1400W is a selective inhibitor of inducible nitric-oxide synthase (iNOS) with a Kd value of ≤ 7 nM, demonstrating slow and tight binding characteristics. This compound effectively inhibits iNOS induction in microglial cells, leading to reduced nitric oxide production, which in turn helps alleviate oxidative stress and neuronal apoptosis in the rat cerebral cortex. 1400W's ability to ameliorate spatial memory dysfunction associated with acute hypobaric hypoxia-reoxygenation makes it a valuable tool for research in neuroprotection and neurodegenerative disease studies.
1400W is a selective inhibitor of inducible nitric-oxide synthase (iNOS) with a Kd value of ≤ 7 nM, demonstrating slow and tight binding characteristics. This compound effectively inhibits iNOS induction in microglial cells, leading to reduced nitric oxide production, which in turn helps alleviate oxidative stress and neuronal apoptosis in the rat cerebral cortex. 1400W's ability to ameliorate spatial memory dysfunction associated with acute hypobaric hypoxia-reoxygenation makes it a valuable tool for research in neuroprotection and neurodegenerative disease studies.
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