| 0.5 mM | 1.4 mL | 7.01 mL | 14.02 mL |
| 1 mM | 0.7 mL | 3.5 mL | 7.01 mL |
| 5 mM | 0.14 mL | 0.7 mL | 1.4 mL |
*The above data is based on the productmolecular weight 1426.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18388 |
|---|---|
| CAS No. | 2270986-66-6 |
| Formula | C68H103N11O22 |
| M. Wt | 1426.61 |
| Solubility | DMSO |
| Purity | >98% |
| SMILES | OCC(COC(N(C)CCN(C)C(OCC(C=C1)=CC=C1NC([[email protected]](CCCCNC(OC(C)(C)C)=O)NC([[email protected]@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN2C=C(CNC(CCCCCN3C(C=CC3=O)=O)=O)N=N2)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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