Orotic acid zinc acts as an active compound involved in the biosynthesis of pyrimidine nucleotides and RNA. It is released as a product from mitochondrial dihydroorotate dehydrogenase (DHODH) and subsequently converted to UMP by UMP synthase in the cytoplasm. This compound is utilized as a biomarker in newborn screening for urea cycle disorders and has been shown to induce hepatic steatosis and hepatomegaly in rodent models, making it relevant for studies in metabolic and liver disorders.
Orotic acid zinc acts as an active compound involved in the biosynthesis of pyrimidine nucleotides and RNA. It is released as a product from mitochondrial dihydroorotate dehydrogenase (DHODH) and subsequently converted to UMP by UMP synthase in the cytoplasm. This compound is utilized as a biomarker in newborn screening for urea cycle disorders and has been shown to induce hepatic steatosis and hepatomegaly in rodent models, making it relevant for studies in metabolic and liver disorders.
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