endo-BCN-PEG2-alcohol is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bicyclo[6.1.0]nonyne (BCN) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its application in PROTAC development facilitates targeted protein degradation and offers significant potential for therapeutic research in various diseases.
endo-BCN-PEG2-alcohol is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bicyclo[6.1.0]nonyne (BCN) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its application in PROTAC development facilitates targeted protein degradation and offers significant potential for therapeutic research in various diseases.
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