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PBI-6DNJ

Catalog No.: A75123
α-Glucosidase Inhibitor
PBI-6DNJ is a potent α-glucosidase inhibitor that functions as a multivalent glycosidase inhibitor. It demonstrates significant inhibitory activity against mouse α-glucosidase, with an affinity constant (Ki) of 0.14 μM. The compound also exhibits notable hypoglycemic effects, making it a valuable tool for research related to type 2 diabetes.
PBI-6DNJ 2857098-72-5 α-Glucosidase Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPBI-6DNJ is a potent α-glucosidase inhibitor that functions as a multivalent glycosidase inhibitor. It demonstrates significant inhibitory activity against mouse α-glucosidase, with an affinity constant (Ki) of 0.14 μM. The compound also exhibits notable hypoglycemic effects, making it a valuable tool for research related to type 2 diabetes.
Product Information
Catalog NumA75123
FormulaC120H146N26O36
Molecular Weight2528.60
CAS Number2857098-72-5
SMILESOC[C@H]1[C@@H]([C@H]([C@@H](CN1CCCN2C=C(COC3=CC=C(C=C3)OC4=CC(C(N5CC6=CN(CCCN7[C@@H](CO)[C@@H]([C@H]([C@@H](C7)O)O)O)N=N6)=O)=C8C9=C4C%10=C%11C(C(C%12=O)=CC(OC%13=CC=C(C=C%13)OCC%14=CN(CCCN%15[C@H](CO)[C@H]([C@@H]([C@H](C%15)O)O)O)N=N%14)=C%11C9=C(C=C8C5=O)OC%16=CC=C(C=C%16)OCC%17=CN(CCCN(C[C@H]([C@@H]([C@H]%18O)O)O)[C@H]%18CO)N=N%17)=C(C=C%10OC%19=CC=C(OCC%20=CN(CCCN%21[C@H](CO)[C@H]([C@@H]([C@H](C%21)O)O)O)N=N%20)C=C%19)C(N%12CC%22=CN(CCCN%23[C@H](CO)[C@H]([C@@H]([C@H](C%23)O)O)O)N=N%22)=O)N=N2)O)O)O
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Metabolism > Glucosidase