Atg8/LC3

CAA-0225 is a selective inhibitor of the tissue protease L, specifically targeting TbCATL with an IC50 of 1.9 nM. This compound has demonstrated significant biological activity, including the degradation of autophagosome membrane markers such as LC3-II and GABARAP. Additionally, CAA-0225 improves cardiac function in models of reperfusion injury and exhibits efficacy against Trypanosoma brucei, highlighting its potential applications in cardiovascular research and parasitology studies.

TH152 is a reversible pan ligand targeting LC3/GABARAP, exhibiting a dissociation constant (KD) of 2 µM. This compound plays a critical role in autophagy regulation, making it valuable for studies investigating autophagic processes and cellular homeostasis. TH152 can be utilized in research delineating the roles of LC3/GABARAP in various biological systems and disease models.

K1 peptide is a high-affinity ligand for GABAA receptor-associated protein (GABARAP). It plays a crucial role in mediating protein interactions involved in cellular processes such as autophagy and synaptic transmission. K1 peptide is valuable for research applications focused on GABARAP function and its implications in neurobiology and cellular signaling pathways.