Catalog No.
Product Name
Application
Product Information
Citations
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Tubulin Inhibitor
Tubulin polymerization-IN-6 is a potent tubulin polymerization inhibitor with an IC50 of 1.09 μM. This compound effectively impairs cell migration and tube formation, playing a significant role in anti-angiogenesis. In vivo studies demonstrate that Tubulin polymerization-IN-6 substantially inhibits tumor growth in HT29 xenograft models using Balb/c nude mice, making it a valuable reagent for cancer research. -
VEGFR-2/β-tubulin Inhibitor
VEGFR-2-IN-22 is a dual inhibitor targeting VEGFR-2 and β-tubulin polymerization, demonstrating an IC50 of 19.82 nM against VEGFR-2. This compound promotes apoptosis, making it a valuable tool for studying angiogenesis and cancer biology. Its mechanism of action provides insights into vascular endothelial growth factor pathways and their role in tumor progression. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-17 is a potent inhibitor of tubulin polymerization, effectively disrupting microtubule dynamics. This compound induces depolymerization of tubulin, leading to apoptosis in cancer cells and inhibiting their migratory capabilities. Tubulin polymerization-IN-17 is valuable for research focused on cancer biology and therapies targeting microtubule dynamics. -
Tubulin polymerization inhibitor
Tubulin polymerization-IN-84 is a selective inhibitor of tubulin polymerization that targets the colchicine-binding site, exhibiting an IC50 of 10.9 μM. This compound demonstrates significant antiproliferative effects against various cancer cell lines, including Jurkat, B16-F10, HCT116, and MDA-MB-231, with IC50 values of 60 nM, 380 nM, 138 nM, and 1.054 μM, respectively. Tubulin polymerization-IN-84 induces G2/M-phase arrest and promotes apoptosis in B16-F10 cells, while also suppressing tumor growth in a B16-F10 melanoma model. Additionally, it enhances anti-tumor immunity in conjunction with PD-L1 monoclonal antibodies, making it a valuable reagent for research in T-cell acute lymphoblastic leukemia, melanoma, colon cancer, and breast cancer studies. -
Microtubule-Binding Molecule
Myoseverin is a microtubule-binding molecule that acts as an angiogenesis inhibitor. This compound induces the reversible fission of multinucleated myotubes into mononucleated fragments, thereby affecting muscle cell dynamics. Additionally, Myoseverin demonstrates anti-angiogenic properties by inhibiting both endothelial cell function and the differentiation of endothelial progenitor cells. Its unique mechanism makes it a valuable tool for research in muscle biology and vascular development. -
Tubulin Inhibitor
Antitumor agent-68 is a potent tubulin inhibitor that demonstrates significant anticancer activity, with IC50 values of 3.6 μM and 3.8 μM against HeLa and MCF-7 cancer cell lines, respectively. This compound exhibits strong reactive oxygen species (ROS) and DPPH radical scavenging activity in a dose-dependent manner, making it relevant for oxidative stress research. Antitumor agent-68 also features an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, facilitating advancements in chemical biology applications. -
Microtubule Inhibitor
Polatuzumab vedotin is an antibody-drug conjugate that targets CD79b and functions primarily as a microtubule inhibitor. This compound consists of a humanized anti-CD79b IgG1 monoclonal antibody conjugated to monomethyl auristatin E (MMAE), a potent agent that disrupts microtubule dynamics. Its unique mechanism makes Polatuzumab vedotin a valuable tool for studying large B-cell lymphomas (LBCL) and exploring therapeutic approaches in related malignancies. Researchers can leverage its targeted delivery system for enhanced therapeutic efficacy in the context of cancer research. -
Tubulin ADC
Anetumab ravtansine is a potent antibody-drug conjugate (ADC) that specifically targets tubulin via a conjugation of a human anti-mesothelin antibody to the maytansinoid tubulin inhibitor DM4. This compound demonstrates significant antitumor activity, which correlates with mesothelin expression levels in patient-derived xenograft tumor models. Anetumab ravtansine is primarily used in cancer research, particularly in studies focusing on targeted therapies for mesothelin-expressing tumors. -
Microtubule Disassembly Inhibitor
10-Acetyl docetaxel is a microtubule disassembly inhibitor known for its antimitotic activity. As an analog of Docetaxel, this compound effectively disrupts microtubule dynamics, making it a valuable reagent in cancer research. Its mechanism of action can be leveraged to study cellular processes related to mitosis and the development of anticancer therapies. -
Antitubulin Agent
MMAF hydrochloride (Monomethylauristatin F) is a potent inhibitor of tubulin polymerization, primarily functioning as an antitumor agent. It demonstrates significant cytotoxic activity and is commonly utilized as a key component in antibody-drug conjugates (ADCs), including Vorsetuzumab mafodotin and SGN-CD19A. This reagent is essential for research applications focused on cancer therapeutics and the development of targeted drug delivery systems. -
Microtubule/Tubulin Inhibitor
DM4-SMe is a potent tubulin inhibitor, primarily targeting microtubules to disrupt cytoskeletal functions. As a metabolite of antibody-maytansinoid conjugates, it serves as a cytotoxic component in antibody-drug conjugates. DM4-SMe exhibits significant biological activity, demonstrating an IC50 of 0.026 nM against KB cells. Additionally, this highly toxic metabolite undergoes oxidation and detoxification by human liver microsomes, which may influence its pharmacokinetic profile in biological systems. -
Antitubulin Agent
MMAF sodium (Monomethylauristatin F sodium) is a potent antitubulin agent that functions as an inhibitor of tubulin polymerization. It exhibits significant cytotoxic activity, making it a crucial component in the development of antibody-drug conjugates (ADCs), including Vorsetuzumab mafodotin and SGN-CD19A. This compound is widely employed in cancer research to explore strategies for targeted therapy and to enhance the efficacy of therapeutic agents against various malignancies. -
Tubulin Polymerization Inhibitor
Fmoc-MMAF-OMe is a tubulin polymerization inhibitor that features an Fmoc protecting group. The active component, MMAF, serves as a cytotoxic agent in antibody-drug conjugates (ADCs), making it critical for cancer research. Its ability to disrupt microtubule dynamics positions Fmoc-MMAF-OMe as a valuable tool for studying various cancer pathways and evaluating potential therapeutic strategies. -
Microtubule Inhibitor
S-methyl DM1 is a thiomethyl derivative of Maytansine and functions as a microtubule inhibitor. It binds to tubulin with a dissociation constant (Kd) of 0.93 μM, effectively inhibiting microtubule polymerization and potently suppressing microtubule dynamic instability. Due to its mechanism of action, S-methyl DM1 exhibits significant anticancer properties, making it a valuable reagent for research in cancer biology and therapeutics. -
Microtubule/Tubulin Inhibitor
DM3-SMe is a maytansine derivative that acts as a potent tubulin inhibitor. This compound exhibits remarkable cytotoxic activity in vitro, with an IC50 of 0.0011 nM, making it suitable for various research applications, particularly in the development of antibody-drug conjugates (ADCs). DM3-SMe can be conjugated to antibodies via disulfide or stable thioether bonds, enhancing the targeted delivery of cytotoxic agents in cancer therapy research. -
Anti-microtubule Toxins
Tubulysin C is a potent anti-microtubule toxin that targets tubulin, effectively disrupting microtubule dynamics. This compound exhibits significant cytotoxic activity in mammalian cells, including those resistant to multiple drugs, with IC50 values in the low nanomolar range. Tubulysin C inhibits microtubule polymerization, resulting in cell cycle arrest and apoptosis. It is valuable for research in cancer biology and the development of targeted therapies. -
Microtubule Disrupting Agent
AGD-0182 is a microtubule disrupting agent that functions by binding to tubulin and inhibiting microtubule polymerization. As a synthetic analogue of the natural compound Dolastatin 10, AGD-0182 serves as a valuable tool for studying microtubule dynamics. In addition to its primary function, it features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules. This dual functionality makes AGD-0182 suitable for diverse applications in chemical biology and bioconjugation research. -
Microtubule/Tubulin Inhibitor
Tubulysin IM-2 is a potent microtubule and tubulin inhibitor that disrupts microtubule polymerization, leading to cell cycle arrest and apoptosis in tumor cells. This compound serves as a valuable component in antibody-drug conjugates (ADCs) by imparting cytotoxic effects and enhancing therapeutic efficacy. It is particularly useful in cancer research where targeting microtubule dynamics is crucial for investigating tumor progression and treatment responses. -
Anti-microtubule Toxins
Tubulysin IM-3 is an anti-microtubule toxin that inhibits tubulin polymerization, disrupting microtubule dynamics. Its primary mechanism involves binding to tubulin, which effectively impedes cellular mitosis and triggers apoptotic pathways. This compound serves as a valuable cytotoxic agent in antibody-drug conjugate (ADC) synthesis, enhancing the therapeutic efficacy of targeted cancer treatments. -
Tubulin Polymerisation Inhibitor
Tubulin Polymerization-IN-38 is a tubulin polymerization inhibitor that disrupts microtubule dynamics, leading to enhanced apoptosis in cancer cells. As an analogue of Tubulysin, it demonstrates powerful anticancer activity and serves a pivotal role in research applications focusing on cancer treatment and drug discovery. This compound can also be utilized as an antibody-drug conjugate (ADC) cytotoxin, facilitating the synthesis of targeted therapies for oncology research. -
Tubulin Polymerization Inhibitor
Tubulysin D is a potent tubulin polymerization inhibitor that disrupts microtubule dynamics. This highly cytotoxic compound, derived from the myxobacteria Archangium geophyra and Angiococcus disciformis, exhibits significant activity against mammalian cells, including those with multidrug resistance, with IC50 values in the low nanomolar range. By preventing microtubule assembly, Tubulysin D induces cell cycle arrest and apoptosis, making it a valuable tool for cancer research and studies on microtubule-targeting therapies. -
Tubulin Inhibitor
Bi-Mc-VC-PAB-MMAE is a drug-linker conjugate that targets tubulin through a potent microtubule destabilizer, MMAE. The compound combines the ADC linker Bi-Mc-Val-Cit-PAB with MMAE to inhibit microtubule polymerization, effectively disrupting cellular mitotic processes. This reagent is primarily used in antibody-drug conjugate (ADC) research for its potential applications in targeted cancer therapies. -
Tubulin Inhibitor
PC5-VC-PAB-MMAE is a potent tubulin inhibitor linked to an antibody-drug conjugate (ADC) via the PC5-VC-PAB linker. This compound demonstrates significant biological activity by disrupting microtubule dynamics, thereby inhibiting cell proliferation. It serves as a valuable tool for research applications focused on cancer therapy and the study of microtubule-targeting agents. -
Microtubule Inhibitor
Lisavanbulin dihydrochloride is a microtubule inhibitor that functions as a prodrug for the active compound Avanbulin. It demonstrates significant antitumor activity, particularly in tumors with elevated levels of end-binding protein 1, by targeting tumor cell proliferation and modulating the tumor microenvironment through the reduction of tumor microvasculature. Additionally, Lisavanbulin dihydrochloride activates the spindle assembly checkpoint, leading to cell cycle arrest, cell death, or aberrant chromosome segregation. This compound is relevant for research focused on diffuse large B cell lymphoma (DLBCL) and glioblastoma. -
Microtubule Inhibitor
Lisavanbulin is a prodrug of the microtubule-targeting agent Avanbulin, functioning as an effective antitumor agent with the ability to penetrate the blood-brain barrier. It primarily targets tumor cell proliferation and modifies the tumor microenvironment by reducing tumor microvasculature. Additionally, Lisavanbulin activates the spindle assembly checkpoint, leading to cell cycle arrest, cell death, or abnormal chromosome segregation. This reagent is relevant for research applications in diffuse large B cell lymphoma (DLBCL) and glioblastoma. -
Microtubule Stabilizer
Flutax-2 is a fluorescent derivative of Paclitaxel, functioning as a microtubule stabilizer through specific binding to polymerized αβ-tubulin dimers. This reagent is ideal for imaging microtubules in live cells, isolated cytoskeletons, and certain parasitic organisms, with excitation and emission wavelengths of 496 nm and 526 nm, respectively. Its high sensitivity enables researchers to investigate microtubule dynamics and cellular processes in real-time applications. -
Microtubule/Tubulin Inhibitor
Bis-ANS dipotassium is a fluorescent probe that targets tubulin, acting as a microtubule inhibitor. It exhibits a binding affinity with tubulin characterized by a Kd of 2 μM. This compound serves as a potent biphasic modulator of protein liquid-liquid phase separation (LLPS), promoting LLPS at low concentrations while suppressing it at elevated concentrations. Its unique properties make it valuable for studying microtubule dynamics and phase separation mechanisms in cellular processes. -
Microtubule Inhibitor
Combretastatin A-1 acts as a microtubule polymerization inhibitor by binding to the colchicine-binding site on tubulin. This compound disrupts microtubule dynamics, leading to the deactivation of AKT and inhibition of the Wnt/β-catenin signaling pathway. Combretastatin A-1 is recognized for its anti-tumor and anti-vascular properties, making it a valuable tool for cancer research and the study of vascular dynamics. -
Microtubule Inhibitor
Combretastatin A-1 phosphate tetrasodium is a microtubule inhibitor that targets the colchicine-binding site of tubulin, leading to disruption of microtubule polymerization. This compound has been shown to inhibit the Wnt/β-catenin signaling pathway through AKT deactivation mediated by tubulin depolymerization. Its key biological activities include anti-tumor and anti-vascular effects, making it a valuable reagent for cancer research and studies involving microtubule dynamics. -
Microtubule/Tubulin Inhibitor
D011-2120 is a microtubule/tubulin inhibitor that disrupts microtubule polymerization, interfering with the Golgi complex's function. This inhibition hampers viral trafficking to the plasma membrane, thereby blocking virus egress. D011-2120 is valuable in virology research for studying antiviral mechanisms and cellular pathways involved in viral replication and dissemination. -
Antitubulin Agent
AVE-8063, an aminocombretastatin, serves as a potent antitubulin agent. It demonstrates strong cytotoxic effects, making it a valuable compound for research into leukemic and breast cancer treatments. Its ability to disrupt microtubule dynamics can provide insights into cancer cell proliferation and survival mechanisms. -
Tubulin Inhibitor
ON 01500 is a potent tubulin inhibitor with a Kd of 21 nM, demonstrating significant microtubule-destabilizing effects in cellular environments. This compound is valuable for investigating mechanisms underlying cancer biology and the role of microtubule dynamics in cellular processes. Research applications include elucidating the effects of microtubule disruption on tumor growth and progression. -
Tubulin Polymerization Inhibitor
ER-076349 is a potent inhibitor of tubulin polymerization that effectively induces G2-M cell cycle arrest and disrupts mitotic spindle formation. This compound demonstrates significant anti-cancer activity by inhibiting the growth of various human tumor xenografts. As an analog of Halichondrin B, ER-076349 serves as a valuable reagent for research focused on cancer biology and therapeutic development targeting microtubule dynamics. -
Tubulin Inhibitor
Vindesine sulfate is a potent tubulin inhibitor with a Ki of 0.110 μM. It exhibits significant anti-proliferative activity in vitro and demonstrates antitumor effects in vivo, making it a valuable tool for cancer research. This compound is utilized in studies exploring microtubule dynamics and the mechanisms of action in various tumor models. -
Tubulin Assembly Inhibitor
Avanbulin is a potent tubulin assembly inhibitor that targets the Colchicine binding site on tubulin. It effectively inhibits tubulin polymerization at a temperature of 37 °C, exhibiting an IC50 value of 1.4 μM and an apparent Kd of 244 nM for tubulin binding. This compound is valuable for research applications in cancer biology and the study of cell division mechanisms. -
β-tubulin Polymerization Inhibitor
Valecobulin hydrochloride is a potent β-tubulin polymerization inhibitor that serves as a vascular disrupting agent. It demonstrates significant antitumor activity against both murine and human solid tumors, making it an important tool for cancer research. Valecobulin hydrochloride is utilized in studies focused on understanding tumor vascularization and therapeutic strategies aimed at disrupting the tumor microenvironment. -
Microtubule/Tubulin
MAP4343 is a 3-methylether derivative of pregnenolone that targets microtubules by binding to microtubule-associated protein 2 (MAP2). It stimulates tubulin polymerization, promotes neurite extension, and provides neuroprotective effects against neurotoxic agents. This compound has significant applications in neurobiology research and studies focused on neuronal development and protection. -
Microtubule/Tubulin Inhibitor
TN-16 is a potent microtubule polymerization inhibitor with an IC50 value ranging from 0.4 to 1.7 µM. It targets tubulin to disrupt microtubule dynamics, thereby affecting cellular processes such as mitosis and intracellular transport. TN-16 is useful in research applications exploring cancer biology and cellular function, making it an important tool for studying the role of microtubules in various diseases. -
Microtubule/Tubulin Inhibitor
Pironetin is an α/β unsaturated lactone derived from Streptomyces species that acts as a potent microtubule/tubulin inhibitor. By binding to α-tubulin, Pironetin effectively inhibits microtubule polymerization, leading to cell cycle arrest and exhibiting significant antitumor activity. This compound is valuable for research into cancer biology and the mechanisms of microtubule dynamics. -
Tubulin Destabilizer
RGN6024 is a reversible small molecule tubulin destabilizer that effectively inhibits microtubule polymerization by targeting the colchicine binding pocket of β-tubulin. With a binding affinity of Kd = 6.7 μM as measured by surface plasmon resonance, RGN6024 induces G2/M phase arrest in glioblastoma cells and demonstrates efficacy in βIII-tubulin overexpressing cell models. Additionally, RGN6024 inhibits tumor growth in glioblastoma xenograft mouse models, making it a valuable tool for research into glioblastoma pathophysiology and therapeutic strategies. -
Microtubule/Tubulin Inhibitor
Taccalonolide B is a microtubule stabilizer that targets tubulin, exhibiting notable antitumor activity. This compound demonstrates efficacy in vitro against cell lines with overexpression of P-glycoprotein (Pgp) and multidrug-resistance protein 7 (MRP7). Taccalonolide B effectively inhibits the growth of SK-OV-3 cells, yielding an IC50 value of 208 nM, making it a valuable tool for cancer research and drug resistance studies. -
Microtubule/Tubulin Inhibitor
OXi8007 is a water-soluble phosphate proagent of OXi8006, functioning as a microtubule/tubulin inhibitor. This compound effectively disrupts microtubule dynamics, leading to inhibition of cell proliferation and promotion of apoptotic processes. OXi8007 is widely utilized in cancer research and investigations focusing on the modulation of cytoskeletal structures. -
Tubulin Inhibitor
Podophyllotoxone is a natural compound derived from the roots of Dysosma versipellis that acts as a tubulin inhibitor. It effectively disrupts tubulin polymerization, thereby interfering with the processes of cell division and inducing anti-cancer effects. This compound is utilized in cancer research to study its potential therapeutic applications in various malignancies. -
Tubulin Inhibitor
Phomopsin A is a cyclic hexapeptide mycotoxin that functions as a noncompetitive inhibitor of tubulin. It disrupts the binding of vincristine to tubulin, which is essential for microtubule dynamics. This compound is valuable in research exploring cell division and cancer biology, particularly in studies investigating the mechanistic action of tubulin-targeting agents. -
Tubulin Inhibitor
Tubulin polymerization-IN-75 is a selective inhibitor of tubulin polymerization, demonstrating an IC50 of 30 μM. This compound significantly reduces the proliferation of cancer cell lines Huh7 and 293T, exhibiting IC50 values of 14.3 μM and 13.8 μM, respectively. It serves as a valuable tool for research aimed at investigating the mechanisms of cancer cell growth and the modulation of the cytoskeleton. -
β-tubulin Inhibitor
Icafolin-methyl is an inhibitor of β-tubulin, targeting the colchicine binding site to prevent tubulin polymerization. This compound exhibits powerful post-emergence herbicidal activity against a range of weeds, including resistant strains such as ryegrass and darnel, making it suitable for application in both cool-season and warm-season cropping systems. Icafolin-methyl is valuable for research into herbicide mechanisms and the development of novel weed management strategies. -
Tubulin Inhibitor
DJ101 is a potent tubulin inhibitor that binds to the colchicine site, effectively overcoming taxane resistance in cancer cells. This compound demonstrates significant biological activity by inhibiting tumor growth in melanoma and lung metastasis. DJ101 is a valuable reagent for research applications focused on prostate cancer and related pathways. -
Microtubule/Tubulin Inhibitor
Curvulin is a microtubule/tubulin inhibitor that disrupts microtubule assembly, affecting cytoskeletal integrity and cellular dynamics. It also inhibits the expression of inducible nitric oxide synthase (iNOS), thereby modulating nitric oxide production. This compound is useful for research in cell biology, cancer studies, and investigations involving inflammation and nitric oxide signaling pathways. -
Tubulin Inhibitor
Tubulin Inhibitor 24 is a potent agent targeting tubulin polymerization. This compound effectively induces cell cycle arrest at the G2/M phase in a concentration-dependent manner, demonstrating significant antitumor activity. Its low toxicity profile makes it a valuable tool for cancer research applications. -
Tubulin Distabilizer
Suprafenacine is a cell-permeable tubulin destabilizer that binds to microtubules at the colchicine-binding site, thereby inhibiting polymerization. By disrupting microtubule dynamics, Suprafenacine induces G2/M cell cycle arrest and promotes apoptosis, making it a valuable tool for cancer research. Its ability to interfere with microtubule formation provides insights into the mechanisms of tumor growth and potential therapeutic applications in oncology.
