CL2 Linker

Catalog No.: A18388

cleavable ADC linker

CL2 Linker

CL2 Linker Chemical Structure

CAS NO. 2270986-66-6

CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours).

Availability: In stock

Package Price Qty
1 mg
$320.00
5 mg
$960.00
10 mg
$1,600.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 7.01 mL 35.05 mL 70.1 mL
0.5 mM 1.4 mL 7.01 mL 14.02 mL
1 mM 0.7 mL 3.5 mL 7.01 mL
5 mM 0.14 mL 0.7 mL 1.4 mL

*The above data is based on the productmolecular weight 1426.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18388
M. Wt 1426.61
Formula C68H103N11O22
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 2270986-66-6
SMILES OCC(COC(N(C)CCN(C)C(OCC(C=C1)=CC=C1NC([[email protected]](CCCCNC(OC(C)(C)C)=O)NC([[email protected]@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN2C=C(CNC(CCCCCN3C(C=CC3=O)=O)=O)N=N2)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy CL2 Linker | CL2 Linker Supplier | purchase | cost | manufacturer | order | distributor | buy 2270986-66-6| 2270986-66-6 Supplier | purchase 2270986-66-6 | 2270986-66-6 cost | 2270986-66-6 manufacturer | order 2270986-66-6 | 2270986-66-6 distributor
Rewards