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Catalog No.
Product Name
Application
Product Information
Citations
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Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-10 is a potent inhibitor of tubulin polymerization, exhibiting an IC50 of 4.25±0.75 μM. This compound demonstrates significant anti-tumor activity, making it a valuable tool for cancer research and studies focusing on microtubule dynamics. Its ability to disrupt tubulin assembly can be leveraged in the investigation of various cancer therapies. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-37 is an effective tubulin polymerization inhibitor, exhibiting an IC50 value of 2.3 μM. By binding to the colchicine site on tubulin, it disrupts the normal polymerization process and inhibits colchicine binding. This compound is valuable in cancer research, particularly in studying various lymphomas and their underlying mechanisms. -
Tubulin inhibitor
Tubulin Inhibitor 15 is a potent compound that disrupts microtubule dynamics by binding to tubulin. This reagent demonstrates significant antiproliferative activity, exhibiting cytotoxic effects specifically in HepG2 liver cancer cells. It is a valuable tool for research focused on cancer biology and the mechanisms of cell division and proliferation. -
Tubulin Inhibitor
BNZ-111 is an orally bioavailable inhibitor of tubulin, targeting microtubule dynamics. This compound exhibits significant antitumor activity, making it a valuable tool for cancer research. BNZ-111 can be utilized in studies focused on the mechanistic understanding of microtubule-targeting therapies and their potential clinical applications in oncology. -
Polymerization Inhibitor Prodrug
Tubulin Polymerization-IN-1 prodrug is a palladium-mediated inhibitor of tubulin polymerization, developed to target the colchicine binding site. This prodrug demonstrates significantly reduced cytotoxicity compared to its parent compound, offering a 68.3-fold reduction in toxicity while maintaining effectiveness upon activation by Pd resin. Mechanistic investigations align its anticancer activity with that of colchicine binding site inhibitors. In vivo studies have shown that treatment with Tubulin Polymerization-IN-1 prodrug results in a substantial inhibition of tumor growth (63.2%) following Pd resin activation. This compound holds potential for advancing research in anticancer therapeutics. -
Tubulin Inhibitor
Tubulin Inhibitor 44 is a potent inhibitor targeting tubulin, disrupting its function in microtubule dynamics. This compound exhibits significant cytotoxicity in cancer cell lines such as NCI-H460, BxPC-3, and HT-29, with IC50 values of 0.96 nM, 0.66 nM, and 0.61 nM, respectively. Its efficacy makes it a valuable tool for research in cancer biology and drug discovery focused on microtubule-targeting agents. -
Tubulin Inhibitor
Ohchinolide B is a potent tubulin inhibitor that effectively disrupts microtubule polymerization with an IC50 of 2.3 μM. This compound induces G2/M phase cell cycle arrest and activates mitochondrial apoptotic pathways, making it a valuable tool for studying cancer biology. Ohchinolide B is particularly promising for research involving solid tumors, including breast and lung cancer. -
Tubulin Inhibitor
3,3'-Dihydroxy-2,6-bis(4-hydroxybenzyl)-5-methoxybibenzyl is a potent tubulin inhibitor with an IC50 of 10 μM, effectively inhibiting tubulin polymerization. This stilbenoid compound enhances the cytotoxic effects of SN-38 in BCRP-transduced cancer cells, making it a valuable tool for cancer research. Its application is particularly relevant in the study of breast cancer, where it can help elucidate mechanisms of drug resistance and potential therapeutic strategies. -
Microtubule Inhibitor
Isodienestrol is a microtubule inhibitor that disrupts the normal function of the cytoskeletal structure. This compound is primarily utilized in cancer research, where it demonstrates potential effectiveness in inhibiting tumor cell proliferation and inducing apoptosis. Its mechanism of action makes it a valuable tool for investigating microtubule dynamics and their role in oncogenic processes. -
Tubulin Inhibitor
Tubulin Inhibitor 12 is a selective antagonist of tubulin with an IC50 value of 25.3 μM. This compound exhibits significant anti-tumor and anti-proliferative activities, making it a valuable tool for cancer research. It is ideally suited for studies focused on cell cycle regulation and mechanisms of tumor growth inhibition. -
Microtubule Assembly Inhibitor
Myoseverin B is a microtubule assembly inhibitor that effectively disrupts tubulin polymerization with an IC50 of 2 μM. This compound demonstrates low cytotoxicity across various cell types, making it a valuable tool in cellular studies. Myoseverin B is primarily utilized in research focused on antitumor mechanisms and the exploration of microtubule dynamics in cancer biology. -
Tubulin polymerization Inhibitor
Tubulin polymerization-IN-29 is a potent inhibitor of tubulin polymerization, effectively disrupting microtubule dynamics. This compound demonstrates significant antiproliferative activity and is capable of inducing cell cycle arrest in HeLa cells at the G2/M phase. It serves as a valuable tool for research involving cancer biology and cell proliferation studies. -
Tubulin Polymerization Inhibitor
Tubulin Polymerization-IN-52 is a selective inhibitor of tubulin polymerization, demonstrating an IC50 of 2.9 μM. This compound disrupts microtubule dynamics, making it a valuable tool for studying cytoskeletal function and cell division. Its inhibitory effects on tubulin polymerization can be leveraged in cancer research and investigations into related disorders. -
Angiogenesis inhibitors
Denibulin hydrochloride is an anti-angiogenic agent that targets and disrupts the formation of blood vessels in solid tumors. This compound demonstrates significant anticancer activity by promoting rapid closure of tumor-associated vasculature, which can lead to a dose-dependent reduction in tumor cell viability. Denibulin hydrochloride enhances the efficacy of radiation and cisplatin chemotherapy, making it a valuable tool for research in cancer therapeutics and vasculature dynamics. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-55 is a potent inhibitor of tubulin polymerization, disrupting microtubule dynamics. This reagent exhibits significant antiproliferative activity against various cancer cell lines, including A549, K562, HepG2, MDA-MB-231, and HFL-1, with IC50 values of 8, 3, 9, 24, and 62 nM, respectively. It serves as a valuable tool for researchers studying cancer biology and cellular mechanisms involving microtubules. -
Tubulin Polymerization/Akt Pathway Inhibitor
KS-99 is an inhibitor that targets both tubulin polymerization and the Akt signaling pathway. This compound demonstrates significant biological activity by inhibiting cancer cell proliferation and inducing apoptosis in various cancer cell types. KS-99 is suitable for research applications involving colorectal cancer, breast cancer, lung epithelial cancer, and melanoma. -
Microtubule Inhibitor
Taxinine B is a microtubule inhibitor derived from the Japanese Yew (Taxus cuspidata). It effectively inhibits CaCl2-induced depolymerization of microtubules, contributing to its potential in cancer research. Taxinine B may also be valuable for overcoming multidrug resistance in tumor cells, making it a significant compound for studies focused on cancer treatment and cellular mechanisms. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-77 is a potent inhibitor of tubulin polymerization, specifically targeting the microtubule dynamics crucial for cell division. This compound exhibits notable anti-glioblastoma activity by inducing G2/M phase arrest and promoting apoptosis in glioblastoma cells. Additionally, Tubulin polymerization-IN-77 is characterized by significant permeability across the blood-brain barrier and effectively reduces tumor cell migration, making it a valuable reagent for cancer research applications focused on glioblastoma therapeutics. -
Microtubule Inhibitor
JC168 is a phenyl analog of peloruside that acts as a microtubule inhibitor. It exhibits significant antiproliferative and anticancer activities by promoting tubulin polymerization, thus disrupting microtubule dynamics. This compound is valuable for research on microtubule-associated disorders and offers potential insights into cancer biology. -
Microtubule Inhibitor
Anticancer agent 98 is a microtubule inhibitor that disrupts tubulin polymerization with a Kd of 16.9 μM. This compound demonstrates significant antiproliferative activity against various tumor cell lines and exhibits an anti-angiogenic effect in vitro. Additionally, Anticancer agent 98 shows favorable stability in human and mouse liver microsomes, with a half-life greater than 300 minutes, making it a valuable candidate for further research in cancer therapeutics. -
Tubulin Inhibitor
ALB-109564 hydrochloride, a tubulin inhibitor, effectively disrupts mitosis in cancer cells, leading to cytotoxicity. This compound is utilized in research focused on cancer biology and treatment strategies, particularly in studies examining the mechanisms of cell division and potential therapeutic interventions for tumor growth. Its ability to impair microtubule dynamics makes it a valuable tool for investigating novel anti-cancer modalities. -
Tubulin Inhibitor
Neuroinflammatory-IN-3 is a tubulin inhibitor that exhibits anti-neuroinflammatory properties. It acts by preventing tubulin polymerization, which disrupts microtubule dynamics. This compound has demonstrated potential as an effective antitumor agent, making it valuable for research in cancer biology and neuroinflammatory diseases. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-8 is a potent inhibitor of tubulin polymerization, primarily targeting microtubule dynamics. It effectively induces G2/M phase cell cycle arrest in HCT116 tumor cells, demonstrating a significant inhibitory potency with an IC50 value of 12.7 μM. This compound is valuable for research applications in cancer biology, particularly in studies focused on tumor cell proliferation and microtubule-targeting therapies. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-20 is a potent inhibitor of tubulin polymerization, targeting the assembly of microtubules crucial for cell division. This compound exhibits significant potential in the study of breast cancers and chemoresistant colon cancers, facilitating research into mechanisms of resistance and offering insights for therapeutic strategies. Its effectiveness in disrupting microtubule dynamics makes it a valuable tool for cancer research applications. -
Melanoma Inhibitor
Anti-melanoma agent 3 is a 2-aryl-4-benzoyl-imidazole (ABI) derivative designed to inhibit melanoma xenografts. This compound demonstrates significant anticancer activity by targeting the colchicine binding site, leading to the inhibition of tubulin polymerization. It is particularly useful in research focused on developing effective treatments for melanoma by disrupting cellular mitosis and tumor growth. -
Tubulin Inhibitor
Tubulin Inhibitor 20 is a potent inhibitor of tubulin, disrupting microtubule dynamics and thereby affecting cellular processes such as mitosis and intracellular transport. This compound demonstrates significant anti-cancer activity, making it a valuable tool for research into cancer biology and therapeutic development. Its ability to inhibit tubulin polymerization positions it as a critical reagent for studies aimed at understanding tumor progression and the mechanisms of action of anti-cancer therapies. -
Tubulin Inhibitor
Cemadotin hydrochloride is a potent tubulin inhibitor that disrupts microtubule dynamics, leading to cell cycle arrest in the mitotic phase. With a Ki value of 1 μM, it effectively inhibits cell proliferation in vitro and reduces tumor xenograft growth in murine models. This compound is an important tool for investigating anticancer mechanisms and potential therapeutic applications in cancer research. -
Tubulin Inhibitor
IKP-104 is a potent tubulin inhibitor with an IC50 of 1.31 μM, targeting microtubule polymerization to arrest cells in mitosis during the M phase. This compound induces cytoskeletal microtubule depolymerization, effectively inhibiting the growth of various mouse and human tumor cell lines. Additionally, IKP-104 demonstrates notable anti-tumor effects in mouse ascites tumors and lung cancer models, making it a valuable tool for research in leukemia, lung cancer, and melanoma. -
Microtubule Inhibitor
(Rac)-Deox B 7,4 is a homoisoflavanoid compound that acts as a microtubule inhibitor by binding near the colchicine site, disrupting microtubule polymerization and leading to reversible G2 phase arrest. This compound exhibits potent nanomolar anti-leukemic activity, making it a valuable tool for research into cancer therapeutics and cellular dynamics. Its ability to modulate cytoskeletal functions holds promise for studies related to cell cycle regulation and tumor progression. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-15 is a selective inhibitor of tubulin polymerization, effectively disrupting microtubule dynamics. This compound exhibits significant potential in cancer research by hindering cell division and inducing apoptosis in tumor cells. It can be utilized to study the mechanisms of cancer progression and the role of microtubules in cellular processes. -
Tubulin Inhibitor
SPA107 is a tubulin inhibitor that prevents tubulin polymerization, demonstrating potent antimitotic activity with an IC50 of 0.5 nM. In addition, SPA107 exhibits significant cytotoxic effects in p53 mutated MCF-7 cells, with an IC50 of 0.5 nM. This compound is valuable for research in cancer biology, particularly in studies focused on mitotic disruption and the mechanisms underlying drug resistance. -
Tubulin Inhibitor
HD-800 is a potent tubulin inhibitor, exhibiting an IC50 of 4.3 nM and an EC50 for depolymerization of 24 nM. This compound is valuable for generating the radioactive tracer [11C]HD-800, which is capable of penetrating the blood-brain barrier. [11C]HD-800 serves as a useful tool for positron emission tomography (PET) applications in studying various neurological disorders. -
Tubulin Inhibitor
isoCA-4 is a tubulin polymerization inhibitor derived from Combretastatin A4. It exhibits significant anti-proliferative activity, making it a valuable tool for studying cancer cell growth and metastasis. This compound can be utilized in research applications focused on tumor biology and the development of novel cancer therapeutics. Its mechanism of action provides insights into disrupting microtubule dynamics in cellular systems. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-27 is a selective inhibitor of tubulin polymerization, disrupting microtubule dynamics and thereby arresting the cell cycle at the G2/M phase. This compound induces apoptosis in cancer cells, making it a valuable tool for studying cell cycle regulation and apoptosis mechanisms in various research applications. It is suitable for investigations into cancer biology and therapeutic strategies targeting microtubule assembly. -
Microtubule Inhibitor
Tubulozole is a synthetic microtubule inhibitor that exerts its effects by disrupting microtubule dynamics, leading to cell cycle arrest and apoptosis in cancer cells. It is primarily utilized in research focused on cancer biology, particularly in the study of tumor growth and metastasis. Tubulozole's ability to inhibit microtubule polymerization makes it a valuable tool in the investigation of novel therapeutic strategies for cancer treatment. -
Microtubule Polymerization Inhibitor
Bruceoside D is a microtubule polymerization inhibitor derived from the quassinoid glucoside found in Brucea javanica. This compound exhibits cytotoxic effects against several cancer cell lines, including leukemia (CCRF-CEM), non-small cell lung cancer (A549), and ovarian cancer (OVCAR-3). Bruceoside D is a valuable tool for researchers investigating potential cancer therapeutics and the mechanisms underlying tumor cell growth and proliferation. -
Microtubule Inhibitor
ER-67880 is a potent microtubule inhibitor that disrupts microtubule dynamics with an IC50 of 9.5 μM. This compound demonstrates significant anti-proliferative effects against KB, Colon 38, and P338 cancer cell lines, with IC50 values of 0.55, 0.2, and 0.76 μg/mL, respectively. It causes G2/M phase cell cycle arrest and results in altered DNA replication patterns, alongside the down-regulation of G1 phase-related genes. ER-67880 is applicable in various cancer research studies, including those focused on nasopharyngeal carcinoma and murine adenocarcinoma. -
Microtubule/Tubulin Inhibitor
BP-M345 is a potent microtubule/tubulin inhibitor that effectively targets cancer cells while demonstrating low toxicity to non-tumor cells. This compound exhibits significant antiproliferative activity, with a GI50 value ranging from 0.17 to 0.45 μM, making it an important tool for cancer research and therapeutic studies. Its ability to selectively inhibit cancer cell proliferation positions BP-M345 as a valuable reagent for exploring cancer biology and potential treatment options. -
Tubulin Inhibitor
Tubulin inhibitor 18 is a potent inhibitor of tubulin, primarily functioning through disruption of microtubule polymerization. As a chalcone derivative, it exhibits significant anti-proliferative activity in various cancer cell lines. This compound is valuable for research applications targeting cancer diseases, enabling further investigation into tubulin dynamics and therapeutics. -
Inhibitors of Tubulin Polymerization
KGP591 is a potent inhibitor of tubulin polymerization with an IC50 of 0.57 µM. It effectively induces G2/M phase stagnation, inhibits cell migration, and disrupts microtubule structure and cell morphology in MDA-MB-231 human breast cancer cells. Additionally, KGP591 exhibits notable antitumor activity in an orthotopic kidney cancer model (RENCA), making it a valuable reagent for cancer research applications. -
Tubulin Inhibitor
Tubulin polymerization-IN-12 is a potent tubulin polymerization inhibitor with an IC50 of 0.75 μM. By disrupting normal tubulin assembly, it effectively arrests the cell cycle at the G2/M phase, leading to significant cytotoxic effects against cancer cells. This compound is valuable for research in cancer biology and the mechanisms of cell cycle regulation. -
Tubulin Polymerization Inhibitor
Tubulin polymerization-IN-16 is a potent tubulin polymerization inhibitor designed to disrupt microtubule dynamics. This compound demonstrates significant anti-cancer activity with IC50 values ranging from 0.084 to 0.221 μM, effectively inducing cell cycle arrest at the G2/M phase in SGC-7901 cells. Its ability to inhibit tubulin polymerization makes it a valuable tool for research in cancer biology and therapeutic development. -
Tubulin Polymerisation Inhibitor
N-Acetylcolchinol phosphate is a potent inhibitor of tubulin polymerization. It binds to the tubulin cytoskeleton in the endothelial cells of tumor blood vessels, disrupting microtubule dynamics. This compound is valuable in anti-cancer research, providing insights into tumor vasculature and potential therapeutic strategies. Its application facilitates the study of tumor progression and vascularization in various cancer models. -
Centrosomal Clustering Inhibitor
GF 15 is a centrosomal clustering inhibitor that acts by inducing multipolar spindles with an EC50 value of 900 nM. As a derivative of griseofulvin, it effectively inhibits tubulin polymerization at concentrations exceeding 25 μM. GF 15 demonstrates notable antitumor activity, significantly inhibiting tumor growth and improving survival rates in mouse xenograft models of human colon cancer and multiple myeloma. This reagent is valuable for researchers studying cellular mitosis and the mechanisms of cancer progression. -
Microtubule Inhibitor
IQTub4P is a potent microtubule inhibitor that disrupts microtubule structure and function. It exhibits significant cytotoxicity in HeLa cells with an EC50 value of 170 nM, highlighting its potential for targeting cancer cell proliferation. This compound demonstrates favorable tolerability in vivo, making it a valuable tool for studying microtubule dynamics and exploring therapeutic applications in cancer research. -
Microtubule Inhibitor
Desacetylvinblastine hydrazide is a microtubule inhibitor that disrupts mitotic spindle formation, effectively inhibiting cell division and promoting apoptosis in cancer cells. This compound demonstrates significant antitumor activity specifically against folate receptor (FR)-positive tumors. It is widely utilized in cancer research to investigate mechanisms of drug resistance and therapeutic efficacy in targeted cancer therapies. -
Microtubule Growth Inhibitor
α-Tubulin (residues 440–451) functions as a microtubule growth inhibitor by transiently interacting with the longitudinal polymerization interface of α-tubulin. This interaction effectively regulates the association and dissociation rates of tubulin at the growing ends of microtubules, leading to inhibited microtubule growth. This reagent can be utilized in studies exploring microtubule dynamics, cellular morphology, and potential therapeutic targets for diseases associated with abnormal microtubule formation. -
Tubulin Inhibitor
Tubulin Inhibitor 49 is a potent tubulin polymerization inhibitor with an IC50 value of 48 μM. This compound disrupts the microtubule network, leading to G2 phase cell cycle arrest and demonstrating cytotoxicity with an IC50 of 8.8 μM in HeLa cells. Tubulin Inhibitor 49 serves as a valuable tool for researching cervical cancer and understanding the mechanisms of microtubule dynamics in cancer cell proliferation. -
Tubulin Inhibitor
Tubulin polymerization-IN-48 is a potent inhibitor of tubulin polymerization, demonstrating the ability to disrupt microtubule networks. This compound exhibits significant anti-proliferative activity in neuroblastoma cancer cell lines, with IC50 values of 79 nM for Chp-134 and 165 nM for Kelly cells. Its mechanism makes it a valuable tool for research in cancer biology and cellular dynamics. -
Microtubule Polymerization Inhibitor
Acodazole is a microtubule polymerization inhibitor that exhibits potent anticancer activity. By disrupting the assembly of microtubules, Acodazole interferes with mitotic spindle formation, leading to cell cycle arrest and apoptosis in cancer cells. This compound is valuable for research in cancer biology and for exploring novel therapeutic strategies targeting microtubule dynamics.
