Catalog No.
Product Name
Application
Product Information
Citations
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tubulin inhibitor
altobulin (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin. -
cytotoxic tubulin modifier
Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAF analog and cytotoxin in Antibody-drug conjugates. Auristatin F inhibits cell division by blocking the polymerisation of tubulin. -
cytotoxic tubulin modifier
Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates. Auristatin E inhibits cell division by blocking the polymerisation of tubulin. - Dolastatin 10 (DLS 10) is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia, that inhibits tubulin polymerization.
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tubulin inhibitor
Tubulin inhibitor 1 is a tubulin inhibitor, inhibits tubulin polymerization. -
tubulin polymerization inhibitor
MC-Sq-Cit-PAB-Dolastatin10 is a drug-linker conjugate for ADC with potent antitumor activity by using Dolastatin10 (a tubulin polymerization inhibitor), linked via the ADC linker MC-Sq-Cit-PAB. -
Microtubule inhibitor
VCP-Eribulin consists the ADCs linker (VCP) and Eribulin. Eribulin is a mechanistically unique microtubule inhibitor for cancer. VCP-Eribulin is an Eribulin-based drug for antibody conjugates. -
Microtubule inhibitor
Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin. Eribulin is a mechanistically unique microtubule inhibitor for cancer. Mal-PEG2-VCP-Eribulin is an Eribulin-based drug for antibody conjugates. -
oral α and β tubulin inhibitor
VERU-111 is a novel, oral α and β tubulin inhibitor that blocks tubulin polymerization and is not a substrate for multi-drug resistance mechanisms. -
Microtubule assembly inhibitor
Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 8.79?nM, and exhibits a broad-spectrum anthelmintic activity. -
Microtubule polymerization inhibitor
Cucurbitacin B, a natural triterpenoid is well-known for its strong anticancer activity, and recent studies showed that the compound inhibits JAK/STAT3 pathway. Also it is an potent Microtubule polymerization inhibitor - 7-Epi 10-Desacetyl Paclitaxel is a derivative of Paclitaxel, which is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
- 7-xylosyltaxol is a taxol derivative, Paclitaxel binds to tubulin and inhibits the disassembly of microtubules.
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tubulin polymerization inhibitor
Crolibulin, also known as EPC2407 and crinobulin, is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. - Estramustine phosphate sodium is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.
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microtubule destabilizing agents
Tubulysin family of secondary metabolites are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizing agents with IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties. Tubulysins have limited therapeutic utility due to severe toxicity, so Tubulysins are ideal candidates to be incorporated into molecule drug conjugate (SMDC) delivery system. -
Microtubule/Tubulin Inhibitor
Tubulysin B is a potent microtubule destabilizing agent that selectively inhibits tubulin polymerization. Naturally derived from the myxobacteria Archangium geophyra and Angiococcus disciformis, it exhibits high cytotoxicity with IC50 values in the picomolar range across various cancer cell lines, including those exhibiting multidrug resistance. This compound is valuable for studies focused on cancer biology, specifically in elucidating mechanisms of cell cycle arrest and apoptosis. -
Src/Tubulin Inhibitor
KX2-361 is an inhibitor of Src-kinase and tubulin polymerization. This compound exhibits significant anti-tumor activity and induces apoptosis in glioblastoma (GBM) cells. With good oral bioavailability and the ability to cross the blood-brain barrier in murine models, KX2-361 is a valuable tool for investigating Src-related signaling pathways and therapeutic strategies in cancer research. -
Tubulin/JAK2-IN-1 inhibitor, Antitumor
Tubulin/JAK2-IN-1 is a dual inhibitor targeting Janus kinase 2 (JAK2) and microtubules, exhibiting potent antitumor activity. This compound demonstrates significant antiproliferative effects against various cancer cell lines, making it a valuable tool in cancer research. Its dual mechanism of action supports investigations into therapies that disrupt cell division and signaling pathways in malignancies. -
Microtubule-Binding Molecule
Myoseverin is a microtubule-binding molecule that acts as an angiogenesis inhibitor. This compound induces the reversible fission of multinucleated myotubes into mononucleated fragments, thereby affecting muscle cell dynamics. Additionally, Myoseverin demonstrates anti-angiogenic properties by inhibiting both endothelial cell function and the differentiation of endothelial progenitor cells. Its unique mechanism makes it a valuable tool for research in muscle biology and vascular development. -
Tubulin Inhibitor
Antiproliferative agent-30 is a tubulin inhibitor that disrupts tubulin assembly and effectively inhibits FLT3 and Abl1 activity. This compound demonstrates impressive antiproliferative effects against various cancer cell lines, exhibiting IC50 values of 0.054 nM, 0.008 nM, and 0.144 nM for HCT-116, K562, and MV-4-11 cells, respectively. Additionally, Antiproliferative agent-30 shows potential in targeting acute myeloid leukemia (AML) cells with FLT3-ITD-TKD mutations, highlighting its significance in cancer research and potential therapeutic applications. -
Microtubule Inhibitor
MPT0B002 is a potent microtubule inhibitor that targets tubulin polymerization, leading to significant anticancer effects. This compound induces apoptosis and effectively arrests the cell cycle at the G2/M phase. MPT0B002 is useful in various cancer research applications, providing insights into microtubule dynamics and the mechanisms of tumor cell proliferation. -
Tubulin/VEGFR Inhibitor
Tubulin/VEGFR-2-IN-2 is an orally active inhibitor targeting tubulin and VEGFR-2, exhibiting IC50 values of 3.27 μM and 0.09 μM, respectively. This compound demonstrates significant antitumor activity by enhancing reactive oxygen species generation, disrupting mitochondrial membrane potential, inducing apoptosis, and arresting the cell cycle. Additionally, Tubulin/VEGFR-2-IN-2 possesses anti-angiogenic effects, impairing endothelial cell migration, invasion, and tube formation in vitro. It effectively suppresses angiogenesis, tumor growth, and metastasis in vivo, making it a valuable tool for research involving non-small cell lung cancer, breast cancer, gastric cancer, and lymphoma. -
Tubulin polymerization Inhibitor
Tubulin polymerization-IN-11 is a potent inhibitor of tubulin polymerization with an IC50 value of 3.4 μM. It demonstrates significant antiproliferative activity by inducing apoptosis and causing cell cycle arrest at the G2/M phase. Mechanistically, Tubulin polymerization-IN-11 reduces the expression levels of cyclin B1, phosphorylated cdc2, and Bcl-2 while increasing the expression of cleaved PARP, making it valuable for research in cancer biology and cell cycle regulation. -
Tubulin Polymerization Inhibitor
Tubulin Inhibitor 17 is a potent tubulin polymerization inhibitor, demonstrating an IC50 value of 12.38 µM. This compound exhibits significant anticancer activity by inducing apoptosis in tumor cells. It is suitable for research applications focused on cancer biology and the study of microtubule dynamics. -
Microtubule Inhibitor
4SC-207 is a potent microtubule inhibitor that induces cell cycle arrest and apoptosis by obstructing microtubule growth. This compound effectively inhibits tumor cell proliferation both in vitro and in vivo, demonstrating significant activity against taxane-resistant xenograft mouse models. 4SC-207 is suitable for cancer research applications, particularly in the study of colon adenocarcinoma and other malignancies. -
Tubulin/HDAC Inhibitor
Tubulin/HDAC-IN-1 is a dual inhibitor targeting tubulin and histone deacetylase 8 (HDAC8) through CH/π interaction and hydrogen bonding, respectively. This compound effectively inhibits tubulin polymerization and selectively inhibits HDAC8 with an IC50 value of 150 nM. Tubulin/HDAC-IN-1 demonstrates cytotoxic effects against a range of human cancer cell lines, induces cell cycle arrest in the G2/M phase, and promotes apoptosis. It is a valuable reagent for research involving hematologic malignancies and solid tumors, including neuroblastoma and leukemia. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-28 is a selective inhibitor of microtubule protein polymerization, primarily targeting tubulin. This compound demonstrates significant anticancer activity by activating NQO1, leading to the release of combretastatin A-4, which promotes apoptosis in tumor cells. Tubulin polymerization-IN-28 is valuable for research applications focused on cancer therapy and the mechanisms of cell death. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-60 is a tubulin polymerization inhibitor that targets the colchicine binding site on tubulin, effectively disrupting microtubule assembly. This compound induces cell cycle arrest at the G2/M phase, leading to increased apoptosis in cancer cells. It serves as a valuable tool in cancer research, enabling the study of microtubule dynamics and the development of novel therapeutic strategies against malignant tumors. -
Tubulin Inhibitor
Tubulin polymerization-IN-9 is a potent inhibitor of tubulin polymerization, exhibiting an IC50 value of 1.82 μM. This compound effectively induces cell cycle arrest at the G2/M phase and triggers apoptosis in K562 cells, accompanied by depolarization of mitochondria. Tubulin polymerization-IN-9 demonstrates significant anti-vascular and antitumor activities, making it a valuable tool in cancer research and therapeutic studies. -
Tubulin Inhibitor
Tubulin Inhibitor 23 is a potent inhibitor of tubulin with an IC50 value of 4.8 µM. This compound induces apoptosis in cancer cells and exhibits antiangiogenic activity in a dose-dependent manner. Tubulin Inhibitor 23 is relevant for research applications related to leukemia and other malignancies involving aberrant angiogenesis and cell proliferation. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-13 is an inhibitor of tubulin polymerization, exhibiting an IC50 of 0.37 μM. This compound demonstrates significant anti-proliferative activity against various cancer cell lines, inducing apoptosis and potentially exhibiting antivascular properties. It serves as a valuable tool for research focused on cancer therapeutics and the mechanisms of cell division. -
Tubulin Inhibitor
Tubulin Inhibitor 14 targets NQO2 (quinone oxidoreductase 2) and exhibits a potent inhibitory effect with an IC50 of 1.0 μM. It disrupts tubulin polymerization and impedes the formation of capillary-like structures in endothelial cells. This microtubule-destabilizing agent possesses potential tumor-selectivity and exhibits antiangiogenic and vascular-disruptive properties, making it valuable for research in cancer biology and angiogenesis. -
Tubulin polymerization Inhibitor
Tubulin polymerization-IN-4 is a potent inhibitor of tubulin polymerization, exhibiting an IC50 value of 4.6 μM. This compound effectively disrupts tubulin dynamics, leading to cell cycle arrest at the G2/M phase, induction of apoptosis, and inhibition of both clonogenesis and migration in HeLa cells. Tubulin polymerization-IN-4 serves as a valuable tool in research related to cervical cancer, facilitating the exploration of therapeutic strategies targeting tubulin dynamics. -
Tubulin Inhibitor
Disorazol A is a potent tubulin inhibitor that disrupts microtubule formation by hindering tubulin polymerization. This action effectively blocks mitosis, leading to cell cycle arrest at the G2/M phase and subsequent induction of apoptosis. Additionally, Disorazol A has demonstrated inhibitory effects on L929 mouse fibroblasts, with an IC50 value of 3 pM, and promotes the accumulation of p53 protein within the nucleus. This compound holds potential for research in cancer biology and therapeutic applications. -
Tubulin/NRP1 Inhibitor
Tubulin/NRP1-IN-1 is a dual inhibitor targeting tubulin and neuropilin-1 (NRP1), exhibiting IC50 values of 0.71 μM and 0.85 μM, respectively. This compound effectively decreases the viability of prostate tumor cell lines and promotes apoptotic processes. Its unique mechanism makes it a valuable tool for studying cancer biology and exploring potential therapeutic strategies.
