Catalog No.
Product Name
Application
Product Information
Citations
- KI696 isomer is the less active isomer of KI696. KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction.
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Nrf2 Activator
Artemisitene is a natural derivative of Artemisinin that functions as a Nrf2 activator. It enhances antioxidant and anticancer activities by reducing Nrf2 ubiquitination, thereby increasing its stability. This compound is utilized in research focused on oxidative stress, cancer biology, and the modulation of cellular defense mechanisms. -
Apoptosis Inducer
Ganoderic Acid D is a tetracyclic triterpenoid derived from Ganoderma lucidum, known for its role as an apoptosis inducer. This compound facilitates the upregulation of SIRT3 protein expression, leading to enhanced deacetylation of cyclophilin D (CypD). Ganoderic Acid D effectively disrupts energy metabolism in colon cancer cells by inhibiting glucose uptake, lactate production, and the synthesis of pyruvate and acetyl-CoA. Additionally, it demonstrates potent apoptotic effects in HeLa human cervical carcinoma cells, making it a valuable reagent for cancer research applications. -
COX-2 Specific Inhibitor
SC-236 is a selective inhibitor of cyclooxygenase-2 (COX-2) with an IC50 of 10 nM and also acts as a PPARĪ³ agonist. It effectively suppresses activator protein-1 (AP-1) through the inhibition of c-Jun NH2-terminal kinase, demonstrating significant anti-inflammatory effects. SC-236 has been shown to reduce ERK phosphorylation in murine models, highlighting its potential for investigating inflammatory pathways and therapeutic interventions. -
TLR-9 Agonist
ODN M362 is a class C oligodeoxynucleotide that acts as a TLR-9 agonist, promoting immune responses through the stimulation of toll-like receptor 9. This reagent is effective in inducing apoptosis in cancer cells, making it valuable for immunological studies and the development of therapeutic vaccines. Its application as a vaccine adjuvant enhances the efficacy of antigen-specific responses in research settings. -
Arginase Inhibitor
Nor-NOHA dihydrochloride is a selective and reversible inhibitor of arginase, particularly impacting the activity of ARG2 under hypoxic conditions. This compound has been shown to induce apoptosis in ARG2-expressing cells and demonstrates anti-leukemic properties. Nor-NOHA dihydrochloride is useful for research applications related to endothelial dysfunction, immunosuppression, and metabolic studies. -
COX-2 Inhibitor
Humulone, a prenylated phloroglucinol derivative, is a selective inhibitor of cyclooxygenase-2 (COX-2). It demonstrates significant anti-inflammatory properties and serves as a positive modulator of GABAA receptors at low micromolar concentrations. Additionally, Humulone is known to inhibit bone resorption and exhibits antioxidant, anti-angiogenic, and pro-apoptotic activities, making it valuable for various research applications in inflammation and cancer studies. -
PD-L1 Inhibitor
PD-L1-IN-1 is a potent inhibitor targeting programmed cell death ligand 1 (PD-L1) with an IC50 of 115 nM. It effectively disrupts the PD-L1 and PD-1 interaction, enhancing antitumor immune responses in co-cultures of PD-L1 expressing cancer cells and peripheral blood mononuclear cells. Additionally, PD-L1-IN-1 demonstrates low cytotoxicity towards healthy cells, making it a valuable tool for immunological research and therapeutic applications in cancer treatment. -
COX-2 Inhibitor
DuP-697 is a potent, irreversible, and selective inhibitor of cyclooxygenase-2 (COX-2), exhibiting an IC50 of 10 nM for human COX-2 and 800 nM for COX-1. This compound demonstrates significant antiproliferative effects on HT29 colorectal cancer cells with an IC50 of 42.8 nM, as well as antiangiogenic and pro-apoptotic activities. By inhibiting prostaglandin synthesis, DuP-697 offers potential applications in studies related to inflammation, cancer, and fever reduction. -
CD47 Agonist
Thrombospondin-1 (1016-1023) is a peptide derived from the C-terminal region of Thrombospondin-1 (TSP-1) and functions as a CD47 agonist. This peptide plays a crucial role in modulating immune responses and promoting cell survival by interacting with the CD47 receptor. It is widely utilized in research focusing on immunology, cancer biology, and the study of cell migration and adhesion. -
Antioxidant/Anti-inflammatory Agent
S-Allylmercaptocysteine is an organic sulfur compound that acts as both an antioxidant and anti-inflammatory agent. This compound exhibits significant efficacy in various pulmonary diseases by reducing oxidative stress and inflammation. S-Allylmercaptocysteine also demonstrates potential anti-cancer activity by inducing apoptosis in cancer cells via the TGF-Ī² signaling pathway, while modulating NF-ĪŗB activity and up-regulating Nrf2 to enhance its therapeutic effects. -
Anti-inflammatory Agent
Sodium taurodeoxycholate hydrate is an anionic detergent derived from bile salts, primarily acting as an anti-inflammatory agent. Its key biological activity includes facilitating the isolation of membrane proteins, particularly those associated with the inner mitochondrial membrane. Additionally, sodium taurodeoxycholate hydrate exhibits neuroprotective properties, making it useful in various research applications related to inflammation and neurobiology. -
Keap1-Nrf2 PPI Inhibitor
Tricetin is a competitive inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI). This compound exhibits neuroprotective effects by activating the Nrf2/HO-1 signaling pathway, which mitigates 6-OHDA-induced neurotoxicity in models of Parkinson's disease. Its mechanism of action helps to prevent apoptosis through mitochondrial pathways, making it a valuable reagent for research into neurodegenerative diseases and oxidative stress response. -
Anti-Inflammatory Agent
Cannflavin A is a natural flavonoid extracted from Cannabis sativa L., primarily functioning as an anti-inflammatory agent. It exhibits significant anti-cancer and neuroprotective properties, inhibiting AĪ²1-42 aggregation and demonstrating activity against kynurenine-3-monooxygenase with an IC50 of 29.4 Ī¼M. Cannflavin A promotes apoptosis through caspase-3 cleavage and effectively reduces inflammation by targeting pro-inflammatory enzymes such as prostaglandin E2 and cytochrome c oxidases I and II in PC12 cell line studies. This compound is valuable for research related to inflammatory diseases and neurodegenerative disorders. -
ADAM-17 Inhibitor
ZLDI-8 is an inhibitor of the metalloproteinase enzyme ADAM-17, targeting the cleavage of Notch protein. This compound effectively reduces the expression of proteins associated with pro-survival pathways and epithelial-mesenchymal transition (EMT). Additionally, ZLDI-8 functions as a competitive and irreversible inhibitor of the tyrosine phosphatase Lyp, exhibiting an IC50 of 31.6 Ī¼M and a Ki of 26.22 Ī¼M. Notably, ZLDI-8 demonstrates potent growth inhibition of MHCC97-H cells with an IC50 of 5.32 Ī¼M, making it valuable for research into cellular signaling and cancer biology. -
MALT1 Inhibitor
SGR-1505 is a small molecule inhibitor targeting MALT1, effectively modulating the NF-ĪŗB signaling pathway. This compound demonstrates significant anti-proliferative and antitumor activities by inhibiting MALT1 enzymatic activity, leading to alterations in cell cycle progression, DNA damage response, and apoptosis-related gene expression in in vivo tumor models. SGR-1505 exhibits both tumorostatic and regressive effects in activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) xenograft models. It is a valuable tool for research into activated B-cell-like diffuse large B-cell lymphoma, non-Hodgkin B-cell lymphomas, chronic lymphocytic leukemia, and mature B cell neoplasms. -
Anti-inflammatory Agent
Aloesone is a phenolic compound that serves as an anti-inflammatory agent. It effectively inhibits the production of reactive oxygen species (ROS), the release of nitric oxide (NO), M1 polarization, and apoptosis in LPS-stimulated RAW264.7 cells. This compound exhibits notable anti-inflammatory and antioxidant properties, making it a valuable tool for research in inflammation and oxidative stress. -
Anti-cancer Agent
Dihydromethysticin is a naturally occurring compound primarily targeting carboxylesterase 1 and CYP2A5. This orally active agent has demonstrated the ability to upregulate NLRC3 and induce apoptosis, showcasing its potential as an anti-cancer agent. Research indicates that dihydromethysticin exhibits significant anticancer activity against colorectal cancer and lung adenoma, making it a valuable tool in cancer research and therapeutic development. -
COX Inhibitor
Metamizole sodium is a potent cyclooxygenase (COX) inhibitor that exhibits significant anti-inflammatory, analgesic, and antipyretic properties. This compound not only inhibits cell proliferation but also promotes apoptosis in various cell types. Additionally, Metamizole sodium serves as a spasmolytic agent, making it a valuable tool for research applications aimed at pain relief and the study of inflammatory processes. Its multifunctional activities contribute to its utility in diverse areas of biomedical research. -
iNOS Inhibitor
1400W is a selective inhibitor of inducible nitric-oxide synthase (iNOS) with a Kd value of ā¤ 7 nM, demonstrating slow and tight binding characteristics. This compound effectively inhibits iNOS induction in microglial cells, leading to reduced nitric oxide production, which in turn helps alleviate oxidative stress and neuronal apoptosis in the rat cerebral cortex. 1400W's ability to ameliorate spatial memory dysfunction associated with acute hypobaric hypoxia-reoxygenation makes it a valuable tool for research in neuroprotection and neurodegenerative disease studies. -
Keap1-Nrf2 Activator
CDDO-TFEA is a trifluoroacetamide derivative of CDDO and serves as a potent Keap1-Nrf2 activator. This compound effectively enhances Nrf2 expression and signaling in various models of neurodegenerative diseases, such as multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. In cancer research, CDDO-TFEA demonstrates significant biological activity by inducing apoptosis and inhibiting colony formation in Ewing's sarcoma and neuroblastoma cell lines, with IC50 values ranging from 85 to 170 nM. -
CD37-Targeted ADC
Naratuximab emtansine is a CD37-targeted antibody-drug conjugate (ADC) that combines a humanized IgG1 monoclonal antibody with the microtubule disruptor DM1. This compound exhibits high affinity and specificity for the CD37 antigen, facilitating internalization and subsequent release of DM1 intracellularly. By disrupting microtubule assembly, Naratuximab emtansine leads to cell cycle arrest and apoptosis, making it a valuable tool for research in targeted cancer therapies and hematological malignancies. -
Anti-inflammatory Agent
[D-Leu-4]-OB3 is an anti-inflammatory agent that selectively inhibits the expression of pro-inflammatory, proliferative, and metastatic genes while downregulating PD-L1 expression. Additionally, it promotes the expression of pro-apoptotic genes, contributing to its potential in cancer research. This compound is valuable for studies focused on inflammatory responses and cancer progression. -
pan-SIK/PAK2/3 Inhibitor
MRIA9 is an ATP-competitive inhibitor targeting pan Salt-Inducible kinases (SIK) as well as PAK2 and PAK3. It exhibits potent biological activity with IC50 values of 516 nM for SIK1, 180 nM for SIK2, and 127 nM for SIK3. MRIA9 is suitable for applications in signaling pathway research and the study of various cellular processes influenced by SIK and PAK kinases. -
Anti-inflammatory Agent
Delphinidin-3-sambubioside chloride is a naturally occurring anthocyanin recognized for its anti-inflammatory properties. This compound effectively inhibits the release of inflammatory factors induced by lipopolysaccharides (LPS) and demonstrates the ability to reduce hepatic lipid accumulation in high-fat diet rat models. Delphinidin-3-sambubioside chloride is extracted from Hibiscus sabdariffa L. and serves as a valuable tool for studying inflammation-related biological processes. -
E3 ligase ligand-linker conjugate
Thalidomide-4-O-C6-NH2 hydrochloride is an E3 ligase ligand-linker conjugate that plays a critical role in the targeted protein degradation (PROTAC) system, specifically in dTAG-13 applications. This compound is utilized for its ability to degrade FKBP12F36V and bromodomain and extraterminal (BET) proteins, facilitating the modulation of various cellular processes. Its utility in research allows for advancements in understanding protein function and the development of therapeutic strategies. -
Nrf2 Activator
Danshensu sodium, a phenolic compound, serves as an Nrf2 activator, effectively inducing the Nrf2/HO-1 signaling pathway while inhibiting NF-ĪŗB activity. It diminishes reactive oxygen species (ROS) production, enhances antioxidant defenses, and suppresses intrinsic apoptosis. Additionally, Danshensu sodium exhibits significant antiviral properties against SARS-CoV-2, with an EC50 value of 0.97 Ī¼M. This compound is valuable for researching its anti-oxidative, anti-inflammatory, and anti-apoptotic effects, holding potential implications for COVID-19, cardiovascular, and cerebrovascular diseases. -
GCK/MAP4K2 Inhibitor
TL4-12 is a selective inhibitor of MAP4K2 and GCK, demonstrating a dose-dependent ability to downregulate IKZF1 and BCL-6. This compound effectively inhibits cell proliferation in multiple myeloma with an IC50 of 37 nM, and it also induces apoptosis in cancerous cells. TL4-12 holds potential for overcoming resistance to immunomodulatory agents in the treatment of multiple myeloma. -
PTPN2/1 Dual Inhibitor
PTPN2/1-IN-4 is a potent dual inhibitor of PTPN1 and PTPN2, exhibiting IC50 values of 12.8 nM and 5.8 nM, respectively. This compound effectively modulates the IFNĪ³-JAK-STAT signaling pathway, resulting in enhanced CD8+ T-cell infiltration into tumors. PTPN2/1-IN-4 demonstrates significant anticancer activity, inhibiting tumor growth both as a standalone treatment and in combination with anti-PD-1 antibodies in B16-OVA syngeneic mouse models, making it a valuable tool for cancer research. -
JAK2 Inhibitor
Tkip is a selective inhibitor of JAK2, targeting the JAK2 autophosphorylation site. It effectively inhibits JAK2 autophosphorylation and the phosphorylation of the IFN-Ī³ receptor subunit IFNGR-1, thereby reducing the antiviral effects of IFN-Ī³ and downregulating MHC Class I molecule expression. Tkip is a valuable tool for investigating the IFN-Ī³ signaling pathway and its implications in various biological processes. -
Cardioprotective Agent
Kanglexin is a novel anthraquinone compound that acts as a cardioprotective agent by inhibiting NLRP3 inflammasome activation and cell pyroptosis. This compound promotes angiogenesis through the FGFR1/ERK signaling pathway and enhances diabetic wound healing. Additionally, Kanglexin exhibits lipid-lowering effects and inhibits the dedifferentiation of vascular smooth muscle cells, making it a valuable tool for researching hyperlipidemia, fatty liver disease, and atherosclerosis. -
Antiinflammatory Agent
Resolvin D3 (RvD3) is a bioactive mediator derived from docosahexaenoic acid (DHA) with potent anti-inflammatory properties. This compound plays a crucial role in resolving inflammation, making it particularly relevant for research into inflammatory conditions such as arthritis. By modulating immune responses, Resolvin D3 facilitates the resolution of inflammation, providing insights into therapeutic strategies for inflammatory diseases. -
StableĀ Isotope
Carvedilol-d3 is a deuterium-labeled analogue of Carvedilol, functioning primarily as a non-selective Ī²/Ī±-1 adrenergic receptor blocker. It exhibits significant biological activity by inhibiting lipid peroxidation in a dose-dependent manner with an IC50 value of 5 Ī¼M. This compound serves as a versatile antihypertensive agent and has potential applications in the treatment of angina and congestive heart failure. Furthermore, Carvedilol-d3 promotes autophagy and is known to inhibit the NLRP3 inflammasome, making it valuable for research involving inflammatory processes. -
StableĀ Isotope
Carvedilol-d5 is a deuterium-labeled analogue of Carvedilol, a non-selective Ī²/Ī±-1 adrenergic receptor blocker. It exhibits lipid peroxidation inhibition with an IC50 of 5 Ī¼M and serves as a versatile antihypertensive agent, showing potential in the treatment of angina and congestive heart failure. Additionally, Carvedilol functions as an autophagy inducer and inhibits the NLRP3 inflammasome, making it relevant for research in inflammatory pathways and cardiovascular health. -
COX Inhibitor
Indomethacin farnesil is a prodrug of indomethacin, primarily targeting cyclooxygenase (COX) enzymes. This potent, blood-brain barrier-permeable inhibitor exhibits nonselective activity against COX-1 and COX-2, with IC50 values of 18 nM and 26 nM, respectively. Indomethacin farnesil has been shown to disrupt autophagic flux by impairing lysosomal function, making it useful for investigating inflammatory pathways and autophagy-related processes in research applications. -
ULK1/ULK2 Inhibitor
SBP-5147 is a potent inhibitor of ULK1 and ULK2, exhibiting an IC50 of 2 nM for ULK1 and 53 nM for ULK2. This compound effectively inhibits the phosphorylation of Beclin-1 and Vps34, reduces autophagic flux, and downregulates the expression of key autophagy-related proteins ATG13 and ATG101. Additionally, SBP-5147 enhances MHC-I expression, induces caspase-dependent apoptosis, and decreases the viability of non-small cell lung cancer cells. Its mechanism of action makes SBP-5147 a valuable tool for research in non-small cell lung cancer and autophagy modulation. -
CATS Inhibitor
Z-Val-Val-Nle-diazomethylketone is a selective inhibitor of cathepsin S (CATS). This compound effectively reduces the IFNg-induced upregulation of MHCII molecules, specifically HLA-DR and Ii-p33/35, while promoting an increase in the Ii-p10 protein level. It is valuable for research into dermatological conditions such as psoriasis, atopic dermatitis, and actinic keratosis. -
Anti-inflammatory Agent
Fmoc-Leucine, an anti-inflammatory agent, functions primarily as a selective ligand for PPARĪ³, with a binding affinity (Ki) of 15 Ī¼M. It promotes both extracellular Ca2+ influx and intracellular Ca2+ release while exhibiting insulin-sensitizing effects with minimal fatogenic activity. This compound demonstrates unique self-assembly characteristics, forming transient gels, stable gels, or crystals/2D sheets under varying conditions. Fmoc-Leucine is valuable for research related to diabetes, colitis, and bladder cancer. -
Anti-inflammatory Agent
Hexadecanamide is a fatty acid amide that serves as an anti-inflammatory agent, exhibiting protective effects against Staphylococcus aureus and SARA-induced mastitis. It functions by suppressing S. aureus-mediated NF-ĪŗB activation and enhancing blood-milk barrier integrity. Additionally, Hexadecanamide activates PPARĪ± and has been shown to improve sperm motility in vitro. This compound is relevant for research applications involving mastitis and asthenozoospermia. -
Anti-Inflammatory/Cancer Agent
Norathyriol is a natural metabolite derived from Mangifera, exhibiting significant anti-inflammatory and anticancer properties. It functions as a noncompetitive inhibitor of Ī±-glucosidase with an IC50 value of 3.12 Ī¼M. Additionally, Norathyriol inhibits the peroxisome proliferator-activated receptors (PPARs) Ī±, Ī², and Ī³, with IC50s of 92.8 Ī¼M, 102.4 Ī¼M, and 153.5 Ī¼M, respectively. This compound demonstrates a range of biological activities, including antioxidant, antimicrobial, and antibacterial effects, making it valuable for diverse research applications in inflammation and cancer therapeutics. -
Anti-inflammatory
1-O-Hexadecylglycerol serves as an anti-inflammatory agent by upregulating PPAR-Ī³ expression and inhibiting prostaglandin E2 (PGE2) synthesis. This compound demonstrates significant biological activity in reducing inflammation and is suitable for various research applications focused on inflammatory processes. Its efficacy is noted in oral administration, facilitating its potential use in preclinical studies and therapeutic exploration. -
Anti-inflammatory Agent
Adelmidrol is an anti-inflammatory agent that primarily targets peroxisome proliferator-activated receptor gamma (PPARĪ³). This compound mediates significant reductions in NF-ĪŗB translocation and COX-2 expression, contributing to its anti-inflammatory effects. Adelmidrol is utilized in research focused on inflammation pathways and therapeutic potential in various inflammatory conditions. -
mPGES-1/5-LOX Inhibitor
YS121 is a dual inhibitor targeting microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LOX), with IC50 values of 3.4 Ī¼M and 6.5 Ī¼M, respectively. It demonstrates specific, reversible binding to mPGES-1, indicated by a KD of 10-14 Ī¼M. YS121 reduces PGE2 production in IL-1Ī²-stimulated A549 cells with an EC50 of 12 Ī¼M and activates PPAR-Ī± and PPAR-Ī³, with EC50 values of 1 Ī¼M and 3.6 Ī¼M, respectively. Additionally, YS121 exhibits significant anti-inflammatory effects in human whole blood and in vivo, making it a valuable tool for pleurisy research. -
Anti-Inflammatory Agent
3-Aminoisobutyric acid is an anti-inflammatory agent that exhibits both anti-inflammatory and antioxidant properties. It enhances the expression of genes associated with brown adipocytes in white adipose tissue and promotes fatty acid Ī²-oxidation in hepatocytes. Additionally, 3-Aminoisobutyric acid mitigates insulin resistance and inflammation triggered by palmitate or a high-fat diet through an AMPK-PPARĪ“-dependent pathway in murine models. This compound also serves as a catabolic metabolite of thymine and valine within skeletal muscle, making it relevant for metabolic research. -
Anti-Inflammatory Agent
Romazarit, a PPARĪ± agonist, serves as an effective anti-inflammatory agent with demonstrated antirheumatic properties. In studies, Romazarit has been shown to inhibit the development of hindpaw inflammation at a dosage of 30 mg/kg in an adjuvant arthritis model. This compound is of interest for research applications focusing on inflammatory diseases and therapeutic interventions in arthritis. -
Anti-inflammatory Agent
(3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-Ī²-D-glucopyranoside functions as an anti-inflammatory agent. This diarylheptanol glycoside, derived from Tacca plantaginea, effectively inhibits TNF-Ī±-induced NF-ĪŗB transcriptional activity with an IC50 of 9.4 Ī¼M. Additionally, it activates PPAR transcriptional activity (EC50 = 9.9 Ī¼M) and exhibits a specific activating effect on PPAR Ī²(Ī“) with an EC50 of 23.1 Ī¼M. Non-toxic to cells at tested concentrations, this compound is suitable for research on inflammatory conditions. -
COX-2 Inhibitor/PPAR-Ī³ Activator
Zaltoprofen sulfoxide is a selective COX-2 inhibitor with an IC50 of 45.38 nM, as well as a PPAR-Ī³ activator. This compound effectively inhibits NF-ĪŗB and MAPK inflammatory signaling pathways, making it a valuable tool in the study of inflammation and acute lung injury models. It is particularly relevant for research focused on LPS-induced acute lung injury. -
Antioxidant
Dihydrolipoic Acid (DHLA) is a potent antioxidant primarily targeting reactive oxygen species. It demonstrates significant anti-inflammatory effects across various disease models. Research indicates that DHLA can modulate the ERK/Nrf2/HO-1/ROS/NLRP3 signaling pathway, effectively mitigating sickness behavior in LPS-induced rat models. This compound is valuable for studies related to depression and oxidative stress-related disorders. -
Nrf2 Inhibitor
Nrf2-IN-3 is a small-molecule inhibitor targeting Nrf2 by enhancing the production of reactive oxygen species (ROS). It specifically binds to KEAP1 mutants, restoring their ability to inhibit Nrf2 and facilitating proteasome-dependent degradation of Nrf2 in cells. This compound has shown potential in sensitizing KEAP1-mutated tumor cells to chemotherapeutic agents such as Cisplatin and Gefitinib, making it a valuable tool for research in cancer therapeutics and Nrf2-related signaling pathways.
