Catalog No.
Product Name
Application
Product Information
Citations
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Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-17 is a potent inhibitor of tubulin polymerization, effectively disrupting microtubule dynamics. This compound induces depolymerization of tubulin, leading to apoptosis in cancer cells and inhibiting their migratory capabilities. Tubulin polymerization-IN-17 is valuable for research focused on cancer biology and therapies targeting microtubule dynamics. -
Tubulin polymerization inhibitor
Tubulin polymerization-IN-84 is a selective inhibitor of tubulin polymerization that targets the colchicine-binding site, exhibiting an IC50 of 10.9 μM. This compound demonstrates significant antiproliferative effects against various cancer cell lines, including Jurkat, B16-F10, HCT116, and MDA-MB-231, with IC50 values of 60 nM, 380 nM, 138 nM, and 1.054 μM, respectively. Tubulin polymerization-IN-84 induces G2/M-phase arrest and promotes apoptosis in B16-F10 cells, while also suppressing tumor growth in a B16-F10 melanoma model. Additionally, it enhances anti-tumor immunity in conjunction with PD-L1 monoclonal antibodies, making it a valuable reagent for research in T-cell acute lymphoblastic leukemia, melanoma, colon cancer, and breast cancer studies. -
Microtubule-Binding Molecule
Myoseverin is a microtubule-binding molecule that acts as an angiogenesis inhibitor. This compound induces the reversible fission of multinucleated myotubes into mononucleated fragments, thereby affecting muscle cell dynamics. Additionally, Myoseverin demonstrates anti-angiogenic properties by inhibiting both endothelial cell function and the differentiation of endothelial progenitor cells. Its unique mechanism makes it a valuable tool for research in muscle biology and vascular development. -
Tubulin Inhibitor
Antitumor agent-68 is a potent tubulin inhibitor that demonstrates significant anticancer activity, with IC50 values of 3.6 μM and 3.8 μM against HeLa and MCF-7 cancer cell lines, respectively. This compound exhibits strong reactive oxygen species (ROS) and DPPH radical scavenging activity in a dose-dependent manner, making it relevant for oxidative stress research. Antitumor agent-68 also features an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, facilitating advancements in chemical biology applications. -
Microtubule Inhibitor
Polatuzumab vedotin is an antibody-drug conjugate that targets CD79b and functions primarily as a microtubule inhibitor. This compound consists of a humanized anti-CD79b IgG1 monoclonal antibody conjugated to monomethyl auristatin E (MMAE), a potent agent that disrupts microtubule dynamics. Its unique mechanism makes Polatuzumab vedotin a valuable tool for studying large B-cell lymphomas (LBCL) and exploring therapeutic approaches in related malignancies. Researchers can leverage its targeted delivery system for enhanced therapeutic efficacy in the context of cancer research. -
Tubulin ADC
Anetumab ravtansine is a potent antibody-drug conjugate (ADC) that specifically targets tubulin via a conjugation of a human anti-mesothelin antibody to the maytansinoid tubulin inhibitor DM4. This compound demonstrates significant antitumor activity, which correlates with mesothelin expression levels in patient-derived xenograft tumor models. Anetumab ravtansine is primarily used in cancer research, particularly in studies focusing on targeted therapies for mesothelin-expressing tumors. -
Microtubule Disassembly Inhibitor
10-Acetyl docetaxel is a microtubule disassembly inhibitor known for its antimitotic activity. As an analog of Docetaxel, this compound effectively disrupts microtubule dynamics, making it a valuable reagent in cancer research. Its mechanism of action can be leveraged to study cellular processes related to mitosis and the development of anticancer therapies. -
Antitubulin Agent
MMAF hydrochloride (Monomethylauristatin F) is a potent inhibitor of tubulin polymerization, primarily functioning as an antitumor agent. It demonstrates significant cytotoxic activity and is commonly utilized as a key component in antibody-drug conjugates (ADCs), including Vorsetuzumab mafodotin and SGN-CD19A. This reagent is essential for research applications focused on cancer therapeutics and the development of targeted drug delivery systems. -
Microtubule/Tubulin Inhibitor
DM4-SMe is a potent tubulin inhibitor, primarily targeting microtubules to disrupt cytoskeletal functions. As a metabolite of antibody-maytansinoid conjugates, it serves as a cytotoxic component in antibody-drug conjugates. DM4-SMe exhibits significant biological activity, demonstrating an IC50 of 0.026 nM against KB cells. Additionally, this highly toxic metabolite undergoes oxidation and detoxification by human liver microsomes, which may influence its pharmacokinetic profile in biological systems. -
Antitubulin Agent
MMAF sodium (Monomethylauristatin F sodium) is a potent antitubulin agent that functions as an inhibitor of tubulin polymerization. It exhibits significant cytotoxic activity, making it a crucial component in the development of antibody-drug conjugates (ADCs), including Vorsetuzumab mafodotin and SGN-CD19A. This compound is widely employed in cancer research to explore strategies for targeted therapy and to enhance the efficacy of therapeutic agents against various malignancies. -
Tubulin Polymerization Inhibitor
Fmoc-MMAF-OMe is a tubulin polymerization inhibitor that features an Fmoc protecting group. The active component, MMAF, serves as a cytotoxic agent in antibody-drug conjugates (ADCs), making it critical for cancer research. Its ability to disrupt microtubule dynamics positions Fmoc-MMAF-OMe as a valuable tool for studying various cancer pathways and evaluating potential therapeutic strategies. -
Microtubule Inhibitor
S-methyl DM1 is a thiomethyl derivative of Maytansine and functions as a microtubule inhibitor. It binds to tubulin with a dissociation constant (Kd) of 0.93 μM, effectively inhibiting microtubule polymerization and potently suppressing microtubule dynamic instability. Due to its mechanism of action, S-methyl DM1 exhibits significant anticancer properties, making it a valuable reagent for research in cancer biology and therapeutics. -
Microtubule/Tubulin Inhibitor
DM3-SMe is a maytansine derivative that acts as a potent tubulin inhibitor. This compound exhibits remarkable cytotoxic activity in vitro, with an IC50 of 0.0011 nM, making it suitable for various research applications, particularly in the development of antibody-drug conjugates (ADCs). DM3-SMe can be conjugated to antibodies via disulfide or stable thioether bonds, enhancing the targeted delivery of cytotoxic agents in cancer therapy research. -
Anti-microtubule Toxins
Tubulysin C is a potent anti-microtubule toxin that targets tubulin, effectively disrupting microtubule dynamics. This compound exhibits significant cytotoxic activity in mammalian cells, including those resistant to multiple drugs, with IC50 values in the low nanomolar range. Tubulysin C inhibits microtubule polymerization, resulting in cell cycle arrest and apoptosis. It is valuable for research in cancer biology and the development of targeted therapies. -
Microtubule Disrupting Agent
AGD-0182 is a microtubule disrupting agent that functions by binding to tubulin and inhibiting microtubule polymerization. As a synthetic analogue of the natural compound Dolastatin 10, AGD-0182 serves as a valuable tool for studying microtubule dynamics. In addition to its primary function, it features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules. This dual functionality makes AGD-0182 suitable for diverse applications in chemical biology and bioconjugation research. -
Microtubule/Tubulin Inhibitor
Tubulysin IM-2 is a potent microtubule and tubulin inhibitor that disrupts microtubule polymerization, leading to cell cycle arrest and apoptosis in tumor cells. This compound serves as a valuable component in antibody-drug conjugates (ADCs) by imparting cytotoxic effects and enhancing therapeutic efficacy. It is particularly useful in cancer research where targeting microtubule dynamics is crucial for investigating tumor progression and treatment responses. -
Anti-microtubule Toxins
Tubulysin IM-3 is an anti-microtubule toxin that inhibits tubulin polymerization, disrupting microtubule dynamics. Its primary mechanism involves binding to tubulin, which effectively impedes cellular mitosis and triggers apoptotic pathways. This compound serves as a valuable cytotoxic agent in antibody-drug conjugate (ADC) synthesis, enhancing the therapeutic efficacy of targeted cancer treatments. -
Tubulin Polymerisation Inhibitor
Tubulin Polymerization-IN-38 is a tubulin polymerization inhibitor that disrupts microtubule dynamics, leading to enhanced apoptosis in cancer cells. As an analogue of Tubulysin, it demonstrates powerful anticancer activity and serves a pivotal role in research applications focusing on cancer treatment and drug discovery. This compound can also be utilized as an antibody-drug conjugate (ADC) cytotoxin, facilitating the synthesis of targeted therapies for oncology research. -
Tubulin Polymerization Inhibitor
Tubulysin D is a potent tubulin polymerization inhibitor that disrupts microtubule dynamics. This highly cytotoxic compound, derived from the myxobacteria Archangium geophyra and Angiococcus disciformis, exhibits significant activity against mammalian cells, including those with multidrug resistance, with IC50 values in the low nanomolar range. By preventing microtubule assembly, Tubulysin D induces cell cycle arrest and apoptosis, making it a valuable tool for cancer research and studies on microtubule-targeting therapies. -
Tubulin Inhibitor
Bi-Mc-VC-PAB-MMAE is a drug-linker conjugate that targets tubulin through a potent microtubule destabilizer, MMAE. The compound combines the ADC linker Bi-Mc-Val-Cit-PAB with MMAE to inhibit microtubule polymerization, effectively disrupting cellular mitotic processes. This reagent is primarily used in antibody-drug conjugate (ADC) research for its potential applications in targeted cancer therapies. -
Tubulin Inhibitor
PC5-VC-PAB-MMAE is a potent tubulin inhibitor linked to an antibody-drug conjugate (ADC) via the PC5-VC-PAB linker. This compound demonstrates significant biological activity by disrupting microtubule dynamics, thereby inhibiting cell proliferation. It serves as a valuable tool for research applications focused on cancer therapy and the study of microtubule-targeting agents. -
Microtubule Inhibitor
Lisavanbulin dihydrochloride is a microtubule inhibitor that functions as a prodrug for the active compound Avanbulin. It demonstrates significant antitumor activity, particularly in tumors with elevated levels of end-binding protein 1, by targeting tumor cell proliferation and modulating the tumor microenvironment through the reduction of tumor microvasculature. Additionally, Lisavanbulin dihydrochloride activates the spindle assembly checkpoint, leading to cell cycle arrest, cell death, or aberrant chromosome segregation. This compound is relevant for research focused on diffuse large B cell lymphoma (DLBCL) and glioblastoma. -
Microtubule Inhibitor
Lisavanbulin is a prodrug of the microtubule-targeting agent Avanbulin, functioning as an effective antitumor agent with the ability to penetrate the blood-brain barrier. It primarily targets tumor cell proliferation and modifies the tumor microenvironment by reducing tumor microvasculature. Additionally, Lisavanbulin activates the spindle assembly checkpoint, leading to cell cycle arrest, cell death, or abnormal chromosome segregation. This reagent is relevant for research applications in diffuse large B cell lymphoma (DLBCL) and glioblastoma. -
Microtubule Stabilizer
Flutax-2 is a fluorescent derivative of Paclitaxel, functioning as a microtubule stabilizer through specific binding to polymerized αβ-tubulin dimers. This reagent is ideal for imaging microtubules in live cells, isolated cytoskeletons, and certain parasitic organisms, with excitation and emission wavelengths of 496 nm and 526 nm, respectively. Its high sensitivity enables researchers to investigate microtubule dynamics and cellular processes in real-time applications. -
Microtubule/Tubulin Inhibitor
Bis-ANS dipotassium is a fluorescent probe that targets tubulin, acting as a microtubule inhibitor. It exhibits a binding affinity with tubulin characterized by a Kd of 2 μM. This compound serves as a potent biphasic modulator of protein liquid-liquid phase separation (LLPS), promoting LLPS at low concentrations while suppressing it at elevated concentrations. Its unique properties make it valuable for studying microtubule dynamics and phase separation mechanisms in cellular processes. -
Microtubule Inhibitor
Combretastatin A-1 acts as a microtubule polymerization inhibitor by binding to the colchicine-binding site on tubulin. This compound disrupts microtubule dynamics, leading to the deactivation of AKT and inhibition of the Wnt/β-catenin signaling pathway. Combretastatin A-1 is recognized for its anti-tumor and anti-vascular properties, making it a valuable tool for cancer research and the study of vascular dynamics. -
Microtubule Inhibitor
Combretastatin A-1 phosphate tetrasodium is a microtubule inhibitor that targets the colchicine-binding site of tubulin, leading to disruption of microtubule polymerization. This compound has been shown to inhibit the Wnt/β-catenin signaling pathway through AKT deactivation mediated by tubulin depolymerization. Its key biological activities include anti-tumor and anti-vascular effects, making it a valuable reagent for cancer research and studies involving microtubule dynamics. -
Microtubule/Tubulin Inhibitor
D011-2120 is a microtubule/tubulin inhibitor that disrupts microtubule polymerization, interfering with the Golgi complex's function. This inhibition hampers viral trafficking to the plasma membrane, thereby blocking virus egress. D011-2120 is valuable in virology research for studying antiviral mechanisms and cellular pathways involved in viral replication and dissemination. -
Antitubulin Agent
AVE-8063, an aminocombretastatin, serves as a potent antitubulin agent. It demonstrates strong cytotoxic effects, making it a valuable compound for research into leukemic and breast cancer treatments. Its ability to disrupt microtubule dynamics can provide insights into cancer cell proliferation and survival mechanisms. -
Tubulin Inhibitor
ON 01500 is a potent tubulin inhibitor with a Kd of 21 nM, demonstrating significant microtubule-destabilizing effects in cellular environments. This compound is valuable for investigating mechanisms underlying cancer biology and the role of microtubule dynamics in cellular processes. Research applications include elucidating the effects of microtubule disruption on tumor growth and progression. -
Intermediate Reactant
Monomethyl auristatin E intermediate-1 is a key intermediate reactant used in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor with notable anticancer activity. MMAE serves as the cytotoxic agent in antibody-drug conjugates (ADCs), making it valuable in targeted cancer therapies. This intermediate is essential for the development of innovative ADC formulations aimed at enhancing therapeutic efficacy in oncology research. -
Amino acid residues of Dolastatin 10
N-Boc-dolaproine, as a derivative of Dolastatin 10, targets the amino acid residues critical for the pentapeptide's function. It is known to inhibit tubulin polymerization, thereby disrupting mitosis and demonstrating significant anticancer activity. This compound is valuable for researchers investigating cellular dynamics and developing potential cancer therapies. -
Plant Microtubule Inhibitor
Oryzalin is a dinitroaniline herbicide that functions as a plant microtubule inhibitor. It binds to tubulin, disrupting microtubule polymerization in plant cells, which subsequently impairs chromosome migration. Oryzalin also serves as an effective reagent for inducing chromosome doubling, making it valuable for various research applications in plant biology and genetics. -
Tubulin Polymerization Inhibitor
ER-076349 is a potent inhibitor of tubulin polymerization that effectively induces G2-M cell cycle arrest and disrupts mitotic spindle formation. This compound demonstrates significant anti-cancer activity by inhibiting the growth of various human tumor xenografts. As an analog of Halichondrin B, ER-076349 serves as a valuable reagent for research focused on cancer biology and therapeutic development targeting microtubule dynamics. -
Active Metabolite of Taxol
7-epi-Taxol is an active metabolite of Taxol that primarily targets microtubules, promoting their stabilization and microtubule bundle formation while inhibiting depolymerization. This compound exhibits potent antitumor activity, making it a valuable tool for research in cancer biology and drug discovery. Its effects on cell replication highlight its potential applications in studying mitotic processes and cellular dynamics. -
Tubulin Inhibitor
Vindesine sulfate is a potent tubulin inhibitor with a Ki of 0.110 μM. It exhibits significant anti-proliferative activity in vitro and demonstrates antitumor effects in vivo, making it a valuable tool for cancer research. This compound is utilized in studies exploring microtubule dynamics and the mechanisms of action in various tumor models. -
Microtubule Regulators
Tetrahydrocortisol is a cortisol metabolite that targets microtubule regulators. It inhibits dexamethasone-induced formation of cross-linked actin networks, making it a valuable tool for studying cellular dynamics. This compound is applicable in research related to primary open-angle glaucoma, glucocorticoid-induced ocular hypertension, Lewis lung carcinoma, and EMT-6 mouse breast cancer. -
Anti-5T4 Antibody
Cys-McMMAF is the active payload derived from AlMcMMAF, a humanized A1 antibody specifically targeting the 5T4 antigen, conjugated to the microtubule-disrupting agent MMAF through a maleimidocaproyl linker. This compound demonstrates significant antitumor efficacy in mouse models, specifically H1975 and MDA-MB-361-DYT2, making it a valuable tool for cancer research and the development of targeted therapeutics. Cys-McMMAF is ideal for studies focused on antibody-drug conjugates and their potential in oncological therapies. -
Tubulin Assembly Inhibitor
Avanbulin is a potent tubulin assembly inhibitor that targets the Colchicine binding site on tubulin. It effectively inhibits tubulin polymerization at a temperature of 37 °C, exhibiting an IC50 value of 1.4 μM and an apparent Kd of 244 nM for tubulin binding. This compound is valuable for research applications in cancer biology and the study of cell division mechanisms. -
sGC Inhibitor
Methylene blue hydrate is a selective inhibitor of soluble guanylyl cyclase (sGC), as well as monoamine oxidase A (MAO-A) and nitric oxide synthase (NOS). This compound exhibits significant biological activities, including the modulation of the nitric oxide syntase/guanylate cyclase signaling pathway, which results in decreased prepulse inhibition. Methylene blue hydrate also acts as a REDOX cycling agent capable of crossing the blood-brain barrier, demonstrating neuroprotective effects such as inhibition of Tau aggregation, reduction of cerebral edema, and attenuation of neuroinflammation through the modulation of microglial activation. These properties make it valuable for research in neurodegenerative diseases and neuroinflammation studies. -
β-tubulin Polymerization Inhibitor
Valecobulin hydrochloride is a potent β-tubulin polymerization inhibitor that serves as a vascular disrupting agent. It demonstrates significant antitumor activity against both murine and human solid tumors, making it an important tool for cancer research. Valecobulin hydrochloride is utilized in studies focused on understanding tumor vascularization and therapeutic strategies aimed at disrupting the tumor microenvironment. -
Disinfection Byproduct
2-Bromoacetamide is a disinfection byproduct that primarily targets liver alcohol dehydrogenase, leading to its inactivation. This compound also disrupts microtubule and actin cytoskeletal functions, which can have significant effects on cellular processes. Additionally, 2-Bromoacetamide exhibits powerful developmental toxicant properties in animal models, making it relevant for studies in toxicology and developmental biology. -
Plant Microtubule Polymerization Inhibitor
Amiprofos methyl is a phosphoric amide herbicide that functions as a potent inhibitor of plant microtubule polymerization. This compound disrupts microtubule dynamics in plant cells, leading to significant impairments in cell division and growth. Its specific activity makes it a valuable tool for research into the mechanisms of herbicide action and the cellular processes regulated by microtubules in plant biology. -
TG Inhibitor
NC9 (Cbz-Lys(Acr)-PEG2-dansyl) is an irreversible inhibitor of transglutaminase (TG), a crucial enzyme in various biological processes. This compound effectively inhibits osteoblast differentiation and mineralization while also destabilizing microtubules. NC9 is valuable for research focused on osteoblast differentiation and the underlying mechanisms governing bone formation. -
Microtubule Stabilizer
TPI-287 is a microtubule stabilizer that effectively penetrates the blood-brain barrier. This compound demonstrates significant inhibitory effects on metastatic colonization of breast cancer in the brain. TPI-287 is useful in research aimed at understanding tumor progression and developing therapeutic strategies for brain metastases. -
Neurosteroid
Pregnenolone acetate is a neurosteroid that functions as an analog of pregnenolone, promoting neurite extension and altering growth cone morphology in primary cultures of cerebellar granule neurons. This compound enhances microtubule polymerization, making it a valuable tool for researching neurodevelopmental diseases. Its mechanism offers insights into neuronal growth and plasticity, supporting various applications in neuroscience research. -
Amino acid residues of Dolastatin 11
N-Boc-dolaproine dicyclohexylamine is an amino acid derivative of the peptide Dolastatin 10, targeting the amino acid residues of Dolastatin 11. This compound exhibits potent inhibition of tubulin polymerization, thereby disrupting mitosis and demonstrating significant anticancer properties. It serves as a critical tool for research in cancer biology and drug development, providing insights into the mechanisms of microtubule dynamics and cell division. -
Paclitaxel Derivative
Paclitaxel-2'-succinate NHS ester is a reactive paclitaxel derivative that features a succinic acid linker with a highly activated NHS ester group. This compound facilitates efficient conjugation with amino or hydroxyl groups, making it suitable for coupling with peptides, proteins, antibodies, enzymes, or polymers. Its applications extend to the development of innovative nanomedicines and the exploration of targeted strategies in cancer therapy. -
Intermediate Reactant
Monomethyl auristatin E intermediate-7 is a key intermediate in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor with established anticancer properties. MMAE serves as a cytotoxic component in antibody-drug conjugates (ADCs), which are utilized in targeted cancer therapies. This reagent is essential for researchers engaged in the development and optimization of ADC formulations aimed at enhancing therapeutic efficacy in oncology. -
Microtubule-targeting Agent
Epothilone F is a 16-membered macrolide that targets microtubules, functioning as a potent anticancer agent. It demonstrates remarkable efficacy against paclitaxel-resistant cancer cells and effectively inhibits the proliferation of breast cancer cells, non-small cell lung cancer cells, and drug-resistant ovarian cancer cells. This compound is extensively utilized in research focused on cancer biology and therapeutics.
