DNA Damage

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  1. Purine Nucleoside Analog

    3’-Azido-3’-deoxy-beta-L-cytidine is a purine nucleoside analog that exhibits significant antitumor activity against indolent lymphoid malignancies. Its anticancer effects are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound serves as an efficient click chemistry reagent due to its azide functional group, allowing it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It is also compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) for reactions involving DBCO or BCN-modified compounds.
  2. Nucleoside Metabolite

    Glutathioselenol (GS-SeH) is a nucleoside metabolite that acts as a potent antioxidant, facilitating the detoxification of reactive oxygen species. This compound is involved in redox regulation and cellular defense mechanisms, making it relevant for research on oxidative stress, cancer biology, and neuroprotection. Its unique properties allow for exploration in the study of metabolic pathways and potential therapeutic applications in related diseases.
  3. Purine Nucleoside Analog

    3,5-Bis-O-(4-methylbenzoyl)-2-C-methyl-D-ribonic acid gamma-lactone is a purine nucleoside analog that exerts significant antitumor activity, particularly against indolent lymphoid malignancies. Its mode of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound can be utilized effectively in studies aimed at understanding the mechanisms of tumor growth and developing novel therapeutic strategies.
  4. Purine Nucleoside Analog

    5′-Amino-5′-deoxythymidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. This compound functions primarily by inhibiting DNA synthesis and inducing apoptosis, thereby disrupting cancer cell proliferation. It serves as a valuable tool in cancer research and therapeutic applications aimed at understanding and targeting tumorigenic processes.
  5. Nucleoside Metabolite

    11,12,15(S)-THETA, also known as 11,12,15(S)-Trihydroxyicosatrienoic acid, is a nucleoside metabolite that plays a crucial role in cellular signaling pathways. It is involved in the regulation of various biological processes, including inflammation and vascular function. This compound is of interest in research applications focusing on metabolic pathways and the effects of nucleoside metabolites in health and disease.
  6. Purine Nucleoside Analog

    1,2-Di-O-acetyl-3,5-di-O-benzoyl-D-xylofuranose is a purine nucleoside analog that exhibits significant antitumor activity. This compound primarily targets indolent lymphoid malignancies through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. Its potential applications in cancer research include the study of therapeutic strategies aimed at disrupting nucleotide metabolism in tumor cells.
  7. Thymidine Analog

    5-[3-[(2,2,2-Trifluoroacetyl)amino]-1-propyn-1-yl]uridine is a thymidine analog that exhibits insertional activity towards replicated DNA. This compound can effectively label cells, allowing for the tracking of DNA synthesis in various biological contexts. Additionally, it serves as a click chemistry reagent due to its alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its utility in DNA research and labeling makes it a valuable tool for cell biology studies.
  8. Thymidine Analog

    2’,3’,5’-Tri-O-benzoyl-5-hydroxymethyl-2’-β-C-methyluridine is a thymidine analog that exhibits insertional activity towards replicated DNA. This compound can be utilized to label cells, enabling the tracking of DNA synthesis in various biological systems. Its unique structure allows for enhanced applications in molecular biology and cancer research, providing insights into replication processes.
  9. Product of 3,4-Dihydroxyphenylacetate

    5-Formyl-2-hydroxy-2,4-heptadienedioic acid is a product formed through the meta-cleavage of 3,4-dihydroxyphenylacetate. This compound exhibits key biological activities related to phenolic compound metabolism and can be utilized in studies of metabolic pathways and environmental biochemistry. Its unique structure may also serve as a valuable tool for investigating the biochemical roles of phenolic acids in various biological systems.
  10. Nucleoside Metabolite

    Episterone is a nucleoside metabolite that exhibits properties of a steroid hormone. It plays a significant role in various biological processes, including the modulation of gene expression and cellular metabolism. Episterone is utilized in research applications focused on steroidogenesis, hormonal regulation, and related biochemical pathways. Its unique profile makes it a valuable tool for investigating the effects of steroid metabolites in both in vitro and in vivo models.
  11. Purine Nucleoside Analog

    3’-Azido-3’-deoxy-5-methyl-beta-L-uridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. Additionally, this compound serves as a versatile click chemistry reagent, featuring an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, such as those with DBCO or BCN moieties.
  12. Purine Nucleoside Analog

    N6-Bz-5'-O-DMTr-2'-O-hexadecanyl adenosine is a purine nucleoside analog that exhibits significant antitumor activity. This compound primarily targets indolent lymphoid malignancies, functioning through mechanisms such as inhibition of DNA synthesis and induction of apoptosis. It serves as a valuable tool for research applications focused on cancer biology and therapeutic development.
  13. Purine Nucleoside Analog

    Methyl 3'-O-benzyl xyloriboside is a purine nucleoside analog with significant biological activity in inhibiting DNA synthesis and inducing apoptosis. This compound demonstrates broad antitumor effects, particularly in the treatment of indolent lymphoid malignancies. Its mechanisms make it a valuable tool for cancer research and therapeutic investigations.
  14. Purine Nucleoside Analog

    5-Me-3’-dU-2’-phosphoramidite is a purine nucleoside analog designed to inhibit DNA synthesis, contributing to its antitumor activity. This compound demonstrates effectiveness in targeting indolent lymphoid malignancies, mediating cellular apoptosis and disrupting cellular proliferation. Its applications extend to cancer research, particularly in exploring therapeutic strategies against hematological malignancies.
  15. Purine Nucleoside Analog

    7-(3-Deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action includes the inhibition of DNA synthesis and the induction of apoptosis in cancerous cells. This compound is valuable for research applications focused on cancer biology and therapeutic development for lymphoid cancers.
  16. Fatty Acid

    9,10-Epoxy-13-hydroxy-11-octadecenoic acid is a fatty acid known for its role in lipid metabolism. This compound exhibits bioactive properties and is involved in various biochemical pathways, making it suitable for research in cellular signaling and metabolic regulation. It serves as a valuable tool for investigating the physiological effects of fatty acids and their derivatives in diverse biological systems.
  17. Cytidine Analog

    4'-C-Methyl-5-methylcytidine is a cytidine nucleoside analog specifically designed to inhibit DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor activities, making it a valuable tool in cancer research and epigenetic studies. Researchers may utilize this reagent to investigate the role of DNA methylation in gene regulation and the development of therapeutic strategies targeting aberrant methylation patterns.
  18. Purine Nucleoside Analog

    6-Methylpurine-β-D-(3-azido-3-deoxy)riboside is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms include the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound serves as a versatile click chemistry reagent, featuring an azide group capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds.
  19. Purine Nucleoside Analog

    1-(5-O-Methoxytrityl-2-deoxy-β-D-xylofuranosyl)uracil is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis in cancer cells, making it a valuable tool for cancer research. This compound can be used in studies focused on elucidating mechanisms of tumorigenesis and therapeutic resistance in various malignancies.
  20. Purine Nucleoside Analog

    2′-O-Hexadecyl-adenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a vital tool in cancer research. This compound is suitable for studies focusing on nucleoside metabolism and therapeutic interventions in hematological cancers.
  21. Guanine Adduct

    AFB1-FapyGua is a prominent guanine adduct formed from the alkylation of nucleic acids by aflatoxin B1 (AFB1). This compound has been shown to exert significant mutagenic effects, making it crucial for studying DNA damage and repair mechanisms. AFB1-FapyGua serves as an important tool in cancer research, particularly in understanding the cellular response to genotoxic stress and the mutational processes involved in tumorigenesis.
  22. Purine Nucleoside Analog

    2'-Deoxy-8-(phenylmethoxy)guanosine is a purine nucleoside analog that exhibits notable antitumor activity, particularly against indolent lymphoid malignancies. Its biological mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable reagent for cancer research. This compound is significant for studies aimed at exploring therapeutic strategies in oncology and understanding the underlying pharmacological effects of nucleoside analogs.
  23. Purine Nucleoside Analog

    Isocytidine is a purine nucleoside analog that targets nucleic acid synthesis. This compound exhibits notable antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research and therapeutic applications.
  24. Purine Nucleoside Analog

    8-Bromo-9-(β-D-xylofuranosyl) guanine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis. This compound is a valuable tool for research applications focused on cancer therapeutics and the mechanistic study of nucleoside analogs in oncology.
  25. Purine Nucleoside Analog

    5'-DMTr-2,2'-anhydrothymidine is a purine nucleoside analog that exhibits significant antitumor activity. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it particularly relevant for research into indolent lymphoid malignancies. This compound serves as a valuable tool in cancer research, aiding in the exploration of therapeutic strategies targeting nucleoside metabolism and cellular proliferation.
  26. Purine Nucleoside Analog

    3′-Azido-3′-deoxy-5′-O-(triphenylmethyl)thymidine is a purine nucleoside analog that demonstrates significant antitumor activity primarily against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is useful in research applications focused on cancer biology and therapeutic development.
  27. Purine Nucleoside Analog

    N4-Benzyloxy-5’-O-(4,4’-dimethoxytrityl)-aracytidine is a purine nucleoside analog primarily designed to interfere with DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inducing apoptosis and disrupting cellular replication processes. It serves as a valuable tool in cancer research, facilitating investigations into therapeutic strategies targeting nucleoside metabolism and tumor cell proliferation.
  28. Purine Nucleoside Analog

    1-O-Acetyl-2,3,5-tri-O-benzoyl-5(R)-C-methyl-D-ribo furanose is a purine nucleoside analog that primarily targets nucleoside metabolism pathways. It exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, through mechanisms that involve the inhibition of DNA synthesis and induction of apoptosis. This compound is valuable for research applications focused on cancer biology and therapeutic development.
  29. Purine Nucleoside Analog

    6-Methylpurine-2’-deoxy-2’-fluoro-beta-D-arabinoriboside is a purine nucleoside analog that exerts its effects primarily through the inhibition of DNA synthesis. This compound demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies, and induces apoptosis in cancer cells. Its properties make it a valuable tool for research into cancer mechanisms and therapeutic interventions.
  30. Purine Nucleoside Analog

    3’-O-(4,4’-Dimethoxy trityl)-2’-O-(2-methoxyethyl)-5-methyluridine is a purine nucleoside analog that exhibits significant antitumor activity. It primarily targets indolent lymphoid malignancies, functioning through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research applications focused on the development of new anticancer therapies.
  31. Purine Nucleoside Analog

    3’-O-(t-Butyldiphenylsilyl) thymidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for cancer research. This analog is instrumental in studying the pathways related to tumorigenesis and cell death, contributing to the development of novel therapeutic strategies.
  32. Purine Nucleoside Analog

    (1S)-1,4-Anhydro-1-C-(2,4-difluorophenyl)-D-ribitol is a purine nucleoside analog that exhibits significant antitumor activity against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is suitable for investigating therapeutic strategies aimed at targeting specific types of lymphoid cancers.
  33. Purine Nucleoside Analog

    5-Iodo-3’-deoxy-3’-fluorouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is suitable for studies focusing on nucleoside metabolism and therapeutic strategies in oncology.
  34. Uridine Analog

    4’-Azido-2’-deoxy-2’-fluoro-beta-D-arabinouridine is a uridine analog with significant research applications in the study of antiepileptic and anxiolytic effects. This compound features an azide group, enabling its use in click chemistry, specifically in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules and DBCO or BCN groups. Additionally, it serves as a valuable tool for the development of new antihypertensive agents through its innovative chemical reactivity.
  35. Nucleoside Metabolite

    5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide is a nucleoside metabolite that plays a crucial role in the biosynthesis of nucleotides. This compound is involved in various metabolic pathways, making it valuable for research focused on nucleotide synthesis and cellular signaling processes. It can be utilized in studies examining metabolic disorders and related biochemical pathways.
  36. Purine Nucleoside Analog

    2-Deoxyuridine is a purine nucleoside analog that primarily targets DNA synthesis mechanisms. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting DNA replication and promoting apoptosis in cancer cells. Its applications include the study of cancer biology and the development of novel therapeutic strategies.
  37. Thymidine Analog

    2'-Deoxy-2'-fluoro-5-trifluoromethyl-arabinouridine is a thymidine analog that interferes with DNA replication. This compound exhibits insertional activity, enabling it to integrate into newly synthesized DNA strands. It is valuable for labeling cells and tracking DNA synthesis in various biological research applications.
  38. Purine Nucleoside Analog

    1,2-O-Isopropylidene-5-O-p-toluoyl-a-D-xylofuranose is a purine nucleoside analog that exhibits significant antitumor activity against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for cancer research. This reagent is suitable for studies focused on understanding the effects of nucleoside analogs in tumor cell biology.
  39. Purine Nucleoside Analog

    2′,3′,5′-Tri-O-acetyl-6-chloroguanosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is useful for investigations into the molecular pathways of tumorigenesis and therapeutic resistance.
  40. Purine Nucleoside Analog

    4’,5’-Didehydro-5’-deoxy thymidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is useful for exploring therapeutic strategies and mechanisms involved in the treatment of various malignancies.
  41. Purine Nucleoside Analog

    2’-beta-C-Methyl-4-thiouridine is a purine nucleoside analog exhibiting significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound can be used to explore therapeutic strategies and evaluate the cellular responses within various malignancies.
  42. Nucleoside Analog

    3'-NH2-ddT (3′-Amino-2′,3′-dideoxythymidine) serves as a nucleoside analog for the synthesis of nucleic acids. This compound is utilized to introduce amino functionalities into oligonucleotides, allowing for enhanced binding properties and biological stability. It plays a crucial role in various areas of genetic research, including the development of therapeutic oligonucleotides and the study of nucleic acid interactions.
  43. Purine Nucleoside Analog

    2’,3’,5’-Tri-O-benzoyl-5-iodouridine is a purine nucleoside analog known for its potent antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable tool for researchers studying cancer biology and therapeutic strategies targeting nucleoside metabolism.
  44. Nucleoside Metabolite

    Glutamylputrescine is a nucleoside metabolite that plays a critical role in cellular polyamine synthesis. It is involved in various biological processes, including cell proliferation and differentiation. This compound has potential applications in cancer research and studies related to cellular growth regulation.
  45. Nucleoside Metabolite

    4-Guanidinobutanamide is a nucleoside metabolite that acts as a key modulator in various biochemical pathways. It has demonstrated significant biological activity in studies related to nucleoside metabolism and cellular signaling. This compound is primarily utilized in research applications focused on metabolic regulation and the investigation of nucleoside-related processes.
  46. Purine Nucleoside Analog

    2'-Amino-2'-deoxy-β-D-arabino-5-methyl uridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is suitable for studies focusing on cellular proliferation, cancer therapies, and the underlying mechanisms of tumor development.
  47. Adenosine Analog

    8-Allyloxyadenosine is an adenosine analog primarily targeting adenosine receptors. This compound exhibits significant biological activity as a smooth muscle vasodilator and has demonstrated potential in inhibiting cancer progression. It serves as a valuable tool in research applications focused on cardiovascular health and cancer therapy.
  48. Purine Nucleoside Analog

    7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro guanosine is a purine nucleoside analog that exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms include inhibition of DNA synthesis and induction of apoptosis. Additionally, this compound serves as a click chemistry reagent, incorporating an alkyne group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This versatile profile makes it valuable for various biochemical research applications.
  49. Uridine Analog

    3’-O-(t-Butyldimethylsilyl)-2’-O-(2-methoxyethyl) uridine is a uridine analog with potential applications in the study of antiepileptic effects. Research indicates that this compound may facilitate investigations into anticonvulsant and anxiolytic activities. Additionally, it serves as a valuable tool for the development of novel antihypertensive agents, offering insights into the therapeutic potential of uridine derivatives.
  50. Adenosine Analog

    2-(4-Cyanobenzyl)thioadenosine is an adenosine analog that primarily targets adenosine receptors. This compound exhibits potent vasodilatory effects on smooth muscle, making it of interest in cardiovascular research. Additionally, it has demonstrated potential in inhibiting cancer progression, making it a valuable tool for cancer biology studies.

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