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Catalog No.
Product Name
Application
Product Information
Citations
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Microtubule Inhibitor
Lisavanbulin dihydrochloride is a microtubule inhibitor that functions as a prodrug for the active compound Avanbulin. It demonstrates significant antitumor activity, particularly in tumors with elevated levels of end-binding protein 1, by targeting tumor cell proliferation and modulating the tumor microenvironment through the reduction of tumor microvasculature. Additionally, Lisavanbulin dihydrochloride activates the spindle assembly checkpoint, leading to cell cycle arrest, cell death, or aberrant chromosome segregation. This compound is relevant for research focused on diffuse large B cell lymphoma (DLBCL) and glioblastoma. -
Microtubule Inhibitor
Lisavanbulin is a prodrug of the microtubule-targeting agent Avanbulin, functioning as an effective antitumor agent with the ability to penetrate the blood-brain barrier. It primarily targets tumor cell proliferation and modifies the tumor microenvironment by reducing tumor microvasculature. Additionally, Lisavanbulin activates the spindle assembly checkpoint, leading to cell cycle arrest, cell death, or abnormal chromosome segregation. This reagent is relevant for research applications in diffuse large B cell lymphoma (DLBCL) and glioblastoma. -
Microtubule/Tubulin Inhibitor
Bis-ANS dipotassium is a fluorescent probe that targets tubulin, acting as a microtubule inhibitor. It exhibits a binding affinity with tubulin characterized by a Kd of 2 μM. This compound serves as a potent biphasic modulator of protein liquid-liquid phase separation (LLPS), promoting LLPS at low concentrations while suppressing it at elevated concentrations. Its unique properties make it valuable for studying microtubule dynamics and phase separation mechanisms in cellular processes. -
Microtubule Inhibitor
Combretastatin A-1 acts as a microtubule polymerization inhibitor by binding to the colchicine-binding site on tubulin. This compound disrupts microtubule dynamics, leading to the deactivation of AKT and inhibition of the Wnt/β-catenin signaling pathway. Combretastatin A-1 is recognized for its anti-tumor and anti-vascular properties, making it a valuable tool for cancer research and the study of vascular dynamics. -
Microtubule Inhibitor
Combretastatin A-1 phosphate tetrasodium is a microtubule inhibitor that targets the colchicine-binding site of tubulin, leading to disruption of microtubule polymerization. This compound has been shown to inhibit the Wnt/β-catenin signaling pathway through AKT deactivation mediated by tubulin depolymerization. Its key biological activities include anti-tumor and anti-vascular effects, making it a valuable reagent for cancer research and studies involving microtubule dynamics. -
Microtubule/Tubulin Inhibitor
D011-2120 is a microtubule/tubulin inhibitor that disrupts microtubule polymerization, interfering with the Golgi complex's function. This inhibition hampers viral trafficking to the plasma membrane, thereby blocking virus egress. D011-2120 is valuable in virology research for studying antiviral mechanisms and cellular pathways involved in viral replication and dissemination. -
Tubulin Inhibitor
ON 01500 is a potent tubulin inhibitor with a Kd of 21 nM, demonstrating significant microtubule-destabilizing effects in cellular environments. This compound is valuable for investigating mechanisms underlying cancer biology and the role of microtubule dynamics in cellular processes. Research applications include elucidating the effects of microtubule disruption on tumor growth and progression. -
Plant Microtubule Inhibitor
Oryzalin is a dinitroaniline herbicide that functions as a plant microtubule inhibitor. It binds to tubulin, disrupting microtubule polymerization in plant cells, which subsequently impairs chromosome migration. Oryzalin also serves as an effective reagent for inducing chromosome doubling, making it valuable for various research applications in plant biology and genetics. -
Tubulin Polymerization Inhibitor
ER-076349 is a potent inhibitor of tubulin polymerization that effectively induces G2-M cell cycle arrest and disrupts mitotic spindle formation. This compound demonstrates significant anti-cancer activity by inhibiting the growth of various human tumor xenografts. As an analog of Halichondrin B, ER-076349 serves as a valuable reagent for research focused on cancer biology and therapeutic development targeting microtubule dynamics. -
Tubulin Inhibitor
Vindesine sulfate is a potent tubulin inhibitor with a Ki of 0.110 μM. It exhibits significant anti-proliferative activity in vitro and demonstrates antitumor effects in vivo, making it a valuable tool for cancer research. This compound is utilized in studies exploring microtubule dynamics and the mechanisms of action in various tumor models. -
Tubulin Assembly Inhibitor
Avanbulin is a potent tubulin assembly inhibitor that targets the Colchicine binding site on tubulin. It effectively inhibits tubulin polymerization at a temperature of 37 °C, exhibiting an IC50 value of 1.4 μM and an apparent Kd of 244 nM for tubulin binding. This compound is valuable for research applications in cancer biology and the study of cell division mechanisms. -
sGC Inhibitor
Methylene blue hydrate is a selective inhibitor of soluble guanylyl cyclase (sGC), as well as monoamine oxidase A (MAO-A) and nitric oxide synthase (NOS). This compound exhibits significant biological activities, including the modulation of the nitric oxide syntase/guanylate cyclase signaling pathway, which results in decreased prepulse inhibition. Methylene blue hydrate also acts as a REDOX cycling agent capable of crossing the blood-brain barrier, demonstrating neuroprotective effects such as inhibition of Tau aggregation, reduction of cerebral edema, and attenuation of neuroinflammation through the modulation of microglial activation. These properties make it valuable for research in neurodegenerative diseases and neuroinflammation studies. -
β-tubulin Polymerization Inhibitor
Valecobulin hydrochloride is a potent β-tubulin polymerization inhibitor that serves as a vascular disrupting agent. It demonstrates significant antitumor activity against both murine and human solid tumors, making it an important tool for cancer research. Valecobulin hydrochloride is utilized in studies focused on understanding tumor vascularization and therapeutic strategies aimed at disrupting the tumor microenvironment. -
Plant Microtubule Polymerization Inhibitor
Amiprofos methyl is a phosphoric amide herbicide that functions as a potent inhibitor of plant microtubule polymerization. This compound disrupts microtubule dynamics in plant cells, leading to significant impairments in cell division and growth. Its specific activity makes it a valuable tool for research into the mechanisms of herbicide action and the cellular processes regulated by microtubules in plant biology. -
TG Inhibitor
NC9 (Cbz-Lys(Acr)-PEG2-dansyl) is an irreversible inhibitor of transglutaminase (TG), a crucial enzyme in various biological processes. This compound effectively inhibits osteoblast differentiation and mineralization while also destabilizing microtubules. NC9 is valuable for research focused on osteoblast differentiation and the underlying mechanisms governing bone formation. -
Microtubule/Tubulin Inhibitor
TN-16 is a potent microtubule polymerization inhibitor with an IC50 value ranging from 0.4 to 1.7 µM. It targets tubulin to disrupt microtubule dynamics, thereby affecting cellular processes such as mitosis and intracellular transport. TN-16 is useful in research applications exploring cancer biology and cellular function, making it an important tool for studying the role of microtubules in various diseases. -
Microtubule/Tubulin Inhibitor
Pironetin is an α/β unsaturated lactone derived from Streptomyces species that acts as a potent microtubule/tubulin inhibitor. By binding to α-tubulin, Pironetin effectively inhibits microtubule polymerization, leading to cell cycle arrest and exhibiting significant antitumor activity. This compound is valuable for research into cancer biology and the mechanisms of microtubule dynamics. -
Microtubule/Tubulin Inhibitor
Taccalonolide B is a microtubule stabilizer that targets tubulin, exhibiting notable antitumor activity. This compound demonstrates efficacy in vitro against cell lines with overexpression of P-glycoprotein (Pgp) and multidrug-resistance protein 7 (MRP7). Taccalonolide B effectively inhibits the growth of SK-OV-3 cells, yielding an IC50 value of 208 nM, making it a valuable tool for cancer research and drug resistance studies. -
Microtubule/Tubulin Inhibitor
OXi8007 is a water-soluble phosphate proagent of OXi8006, functioning as a microtubule/tubulin inhibitor. This compound effectively disrupts microtubule dynamics, leading to inhibition of cell proliferation and promotion of apoptotic processes. OXi8007 is widely utilized in cancer research and investigations focusing on the modulation of cytoskeletal structures. -
Tubulin Inhibitor
Podophyllotoxone is a natural compound derived from the roots of Dysosma versipellis that acts as a tubulin inhibitor. It effectively disrupts tubulin polymerization, thereby interfering with the processes of cell division and inducing anti-cancer effects. This compound is utilized in cancer research to study its potential therapeutic applications in various malignancies. -
Microtubule Inhibitor
Taccalonolide AJ is a microtubule stabilizing compound with significant antiproliferative properties. This semi-synthetic reagent demonstrates high potency against cancer cells, exhibiting an IC50 of 4.2 nM in HeLa cell lines. Its mechanism of action involves the stabilization of microtubules, making it a valuable tool for research in cancer biology and therapeutic development. -
Tubulin Inhibitor
Phomopsin A is a cyclic hexapeptide mycotoxin that functions as a noncompetitive inhibitor of tubulin. It disrupts the binding of vincristine to tubulin, which is essential for microtubule dynamics. This compound is valuable in research exploring cell division and cancer biology, particularly in studies investigating the mechanistic action of tubulin-targeting agents. -
NQO1 Inhibitor
Diminutol is a selective inhibitor of NADP-dependent quinone oxidoreductase (NQO1), an enzyme implicated in critical cellular processes such as microtubule morphogenesis and cell division. This compound has significant potential for research applications related to cancer biology and cellular dynamics, providing insights into the role of NQO1 in various pathological states. Its ability to modulate NQO1 activity makes it a valuable tool for studying the enzymatic pathways associated with oxidative stress and cellular proliferation. -
Tubulin Inhibitor
Tubulin polymerization-IN-75 is a selective inhibitor of tubulin polymerization, demonstrating an IC50 of 30 μM. This compound significantly reduces the proliferation of cancer cell lines Huh7 and 293T, exhibiting IC50 values of 14.3 μM and 13.8 μM, respectively. It serves as a valuable tool for research aimed at investigating the mechanisms of cancer cell growth and the modulation of the cytoskeleton. -
β-tubulin Inhibitor
Icafolin-methyl is an inhibitor of β-tubulin, targeting the colchicine binding site to prevent tubulin polymerization. This compound exhibits powerful post-emergence herbicidal activity against a range of weeds, including resistant strains such as ryegrass and darnel, making it suitable for application in both cool-season and warm-season cropping systems. Icafolin-methyl is valuable for research into herbicide mechanisms and the development of novel weed management strategies. -
Tubulin Inhibitor
DJ101 is a potent tubulin inhibitor that binds to the colchicine site, effectively overcoming taxane resistance in cancer cells. This compound demonstrates significant biological activity by inhibiting tumor growth in melanoma and lung metastasis. DJ101 is a valuable reagent for research applications focused on prostate cancer and related pathways. -
Microtubule/Tubulin Inhibitor
Curvulin is a microtubule/tubulin inhibitor that disrupts microtubule assembly, affecting cytoskeletal integrity and cellular dynamics. It also inhibits the expression of inducible nitric oxide synthase (iNOS), thereby modulating nitric oxide production. This compound is useful for research in cell biology, cancer studies, and investigations involving inflammation and nitric oxide signaling pathways. -
Centrosome Clustering Inhibitor
CCCI-01 is a centrosome clustering inhibitor that selectively targets cancer cells. It disrupts centrosome clustering, presenting potential as a non-cross-resistant anti-cancer agent. This compound is useful for research applications aimed at understanding cell division anomalies and developing new therapeutic strategies for cancer treatment. -
Tubulin Inhibitor
Tubulin Inhibitor 24 is a potent agent targeting tubulin polymerization. This compound effectively induces cell cycle arrest at the G2/M phase in a concentration-dependent manner, demonstrating significant antitumor activity. Its low toxicity profile makes it a valuable tool for cancer research applications. -
Tubulin Inhibitor
Tubulin polymerization-IN-47 is a potent inhibitor of tubulin polymerization, specifically targeting mitotic processes. This compound demonstrates significant inhibitory effects on neuroblastoma cancer cell proliferation, exhibiting IC50 values of 7 nM and 12 nM against the Chp-134 and Kelly cell lines, respectively. It is a valuable tool for research in cancer biology, particularly in the study of cell division and the mechanisms of tumor growth. -
Tubulin Polymerization Inhibitor
Antiproliferative agent-14 is a potent tubulin polymerization inhibitor with an IC50 of 3.41 μM. This compound demonstrates significant antiproliferative activity, effectively disrupting cell cycle progression by arresting cells at the G2/M phase. It is a valuable tool for studying tumor biology and the mechanisms underlying cell division in cancer research. -
Tubulin/NEDDylation Inhibitor
Tubulin/NEDDylation-IN-1 (compound C11) is a potent dual inhibitor targeting tubulin and NEDDylation, exhibiting an IC50 of 2.40 μM for tubulin. This compound effectively disrupts microtubule dynamics and inhibits the NEDDylation process, a crucial post-translational modification involving the attachment of the ubiquitin-like protein NEDD8 to target proteins. By forming hydrogen bonds with key residues in tubulin and the NEDD8 activating enzyme (NAE) through its methoxy and dithiocarbamate functionalities, Tubulin/NEDDylation-IN-1 demonstrates significant anti-proliferative activity and serves as a valuable tool for research investigating cellular proliferation and microtubule regulation. -
Tubulin Inhibitor
Tubulin Inhibitor 6 targets tubulin polymerization, displaying potent inhibitory activity across various cancer cell lines. It demonstrates an IC50 of 0.87 μM for tubulin polymerization and effectively inhibits the growth of K562 cells with an IC50 of 840 nM. This compound is useful for research applications focused on elucidating mechanisms of cancer cell proliferation and treatment strategies. -
Ubulin Polymerization Inhibitor
Tubulin polymerization-IN-51 is a potent tubulin polymerization inhibitor, exhibiting an IC50 value ranging from 2.55 to 17.89 μM in SK-Mel-28 cells. This compound effectively disrupts microtubule assembly, making it a valuable tool for cancer research. Its application in various experimental settings allows for the exploration of mechanisms underlying tumor cell proliferation and metastasis. -
Microtubule/Tubulin Inhibitor
OSIP-486823 is a novel tubulin inhibitor that disrupts microtubule dynamics. It demonstrates significant biological activity by affecting protein kinase G (PKG) pathways alongside its microtubule-interfering properties. This dual action positions OSIP-486823 as a valuable tool for studying cell division, cytoskeletal organization, and various signaling pathways in cancer research and other related fields. -
Tubulin Inhibitor
Tesetaxel is a taxane tubulin inhibitor that demonstrates oral activity and effective brain penetration. It inhibits tubulin depolymerization with an IC50 of 0.44 μM, leading to a reduction in cancer cell proliferation. This compound exhibits potent antitumor effects, particularly against P-glycoprotein-positive cancer cells, making it valuable for research applications related to solid tumors, liver metastasis, and advanced breast cancer. -
Tubulin Polymerization Inhibitor
S516 is a potent tubulin polymerization inhibitor with an IC50 of 4.29 μM. This active metabolite of CKD-516 exhibits significant antitumor activity, making it a valuable tool for cancer research. Its ability to disrupt microtubule dynamics may provide insights into cell cycle regulation and potential therapeutic strategies against cancer. -
Tubulin Polymerisation Inhibitor
Tubulin Inhibitor 27 (DYT-1) is a potent tubulin polymerisation inhibitor with an IC50 value of 25.6 μM. This compound exhibits significant anti-angiogenic and antitumor activities, making it valuable for research into cancer biology and potential therapeutic applications. Its ability to disrupt microtubule dynamics can aid investigations into cellular processes related to tumor growth and metastasis. -
Microtubule Inhibitor
Microtubule Inhibitor 5 is a potent agent targeting microtubules, demonstrating significant cytotoxicity with an IC50 value of 154.5 nM in NCI-H460 cells. This compound exhibits favorable cell permeability, making it suitable for various research applications related to cancer biology and cell division. It provides valuable insights for studies investigating the mechanisms of microtubule disruption and its implications in tumor growth inhibition. -
Tubulin Inhibitor
Tubulin Inhibitor 22 is a potent inhibitor of tubulin, demonstrating significant anti-angiogenic and anti-cancer properties. It effectively arrests the MGC-803 cell cycle at the G2/M phase, leading to a dose-dependent induction of Caspase-mediated apoptosis through mitochondrial dysfunction. This compound is valuable for research applications in cancer biology and the study of cell cycle regulation. -
Tubulin Inhibitor
ABI-274 is a potent tubulin inhibitor that targets the colchicine binding site. This compound significantly enhances cancer cell apoptosis in vitro when used in combination with vemurafenib, exhibiting strong synergistic effects. In vivo studies demonstrate its efficacy in vemurafenib-resistant xenograft models in nude mice, making ABI-274 a critical tool for research on melanoma and potential therapeutic strategies in resistant cancer forms. -
Tubulin Inhibitor
Tubulin inhibitor 8 (Compound 33b) is a potent inhibitor of tubulin polymerization, demonstrating an IC50 value of 0.73 μM. This compound effectively inhibits the growth of K562 cancer cells, achieving an IC50 of 14 nM. Tubulin inhibitor 8 is valuable for studies in cancer research, particularly in evaluating mechanisms of action related to cytoskeletal dynamics and potential therapeutic interventions in tumor proliferation. -
Tubulin Inhibitor
Tubulin Inhibitor 7 is a potent inhibitor of tubulin polymerization, targeting microtubule dynamics critical for cell division. With an IC50 of 0.52 μM, it effectively disrupts tubulin assembly, exhibiting significant anti-proliferative activity in various cancer cell lines. Notably, Tubulin Inhibitor 7 demonstrates an IC50 of 11 nM against K562 cells, making it a valuable tool for cancer research and studies focused on mitotic disruption. -
Tubulin Inhibitor
Tubulin Inhibitor 29 is a potent inhibitor of tubulin assembly, exhibiting an IC50 value of 1.2 µM. This compound demonstrates significant antiproliferative activity, with an IC50 value of 7.5 µM against MCF-7 breast cancer cells. By binding to the colchicine site on tubulin, Tubulin Inhibitor 29 disrupts microtubule dynamics, making it a valuable tool for cancer research and studies focused on cell cycle regulation. -
Microtubule Inhibitor
Cevipabulin fumarate dihydrate is a potent microtubule inhibitor targeting tubulin to disrupt microtubule dynamics. This orally administered antitumor compound demonstrates significant cytotoxic activity in human tumor cell lines, with an IC50 range of 18-40 nM. Cevipabulin is primarily used in cancer research to explore mechanisms of tumor cell proliferation and resistance, providing valuable insights for therapeutic development. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-63 is a potent inhibitor of tubulin polymerization, demonstrating an IC50 value of 0.29 μM in MES-SA cells. This compound disrupts microtubule dynamics, making it a valuable tool for cancer research. It aids in the exploration of cellular responses to tubulin modulation and contributes to the understanding of tumor biology and therapeutic strategies. -
Tubulin Inhibitor
Tubulin Inhibitor 26 is a potent indazole derivative targeting tubulin. It exhibits low nanomolar potency against various cancer cell lines, including HepG2, HCT116, SW620, HT29, and A549. This compound effectively induces G2/M phase arrest and promotes apoptosis in tumor cells. Furthermore, Tubulin Inhibitor 26 demonstrates the ability to suppress tumor growth in vivo while maintaining normal body weight in mice. -
Tubulin/FTase Inhibitor
Tubulin polymerization-IN-25 is a dual inhibitor targeting tubulin polymerization and farnesyl transferase (FTase), exhibiting IC50 values of 1.11 μM and 0.39 μM, respectively. This compound demonstrates significant cytotoxicity and potent antitumor activity, making it a valuable tool for cancer research. Its ability to disrupt microtubule dynamics and inhibit protein farnesylation underscores its potential in therapeutic applications focused on tumor growth suppression. -
Microtubule Synthesis Inhibitor
Antitumor agent-200 is a microtubule synthesis inhibitor that targets the colchicine site on tubulin, leading to G2/M cell cycle arrest and the generation of reactive oxygen species (ROS). This compound demonstrates significant inhibitory activity against MCF7/ADR and KBV200 cell lines exhibiting P-glycoprotein overexpression, with drug resistance indices of 0.83 and 0.58, respectively. In vivo studies using the MCF-7 xenograft model have shown that Antitumor agent-200 at a dosage of 25 mg/kg via intraperitoneal injection results in a tumor growth inhibition rate of 57.2%. This reagent is valuable for research in the oncology field, particularly in studies related to drug resistance and cancer treatment efficacy. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-87 is a potent inhibitor of tubulin polymerization. This compound disrupts the assembly of microtubules, resulting in G2/M cell cycle arrest and exhibiting significant anti-proliferative effects. It is particularly effective against ovarian cancer, providing valuable insights for research applications in cancer biology and therapeutic development.
