Fig. 1 · Structure
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1-Aminocyclopropane-1-carboxylic acid
Cat. No.
A71175
CAS
22059-21-8
Endogenous Metabolite
1-Aminocyclopropane-1-carboxylic acid (ACC) is an endogenous metabolite that primarily targets NMDA receptors. At low glutamate concentrations, ACC functions as a small molecule agonist, enhancing NMDA receptor activity with an EC50 of 0.7-0.9 μM, while at high glutamate concentrations, it acts as a competitive antagonist with an EC50 of 81.6 nM. This dual action contributes to its neuroprotective effects, preventing neuronal cell death in ischemic models and inducing blood pressure reduction in hypertensive rats. Additionally, ACC has been shown to enhance object recognition memory and cognitive flexibility without affecting impulsivity, making it a valuable compound for studies in neurotoxicity and cognitive function.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 22059-21-8 |
| Applications | Endogenous Metabolite |
| Formula | C4H7NO2 |
| Molecular Weight | 101.10 |
| SMILES | O=C(O)C1(N)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.