NIR-BG2 is a near-infrared fluorescent probe that selectively targets senescence-associated β-galactosidase (SA-β-Gal). Upon activation by SA-β-Gal, NIR-BG2 undergoes hydrolysis to release an electrophilic quinone methide, which covalently labels surrounding proteins, resulting in a 16-fold increase in fluorescence intensity at 709 nm. This compound is valuable for in vivo imaging studies focused on cellular senescence, enabling researchers to visualize senescent cells effectively.
NIR-BG2 is a near-infrared fluorescent probe that selectively targets senescence-associated β-galactosidase (SA-β-Gal). Upon activation by SA-β-Gal, NIR-BG2 undergoes hydrolysis to release an electrophilic quinone methide, which covalently labels surrounding proteins, resulting in a 16-fold increase in fluorescence intensity at 709 nm. This compound is valuable for in vivo imaging studies focused on cellular senescence, enabling researchers to visualize senescent cells effectively.
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