Catalog No.
Product Name
Application
Product Information
Citations
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Fluorescently Tagged Form of C12-Ceramide
Bodipy C12-ceramide (B12Cer) is a fluorescently labeled derivative of C12-Ceramide, characterized by excitation and emission maxima at 505 nm and 540 nm, respectively. This compound is formed through the hydrolysis of BODIPY-C12 sphingomyelin by acid sphingomyelinase in vitro. Bodipy C12-ceramide is primarily utilized for quantifying acid sphingomyelinase activity in plasma samples, particularly in studies related to Niemann-Pick disease, facilitating insights into sphingolipid metabolism and associated pathologies. -
Fluorescent General Anesthetic
1-Anthramine, also known as 1-aminoanthracene, acts as a fluorescent general anesthetic that enhances GABAergic transmission, exhibiting a binding affinity (Kd) of 0.1 mM to the general anesthetic site in horse spleen apoferritin (HSAF). Its fluorescent properties are significantly increased upon binding to HSAF, making it a valuable tool in research. Additionally, 1-Anthramine potentiates chloride currents induced by GABA and can reversibly inhibit the movement of Xenopus laevis, with an EC50 value of 16 μM, thus offering potential applications in neuroscience and anesthesiology studies. -
Tetrapeptide Fluorescent Substrate
Ac-LVSR-AMC is a tetrapeptide fluorescent substrate designed to quantitatively assess the specific activity of Malt1 protease in vitro. This compound serves as a valuable tool for studying proteolytic processes and Malt1-related signaling pathways. Its fluorogenic properties enable sensitive detection, making it suitable for applications in biochemical assays and research on immune responses. -
Fluorescent Substrate
Coumarin-quinone conjugate acts as a fluorescent substrate specifically for NADH:ubiquinone oxidoreductases, featuring a coumarin fluorophore linked to a ubiquinone analog. This reagent facilitates the measurement of kinetic parameters for AIFM2/FSP1, making it valuable in research focused on ferroptosis and related metabolic processes. Its fluorescent properties enhance detection sensitivity in various biochemical assays. -
Fluorescent Peptide
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide designed as a substrate for TNF-α converting enzyme (TACE; ADAM17), ADAM9, and ADAM10. This peptide utilizes fluorescence resonance energy transfer to monitor enzymatic activity, enabling quantification through changes in fluorescence intensity. It is a valuable tool for studying the roles of these metalloproteinases in various biological processes and may facilitate research in cancer biology and inflammatory diseases. -
Fluorescent Probe
18:1 Liss Rhod PE is a fluorescent phospholipid used as a fluorescent probe. It is highly effective for monitoring dip-pen nanolithography-generated structures through fluorescence microscopy, facilitating large-scale imaging of phospholipid inks. Additionally, 18:1 Liss Rhod PE exhibits phase separation and self-quenching behavior under specific conditions in thin lipid membrane stacks, making it valuable for studies of membrane dynamics and organization. -
Dye Reagents
HB-230 is a red fluorescent probe designed specifically for transglutaminase 2 (TG2). It effectively binds to TG2 and α2-macroglobulin through the LRP1 pathway, facilitating efficient endocytosis. HB-230 exhibits excitation and emission wavelengths of 649 nm and 665 nm, respectively, making it suitable for imaging applications in studies involving TG2. This reagent is valuable for researchers investigating cellular processes associated with TG2 activity. -
Fluorescent Substrate
4-Methylumbelliferyl-α-D-Glucopyranoside is a fluorescent substrate targeting α-glucosidase, which releases the fluorescent moiety 4-methylumbelliferyl (4-MU) upon enzymatic cleavage. This compound exhibits pH-dependent fluorescence, with excitation wavelengths of 320 nm in acidic conditions and 360 nm in alkaline conditions, while its emission increases between 445-455 nm as pH decreases. 4-Methylumbelliferyl-α-D-Glucopyranoside serves as a valuable biomarker for assessing α-glucosidase activity in infant blood spot samples, particularly in the context of Fabry and Pompe diseases. -
Near-infrared Fluorescent Probe
NIR-BG2 is a near-infrared fluorescent probe that selectively targets senescence-associated β-galactosidase (SA-β-Gal). Upon activation by SA-β-Gal, NIR-BG2 undergoes hydrolysis to release an electrophilic quinone methide, which covalently labels surrounding proteins, resulting in a 16-fold increase in fluorescence intensity at 709 nm. This compound is valuable for in vivo imaging studies focused on cellular senescence, enabling researchers to visualize senescent cells effectively. -
Fluorescent Dye
Biotin (5-fluorescein) conjugate is a fluorescently labeled biotin derivative designed for effective cell labeling. This compound exhibits high biological activity in detecting and localizing target molecules in various biomedical research applications. It is particularly useful in immunofluorescence staining experiments, enhancing both sensitivity and specificity in the visualization of biomolecular interactions. -
Fluorescent Dye
PDAM (1-Pyrenyldiazomethane) is a fluorescent dye known for its strong biomarker properties and fluorescence activity. It is utilized in cell imaging for histological studies, allowing for clear delineation of specific cell structures. Additionally, PDAM serves as a hematological stain, enhancing the visualization of cellular components to facilitate more accurate diagnoses in various research applications. -
Fluorescent Peptide
Boc-Ile-Glu-Gly-Arg-AMC is a fluorogenic peptide substrate specifically designed for the activated factor X (FXa). This compound exhibits key biological activity by enabling the quantification of FXa in various biological assays. It is particularly useful in research applications focused on coagulation, thrombin generation, and related hemostatic studies. -
Fluorescence Dye
Cholylglycylamidofluorescein (CGamF) is a fluorescent probe designed to study hepatic bile acid transport mechanisms. This compound is composed of cholic acid linked through a glycylamino bond to fluorescein, offering a fluorescence excitation/emission maxima at 492/515 nm in aqueous solutions. CGamF is utilized in research applications involving bile acid metabolism and transport processes within liver cells, enabling in-depth studies of hepatic function and pathology. -
Anthraquinone Dye
Flavokermesic acid is an anthraquinone dye primarily found in extracts of the Diaspididae family of insects. It serves as a valuable tool for studying the biosynthetic pathways associated with insect-derived anthraquinone pigments, contributing to insights into pigment production and its biological significance. This compound is utilized in various research applications focused on natural product chemistry and insect biology. -
Cereblon Protein Fluorescent Probe
BODIPY FL thalidomide is a high-affinity fluorescent probe that targets human cereblon protein, exhibiting a Kd value of 3.6 nM. This compound is utilized in research applications to study cereblon-mediated pathways and drug-protein interactions. Its fluorescent properties facilitate visualization in cellular assays, making it a valuable tool for investigating the roles of cereblon in various biological processes. -
Sigma-2 Receptor Fluorescent Ligand
SW116 free base is a selective fluorescent ligand for the sigma-2 receptor, exhibiting a binding affinity with a Ki value of 14 nM. This compound displays a maximal excitation wavelength of 333 nm and a maximal emission wavelength of 506 nm when dissolved in methanol. SW116 free base can be internalized by MDA-MB-435 cells, achieving 50% maximum fluorescent intensity within 24 minutes. Due to its properties, it serves as a valuable fluorescent probe in cancer research applications. -
Benzothiazole Dye
BTA-2 is a benzothiazole dye that exhibits enhanced fluorescent signaling when bound to amyloid fibrils. Its unique absorption and emission properties in both solution and fibrillar states make it a valuable tool for identifying amyloid fibrils via spectroscopy. BTA-2 is particularly useful in research applications related to neurodegenerative diseases and the study of protein aggregation. -
Fluorescent Substrate Peptide
Mca-SEVNLDAEFK(Dnp) is a fluorescent substrate peptide specifically designed for the estimation of Beta-secretase 1 (BACE-1) activity. Featuring the 'Swedish' mutation of the amyloid precursor protein (APP) β-secretase cleavage site, this substrate undergoes cleavage at the -Leu-Asp- bond, releasing the highly fluorescent 7-methoxycoumarin (Mca) fragment. This release results in a significant increase in fluorescence intensity due to the removal of the quenching effect from the 2,4-dinitrophenyl (Dnp) moiety, making it a valuable tool for research applications in Alzheimer’s disease and related studies of amyloid pathology. -
fluorescent substrate for BACE1
β-Secretase substrate VI, fluorogenic is a fluorogenic peptide labeled with EDANS and DABCYL, specifically designed for the measurement of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) activity. This substrate enables the quantification of BACE1 enzymatic activity through fluorescence emission (Em=360nm, Ex=528nm), providing a direct correlation between enzyme activity levels and fluorescence intensity. It is an essential tool for researchers studying Alzheimer's disease and related amyloidogenic processes. -
Mitochondria Dye
Methylene Violet 3RAX is a phenazine dye primarily targeting mitochondria for cellular staining. This reagent can alter DNA molecular structure and induce the production of reactive singlet oxygen. It also exhibits inhibitory activity against human erythrocyte acetylcholinesterase (AChE) and human plasma butyrylcholinesterase (BChE) with inhibition constants (Ki) of 1.58 and 0.51 µM, respectively. Methylene Violet 3RAX is valuable for researching potential photosensitizers aimed at mitochondrial targeting in photodynamic therapy (PDT). -
Fluorescent Substrate
Z-Gly-Pro-Arg-4MβNA is a fluorescent substrate specifically designed for the detection of thrombin activity through substrate cleavage. The cleavage releases free 4-methoxy-2-naphthylamine (4MβNA), which can subsequently be captured by 5-nitrosalicylaldehyde, generating a yellow fluorescent product. This characteristic makes Z-Gly-Pro-Arg-4MβNA a valuable tool for studying thrombin activity and related processes in biochemical assays and research applications. -
Fluorescent Dye
Z-Gly-Gly-Arg-AMC TFA is a thrombin-specific fluorogenic substrate that enables the assessment of thrombin generation in both platelet-rich plasma (PRP) and platelet-poor plasma (PPP). This TFA salt form enhances its utility as a fluorescent dye, emitting at 480 nm when excited at 390 nm. It is particularly valuable in research applications focused on coagulation and hemostasis mechanisms. -
TrxR Fluorescent Probe
TRFS-green is a selective fluorescent probe designed for the imaging of thioredoxin reductase (TrxR) in living cells. Upon activation by TrxR, TRFS-green exhibits a significant shift in its maximum absorbance from approximately 373 nm to around 440 nm. This property enables enhanced visualization of selenoprotein activity, making TRFS-green a valuable tool in cellular and biochemical research focused on redox biology and oxidative stress. -
Two-Photon Fluorescent TrxR Probe
TP-TRFS is a selective two-photon fluorescent probe designed to target thioredoxin reductase (TrxR). Its primary mechanism involves the detection of TrxR activity through fluorescence, making it a valuable tool for studying redox biology. This probe is particularly useful for research applications involving oxidative stress, cellular signaling, and cancer biology, enabling real-time monitoring of TrxR in live cells. -
Polyazo Dye/Low Toxicity Dye
Direct Red 80 is a polyazo dye primarily employed in histological staining techniques for collagen and amyloid detection. This reagent exhibits low toxicity and does not release benzidine upon degradation, making it a safer alternative to traditional direct dyes. It is extensively utilized in biological research for visualizing extracellular matrix components and pathological deposits. -
Fluorescent Probe
BSB is a Congo red-derived fluorescent probe that specifically targets amyloid β protein in extracellular spaces, as well as abnormal tau and synuclein protein aggregates within cells. Its primary mechanism involves selective binding, allowing for effective visualization of key pathological features associated with neurodegenerative diseases. BSB serves as a valuable imaging agent for Alzheimer's disease research, providing insights into amyloid and tau pathology. -
Fluorescent Probe
Astrophloxine is a fluorescent imaging probe designed to selectively target antiparallel dimers. It exhibits the ability to detect aggregated amyloid-beta (Aβ) in both brain tissue and cerebrospinal fluid samples from Alzheimer's disease (AD) mouse models. This probe serves as a valuable tool for researchers studying the pathology of AD and developing potential therapeutic interventions. -
Fluorescent RXR Agonist
CU-6PMN is a fluorescent retinoid X receptor (RXR) agonist that selectively activates human RXRα with an EC50 value of 22 nM and a Ki value of 230 nM. This compound exhibits a maximum absorption wavelength of 396 nm and an emission wavelength of 453 nm when dissolved in 0.1 N NaOH aqueous solution. CU-6PMN is valuable for research applications involving RXR ligand screening and provides a useful tool for studying RXR-mediated biological processes. -
Tetrazolium Dye
XTT Sodium is a tetrazolium dye primarily utilized for assessing cell viability based on redox potential. Actively respiring cells reduce XTT, resulting in the formation of a water-soluble orange-colored formazan product. This reagent is commonly employed in cytotoxicity assays and proliferation studies to quantify cellular metabolic activity. -
Non-Fluorescent Probe
2,7-Dichlorodihydrofluorescein (DCFH2) is a non-fluorescent probe specifically designed to detect reactive oxygen species (ROS). Upon hydrolysis by intracellular esterases, DCFH2 reacts with various ROS, including hydroxyl radicals, hydrogen peroxide, and peroxynitrite, to produce the highly fluorescent compound 2,7-dichlorofluorescein (DCF). The fluorescence intensity of DCF directly correlates with ROS levels, making it an essential reagent for quantitatively assessing oxidative stress. This compound is suitable for both in vitro and in vivo applications, including oxidative stress analysis in cell models and targeted delivery studies, such as those utilizing liver-targeted liposomes. -
Azo Dye
PAR (p-Aminobenzoic Acid) is an azo dye that serves as a colorimetric reagent for the detection of metal ions. It forms stable chelates with various metal ions, enabling sensitive measurements in analytical applications. Additionally, PAR is capable of complexing with heavy metal ions in polar organic solvents, such as ethanol, making it useful for environmental and industrial analyses. -
Dye
Alkali Blue 6B monosodium (IND) is a basic dye known for its ability to interact with proteins, making it a valuable reagent in biochemical and medical research applications. It is particularly useful in protein adsorption studies, allowing for the analysis of protein dynamics and interactions. Additionally, the presence of sulfonate, amine, and hydroxyl functional groups enables Alkali Blue 6B monosodium (IND) to bind divalent heavy metal ions, which facilitates the removal of heavy metals from aqueous solutions. -
Fluorescent Substrate
ELF97 phosphate is a fluorescent substrate designed for the specific detection of phosphatase activity. Upon hydrolysis by phosphatases, it generates a fluorescent, water-insoluble product known as ELF97 alcohol. This compound is valuable for studying and quantifying the activity of extracellular phosphatases in algal species present in natural water environments. -
Organic Dye
CI Vat Green 1 is an organic dye primarily used for textile applications. This vat dye demonstrates excellent wash, light, and rubbing fastness, making it ideal for use in high-quality fabric dyeing processes. Its robust performance ensures durability in various environmental conditions, enhancing the longevity and aesthetic appeal of dyed materials. Research applications may include studies in textile engineering and color stability assessments. -
DGK Fluorescent Substrate
1-NBD-decanoyl-2-decanoyl-sn-glycerol is a fluorescently labeled diacylglycerol (DAG) derivative, specifically designed as a substrate for diacylglycerol kinase (DGK). This compound enables quantitative detection of DGK enzyme kinetics in vitro, facilitating the study of DAG and phosphatidic acid (PA) dynamics during cellular signaling processes. Its application extends to various research areas, including cell biology and biochemistry, where understanding lipid signaling pathways is critical. -
Fluorescent Substrate
MUF-diNAG (4-Methylumbelliferyl N,N-diacetyl-β-D-chitobioside) serves as a fluorescent substrate, allowing for the detection of enzymatic activity. This compound is particularly useful in studies involving glycosidases and chitinases, enabling researchers to investigate carbohydrate metabolism and related biochemical pathways. Its fluorescent properties make it an essential tool in various life science applications, including enzyme assays and cellular imaging. -
Dye
Celliton Fast Blue Green B is a synthetic dye primarily used in textile applications. This compound exhibits excellent color fastness while demonstrating minimal skin irritation and sensitization in laboratory studies. It is suitable for research focused on colorant safety and biocompatibility in various consumer products. -
Fluorescent Tag
2-Aminobenzanilide serves as a fluorescent tag, primarily utilized in glycan analysis. This stable and neutral compound acts as a competent ambident nucleophile, facilitating various important reactions, including the Bargellini reaction. Additionally, 2-aminobenzanilide and its derivatives play a role in the blood coagulation cascade, making them valuable in biochemical research and analysis. -
pH-Indicating Dye
Bromochlorophenol Blue sodium salt is a pH-indicating dye that exhibits acid-sensitive properties. This compound is widely used in various biochemical assays and laboratory applications to monitor pH changes in solution. Its color transition occurs within a pH range of approximately 3.0 to 4.6, making it suitable for applications in analytical chemistry and microbiology. -
Triarymethane Dye
Acid Blue 9 (Diammonium) is a triarylmethane dye known for its role as a chromosomal aberration inducer. It demonstrates cytogenetic toxicity, particularly in onion root tip meristematic cells, making it a valuable tool for studies in genotoxicity and cytogenetics. This reagent can be utilized in research applications aimed at understanding the mechanisms of DNA damage and the effects of chemical exposures on plant cells. -
Fluorescent Probe
Citrulline-specific probe-biotin is a biotinylated fluorescent probe designed for the detection of citrulline, a hydrolysis product of arginine produced by the enzyme protein arginine deiminase (PAD). Increased PAD activity is implicated in various pathological conditions, including autoimmune diseases and inflammatory disorders. This probe facilitates the identification of diseases characterized by elevated citrulline levels and is particularly useful in animal models of ulcerative colitis for studying disease mechanisms and potential therapeutic interventions. -
Fluorescent Substrate
NBD-sphinganine is a fluorescent substrate for ceramide synthase (CerS), enabling the detection of CerS activity. Its fluorescence properties make it a valuable tool for studying sphingolipid metabolism and ceramide signaling pathways in various biological contexts. This compound is useful in research applications focusing on cell signaling, lipid biology, and related diseases. -
Coumarin Dye
6-Aminocoumarin hydrochloride is a coumarin dye characterized as a donor-acceptor compound, featuring an amine group as the electron donor and a carbonyl group as the acceptor. This compound exhibits fluorescence properties, making it useful in various biological and chemical assays. Its applications extend to studying cellular imaging, protein labeling, and as a fluorescent probe in biochemical research. -
Azo Dye
Methyl red hydrochloride is an azo dye primarily utilized as a pH indicator. It exhibits distinct color changes from red at pH 4.4 to yellow at pH 6.0, making it valuable for monitoring pH levels in various biological and chemical experiments. Its applications span across microbiology, pharmaceuticals, and environmental testing, where precise pH measurements are crucial. -
Fluorescent Dye
H-L-Ile-Amc TFA is a fluorescent dye that serves as a substrate for aminopeptidases, enabling the detection of yeasts and molds in various samples. This compound is particularly useful in microbiological research and diagnostics, facilitating the identification and quantification of fungal contamination. Its sensitivity and specificity make it a valuable tool in microbial monitoring and food safety applications. -
Fluorescent Dye
4-Nitrophenyl 2-O-(β-L-Fucopyranosyl)-β-D-Galactopyranoside is a synthetic chromogenic substrate primarily utilized for the assessment of α-fucosidase activity. This compound is hydrolyzed by α-fucosidase, releasing a measurable p-nitrophenol as a product, which can be quantified through subsequent action of exogenous exo-β-D-galactosidase. It is valuable in biochemical research involving fucosidase assays and the study of glycosidic bond hydrolysis. -
Yellow Dye
C.I. Solvent Yellow 33 is a yellow dye primarily employed for its coloring properties in industrial applications and signaling devices. This non-toxic compound exhibits strong dyeing capabilities, making it suitable for various formulations. Its utility spans across multiple sectors, including manufacturing and maritime signaling. -
Fluorescent Dye
L-Arginine 7-amido-4-methylcoumarin dihydrochloride is a fluorescent substrate designed for the detection of cathepsin H activity. This compound generates highly sensitive fluorescent signals, making it valuable for various biological research applications, particularly in enzyme activity analysis. Its specificity and sensitivity enhance the study of protease-related biological processes, facilitating advancements in the understanding of cellular functions and disease mechanisms. -
Fluorescent Dye
7-Amino-1,3-naphthalenedisulfonic acid monopotassium monohydrate functions primarily as a fluorescent dye. It is effective in labeling carbohydrates, exhibiting excitation and emission wavelengths at 310 nm and 450 nm, respectively. This reagent is valuable for studies in carbohydrate biochemistry and various fluorescence-based applications in biochemical research. -
Fluorescent Substrate
Z-LRGG-AMC (Z-Leu-Arg-Gly-Gly-AMC) is a fluorescent substrate that specifically targets proteases for hydrolysis, resulting in the release of the fluorescent molecule 7-amino-4-methylcoumarin (AMC). This compound is utilized in various research applications, particularly for studying protease activity in different biological systems. The fluorescence of AMC can be detected at an excitation/emission wavelength of 360/460 nm, making Z-LRGG-AMC a valuable tool for quantitative protease assays.
