DNA Damage

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  1. Purine Nucleoside Analog

    4’-C-Methyl-2-thiouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research applications aimed at understanding the biochemical pathways involved in cancer progression and therapeutic resistance.
  2. Nucleoside Analogue

    Methyl 3,5-di-O-(2,4-dichlorobenzyl)-D-ribofuranoside is a ribofuranose nucleoside analogue that acts as a structural mimic of naturally occurring nucleosides. It exhibits potential biological activity by interfering with nucleic acid synthesis and cellular processes. This compound is primarily utilized in research related to antiviral drug development and studies on nucleoside transport mechanisms.
  3. Nucleoside Metabolite

    8(R)-HPODE, or 8(R)-Hydroperoxylinoleic acid, is a nucleoside metabolite derived from the metabolic conversion of linoleic acid by the fungus Gaeumannomyces graminis. This compound plays a significant role in the study of lipid peroxidation and oxidative stress, serving as a valuable tool in research focused on cell signaling and inflammatory responses. Its biological activity is of particular interest in investigations of lipid metabolism and potential therapeutic applications in inflammatory diseases.
  4. Nucleoside Metabolite

    5-Amino-1H-imidazole-4-carboxylic acid is a nucleoside metabolite involved in the purine biosynthesis pathway. It exhibits key biological activities associated with cellular metabolism and energy production. This compound is suitable for research applications investigating nucleic acid synthesis and the role of purines in cellular function and development.
  5. Purine Nucleoside Analog

    5’-Deoxy-5’-furfurylamino thymidine is a purine nucleoside analog known for its broad antitumor activity, particularly against indolent lymphoid malignancies. This compound primarily functions by inhibiting DNA synthesis, leading to the induction of apoptosis in cancer cells. It serves as a valuable tool for research focused on cancer treatment and the mechanisms of action of nucleoside analogs in therapeutic applications.
  6. Purine Nucleoside Analog

    5-(2-Amino-2-oxoethyl)uridine is a purine nucleoside analog that exerts significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological mechanisms include inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is applicable in studies aimed at understanding cellular responses to nucleoside analogs and their effects on tumor progression.
  7. Nucleoside Metabolite

    (E)-2-Methylbutanal oxime is a nucleoside metabolite derived from isoleucine via P450 enzyme catalysis. This compound exhibits potential biological activity important for studying metabolic pathways and enzyme interactions. Its utility in research includes the investigation of metabolic processes and the assessment of enzyme function in various biological systems.
  8. Nucleoside Metabolite

    4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde is a nucleoside metabolite that plays a critical role in various biochemical pathways. This compound is of interest in research involving nucleotide metabolism and related cellular processes. Its potential applications include studies on metabolic disorders and the regulation of nucleoside biosynthesis, making it a valuable tool for elucidating complex metabolic networks.
  9. Purine Nucleoside Analog

    3’-F-3’-dG(iBu)-2’-phosphoramidite is a purine nucleoside analog primarily targeting DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are attributed to mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis, making it valuable for research in cancer biology and therapeutic applications.
  10. Purine Nucleoside Analog

    3’-Deoxy-5-fluorouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves inhibiting DNA synthesis, which subsequently leads to the induction of apoptosis in cancer cells. This compound is utilized in various research applications focused on cancer therapeutics and the study of nucleoside metabolism.
  11. Thymidine Analog

    2’-Chlorothymidine is a thymidine analog that exhibits insertional activity towards replicated DNA. This compound facilitates the labeling of cells and the monitoring of DNA synthesis, making it a valuable tool for researchers studying cell proliferation and nucleic acid metabolism. Its application extends to various fields, including molecular biology and cancer research, where understanding DNA replication and cellular processes is critical.
  12. Purine Nucleoside Analog

    9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(naphthalen-1-yl)purine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable tool in cancer research, enabling the exploration of therapeutic strategies targeting nucleoside metabolism and cellular proliferation.
  13. Purine Nucleoside Analog

    1-(3’-O-[4,4’-Dimethoxytrityl]-alpha-L-threofuranosyl)-thymine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research focused on cancer biology and the development of novel therapeutic strategies targeting lymphoid malignancies.
  14. Purine Nucleoside Analog

    5’-Deoxy-5’-N-methylaminothymidine is a purine nucleoside analog that exhibits significant antitumor activity. It targets indolent lymphoid malignancies primarily through the inhibition of DNA synthesis and the induction of apoptosis. This compound is highly valuable for research applications focused on cancer biology and therapeutic development.
  15. Purine Nucleoside Analog

    2’,3’,5’-Tri-O-acetyl-6-S-methyl-6-thio-guanosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily mediated through the inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable tool for research into cancer therapeutics and the mechanistic understanding of purine metabolism in malignant cells.
  16. Nucleoside Metabolite

    L-Normetanephrine is a nucleoside metabolite that plays a critical role in the metabolism of catecholamines, influencing adrenergic signaling pathways. This compound has key applications in biochemical research, particularly in studies related to neuroendocrine function and the pathophysiology of various cardiovascular disorders. Its utilization can enhance the understanding of stress responses and related metabolic processes.
  17. Purine Nucleoside Analog

    4-Amino-5-cyano-1-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a purine nucleoside analog that exhibits significant antitumor activity. It primarily targets indolent lymphoid malignancies through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable tool in cancer research, particularly in studying therapeutic strategies against specific malignancies.
  18. Nucleoside Metabolite

    12(R),13(S)-Epoxy-9(S)-hydroxy-10(E)-octadecenoic acid is a nucleoside metabolite that plays a critical role in various biochemical pathways. This compound exhibits significant biological activity, influencing lipid metabolism and cellular signaling processes. It is valuable for research applications focused on metabolic regulation and the study of lipid-derived signaling molecules.
  19. Purine Nucleoside Analog

    2’-Deoxy-2’-fluoro-5-methyl-4’-thio-a-D-arabino uridine is a purine nucleoside analog designed to interfere with nucleic acid metabolism. It exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting DNA synthesis and inducing apoptosis. This compound is valuable for cancer research, particularly in studying the mechanisms of tumor cell proliferation and potential therapeutic strategies.
  20. Purine Nucleoside Analog

    3'-Deoxy-3'-fluoro-3-deazauridine is a purine nucleoside analog that primarily targets DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting nucleic acid synthesis and inducing apoptosis. Its applications in cancer research make it a valuable tool for investigating therapeutic strategies against various malignancies.
  21. Purine Nucleoside Analog

    2’-O-Methyl-5-hydroxymethyluridine is a purine nucleoside analog primarily involved in inhibiting DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, through mechanisms such as the induction of apoptosis. Its potential applications in cancer research make it a valuable tool for studying tumor biology and therapeutic strategies.
  22. Purine Nucleoside Analog

    3’-Deoxy-3’-α-C-methyl-N6,N6-dimethyladenosine is a purine nucleoside analog that exerts significant antitumor activity by targeting indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This reagent is essential for studies on nucleoside metabolism and therapeutic strategies in oncology.
  23. Purine Nucleoside Analog

    2',3'-Isopropylidene-5-hydroxyuridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms of action involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is useful in studies aimed at understanding nucleoside metabolism and therapeutic interventions in oncology.
  24. Purine Nucleoside Analog

    9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(5-phenylpyridin-3-yl)purine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound can be utilized in investigations aimed at understanding nucleotide metabolism and developing novel therapeutic strategies for malignancies.
  25. Nucleoside Metabolite

    Allodeoxycholic acid is a nucleoside metabolite known for its role in cellular lipid metabolism. It exhibits significant biological activity related to the modulation of bile acid synthesis and may influence metabolic pathways associated with cholesterol homeostasis. This compound is valuable for research applications studying lipid metabolism, bile acid signaling, and related metabolic disorders.
  26. Purine Nucleoside Analog

    3′-Deoxy-3′-fluorocytidine is a purine nucleoside analog known for its antitumor activities. This compound effectively inhibits DNA synthesis and induces apoptosis, making it a valuable tool in the study of indolent lymphoid malignancies. Its ability to mimic natural nucleosides allows for versatile applications in cancer research and therapeutic development.
  27. Purine Nucleoside Analog

    (1S)-1,4-Anhydro-1-C-(2,4-difluoro-5-methylphenyl)-D-ribitol is a purine nucleoside analog known for its broad antitumor activity against indolent lymphoid malignancies. This compound exerts its anticancer effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. It serves as a valuable tool in cancer research, particularly in studies focused on lymphoid cancer therapies and the modulation of cellular proliferation pathways.
  28. Uridine Analog

    2',5'-Bis-O-(triphenylMethyl)uridine is a uridine analog that primarily targets nucleotide metabolism. This compound exhibits potential antiepileptic properties and serves as a valuable tool for investigating anticonvulsant and anxiolytic activities. Additionally, it may contribute to the development of novel antihypertensive agents within research applications focused on these therapeutic areas.
  29. Purine Nucleoside Analog

    N4-Benzoyl-5-methylcytidine is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer effects are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable in research applications focused on exploring novel therapies for cancer treatment and understanding the mechanisms of nucleoside analogs in oncological contexts.
  30. Purine Nucleoside Analog

    2-Bromo-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine is a purine nucleoside analog that exhibits significant antitumor activity. This compound primarily targets indolent lymphoid malignancies through mechanisms including the inhibition of DNA synthesis and the induction of apoptosis. It is a valuable tool for researchers investigating therapies for cancer and related cellular processes.
  31. Purine Nucleoside Analog

    2-Amino-3,7-dihydro-5-iodo-7-β-D-ribofuranosyl-4H-pyrrolo[2,3-d]pyrimidin-4-one is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is utilized in various studies aimed at understanding the molecular dynamics of tumorigenesis and therapeutic interventions.
  32. Purine Nucleoside Analog

    3’-Deoxy-5-trifluoromethyluridine is a purine nucleoside analog that exhibits notable antitumor activity, specifically against indolent lymphoid malignancies. Its mechanisms of action involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is suitable for studies focusing on the development of therapeutic strategies targeting nucleoside pathways in oncology.
  33. Adenosine Analog

    N6,N6-Dimethyl-3'-beta-C-methyl-adenosine is an adenosine analog that primarily functions as a smooth muscle vasodilator. This compound has demonstrated potential to inhibit cancer progression, making it valuable for various research applications in oncology and cardiovascular studies. Its unique structural features enable the exploration of adenosine signaling pathways and therapeutic interventions targeting vascular and tumor growth regulation.
  34. Purine Nucleoside Analog

    5-(2-Hydroxyethyl)-2'-deoxyuridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis, leading to cell cycle arrest and the induction of apoptosis in cancer cells. This compound is valuable for research into therapeutic strategies targeting malignancies and understanding the underlying mechanisms of antitumor efficacy.
  35. Purine Nucleoside Analog

    1,2-Di-O-acetyl-3-azido-3-deoxy-5-O-(4-methyl)benzoyl-D-ribofuranose is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptotic pathways. Additionally, this compound serves as a versatile click chemistry reagent, thanks to its azide functionality, allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This dual utility broadens its applicability in chemical biology and medicinal chemistry research.
  36. Thymidine Analog

    5-Ethoxymethyluridine is a thymidine analog known for its ability to incorporate into replicated DNA. This compound demonstrates insertional activity, allowing it to label cells and facilitate the tracking of DNA synthesis. It is a valuable tool in molecular biology studies involving DNA replication and cellular proliferation.
  37. Purine Nucleoside Analog

    DMTr-dH2U-amidite is a purine nucleoside analog that primarily targets DNA synthesis. Its biological activity includes the induction of apoptosis and the inhibition of cell proliferation, making it a valuable tool in cancer research. This reagent is particularly relevant for studying indolent lymphoid malignancies and exploring therapeutic strategies in oncology.
  38. Purine Nucleoside Analog

    (2R-cis)-5-[Tetrahydro-5-(hydroxymethyl)-4-oxo-2-furanyl]-2,4(1H,3H)-pyrimidinedione functions as a purine nucleoside analog, demonstrating significant antitumor activity, particularly against indolent lymphoid malignancies. This compound exhibits its anticancer effects through mechanisms such as the inhibition of DNA synthesis and the induction of apoptosis. It is a valuable tool for research applications aiming to investigate therapies for lymphoid cancers and related diseases.
  39. Purine Nucleoside Analog

    5'-Azido-5'-deoxy-2'-O-(2-methoxyethyl)-5-methyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound functions as a click chemistry reagent due to its azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. It can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with entities possessing DBCO or BCN groups, making it a versatile tool for chemical biological research.
  40. Purine Nucleoside Analog

    5-Bromo-2',3',5'-tri-O-acetyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis in cancer cells, making it a valuable tool for cancer research. This compound is suitable for studies aimed at understanding the effects of nucleoside analogs in therapeutic applications.
  41. Pyrimidine Nucleoside Analog

    4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine functions as a pyrimidine nucleoside analog. This compound exhibits significant biological activity, including the inhibition of DNA and RNA synthesis, as well as antiviral and immunomodulatory effects. It is applicable in biochemical research and cancer studies, providing insights into nucleic acid metabolism and potential therapeutic pathways.
  42. Jasmonic Acid Metabolite

    (+)-7-Isomethyljasmonate is a metabolite involved in the jasmonic acid synthesis pathway. It plays a critical role in plant stress responses and development by modulating plant hormonal signaling. This compound is useful for research in plant biology, particularly in studies investigating stress responses, growth regulation, and the biochemical pathways associated with jasmonic acid functions.
  43. Purine Nucleoside Analog

    3’-Deoxy-N6,N6-dimethyladenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary biological actions include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is applicable in studies focused on therapeutic strategies targeting nucleoside metabolism and cell proliferation in cancer cells.
  44. PNP Inhibitor

    Immucillin-G is a potent inhibitor of purine nucleoside phosphorylase (PNP), a key enzyme in purine metabolism. By inhibiting PNP, Immucillin-G effectively reduces urate levels, making it valuable for research into metabolic disorders, particularly hyperuricemia. Its role in modulating purine metabolism provides significant insights for studies related to gout and metabolic diseases.
  45. Nucleoside Metabolite

    (25R)-3α,7α,12α-Trihydroxy-5β-cholestan-26-oyl-CoA is a nucleoside metabolite that plays a crucial role in cellular metabolism and biochemistry. This compound is involved in the regulation of cholesterol levels and lipid metabolism, making it significant for research in metabolic disorders and cellular signaling pathways. It is particularly useful for studies focusing on cholesterol metabolism and its impact on health and disease mechanisms.
  46. Purine Nucleoside Analog

    5’-O-DMTr-5-iodo-2’-dU-3’-CED phosphoramidite functions as a purine nucleoside analog. It exhibits substantial antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting DNA synthesis and inducing apoptosis. This reagent is suitable for research applications focused on cancer therapeutics and the study of nucleic acid interactions in cellular processes.
  47. Uridine Analog

    2’,3’,5’-Tri-O-acetyl-N3-methyluridine is a uridine analog designed to investigate the biological activities of uridine. This compound exhibits potential antiepileptic properties and serves as a valuable tool for exploring anticonvulsant and anxiolytic mechanisms. Additionally, it may aid in the development of novel antihypertensive agents, expanding its utility in therapeutic research.
  48. Pyrimidine Nucleoside Analog

    7-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a pyrimidine nucleoside analog known for its ability to inhibit DNA and RNA synthesis. This compound exhibits significant biological activities, including antiviral properties and immunomodulation. It is valuable for research applications in cancer therapeutics and virology, providing insights into nucleic acid metabolism and cellular responses.
  49. Protein Modification

    DiBoc-Vidarabine-Ribose(diBoc)-2-cyanoethyl-diisopropylphosphoramidite serves as a phosphoramidite reagent for the modification of proteins. This compound enables the introduction of site-specific modifications to proteins, enhancing their functional properties or stability. It is commonly utilized in biochemical research applications focusing on protein engineering and therapeutic development.
  50. Purine Nucleoside Analog

    N4-Benzoyl-5’-O-DMTr-2’-O-(N3-trifluoroacetyl) aminopropyl cytidine is a purine nucleoside analog. It exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, through mechanisms such as DNA synthesis inhibition and apoptosis induction. This compound is valuable for research in cancer biology, offering insights into therapeutic strategies targeting nucleoside metabolism and DNA replication processes.

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