Catalog No.
Product Name
Application
Product Information
Citations
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tubulin polymerization inhibitor
Crolibulin, also known as EPC2407 and crinobulin, is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. - Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.
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microtubule destabilizing agents
Tubulysin family of secondary metabolites are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizing agents with IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties. Tubulysins have limited therapeutic utility due to severe toxicity, so Tubulysins are ideal candidates to be incorporated into molecule drug conjugate (SMDC) delivery system. -
tubulin inhibitor
Tubulin inhibitor 1 is a tubulin inhibitor, inhibits tubulin polymerization. -
tubulin polymerization inhibitor
MC-Sq-Cit-PAB-Dolastatin10 is a drug-linker conjugate for ADC with potent antitumor activity by using Dolastatin10 (a tubulin polymerization inhibitor), linked via the ADC linker MC-Sq-Cit-PAB. -
Microtubule inhibitor
VCP-Eribulin consists the ADCs linker (VCP) and Eribulin. Eribulin is a mechanistically unique microtubule inhibitor for cancer. VCP-Eribulin is an Eribulin-based drug for antibody conjugates. -
Microtubule inhibitor
Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin. Eribulin is a mechanistically unique microtubule inhibitor for cancer. Mal-PEG2-VCP-Eribulin is an Eribulin-based drug for antibody conjugates. -
oral α and β tubulin inhibitor
VERU-111 is a novel, oral α and β tubulin inhibitor that blocks tubulin polymerization and is not a substrate for multi-drug resistance mechanisms. -
Microtubule assembly inhibitor
Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 8.79?nM, and exhibits a broad-spectrum anthelmintic activity. -
Microtubule polymerization inhibitor
Cucurbitacin B, a natural triterpenoid is well-known for its strong anticancer activity, and recent studies showed that the compound inhibits JAK/STAT3 pathway. Also it is an potent Microtubule polymerization inhibitor - 7-Epi 10-Desacetyl Paclitaxel is a derivative of Paclitaxel, which is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
- 7-xylosyltaxol is a taxol derivative, Paclitaxel binds to tubulin and inhibits the disassembly of microtubules.
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Microtubule/Tubulin Inhibitor
Tubulysin B is a potent microtubule destabilizing agent that selectively inhibits tubulin polymerization. Naturally derived from the myxobacteria Archangium geophyra and Angiococcus disciformis, it exhibits high cytotoxicity with IC50 values in the picomolar range across various cancer cell lines, including those exhibiting multidrug resistance. This compound is valuable for studies focused on cancer biology, specifically in elucidating mechanisms of cell cycle arrest and apoptosis. -
Src/Tubulin Inhibitor
KX2-361 is an inhibitor of Src-kinase and tubulin polymerization. This compound exhibits significant anti-tumor activity and induces apoptosis in glioblastoma (GBM) cells. With good oral bioavailability and the ability to cross the blood-brain barrier in murine models, KX2-361 is a valuable tool for investigating Src-related signaling pathways and therapeutic strategies in cancer research. -
Tubulin/JAK2-IN-1 inhibitor, Antitumor
Tubulin/JAK2-IN-1 is a dual inhibitor targeting Janus kinase 2 (JAK2) and microtubules, exhibiting potent antitumor activity. This compound demonstrates significant antiproliferative effects against various cancer cell lines, making it a valuable tool in cancer research. Its dual mechanism of action supports investigations into therapies that disrupt cell division and signaling pathways in malignancies. -
Tubulin Polymerization Inhibitor
SB-216 is a tubulin polymerization inhibitor that penetrates the blood-brain barrier. It demonstrates significant antitumor activity by inhibiting tumor cell proliferation and migration, as well as inducing apoptosis and cell cycle arrest. With favorable in vivo metabolic stability and low toxicity, SB-216 is suitable for research applications focused on various tumors, including melanoma, although its oral bioavailability is limited. -
Microtubule Stabilizer
Taccalonolide E is a microtubule stabilizer that enhances microtubule polymerization and stability, leading to disruption of mitotic spindle formation. This compound effectively induces apoptosis in various cancer cell types by activating pathways associated with cell cycle arrest. Taccalonolide E is useful for research involving cancer biology, specifically in studies targeting microtubule dynamics and apoptotic mechanisms. -
Tubulin Polymerization Inhibitor
MPT0B014 is a potent tubulin polymerization inhibitor that disrupts microtubule dynamics. This compound has been shown to induce apoptosis in cancer cells, making it a valuable tool for studying cancer biology and therapeutic interventions. MPT0B014 is suitable for research focused on cancer treatment strategies and cellular response to microtubule-targeting agents. -
Tubulin inhibitor
Tubulin inhibitor 11 is a potent inhibitor of tubulin that acts by targeting the colchicine binding site on tubulin. It effectively inhibits tubulin polymerization, resulting in mitotic blockade and the induction of apoptosis. This compound is a valuable tool for research applications investigating cell division, cancer biology, and the mechanisms of drug resistance. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-56 is a potent inhibitor of tubulin polymerization that targets the colchicine binding site. This indazole derivative effectively induces cell cycle arrest and promotes cellular apoptosis. Additionally, Tubulin polymerization-IN-56 reduces cell migration, resulting in significant inhibition of tumor growth in vivo and demonstrating its potential for cancer research applications. -
Tubulin Polymerization Inhibitor
Thiocolchicine is a tubulin polymerization inhibitor that exhibits enhanced biological properties compared to its parent compound, colchicine. With an IC50 of 2.5 µM, it competitively binds to tubulin with a Ki of 0.7 µM, effectively disrupting microtubule dynamics and inducing cell apoptosis. Thiocolchicine serves as a valuable cytotoxin in antibody-drug conjugate (ADC) technology, making it an important reagent for cancer research and therapeutic development. -
Microtubulin polymerization Inhibitor
MY-1442 is a microtubulin polymerization inhibitor that functions by targeting colchicine binding sites on tubulin. This compound exhibits significant anticancer activity, effectively inducing apoptosis in MGC-803 cells. Additionally, MY-1442 has been shown to inhibit cell migration, making it a valuable reagent for research applications in cancer biology and cell motility studies. -
Tubulin Inhibitor
FC-116 is a potent tubulin inhibitor that disrupts microtubule dynamics, leading to the inhibition of colorectal cancer (CRC) cell proliferation. It demonstrates significant activity with IC50 values of 4.52 nM in HCT116 cells and 18.69 nM in CT26 cells. By inducing endoplasmic reticulum stress and generating excess reactive oxygen species (ROS), FC-116 promotes mitochondrial damage and apoptosis in CRC cells. This compound also exhibits substantial anti-tumor effects in vivo, making it a valuable reagent for colorectal cancer research. -
Tubulin Inhibitor
Taltobulin trifluoroacetate is a potent tubulin inhibitor that targets microtubule dynamics. This synthetic analogue of hemiasterlin effectively inhibits the polymerization of purified tubulin, leading to disrupted microtubule organization within cells. Taltobulin trifluoroacetate induces mitotic arrest and apoptosis, making it a valuable compound for research in cancer biology and studies focused on overcoming P-glycoprotein-mediated drug resistance. -
Microtubule-destabilizing Agent
Antiproliferative agent-23 is a microtubule-destabilizing agent that disrupts the tubulin-microtubule system. It induces apoptosis through a mitochondrion-dependent mechanism by downregulating Bcl-2, while upregulating Bax and Cyt c proteins, thereby activating the caspase cascade. Additionally, antiproliferative agent-23 triggers reactive oxygen species (ROS)-mediated endoplasmic reticulum stress in A549/CDDP cells via the PERK/ATF4/CHOP signaling pathway, demonstrating significant anti-tumor activity. This compound is suitable for research applications aimed at understanding cancer biology and therapeutic interventions. -
Antimicrotubule Chemotherapy Agent
Estramustine phosphate is an estradiol analog that functions as an orally active antimicrotubule chemotherapy agent. By binding to microtubule-associated proteins (MAPs) and/or tubulin, it depolymerizes microtubules, disrupting mitosis and promoting cell death through apoptosis. This compound is predominantly utilized in cancer research, particularly for studies related to prostate cancer. -
IDO/Tubulin Inhibitor
IDO/Tubulin-IN-2 is a potent inhibitor targeting both indoleamine 2,3-dioxygenase (IDO) and tubulin. This compound exhibits significant anticancer activity, demonstrated by its effect on various cell lines, including U87, HepG2, A549, HCT-116, and LO2, with IC50 values of 0.43, 0.036, 0.041, 0.095, and 1.04 μM, respectively. IDO/Tubulin-IN-2 is valuable for research applications in cancer biology, particularly in elucidating mechanisms of tumorigenesis and therapeutic resistance. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-61 is a potent tubulin polymerization inhibitor that disrupts microtubule dynamics, leading to the destruction of the microtubule skeleton. This compound effectively blocks the cell cycle at the G2/M phase, inducing apoptosis and inhibiting cancer cell migration and colony formation. In preclinical studies, Tubulin polymerization-IN-61 demonstrates significant antitumor activity in the 4T1 xenograft model, highlighting its potential for cancer research and therapeutic applications. -
Tubulin Polymerization Inhibitor
Tubulin Inhibitor 33 is a tubulin polymerization inhibitor that disrupts microtubule assembly in a dose-dependent manner, with an IC50 of 9.05 μM. This compound exhibits significant antitumor activity by promoting apoptosis in cancer cells. Tubulin Inhibitor 33 is a valuable reagent for research focusing on cancer biology and the mechanisms of tumorigenesis. -
Tubulin/MMP Inhibitor
Tubulin/MMP-IN-2 is a dual inhibitor targeting both tubulin and matrix metalloproteinases (MMPs). It effectively inhibits tubulin polymerization, leading to induced apoptosis in cancer cells. Additionally, Tubulin/MMP-IN-2 demonstrates inhibitory activity against MMP-2, MMP-3, and MMP-9, with IC50 values of 24.95 μM, 31.60 μM, and 22.37 μM, respectively. This compound is valuable for research focused on cancer biology and therapeutic development. -
Tubulin Ligand
SL-3-19 is a tubulin ligand that inhibits microtubule assembly, leading to significant antitumor activity against esophageal squamous cell carcinoma (ESCC) in both in vitro and in vivo models. This compound induces G2/M phase cell cycle arrest and apoptosis, while also disrupting tumor vascularization. SL-3-19 serves as a valuable reagent for research focused on ESCC and related malignancies. -
Microtubule-Binding Molecule
Myoseverin is a microtubule-binding molecule that acts as an angiogenesis inhibitor. This compound induces the reversible fission of multinucleated myotubes into mononucleated fragments, thereby affecting muscle cell dynamics. Additionally, Myoseverin demonstrates anti-angiogenic properties by inhibiting both endothelial cell function and the differentiation of endothelial progenitor cells. Its unique mechanism makes it a valuable tool for research in muscle biology and vascular development. -
Tubulin Inhibitor
Antiproliferative agent-30 is a tubulin inhibitor that disrupts tubulin assembly and effectively inhibits FLT3 and Abl1 activity. This compound demonstrates impressive antiproliferative effects against various cancer cell lines, exhibiting IC50 values of 0.054 nM, 0.008 nM, and 0.144 nM for HCT-116, K562, and MV-4-11 cells, respectively. Additionally, Antiproliferative agent-30 shows potential in targeting acute myeloid leukemia (AML) cells with FLT3-ITD-TKD mutations, highlighting its significance in cancer research and potential therapeutic applications. -
Microtubule Inhibitor
MPT0B002 is a potent microtubule inhibitor that targets tubulin polymerization, leading to significant anticancer effects. This compound induces apoptosis and effectively arrests the cell cycle at the G2/M phase. MPT0B002 is useful in various cancer research applications, providing insights into microtubule dynamics and the mechanisms of tumor cell proliferation. -
Tubulin/VEGFR Inhibitor
Tubulin/VEGFR-2-IN-2 is an orally active inhibitor targeting tubulin and VEGFR-2, exhibiting IC50 values of 3.27 μM and 0.09 μM, respectively. This compound demonstrates significant antitumor activity by enhancing reactive oxygen species generation, disrupting mitochondrial membrane potential, inducing apoptosis, and arresting the cell cycle. Additionally, Tubulin/VEGFR-2-IN-2 possesses anti-angiogenic effects, impairing endothelial cell migration, invasion, and tube formation in vitro. It effectively suppresses angiogenesis, tumor growth, and metastasis in vivo, making it a valuable tool for research involving non-small cell lung cancer, breast cancer, gastric cancer, and lymphoma. -
Tubulin polymerization Inhibitor
Tubulin polymerization-IN-11 is a potent inhibitor of tubulin polymerization with an IC50 value of 3.4 μM. It demonstrates significant antiproliferative activity by inducing apoptosis and causing cell cycle arrest at the G2/M phase. Mechanistically, Tubulin polymerization-IN-11 reduces the expression levels of cyclin B1, phosphorylated cdc2, and Bcl-2 while increasing the expression of cleaved PARP, making it valuable for research in cancer biology and cell cycle regulation. -
Tubulin Polymerization Inhibitor
Tubulin Inhibitor 17 is a potent tubulin polymerization inhibitor, demonstrating an IC50 value of 12.38 µM. This compound exhibits significant anticancer activity by inducing apoptosis in tumor cells. It is suitable for research applications focused on cancer biology and the study of microtubule dynamics.
