Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
GSK 1842799 hydrochloride is a selective agonist for the S1P1 receptor, exhibiting potent agonistic activity with notable selectivity over the S1P3 receptor. This compound demonstrates favorable oral bioavailability and is rapidly converted to its active phosphorylated form. In vivo studies reveal that GSK 1842799 hydrochloride significantly reduces blood lymphocyte counts after oral administration. Additionally, it has shown efficacy comparable to FTY720 in the mouse EAE model of multiple sclerosis, making it a valuable tool for research in immunology and neurodegenerative diseases. -
Endogenous Metabolite
Fenamidone is a potent agricultural fungicide that primarily targets mitochondrial respiratory complex II. It exhibits high biological activity against a range of plant pathogens, leading to effective disease control in various crops. Fenamidone is valuable in research applications focused on plant physiology, fungicide resistance mechanisms, and metabolic pathways in fungi. -
Endogenous Metabolite
SNAP-7941 is a selective antagonist of the melanin concentrating hormone receptor MCH1, exhibiting anxiolytic, antidepressant, and appetite-suppressant properties. In preliminary animal studies, SNAP-7941 demonstrated significant biological activity and the ability to inhibit MCH-induced drinking behavior, highlighting its potential for research in neuropharmacology and metabolic disorders. This compound serves as a valuable tool for investigating the role of MCH1 in various physiological processes. -
Endogenous Metabolite
1-Deoxysphingosine is an endogenous metabolite that acts as a deoxy-sphingoid base, characterized by a (4E) double bond in its structure. This compound is notably elevated in the lymphoblasts of individuals with hereditary sensory neuropathy type 1 (HSAN1), highlighting its potential relevance in neuropathic disorders. It is produced through the catabolism of 1-deoxyceramide, catalyzed by the ceramidase enzyme, making it a valuable target for research in sphingolipid metabolism and related cellular processes. -
Endogenous Metabolite
16-Ketoestradiol is an endogenous metabolite of estrone, a naturally occurring estrogen. It plays a critical role in the regulation of estrogenic activity within the body, influencing various physiological processes. This compound is important for research applications related to hormonal studies and the exploration of estrogen-related disorders. -
Endogenous Metabolite
Ocaphane is an endogenous metabolite with demonstrated potential as an antitumor agent. It exhibits significant cytotoxic activity against a variety of animal tumor models, making it a valuable tool for cancer research. This compound can be utilized to investigate tumor biology and evaluate therapeutic strategies in preclinical studies. -
Endogenous Metabolite
Kahalalide A is an anti-mycobacterial compound derived from the marine mollusk Elysia rufescens, targeting various microbial pathogens. This endogenous metabolite exhibits significant antimicrobial activity, making it a valuable candidate for research in natural product pharmacology. Its unique structure and bioactivity have garnered interest for potential therapeutic applications in combating infectious diseases. -
Endogenous Metabolite
p60 (217–225) is a subdominant epitope derived from Listeria monocytogenes, recognized by H-2Kd MHC class I molecules. This peptide plays a crucial role in the immune response to Listeria infection, facilitating T cell recognition and activation. p60 (217–225) is essential for studying antigen presentation and T cell immunity in infectious disease research and vaccine development. -
Endogenous Metabolite
ISQ-1 hydrochloride is an isoquinolinone compound that functions as an inhibitor of the IKur potassium channel. It demonstrates potential to influence cardiac electrophysiology by modulating arrhythmic activity in atrial tissues. This reagent is primarily utilized in research focused on cardiac rhythm disorders and electrophysiological studies of heart functions. -
Endogenous Metabolite
N4-Acetylsulfamerazine is a sulfonamide derivative that primarily targets endogenous metabolites. It exhibits antibiotic activity, specifically inhibiting bacterial growth through interference with folic acid synthesis. This compound is valuable for studying sulfonamide pharmacology and understanding metabolic pathways in microbial resistance. Its applications extend to research in infectious diseases and pharmacokinetics. -
Endogenous Metabolite
Altertoxin II is an endogenous metabolite derived from Alternaria alternata, known for its mutagenic properties. It exhibits mutagenicity in various strains of Salmonella typhimurium, including TA98, TA100, and TA1537, both in the presence and absence of metabolic activation. This compound serves as a valuable tool for investigating the mechanisms of mutagenesis associated with mycotoxins, contributing to understanding their impact on genetic material. -
Endogenous metabolite
4-Methyltridecane is an endogenous metabolite that is released by cabbage root flies (Delia radicum) during feeding. This volatile compound serves as a significant cue for the parasitoid bee Trybliographa rapae, aiding in the locational identification of its host. Additionally, 4-Methyltridecane can be utilized as a specific marker for detecting root damage in turnips (Brassica rapa subsp. rapa), making it valuable in studies of plant-insect interactions and pest management. -
Endogenous Metabolite
ML395 is a potent and selective allosteric inhibitor of phospholipase D2, demonstrating significant antiviral activity. With a cellular IC50 value for PLD2 of 360 nM and an IC50 value for PLD1 exceeding 30,000 nM, it exhibits remarkable selectivity. ML395 possesses favorable pharmacokinetic profiles in vitro and superior physicochemical properties compared to other phospholipase inhibitors. Its efficacy has been validated in cell-based assays against various strains of the influenza virus, including H1, H3, H5, and H7, making it a valuable tool for antiviral research. -
Endogenous Metabolite
C20 Sphingomyelin (d18:1/20:0) is a naturally occurring sphingolipid that targets cellular membranes and plays a critical role in various biological processes. It is associated with increased levels in the hippocampus of streptozotocin-induced diabetic rats, showing a positive correlation with insulin resistance in obese human subjects. Additionally, C20 Sphingomyelin (d18:1/20:0) is elevated in the liver of mouse models of Niemann-Pick C1 disease, a neurodegenerative disorder characterized by lysosomal storage of cholesterol and sphingolipids. This compound serves as a valuable tool for studying metabolic disorders and neurodegenerative diseases. -
Endogenous Metabolite
YM-355179 fumarate is a selective antagonist of the C-C chemokine receptor type 3 (CCR3), targeting eosinophil-related allergic inflammatory diseases. This compound effectively inhibits the binding of CCL11 and CCL5 to CCR3-expressing cells, exhibiting IC50 values of 7.6 nM and 24 nM, respectively. Functional assays demonstrate that YM-355179 fumarate inhibits CCL11-induced intracellular Ca(2+) influx, chemotaxis, and eosinophil degranulation, with IC50 values of 8.0 nM, 24 nM, and 29 nM, respectively. This makes it a valuable tool for researchers studying allergic inflammation and related conditions. -
Endogenous Metabolite
GS-9851 is a potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B), making it a valuable tool for researching HCV infection. This compound exhibits favorable tolerability, particularly in patients with initial HCV genotype 1 infections. Due to its pharmacokinetic profile, GS-9851 is rapidly eliminated from the body, with a half-life of approximately one hour. -
Endogenous Metabolite
Hydroxythiohomosildenafil is an endogenous metabolite of Sildenafil that plays a role in modulating erectile function. This compound is useful for investigating the pharmacokinetics and metabolic pathways associated with erectile dysfunction. Its biological activity provides insights into the mechanisms underlying penile erection and helps to evaluate therapeutic interventions in related vascular disorders. -
Endogenous Metabolite
Drimentine B is a terpenylated diketopiperazine that acts on endogenous metabolites. Demonstrating significant anticancer activity, it inhibits the proliferation of NS-1 murine β lymphocyte myeloma cells by 41% and 59% at concentrations of 50 and 100 μg/mL, respectively. This compound is valuable for research applications focusing on cancer biology and the exploration of novel therapeutic agents. -
Endogenous Metabolite
Tetranor-12(S)-HETE is an endogenous metabolite derived from the β-oxidation of 12(S)-HETE via peroxisomal metabolism in various tissues. This compound serves as a potential biomarker for psoriasis, facilitating research into the inflammatory processes associated with this skin condition. Its role in fatty acid metabolism makes it valuable for studies investigating related metabolic and inflammatory disorders. -
Endogenous Metabolite
5,6-Dihydro-5-methyluracil-d6 is a deuterium-labeled derivative of 5,6-Dihydro-5-methyluracil, which serves as an endogenous metabolite and an intermediate in the catabolism of thymine. This compound, also known as Dihydrothymine, is derived from both animal and plant sources. Elevated levels of 5,6-Dihydro-5-methyluracil may exhibit toxicity, making it relevant for research into metabolic pathways and potential toxicological studies. -
Endogenous Metabolite
FR 106969 is a potent platelet activating factor antagonist that exhibits anti-inflammatory properties. This compound is primarily utilized for its ability to mitigate inflammatory responses, making it valuable in the study of inflammation-related diseases. Research indicates that FR 106969 may offer significant inhibitory effects on various inflammatory pathways, contributing to its potential therapeutic applications in conditions characterized by excessive inflammation. -
Endogenous Metabolite
Xylamidine tosylate is a serotonin inhibitor that modulates the serotonin system and exhibits reproductive activity. This compound is instrumental in investigating reproductive processes and their underlying mechanisms. Xylamidine tosylate serves as a valuable tool in experimental research focused on serotonin's role in reproductive biology. -
Endogenous Metabolite
D-Ribofuranose serves as an endogenous metabolite that plays a crucial role in cellular metabolism. It is primarily involved in the synthesis of nucleotides and nucleic acids. Research applications include studies related to Ribose 5 Phosphate Isomerase Deficiency and Medium Chain Acyl-CoA Dehydrogenase Deficiency, providing insights into metabolic pathways and associated disorders. -
Fungal Metabolite
Gliorosein is a fungal metabolite derived from Gliocladium, functioning primarily as an isomeric variant of quinol. It exhibits distinct ultraviolet absorption characteristics, differentiating it from related compounds. This unique profile makes Gliorosein valuable for biological research applications, particularly in the study of fungal metabolism and ecological interactions. -
Endogenous Metabolite
Endopeptidase-IN-1 is a potent inhibitor of endopeptidase activity, targeting endogenous metabolites to regulate proteolytic processes. Its biological activity is crucial for research focused on protein processing, cellular signaling pathways, and the modulation of metabolic diseases. This compound is a valuable tool for investigating the role of endopeptidases in physiological and pathological conditions. -
Endogenous Metabolite
YM-75440 is an orally active inhibitor of squalene synthase, a key enzyme in the cholesterol biosynthesis pathway. This compound demonstrates significant biological activity in modulating lipid metabolism, making it useful for research on metabolic disorders and cardiovascular diseases. Its ability to inhibit squalene synthesis positions YM-75440 as a valuable tool for studying cholesterol-related pathways and potential therapeutic interventions. -
Endogenous Metabolite
Wofapyrin, a derivative of Rheumopyrin, primarily acts as an antipyretic and anti-inflammatory agent. This compound has demonstrated significant biological activity in reducing lesion volume, positioning it as a valuable reagent in studies focused on inflammation and fever regulation. Its application is pertinent for researchers investigating metabolic pathways and therapeutic interventions in inflammatory conditions. -
Endogenous Metabolite
alpha-RA-F (α-RA-F) is an endogenous metabolite that promotes collagen synthesis while reducing the expression levels of matrix metalloproteinases (MMPs). Its ability to enhance collagen production in human fibroblasts without cytotoxicity makes α-RA-F a valuable tool for research in tissue regeneration and skin health. This compound holds significant potential for applications in both pharmaceutical and cosmetic industries, particularly in the regulation of collagen dynamics and extracellular matrix remodeling. -
Endogenous Metabolite
R-(-)-Phencynonate hydrochloride is a muscarinic receptor antagonist that exhibits anticholinergic activity. This compound serves as a significant endogenous metabolite, making it integral for investigations related to its concentration in human plasma within medical research contexts. R-(-)-Phencynonate has been effectively analyzed using high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS), demonstrating excellent specificity and linearity for precise quantification. -
Endogenous Metabolite
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid featuring stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. This compound is generated through the oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by the enzyme 15-lipoxygenase in activated human peripheral mononuclear cells. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE serves as an endogenous metabolite, providing valuable insights into lipid metabolism and cell signaling pathways in various biological research applications. -
Endogenous Metabolite
ts-SA is a potent carbonic anhydrase (CA) inhibitor that demonstrates inhibitory activity against seven human CA homologues. It effectively binds to the Zn(II) ion in the enzyme's active site in its deprotonated form, with its organic structure extending into the enzyme cavity, facilitating interactions with amino acid residues and water molecules. With low nanomolar inhibitory activity, ts-SA serves as a multi-target CA inhibitor, making it valuable for research applications in enzymatic regulation and metabolic studies. -
Endogenous Metabolite
DY3002 is a highly selective and potent EGFR inhibitor specifically designed to target T790M-mutated variants associated with non-small cell lung cancer. This compound demonstrates a remarkable inhibitory effect on EGFR T790M mutants with an IC50 of 0.71 nM, while exhibiting significantly reduced activity against wild-type EGFR (IC50 = 448.7 nM). In cellular assays, DY3002 shows an IC50 of 0.037 μM against H1975 cells, indicating enhanced biological efficacy. Additionally, DY3002 maintains an extraordinary selectivity index (SI = 632.0) and does not induce hyperglycemia, making it a promising candidate for further research in overcoming drug resistance in cancer therapy. -
Endogenous Metabolite
Ro 31-1118 Free Base is an endogenous metabolite that exhibits weak antihypertensive activity. It has been shown to reduce heart rates and blood pressure following exercise at various doses, demonstrating linear pharmacokinetics within the 10-80 mg range. Notably, Ro 31-1118 does not significantly affect diastolic blood pressure and shows minimal adverse effects, making it a valuable compound for studies related to cardiovascular function and blood pressure regulation. -
Endogenous Metabolite
1,3-Dioleoyl-2-lauroyl glycerol is an endogenous metabolite recognized for its role in the triglyceride composition of human milk. This compound can be analyzed using liquid chromatography-mass spectrometry, facilitating targeted studies of lipid metabolism and nutritional research. Its characterization contributes to the understanding of dietary fats and their influence on human health. -
Fungal Metabolite
Burnettramic acid A aglycone is a fungal metabolite derived from Aspergillus burnettii, exhibiting potential antimicrobial properties. This compound may play a significant role in research focused on antifungal activity and the exploration of secondary metabolites in fungi. Its unique chemical structure and biological functions make it a valuable reagent for studies in microbiology and natural product chemistry. -
Endogenous Metabolite
11β-13,14-Dihydro-15-keto Prostaglandin F2α is an endogenous metabolite that serves as a derivative of 13,14-Dihydro-15-keto PGF2α. This compound plays a significant role in various biological processes, particularly in pregnancy-related research. Its biological activity may facilitate the investigation of prostaglandin pathways and their implications in reproductive health and pregnancy maintenance. -
Endogenous Metabolite
MAO-B-IN-35 is a potent, selective, reversible inhibitor of monoamine oxidase B (MAO-B). Demonstrating strong inhibitory activity, this compound has significant potential for research applications related to neurodegenerative disorders and the modulation of monoamine neurotransmitter levels. Its design allows for efficient synthesis and superior physicochemical properties, making it a valuable tool for studying MAO-B's role in various biological processes. -
Endogenous Metabolite
Pyrimidine-indole hybrid is an endogenous metabolite that functions primarily as an antagonist of the Hedgehog signaling pathway through the destabilization of microtubules. This compound demonstrates significant biological activity by inhibiting ciliogenesis and disrupting the stable form of α-tubulin. Its unique mechanism of action has been validated in in vitro cell studies and in zebrafish embryo models, making it a valuable tool for investigating microtubule dynamics and related signaling processes. -
Endogenous Metabolite
5'-Guanidinonaltrindole TFA is a selective antagonist of the kappa-opioid receptor, demonstrating significant opioid antagonist activity. It exhibits an antagonistic potency five times greater than that of norbinatorphimine in smooth muscle preparations, with a selectivity ratio exceeding 500-fold. Binding and functional studies reveal pA(2) values aligning with the smooth muscle data, indicating its effectiveness. This compound serves as a valuable pharmacological tool for investigating the role of kappa-opioid receptors in opioid research. -
Endogenous Metabolite
Dipotassium glucose-6-phosphate (D-Glucose-6-phosphate dipotassium salt dihydrate) is a phosphorylated sugar that targets endogenous metabolic pathways. As a key intermediate in carbohydrate metabolism, it plays a crucial role in glycolysis and gluconeogenesis. This compound is widely used in biochemical and physiological studies to investigate metabolic processes and enzyme activity related to glucose metabolism. -
Endogenous Metabolite
ML-7 is a myosin light chain kinase inhibitor that primarily targets the regulation of superoxide anion (O2(-)) release in human neutrophils. This compound effectively inhibits extracellular O2(-) release from stimulated cells while leaving intracellular O2(-) production unaffected. Additionally, ML-7 has been shown to modulate neutrophil activity independently of myosin light chain kinase and offers protective effects on cardiac function during ischemia/reperfusion injury. Its unique properties make it valuable for research in inflammation and cardiac protection mechanisms. -
Endogenous Metabolite
Nafenopin is an endogenous metabolite that acts as a peroxidase proliferator, demonstrating liver tumor-promoting activity. This compound is recognized for its role in managing hyperlipoproteinemia and inducing oxidative stress in vivo, particularly in hepatic tissue. Nafenopin's unique mechanisms of action differentiate it from other non-genotoxic carcinogens, making it a valuable tool for research related to liver pathology and metabolic disorders. -
Endogenous Metabolite
Cellobiosan is an anhydrosugar derived from the combustion of biomass. As an endogenous metabolite, it plays a significant role in various biological processes, including energy metabolism and carbohydrate digestion. Cellobiosan is utilized in research applications focusing on metabolic pathways, the environmental impact of biomass burning, and the study of carbohydrate-derived compounds. -
Endogenous Metabolite
2,4-D methyl ester is an endogenous metabolite that serves as a biostimulant, promoting the accumulation of key nutritional and medicinal components. This compound has been shown to enhance the production of bioactive constituents in Cordyceps militaris, exhibiting an inductive effect that is concentration-dependent. Research applications include improving the fruit quality of Cordyceps militaris, making 2,4-D methyl ester a valuable tool for enhancing natural product yields in various biological studies. -
Endogenous Metabolite
04:1 Coenzyme A trisodium is a specific form of coenzyme A (CoA) characterized by a four-carbon acyl chain with one double bond. This reagent plays a critical role in various biochemical pathways, facilitating the transfer of acyl groups and participating in lipid metabolism. It is essential for studying metabolic processes, enzymatic reactions, and cellular signaling mechanisms involving acyl-CoA derivatives. -
Endogenous Metabolite
Xanthosine dihydrate is a nucleoside that serves as an endogenous metabolite, derived from xanthine and ribose. It has been shown to enhance the population of mammary stem cells and promote milk production in livestock such as cattle and goats. This compound is valuable for research in metabolic regulation and agricultural biotechnology. -
Endogenous Metabolite
Monononadecanoin is an endogenous metabolite known for its anti-inflammatory and antioxidant properties. This lipid compound is utilized in various research applications related to skin moisturization and repair, as well as flavor enhancement and preservation in food products. Its biological activities make it a valuable tool in studying skin health and food science. -
Endogenous Metabolite
Amino acid arylamidase, derived from hog kidney, is a metalloprotease that specifically hydrolyzes proteins or peptides with free α-amino or α-imino groups. This enzyme plays a significant role in amino acid metabolism and protein digestion. Its activity can be inhibited through N-terminal acetylation, making it a valuable tool in studies related to hepatic diseases, biliary disorders, and heart failure research. -
Endogenous Metabolite
2-(1-Hydroxypentyl)benzoic acid is an endogenous metabolite with potential therapeutic implications in the treatment of acute ischemic stroke (AIS). This compound may exert neuroprotective effects, making it a valuable candidate for research aimed at understanding stroke pathophysiology and developing novel therapeutic strategies. Its role in metabolic pathways and cellular signaling may provide insights into neuroprotection and recovery processes after ischemic events. -
Endogenous Metabolite
D-Glyceric acid calcium hydrate is an endogenous metabolite primarily involved in metabolic processes. It serves as a valuable research tool for studying primary hyperoxaluria type I and glutaric acidemia type 2. Its biological significance makes it useful in exploring metabolic disorders and related conditions.
