1-Anthramine, also known as 1-aminoanthracene, acts as a fluorescent general anesthetic that enhances GABAergic transmission, exhibiting a binding affinity (Kd) of 0.1 mM to the general anesthetic site in horse spleen apoferritin (HSAF). Its fluorescent properties are significantly increased upon binding to HSAF, making it a valuable tool in research. Additionally, 1-Anthramine potentiates chloride currents induced by GABA and can reversibly inhibit the movement of Xenopus laevis, with an EC50 value of 16 μM, thus offering potential applications in neuroscience and anesthesiology studies.
1-Anthramine, also known as 1-aminoanthracene, acts as a fluorescent general anesthetic that enhances GABAergic transmission, exhibiting a binding affinity (Kd) of 0.1 mM to the general anesthetic site in horse spleen apoferritin (HSAF). Its fluorescent properties are significantly increased upon binding to HSAF, making it a valuable tool in research. Additionally, 1-Anthramine potentiates chloride currents induced by GABA and can reversibly inhibit the movement of Xenopus laevis, with an EC50 value of 16 μM, thus offering potential applications in neuroscience and anesthesiology studies.
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