Catalog No.
Product Name
Application
Product Information
Citations
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CXCR4 Antagonist
Peptide R analogue 10 is a potent CXCR4 antagonist, demonstrating enhanced antagonistic activity, specificity, and plasma stability compared to its predecessor, Peptide R. This compound effectively inhibits CXCL12-mediated cell migration, ERK phosphorylation, and CXCR4 internalization. Peptide R analogue 10 is valuable for research applications involving CXCR4 overexpression in models of leukemia and colon cancer. -
Autophagy Inducer
SR-3677 dihydrochloride is a selective inhibitor of Rho-associated coiled-coil containing protein kinase I (ROCK-I) and II (ROCK-II), exhibiting IC50 values of 56 nM and 3 nM, respectively. This compound serves as an autophagy inducer, promoting cellular degradation pathways that can enhance cell survival and homeostasis. It is particularly useful in research focused on cancer, neurodegenerative diseases, and metabolic disorders, where modulation of autophagy may offer therapeutic benefits. -
Bone Marrow Mesenchymal Stem Cell Inducer
Herpetin is an active lignan that functions as a bone marrow mesenchymal stem cell inducer. It activates the SDF-1/CXCR4 axis and the Wnt/β-catenin signaling pathway, promoting stem cell recruitment and differentiation. This compound is relevant for research applications focused on acute liver injury and related regenerative processes. -
CXCR4/STAT3 Inhibitor
Minecoside is a potent inhibitor of the CXCR4 receptor and STAT3 signaling pathway. It demonstrates significant anticancer and anti-inflammatory activities by downregulating CXCR4 expression and suppressing STAT3 activation, which leads to the inhibition of CXCL12-induced cellular invasion. Minecoside has been shown to effectively hinder cancer metastasis and enhance apoptosis, making it a valuable tool for research in cancer biology and therapeutic development. -
FKBP12 Targeting AUTAC
AUTAC2 is an FKBP12-targeting autophagy-mediated degrader designed to promote selective degradation of specific proteins. This compound incorporates a p-Fluorobenzyl Guanine (FBnG) moiety and an SLF ligand, which non-covalently binds to FKBP12. AUTAC2 facilitates the targeted removal of proteins through the autophagy pathway, making it a valuable tool for research applications focused on protein homeostasis and cellular regulation. -
Autophagy Inducer
Dehydropachymic acid is a triterpene derived from Poria cocos, functioning primarily as an autophagy inducer. It has demonstrated enhanced efficacy in promoting the autophagy-lysosome pathway in cells with impaired autophagic processes compared to normal cells. This compound is valuable for research applications focused on autophagy modulation and cellular homeostasis. -
Cathepsin Inhibitor
LV-320 is a potent uncompetitive inhibitor of cathepsin ATG4B, exhibiting an IC50 of 24.5 μM and a Kd of 16 μM. This compound effectively inhibits the enzymatic activity of ATG4B, thereby obstructing autophagic flux in cellular environments. Due to its stability and low toxicity, LV-320 is suitable for in vivo applications, making it a valuable tool for research on autophagy-related pathways. -
ATG4B Activator
STK683963 is an activator of the autophagy-related protein ATG4B, which plays a critical role in the regulation of autophagy and cellular homeostasis. This compound enhances ATG4B activity, contributing to the redox-regulation mechanisms within cells. STK683963 is valuable for research applications focused on cancer biology, particularly in studies investigating the modulation of autophagy pathways. -
MetAP2 Targeting AUTAC
AUTAC1 is an autophagy-mediated degrader specifically targeting MetAP2. This compound features a degradation tag and a warhead that ensures target specificity. The structure of AUTAC1 includes p-Fluorobenzyl Guanine (FBnG) and a Fumagillol moiety, with Fumagillol covalently binding to MetAP2. This compound is valuable for research applications focused on the regulation of protein degradation pathways and the study of MetAP2's role in cellular processes. -
Autophagy Inhibitor/Purinergic Receptors Antagonist
Indophagolin is a potent autophagy inhibitor targeting purinergic receptors, demonstrating an IC50 of 140 nM. It effectively antagonizes the P2X4, P2X1, and P2X3 receptors with IC50 values of 2.71, 2.40, and 3.49 μM, respectively. Additionally, Indophagolin inhibits Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors, with IC50s ranging from 3.4 to 15.4 μM. It exhibits strong antagonistic effects on the serotonin receptor 5-HT6 (IC50=1.0 μM) and moderate effects on multiple serotonin receptors, making it a valuable tool for research into autophagy and neurological pathways. -
AUTAC4 Ligand
TSPO ligand-1 is a ligand of AUTAC4, serving as a key component in the synthesis of PROTACs. It interacts with the transmembrane structural domain protein of the mitochondrial outer membrane, facilitating the regulation of mitochondrial autophagy and promoting targeted mitochondrial renewal. Additionally, TSPO ligand-1 is implicated in the transport of cholesterol between mitochondrial membranes and serves as a sensitive biomarker for brain injury and neurodegenerative conditions. -
Autophagy Inhibitor
Autogramin-1 is a potent autophagy inhibitor that effectively suppresses autophagic processes triggered by nutrient deprivation or mTORC1 inhibition. With an IC50 of 0.17 μM against starvation-induced autophagy and 0.44 μM against Rapamycin-induced autophagy, it serves as a valuable tool for researching the role of autophagy in cellular processes and disease models. This compound provides insights into autophagic regulation and its implications in various cancer and neurodegenerative studies. -
Autophagy Inhibitor
NEO214 is an autophagy inhibitor that acts by preventing autophagy-lysosome fusion, effectively blocking autophagic flux. This compound, a covalent conjugate of the PDE4 inhibitor Rolipram and perillyl alcohol, exhibits anti-cancer activity and is capable of penetrating the blood-brain barrier. Its mechanism involves the activation of mTOR and aggregation of the transcription factor EB (TFEB), promoting the death of glioma cells. NEO214 may provide a strategy to combat chemotherapy resistance in glioblastoma. -
Atg4B Inhibitor
Atg4B-IN-2 is a selective inhibitor of Atg4B with a competitive mechanism, exhibiting a Ki value of 3.1 μM. In addition, it displays moderate inhibitory activity against phospholipase A2, with IC50 values of 11 μM and 3.5 μM for Atg4B and PLA2, respectively. This compound effectively enhances the anticancer efficacy of agents targeting castration-resistant prostate cancer through the inhibition of autophagy, making it a valuable tool for cancer research. -
Autophagy Inducer
(Rac)-BL-918 is a potent autophagy inducer that activates UNC-51-like kinase 1 (ULK1). This compound facilitates cytoprotective autophagy, making it a valuable tool for research focused on neurodegenerative diseases, particularly Parkinson's disease. Its ability to modulate autophagy pathways offers insights into therapeutic strategies for enhancing neuronal survival and function. -
Autophagy Inducer
Autophagy Inducer 4 is a Mannich base derivative of Magnolol that promotes autophagy. This compound exhibits significant anticancer properties by enhancing autophagy, leading to suppression of cancer cell viability, particularly with a 76-fold increase in cytotoxicity against T47D cells compared to Magnolol. Additionally, Autophagy Inducer 4 demonstrates inhibitory effects on the migration of T47D and HeLa cancer cells, making it a valuable reagent for cancer research. -
Peptide
PHF6 (VQIVYK) is a peptide that facilitates the self-assembly and aggregation of the full-length tau protein, specifically targeting the third microtubule-binding repeat region of tau. This peptide is instrumental in studies of tau pathology associated with neurodegenerative diseases, particularly in understanding the mechanisms underlying tau aggregation and its implications in tau-related disorders. Its unique structure makes it a valuable tool for investigating tau fibrillogenesis and potential therapeutic interventions. -
Antioxidant/Autophagy Enhancer
Thonningianin B is an antioxidant that enhances autophagy. This compound is known for its role in mitigating oxidative stress and promoting cellular renewal processes. Its ability to modulate autophagy pathways makes it a valuable reagent for research in fields such as neuroprotection, cancer biology, and age-related diseases. Thonningianin B may facilitate studies aimed at understanding the interplay between oxidative stress and cellular homeostasis. -
Autophagy Inducer
Desethylamiodarone hydrochloride is a significant active metabolite of Amiodarone, primarily functioning as an autophagy inducer. It is produced through the action of CYP3A isoenzymes and plays a critical role in cellular processes affecting autophagy. This compound is utilized in research applications focusing on cardiovascular pharmacology and cellular stress responses, due to its influence on potassium channels and potential therapeutic implications in arrhythmias. -
Autophagy Inducer
Glaucocalyxin B is an ent kaurane diterpenoid that acts as an autophagy inducer. This compound has demonstrated significant anticancer and antitumor properties, effectively reducing the growth of HL-60 cells with an IC50 of approximately 5.86 μM after 24 hours. Its mechanism and biological activity make it a valuable tool for research in cancer biology and therapeutic development. -
Autophagy Inhibitor
CUR5g is a selective autophagy inhibitor that targets the fusion of autophagosomes and lysosomes. By inhibiting the recruitment of STX17 to autophagosomes through a UVRAG-dependent mechanism, CUR5g effectively disrupts the degradation of autophagic substrates in cancer cells. This compound enhances the anticancer efficacy of Cisplatin in both in vitro and in vivo models, making it a valuable tool for studying autophagy's role in cancer treatment and potential therapeutic synergies. -
IKKε/TBK-1 Inhibitor
MRT67307 hydrochloride is a selective inhibitor of IKKε and TBK-1, exhibiting IC50 values of 160 nM and 19 nM, respectively. Additionally, it inhibits ULK1 and ULK2 with IC50s of 45 nM and 38 nM, respectively. This compound is employed in research to study autophagy regulation and related cellular processes. It is particularly useful in investigations of inflammatory signaling pathways and cancer biology. -
Autophagy Inducer
Atorvastatin-d5 sodium is a deuterium-labeled analog of atorvastatin, an oral HMG-CoA reductase inhibitor. This compound effectively lowers blood lipid levels and acts as an autophagy inducer. It has been shown to inhibit human smooth muscle cell proliferation and invasion, with IC50 values of 0.39 μM and 2.39 μM, respectively. Atorvastatin-d5 sodium is valuable for research applications related to lipid metabolism and cellular growth regulation. -
REV-ERB/Autophagy Inhibitor
ARN5187 is a lysosomotropic ligand targeting REV-ERBβ, known for its dual inhibitory effects on REV-ERB-mediated transcriptional regulation and autophagy. This compound exhibits significant lysosomotropic potency and has cytotoxic properties, leading to the induction of apoptosis. ARN5187 serves as a valuable tool for research into the mechanisms of autophagy and the role of REV-ERBβ in cellular processes. -
Autophagy Inducer
SGI-1776 is a selective inhibitor of Pim kinases, exhibiting IC50 values of 7 nM for Pim-1, 363 nM for Pim-2, and 69 nM for Pim-3. This compound has been identified as an autophagy inducer, showcasing potential mechanisms in cellular pathways associated with cancer and metabolic disorders. SGI-1776 is employed in research applications focusing on the modulation of cell survival and proliferation, making it a valuable tool for investigating therapeutic strategies targeting the Pim kinase signaling network. -
Autophagy Inhibitor
IITZ-02 is a lysosomotropic autophagy inhibitor that disrupts lysosomal function, leading to impaired autophagosomal degradation and increased autophagosome accumulation. This compound induces apoptosis through a mitochondria-mediated pathway by abolishing mitochondrial membrane potential. IITZ-02 exhibits potent antitumor activity in MDA-MB-231 xenograft mouse models, making it a valuable tool for cancer research applications focusing on the regulation of autophagy. -
CXCR-4 Inhibitor
SSB-2548 is a selective inhibitor of the chemokine receptor CXCR-4. It has demonstrated significant efficacy in inhibiting the proliferation and migration of acute myeloid leukemia cells, while also promoting apoptosis. Its favorable gastrointestinal absorption profile makes SSB-2548 a valuable tool for investigating the underlying mechanisms of leukemia and exploring potential therapeutic interventions. -
Autophagy Inhibitor
Erythrabyssin II is a potent late-stage autophagy inhibitor that selectively inhibits the fusion of autophagosomes and lysosomes. This compound promotes the accumulation of autophagic substrates without disrupting lysosomal pH or enzyme activity. Erythrabyssin II has demonstrated efficacy in suppressing ovarian cancer organoid growth and inducing apoptosis, making it a valuable tool for research in ovarian cancer studies. -
Autophagy Inhibitor
EAD1 TFA is an autophagy inhibitor that plays a critical role in the regulation of plant growth and development, particularly in maize. This compound is preferentially expressed in the xylem of immature corn ears, where it facilitates the transport of malic acid. Its function is essential for proper ear length and kernel development, with alterations in EAD1 TFA expression correlating with changes in malic acid content. EAD1 TFA represents a valuable tool for researchers investigating the genetic basis of crop yield improvement. -
Autophagy Inducer
Imipramine-d4-1 is a deuterated derivative of Imipramine, primarily targeting autophagy induction. It exhibits significant antitumor activity through inhibition of Fascin1 and has a notable effect on serotonin transporter with an IC50 value of 32 nM. In cellular assays, Imipramine-d4-1 has been shown to stimulate autophagy in U-87MG glioma cells and induce apoptosis in HL-60 cells. Additionally, it demonstrates neuroprotective and immunomodulatory properties, making it valuable for various research applications in cancer biology and neurobiology. -
Autophagy Enhancer
IR-58 is a mitochondria-targeting near-infrared fluorophore that enhances autophagy. It effectively induces apoptosis in tumor cells by promoting excessive autophagy through the activation of the reactive oxygen species (ROS)-Akt-mTOR signaling pathway. This compound is valuable for research applications focused on cancer biology, autophagy modulation, and therapeutic development. -
Anticancer Agent
Tubulosine is an alkaloid that functions as a selective inhibitor of the Janus kinase 3 (JAK3) with an IC50 of 9.9 nM. It exhibits enhanced inhibition of JAK3 compared to other JAK family members, with IC50 values of 69.5 nM for JAK1, 84.9 nM for JAK2, and 76.3 nM for TYK2. Tubulosine induces both apoptotic and necrotic/autophagic cell death in cancer cells and disrupts peptide chain elongation in eukaryotic polysomes. This compound demonstrates promising anticancer activity, particularly in breast cancer cell lines, making it a valuable tool for cancer research. -
Autophagy Inducer
Autophagy Inducer 2 is a potent activator of autophagy, primarily targeting cellular mechanisms involved in this critical survival process. It demonstrates significant antiproliferative effects on MCF-7 breast cancer cells, with an IC50 value of 1.31 μM, and markedly reduces colony formation in these cells. By modulating cell-cycle-related proteins such as Cdk-1 and Cyclin B1, Autophagy Inducer 2 effectively induces cell cycle arrest in the G2/M phase. This compound offers valuable insights for research in breast cancer therapy and the regulation of autophagy. -
Autophagy Inhibitor/Ionic Compound
Ammonium chloride is an ionic compound known for its role as an autophagy inhibitor. By inducing intracellular alkalization, it can disrupt lysosomal function and alter enzymatic activity, leading to metabolic acidosis. This compound is widely utilized in research applications focused on autophagy modulation and lysosomal pathway studies. -
Autophagy Inhibitor; p62 ZZ Domain Inhibitor
XRK3F2 is a selective inhibitor of the p62 (sequestosome-1) ZZ domain, demonstrating potent inhibition of autophagy processes. This compound effectively blocks TNFα-induced signaling in bone marrow stromal cells and promotes apoptosis in multiple myeloma cells. XRK3F2 is valuable for research applications targeting multiple myeloma bone disease and acute myeloid leukemia, providing insights into cell survival mechanisms and autophagic regulation in hematological malignancies. -
Autophagy Inducer
Eupatilin is a lipophilic flavonoid extracted from Artemisia argyi Lévl. et Van. that acts as an autophagy inducer and PPARα agonist. It demonstrates significant anti-apoptotic, anti-oxidative, and anti-inflammatory activities. This compound is valuable for research in cellular stress responses, inflammation, and neuroprotection studies. -
Cytokinin Nucleoside/Autophagy Inhibitor
N6-Isopentenyladenosine, a cytokinin nucleoside, acts primarily as an autophagy inhibitor. This compound, derived from the mevalonate pathway, has demonstrated notable anti-melanoma activity. Additionally, it plays a critical role in RNA modification, enhancing the efficiency and accuracy of translation in certain tRNAs and regulating plant growth and differentiation. Research applications include investigations into autophagy-related mechanisms and the development of therapeutic strategies for melanoma. -
Autophagy Inducer
Oxyresveratrol is a potent autophagy inducer with significant antioxidant properties, exhibiting an IC50 of 28.9 µM against DPPH free radicals. It serves as a noncompetitive inhibitor of tyrosinase, demonstrating an IC50 value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol has been shown to exhibit antiviral activity against HSV-1, HSV-2, and varicella-zoster virus, as well as providing neuroprotective effects. This compound is valuable for research into cellular protection mechanisms and the regulation of metabolic processes. -
Autophagy Inducer
BGT226 is a dual inhibitor targeting PI3K and mTOR, demonstrating IC50 values of 4 nM, 63 nM, and 38 nM against PI3Kα, PI3Kβ, and PI3Kγ, respectively. This compound effectively induces autophagy, showcasing significant growth-inhibitory effects in human head and neck cancer cells. BGT226 is valuable for research in cancer biology and drug development focused on autophagy modulation and PI3K/mTOR signaling pathways. -
ATG7 Inhibitor
ATG7-IN-2 is a potent inhibitor of ATG7, demonstrating an IC50 of 0.089 μM. This compound effectively inhibits the autophagy marker LC3B, making it a valuable tool for studies involving autophagy modulation. Researchers can utilize ATG7-IN-2 to investigate the role of autophagy in various biological processes and disease states. -
Autophagy Inhibitor
DC-LC3in-D5 functions as an autophagy inhibitor by inhibiting the lipidation of LC3B. It effectively binds to LC3B and disrupts the interaction with LBP2, exhibiting an IC50 value of 200 nM. This compound is valuable in research focused on the modulation of autophagy, contributing to investigations of anti-HCV therapies and potential cancer treatments through autophagy inhibition. -
Autophagy Inducer
Sedanolide is a natural compound recognized for its role as an autophagy inducer. This compound exhibits significant anti-inflammatory and antioxidant properties, making it valuable in various biological research applications. Its ability to modulate cellular processes associated with autophagy allows researchers to explore its potential therapeutic effects in diseases linked to autophagic dysfunction. -
Autophagy Activator
Ginkgolide K is an autophagy activator derived from Ginkgo biloba. It stimulates protective autophagy by modulating the AMPK/mTOR/ULK1 signaling pathway, thereby promoting cellular survival. Additionally, Ginkgolide K exhibits neuroprotective properties, making it a valuable tool for research in neurobiology and cellular stress responses. -
Autophagy Inducer
Pyriproxyfen acts as a juvenile hormone analog, primarily targeting larval development by inhibiting the transition to adulthood. This mechanism effectively reduces reproductive capabilities in various insect species. Pyriproxyfen is widely utilized in chemical research to study autophagy induction and its implications in pest control and developmental biology. -
Autophagy Inhibitor
ATG7-IN-1 is a selective inhibitor of the autophagy-related protein ATG7, exhibiting an IC50 of 62 nM. This compound interferes with autophagy processes by disrupting the function of ATG7, making it a valuable tool for research in autophagy regulation. It is particularly useful for studies investigating the role of autophagy in various diseases, including cancer and neurodegenerative disorders. -
Autophagy Inducer
Pemetrexed disodium heptahydrate is an innovative antifolate that serves as an autophagy inducer. It effectively inhibits key enzymes including thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with Ki values of 1.3, 7.2, and 65 nM, respectively. This compound is valuable in research applications targeting metabolic pathways and autophagic processes in cancer and other diseases. -
Autophagy Inhibitor
Autogramin-2 is a potent autophagy inhibitor that effectively blocks autophagy triggered by nutrient deprivation, demonstrating an IC50 of 0.27 μM, as well as autophagy induced by mTORC1 inhibition with Rapamycin, with an IC50 of 0.14 μM. This compound is valuable for studying the role of autophagy in cellular processes and various diseases, including cancer and neurodegeneration. Its ability to modulate autophagic pathways makes it an essential tool for researchers investigating autophagy's impact on cell survival and metabolism. -
Autophagy Inducer
XIE62-1004-A is a potent inducer of p62-LC3 interaction, specifically targeting the ZZ-domain of p62. Its binding induces p62 oligomerization, thereby activating p62-dependent autophagy processes. This compound is valuable for research applications investigating the mechanisms of autophagy and its role in cellular homeostasis and disease. -
Autophagy Inducer
AMDE-1 is a potent autophagy inducer that activates the AMPK-mTORC1-ULK1 signaling pathway. While promoting autophagy, AMDE-1 also disrupts lysosomal function, thereby inhibiting autophagy-mediated degradation. This dual mechanism makes AMDE-1 a valuable tool for investigating autophagy-related processes in cancer research. -
Autophagy Inducer
Paroxetine hydrochloride hemihydrate is a selective serotonin reuptake inhibitor that also functions as an autophagy inducer. With an IC50 of 14 μM for GRK2 inhibition, it demonstrates potential in neuroprotective research and the study of mood disorders. This compound is suitable for investigations into its effects on cellular processes such as autophagy, neurobiology, and therapeutic applications for depression.
